• Nutritional Sciences
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• v.1 no.1
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• pp.22-28
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• 1998

Plasma concentrations of Vitamins E and A were measured in 15 non-insulin dependent Korean female subjects and 15 age-matched normal subjects using reversed-phase high-performance liquid chromatography. No differences were found in plasma Vitamin E concentrations between the 2 groups. Plasma Vitamin A concentrations were higher in subjects with non-insulin dependent diabetes melitus (NIDDM). The effects were evaluated of 4 weeks of daily supplementation of 400 mg Vitamin E on plasma levels of these two vitamins. In addition, the effects were observed for Vitamin E supplementation on oxidative stress and immune-related compound productions in non-insulin dependent diabetic patients and control subjects. After treatment with Vitamin E, plasma Vitamin E concentrations were significantly elevated in both groups. Basal plasma thiobarbituric acid reactive substances (TBABS) were identical, and a decreased level of TBARS caused by Vitamin E was observed only in the diabetic group (0.02739$\pm$0.0024 versus 0.01814$\pm$0.0008 nmols malondialdehyde equivalents/dl plasma ; p<0.05). The basal and after-treatment levels of immunoglobulins A, G, M were identical in control and diabetic groups, indicating that Vitamin E did not appear to alter gross humoral responses in this study. However, elevation of Complement 3 ($C_3$) was noticed due to Vitamin E supplementation, revealing a possible effect of vitamin E on one aspect of humoral immunity, Furthermore, an increase in prostaglandin E_2 ($PGE_2$) levels in diabetic patients was normalized by Vitamin E supplementation. This suggests indirectly that the depressed cell-mediated response due to elevated $PGE_2$ could be normalized. For the definitive antioxidant intake recommendations for prevention and treatment of adverse effects of non-insulin dependent diabetes, evidence from intervention trials like this study should be collected. The present data suggests that Vitamin E may oxen some protective effects against oxidative damage and might have beneficial effects of partial immune-stimulation.

• Geotechnical Engineering
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• v.6 no.1
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• pp.15-24
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• 1990

This paper describes the results of study on major factors influencing time-dependent deformation behaviour of swelling shales. The study was carried out by analyzing all the swell test results available for shales from southern Ontario. Major factors studied are (1) the presence of ambient water, (2) calcite content and (3) the applied stress. The results of the study on seven shales show that the swelling of shale is associated with the formation of cracks and the absorption of water in these cracks. The magnitude of swelling potential is related linearly to the amount of absorbed water. The presence of calcite inhibits the swelling of shales studied, reducing the swelling to zero at about 30% of calcite content. All the shales studied exhibit the stress-dependent swelling behaviour, though there Is a difference in the degree of dependency.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2009.10a
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• pp.227-230
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• 2009

In order to predict failure behavior of advanced high-strength steel sheets (AHSS) in hole expansion tests, damage model was developed considering surface condition sensitivity (with specimens prepared by milling and punching: 340R, TRIP590, TWIP940). To account for the micro-damage initiation and evolution as well as macro-crack formation, the stress triaxiality dependent fracture criterion and rate-dependent hardening and ultimate softening behavior were characterized by performing numerical simulations and experiments for the simple tension and V-notch tests. The developed damage model and the characterized mechanical property were incorporated into the FE program ABAQUS/Explicit to perform hole expansion simulations, which showed good agreement with experiments.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2005.05a
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• pp.350-355
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• 2005

This paper presents a new approach for hysteresis modeling of a magnetorheological (MR) fluid. The field-dependent hysteresis of MR fluid is investigated using the Preisach model. The commercial MR Product (MRF-132LD, Lord Corporation) is employed. Its field-dependent shear stress is then obtained using a rheometer (MCR 300, Physica). In order to show the applicability of the Preisach model to the MR fluid, two significant Properties; the minor loop property and the wiping-out property are experimentally examined. Subsequently, the Preisach model for the MR fluid is identified using experimental first order descending (FOD) curves in discrete manner. The effectiveness of the identified hysteresis model is verified in the time domain by comparing the predicted field-dependent shear stress with the measured one. In addition, the hysteresis model proposed in this work is compared to Bingham model.

• Transactions of Materials Processing
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• v.16 no.2 s.92
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• pp.101-106
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• 2007

Uniaxial displacement controlled tests were performed on annealed Type 304 stainless steel at room temperature. A servo-controlled testing machine and strain measurement on the gage length were employed to measure the response to a given input. The test results exhibit that the flow stress increases nonlinearly with the strain rate and the relaxed stress at the end of the relaxation periods depends strongly on the strain rate preceding the relaxation test. The rate-dependent inelastic deformation behavior is simulated using a new unified viscoplasticity model that has the rate-dependent format of nonlinear kinematic hardening rule, which plays a key role in modeling the rate dependence of relaxation behavior. The model does not employ yield or loading/unloading criteria and consists of a flow law and the evolution laws of two tensor and one scalar-valued state variables.

• Biomedical Science Letters
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• v.20 no.2
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• pp.56-61
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• 2014

This study attempted to confirm the antioxidative potential of luteolin against tert-butyl hydroperoxide (t-BHP) induced oxidative damage and to investigate its molecular mechanism related to glutathione (GSH)-dependent enzymes in HepG2 cells. Treatment with luteolin resulted in attenuation of t-BHP induced generation of reactive oxygen species (ROS) and oxidative stress-mediated cell death. In addition, accelerated expression of GSH-dependent antioxidative enzymes, glutathione peroxidase (GPx) and glutathione reductase (GR), and heme oxygenase (HO)-1, as well as strengthened GSH content was induced by treatment with luteolin, which was in accordance with increased nuclear translocation of nuclear factor-erythroid 2 p45-related factor 2 (Nrf2), a transcription factor for phase 2 enzymes, in a dose-dependent manner. These results suggest that the cytoprotective potential of luteolin against oxidative damage can be attributed to fortified GSH-mediated antioxidative pathway and HO-1 expression through regulation of Nrf2 in HepG2 cells.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.16 no.1 s.106
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• pp.3-11
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• 2006

This paper presents a new approach for hysteresis modeling of a magnetorheological (MR) fluid. The field-dependent hysteresis of MR fluid is investigated using the Preisach model. The commercial MR product (MRF-132LD, Lord Corporation) is employed. Its field-dependent shear stress is then obtained using a rheometer (MCR 300, Physica). In order to show the applicability of the Preisach model to the MR fluid, two significant properties; the minor loop property and the wiping-out. property are experimentally examined. Subsequently, the Preisach model for the MR fluid is identified using experimental first order descending (FOD) curves in discrete manner. The effectiveness of the identified hysteresis model is verified in the time domain by comparing the predicted field-dependent shear stress with the measured one. In addition, the hysteresis model proposed in this work is compared to Bingham model.

• Proceedings of the Korea Concrete Institute Conference
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• 2004.11a
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• pp.493-496
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• 2004

The change of creep deformation mechanism due to the persistent change of stress conditions requires the constitutive relation for the analysis of long tenn behaviors considering age dependent material properties of concrete. In the present research, the process of time dependent behaviors in structure is divided into two stages; the non-mechanical deforming level which causes creep and shrinkage deformations, and the mechanical deforming level which causes mechanical deformations by the restraints of non-mechanical deformations due to internal or external factors. The incremental constitutive relation is derived by expanding the total stress-strain relation on the present time, with respect to the reference time using the Taylor series, and the modulus of elasticity in early ages of concrete was defined thru this process.

• Geomechanics and Engineering
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• v.21 no.5
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• pp.489-501
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• 2020

This paper conducts a complicated coupled effective stress analysis of X-section-in-place concrete (XCC) pile installation and consolidation processes using the dual-stage Eulerian-Lagrangian (DSEL) technique incorporating the modified Cam-clay model. The numerical model is verified by centrifuge data and field test results. The main objective of this study is to investigate the shape effect of XCC pile cross-section on radial total stress, excess pore pressure and time-dependent strength. The discrepancies of the penetration mechanism and set-up effects on pile shaft resistance between the XCC pile and circular pile are discussed. Particular attention is placed on the time-dependent strength around the XCC pile shaft. The results show that soil strength improved more significantly close to the flat side compared with the concave side. Additionally, the computed ultimate shaft resistance of XCC pile incorporating set-up effects is 1.45 times that of the circular pile. The present findings are likely helpful in facilitating the incorporation of set-up effects into XCC pile design practices.

• Journal of the Korean Ceramic Society
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• v.29 no.1
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• pp.65-73
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• 1992

The effect of grain size on the time-dependent piezoelectrice degradation of a poled PZT of MPB composition Pb0.988Sr0.012 (Zr0.52Ti0.48)O3 with 2.4 mol% of Nb2O5 was studied, and the degradation mechanism was discussed. Changes in the internal bias field and the internal stress both responsible for the time-dependent degradation of poled PZT were examined by the polarization reveral technique, XRD and Vickers indentation, respectively. The piezoelectric degradation increased with increasing time and grain size, and the internal bias field due to space charge diffusion decreased with increasing grain size of poled PZT. The internal bias field, however, was almost insensitive to the degradation time regardless of the grain size. On the other hand, both the x-ray diffraction peak intensity ratio of (002) to (200) and the fracture behavior including the crack propagation support that the ferroelectric domain rearrangement of larger grain size showed rapid relaxation of the internal stress compared with smaller one, which is thought the origin of the larger piezoelectric degradation in the former. In conclusion, the contribution of space charge diffusion on the piezoelectric degradation of PZT is strongly dependent on both the grain size and the composition. Thus, the relaxation of internal stress due to the ferroelectric domain rearrangement as well as the amount and time-dependence of the internal bias field due to space charge diffusion should be considered simultaneously in the degradation mechanism of PZT.