• 대한기계학회논문집
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• 제18권3호
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• pp.548-554
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• 1994

The high temperature fatigue crack growth behavior of SUS 304 stainless steel at $550^{\circ}C$ and $650^{\circ}C$ was investigated under various kinds of stress ratio and frequency in sinusoidal waveform on the basis of the non-linear fracture mechanics. The result arranging crack growth rate by modified J-integral J' showed influence of stress ratio and frequency. All the data obtained under the test at $550^{\circ}C$ were plotted within data band of da/dN-${\triangle}J_f$ relationship for cycle-dependent crack growth. On the basis of static creep and cycle-dependent data band; both time- and cycle-dependent crack growth behavior was observed under loading conditions at $650^{\circ}C$, but cycle-dependent crack growth behavior predominantly appeared and time-dependent crack growth behaviour was little observed under loading conditions at $550^{\circ}C$. Fractographic examinations for fracture surface indicated that the fracture mode was generally transgranular. The stripes were found on fracture surface and each stripe was accompanied by a crack tip blunting and an abrupt increase in the load-point displacement. The $J'_{an}$ had a validity in case of $650^{\circ}C, but scarcely had it in case of $550^{\circ}C$.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1989년도 가을 학술발표회 논문집
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• pp.73-76
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• 1989

A numerical procedure is developed to analyze the time-dependent behavior of prestressed concrete bridges constructed by the segmental cantilever method. The developed computer program accounts for the time-dependent properties of prestressed concrete materials due to the varing modulus of elasticity, creep and shrinkage of concrete and the stress relaxation of prestressing steel. It also accounts for the stiffness increase due to the presence of the steel reinforcements and the effects of the shear deformation of the prestressed concrete bridge girders. The program is applied to a multi-span continuous segmental prestressed concrete bridge to demonstrate its capabilities.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1991년도 가을 학술발표회 논문집
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• pp.41-44
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• 1991

Time dependent analysis of prestressed concrete beams subjected to pure torsion is studied. The present theory covers the behavior from the service load range to the ultimate stage. The tensile resistance of concrete is appropriately considered. The biaxial stress effects due to diagonal cracking are also taken into account. The time dependent aging, creep and shringkage effects are modelled by employing the equivalent nonmechanical torque concept. The present theory allows more accurate prediction of the service load behavior of pretressed concrete members.

• 한국식물병리학회:학술대회논문집
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• 한국식물병리학회 2002년도 총회 및 추계학술발표회
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• pp.85.2-86
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• 2002

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2000년도 춘계학술발표대회 논문집
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• pp.76-79
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• 2000

Polymeric composites exhibit highly nonlinear and rate dependent behavior during loading and unloading in off-axis directions. The equilibrium state of stress during loading is lower than the state of stress produced at finite strain rates. The amount of stress relaxation during loading decreases. Interestingly, however, the stress goes up to reach to the equilibrium state of stress for a fixed displacement during unloading. The unloading behavior is quite similar to the loading behavior. The stress relaxation patterns during loading and unloading is also similar, and those depend on the fiber orientation angles and the loading and unloading rates. The AS4/PEEK thermoplastic composite is used to characterize the relaxation behavior for different off-axis angles and loading rates. There exists a transient loading region at the beginning of unloading. The effective stress and effective plastic strain concept is used to establish a master curve of stress recovery pattern for different off-axis angles and unloading rates.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1995년도 가을 학술발표회 논문집
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• pp.173-177
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• 1995

Thermal cracks ard occured when thermal stress due to the hydration of cement exceeds the tensile strength of concrete. Since cracking causes poor durability of concrete, the effect of thermal cracking should be included for the desing and construction of massive concrete structures. In this study, an experiments are performed for the investigation of time dependent temperature and thermal stress of massive concrete structure at early ages. In order to measure temperatures and thermal stresses, concrete stress meter, embedded strain meter, non-stress meter, and thermocouples are used. Based on the analyses of measured thermal stress data, measured values by concrete stress meter are more reliable than those by embedded strain meter and non-stress meter, And measured values by concrete stress meter are compared with the calculated values by FEM program developed by DICT (DWTS2D). Calculated values by DWTS2D show good agreement with measured values.

• Advances in materials Research
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• 제11권4호
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• pp.279-298
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• 2022

In this paper, the important novelty and the defining a physical phenomenon of the resent research is the development of nonlocal stress and strain parameters on the porous sandwich beam with functionally graded materials in the top and bottom face sheets.Also, various beam models including Euler-Bernoulli, Reddy and the generalized formulation of two-variable beam theories are obtained in this research. According to a nonlocal strain elasticity theory, the strain at a reference point in the body is dependent not only on the stress state at that point, but also on the stress state at all of the points throughout the body. Thus, the nonlocal stress-strain elasticity theory is defined that can be actual at micro/nano scales. It can be seen that the critical buckling load and transverse deflection of sandwich beam by considering both nonlocal stress-strain parameters is higher than the nonlocal stress parameter. On the other hands, it is noted that by considering the nonlocal stress-strain parameters simultaneously becomes the actual case.

• 한국지반공학회논문집
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• 제31권11호
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• pp.15-23
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• 2015

반복단순전단시험기를 사용하여 조밀한 해양실트질 모래의 비배수 파괴거동에 대한 평균전단응력과 반복전단응력의 영향을 평가하였다. 시험결과는 평균전단응력비가 0인 경우는 비교적 좌우 대칭형태의 반복전단변형률이 주된 변형모드였으며 영구전단변형률은 상대적으로 작게 발생하였다. 평균전단응력비가 0이상인 경우는 반복횟수가 증가함에 따라 주로 한 방향으로 영구전단변형률이 증가하고 반복전단변형률은 거의 변화가 없었다. 평균전단응력비는 응력-변형률 거동에 상당한 영향을 보였으나, 파괴에 필요한 반복하중횟수 등에 대한 영향이 반복전단응력비에 비해 상대적으로 적었다. 본 논문에서 제안한 응력기반 파괴기준은 해양구조물 설계 시 기초 하부 지반의 반복전단강도를 평가하는 데 효과적으로 사용될 수 있다.

• Molecules and Cells
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• 제47권1호
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• pp.100004.1-100004.11
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• 2024

Insulin is essential for maintaining normoglycemia and is predominantly secreted in response to glucose stimulation by β-cells. Incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide, also stimulate insulin secretion. However, as obesity and type 2 diabetes worsen, glucose-dependent insulinotropic polypeptide loses its insulinotropic efficacy, whereas GLP-1 receptor (GLP-1R) agonists continue to be effective owing to its signaling switch from Gs to Gq. Herein, we demonstrated that endoplasmic reticulum (ER) stress induced a transition from Gs to Gq in GLP-1R signaling in mouse islets. Intriguingly, chemical chaperones known to alleviate ER stress, such as 4-PBA and TUDCA, enforced GLP-1R's Gq utilization rather than reversing GLP-1R's signaling switch induced by ER stress or obese and diabetic conditions. In addition, the activation of X-box binding protein 1 (XBP1) or activating transcription factor 6 (ATF6), 2 key ER stress-associated signaling (unfolded protein response) factors, promoted Gs utilization in GLP-1R signaling, whereas Gq employment by ER stress was unaffected by XBP1 or ATF6 activation. Our study revealed that ER stress and its associated signaling events alter GLP-1R's signaling, which can be used in type 2 diabetes treatment.

• 생명과학회지
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• 제28권3호
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• pp.376-387
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• 2018

식물이 접하는 다양한 환경 스트레스(고온, 저온, 냉해, 고염, 가뭄 등) 중에서 물부족(가뭄) 스트레스는 식물의 생장 및 생산성을 저해하는 가장 주요한 요인으로 보고되어 왔다. 그러므로, 물부족 스트레스에 대한 식물의 반응 기작을 명확히 이해하는 것은 물부족 스트레스 저항성이 증가된 유용 작물 개발에 적용될 수 있을 것으로 기대되며, 그 결과 작물 재배 가능 지역의 확대에 기여할 수 있을 것으로 생각된다. 식물의 물부족 스트레스 신호 과정은 크게 식물 호르몬인 앱시스산 의존적인 과정과 비의존적인 과정으로 분류되며, 각각 AREB/ABF, DREB2 전사 조절 인자가 주요한 전사 조절 인자로 참여하여 하위 단계 반응 유전자의 발현 조절에 참여한다. 이러한 AREB/ABF, DREB2 의존적인 regulon에 대한 연구를 통해 물부족 스트레스 신호 과정 중 전사 수준의 조절에 대한 규명이 활발히 이루어지고 있다. 해당 신호 과정에는 전사 수준의 조절뿐만 아니라 인산화, 유비퀴틴화와 같은 번역 후 변형 과정 및 염색질 변형에 의해 매개되는 후성유전학적 조절도 연관되어 있다. 본 총설에서는 현재까지 보고된 물부족 스트레스 신호 전달 과정을, 이와 관련되어 보고된 다양한 신호 전달 단백질들의 기능과 연계시켜 알아보고자 한다. 이러한 물부족 스트레스 신호 전달 과정에 대한 명확한 이해는 향후 유용 내건성 작물 개발을 위한 이론적 기반 구축에 도움이 될 수 있을 것이라 생각된다.