• Journal of Microbiology and Biotechnology
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• v.22 no.5
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• pp.708-720
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• 2012

In this study, we assessed the effects of ginsenoside Re (GRe) administration on repeated immobilization stress-induced behavioral alterations using the forced swimming test (FST), the elevated plus maze (EPM), and the active avoidance conditioning test (AAT). Additionally, we examined the effect of GRe on the central adrenergic system by observing changes in neuronal tyrosine hydroxylase (TH) immunoreactivity and brain-derived neurotrophic factor (BDNF) mRNA expression in the rat brain. Male rats received 10, 20, or 50 mg/kg GRe (i.p.) 30 min before daily exposures to repeated immobilization stress (2 h/day) for 10 days. Activation of the hypothalamic-pituitary-adrenal (HPA) axis in response to repeated immobilization was confirmed by measuring serum levels of corticosterone (CORT) and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. Repeated immobilization stress increased immobility in the FST and reduced open-arm exploration in the EPM test. It also increased the probability of escape failures in the AAT test, indicating a reduced avoidance response. Daily administration of GRe during the repeated immobilization stress period significantly inhibited the stress-induced behavioral deficits in these behavioral tests. Administration of GRe also significantly blocked the increase in TH expression in the locus coeruleus (LC) and the decrease in BDNF mRNA expression in the hippocampus. Taken together, these findings indicate that administration of GRe prior to immobilization stress significantly improved helpless behaviors and cognitive impairment, possibly through modulating the central noradrenergic system in rats. These findings suggest that GRe may be a useful agent for treating complex symptoms of depression, anxiety, and cognitive impairment.

• Journal of Ginseng Research
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• v.43 no.3
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• pp.402-407
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• 2019

Background: To investigate the neurobiological evidence supporting the adaptogenic effects of Korean Red Ginseng in reducing the harmful consequences of stress using a double-blind, placebo-controlled trial. Method: Sixty-three subjects with high stress levels were randomized to receive an orally administered, double-blind, 6-week treatment with Korean Red Ginseng (n = 32) or placebo (n = 31). All participants underwent a comprehensive psychological evaluation using Beck Depression Inventory and Stress Response Inventory, cognitive evaluation using the continuous performance test, biological evaluation by measuring blood levels of lipids, catecholamines, inflammation markers, and heart rate variability at baseline and after 6 weeks. Results: At baseline, both groups showed no significant differences in age, sex, years of education, Beck Depression Inventory, and Stress Response Inventory. After 6 weeks, triglyceride levels were significantly increased within the normal limit in the Korean Red Ginseng group (F = 4.11, p = 0.048), and the epinephrine level was decreased in this group (F = 4,35, p = 0.043). The triglyceride increase was significantly associated with epinephrine decrease (B = 0.087, p = 0.041), suggesting that Korean Red Ginseng may stabilize the sympathetic nervous system. In addition, we detected a significant group by time effect in the visually controlled continuous performance test, suggesting positive effects of Korean Red Ginseng on cognition. Conclusion: Korean Red Ginseng might help to stabilize the sympathetic nervous system and improve cognition in individuals with high stress.

• Journal of Korean Library and Information Science Society
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• v.30 no.4
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• pp.163-181
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• 1999

The purpose of this study is to confirm what the stress factors are in performing their jobs among librarians in Public libraries. The study further investigates to figure out the difference of the degree in cognition of job stress according to demographic characteristics of individuals and the impacts of the stress factors on job satisfaction. A survey was conducted for the study sending questionaires to 113 librarians working in 14 Public libraries in Pusan. The results of the study are followings: 1) Females experience higher job stress than males. 2) The younger the age, the higher the job stress. Also, the shorter the year at work, the higher the job stress. 3) The lower the license class, the higher the job stress. Also, singles than married have higher job stress. 4) In the impacts of stress factors on job satisfaction, role conflict is the most powerful factor, and then role overload, career development, role underload, role ambiguity and interpersonal relation, each in order.

• Journal of Oriental Neuropsychiatry
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• v.30 no.4
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• pp.341-355
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• 2019

Objectives: The purpose of this study was to check the therapeutic effect of the Dendropanax morbifera Pharmacopuncture for insomnia and cognition caused by psychosocial stress. Methods: We separated Wistar rats (older than age 10 weeks, 300 g) into normal, control, positive control (Zolpidem administered, PC), and Dendropanax morbifera Pharmacopuncture experimental groups (DPA). Psychosocial stress such as circadian rhythm change, clammy straw, predator stress, restraint stress, noise bursts, and flashing lights were applied to the control, PC, DPA groups. The Dendropanax morbifera Pharmacopuncture group was given 0.5×, 1× and 2× amount concentration of Dendropanax morbifera Pharmacopuncture, respectively. The levels of Melatonin, Serotonin, Corticosterone, GABA, BDNF and CREB were measured, and the Y-maze test, weight and blood test were performed. Results: In all of the DPA groups, the Melatonin level showed no noticeable difference. In the DPA-2x group, Serotonin increased significantly. In all the experimental groups, Corticosterone decreased significantly and GABA showed increasing tendency. The DPA-1x and DPA-2x groups showed remarkable increase in BDNF and DPA-0.5x and the DPA-2x groups showed significant increase in CREB. The DPA-2x group showed remarkable increase in the Alternation behavior category of the Y-maze test. In all of the experimental groups the weight change showed increasing tendency, whereas no noticeable differences were found among all experimental groups regarding AST, ALT, BUN, Creatinine and CBC. Conclusions: Dendropanax morbifera Pharmacopuncture increases levels of serotonin and GABA, decreases corticosterone, increases levels of BDNF and CREB, and increases the ratio of alternation behavior in the Y-maze test. Thus, I suggest that Dendropanax morbifera Pharmacopuncture has the effect of treating insomnia caused by psychosocial stress, activating the brain, and improving cognition.

• The Journal of Korean Academic Society of Nursing Education
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• v.10 no.2
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• pp.262-270
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• 2004

Purpose: The purpose of this study was to define cognition of the preceptors on the preceptor's role stress and competency pre-post preceptorship experience. Method: This study was designed as a one group pre-test and post-test study. The subjects of this study were 22 preceptors who had the preceptor preparation education and then worked as preceptor for four weeks at a university hospital. For data analyses, percentage, mean, paired t-test, Pearson's Correlation Coefficient were adopted with the use of SPSS WIN 10.0. Result: The results of this study showed that after the preceptorship experience, role stress of the preceptor decreased significantly compared to before the preceptorship experience. All of the score of sub domains was decreased. Especially, there was a significantly difference in education conducting and evaluation, personal relation and communication, professional development. Also, after the preceptorship experience, competency of the preceptor increased significantly compared to before the preceptorship experience. All of the score of sub domains was increased. Particularly, there was a significantly difference in socialization facilitator and educator except learning planning performance. There was a significant positive correlation between educational experience and the number of learner before preceptorship experience of general characteristics and competency, but was not correlation between general characteristics and role stress. Also there was not correlation between role stress and competency. Conclusion: The finding above indicated that the preceptorship was effective in decreasing preceptor's role and increasing preceptor's competency.

• Journal of People, Plants, and Environment
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• v.22 no.3
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• pp.269-277
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• 2019

This study aims to see what changes flower arrangement programs bring to the stress index of elderly people with chronic diseases and its correlation with cognition. Furthermore, seniors from a day care center and a nursing home were compared for the purpose of identifying the effectiveness of flower arrangement activities as a supplementary remedy designed to relieve the symptoms and improve the quality of life of patients with chronic diseases. In this study, 24 seniors with chronic diseases were divided into two groups: Group A consists of 15 seniors from a day care center and Group B consists of nine seniors from a nursing home. Both groups participated in simple flower arrangement activities in 10 sessions. In each session, red and green cut flowers that were preferred by the elderly were provided to elicit and develop their thoughts and behaviors. The results showed that the overall average stress index was significantly reduced from 58.0±11.6 before the program to 50.6±17.1 after the program (p = .037). This study examined that the program was more effective for Group A (p = .021) than for Group B (p = .678). Results of the correlation analysis showed that there was no correlation between cognitive function and stress index (p = .569), but that the activity was more effective for Group A. This study shows that arranging flowers effectively lowers the stress index of elderly people with chronic diseases. Also, sharing the outcomes of such activities with others or continuously caring for the flowers even after the activity can maximize the effectiveness of the therapy and rehabilitation. Thus, the study concluded that the program needs to be applied continuously, not in the short-term, in order to relieve or treat the symptoms of elderly patients with chronic diseases.

• Journal of the Korean housing association
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• v.8 no.2
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• pp.71-84
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• 1997

The Purpose of this study is to estimate how inclination to move can be appeared by understanding the cognition of a resident on stress due to the residential environment. 240 housewives living in Chiniu were Questioned statistical analysis were used with factor analysis, F-test. Duncan's Multiple range analysis, stepwise regression analysis and stepwise discriminant analysis, The result were summarized as follows 1) The stress of residential environment were clissified by six factors indoor facility, educational environmental. indoor structure, air Pollution noise, traffic convenience. 2) The extent of a stress from residential environment was significantly different in the socio-demographic variable and housing-related variable. 3) The stress of residential environment were affected by the direction of house. 4) The variable discriminating inclination to move were the stress of residential environment(air Pollution). an educational level, the type of housing possession, residential Period and the size of house.

• Korean Journal of Health Education and Promotion
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• v.30 no.3
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• pp.35-46
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• 2013

Objectives: The aim of this study was to investigate the degree of depression cognition and health promoting behaviors of smoking and non-smoking college students. Methods: The research design was a descriptive survey study, and 379 college students were selected by convenience sampling. Measurements were Fagerstrom test for Nicotine Dependence, Depressive cognition and Health Promotion Lifestyle Profile-II. Descriptive statistics, Pearson's correlation, and logistic regression were used to analyze the data. Results: 1) Smoking students showed lower scores in depressive cognitions than non-smoking students, which means that the smoker's depression was higher than the non-smokers. 2) Depressive cognition and health promoting behaviors were negatively correlated for the smokers (r=-.30, p<.01), while they were positively correlated for the non-smokers (r=.45, p<.001). 3) The variables predicting the smoker's health promoting behavior were physical activity (OR .24), health responsibility (OR .25), spiritual growth (OR 5.10), stress management (OR 4.41), extrovert personality (OR .25), and depressive cognition (OR 1.81). Conclusions: Depression and health promoting behavior should be considered in the smoking cessation programs for college students.

• Journal of Korean Public Health Nursing
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• v.19 no.1
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• pp.64-73
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• 2005

The purpose of this study was to discuss the difference of stress by the grade, examine the relationship between characteristics and main stress, and to investigate the effect of the National Examination of Registered Nurses on stress by using the stress self-rating scale targeting university nursing students (n=314), The stress self-rating scale consists of three subscales: stress responses, stressors and coping parts, such as perceived social support and a sense of humor. The data were analyzed by descriptive statistics, t-test, Pearson's correlation coefficient and regression analysis. The results showed that passing the National Examination of Registered Nurses was the first problem among the stressors. Stressors of the living factors and nursing factors, and subjective stressors of the surveyed nursing students were the highest among the senior students, but stressors of nursing factors increased according to the grade of the nursing students. Perceived stress responses were high in psychological responses of other aspects, and perceived stress responses increased according to the grade (p<.001). Senior students had a high weight of perceived stress responses (problem-focused, emotion-focused). and active and negative coping modes. Significant factors that explained the stressors were coping mode(r=.62-82. p<.01) and cognition(r=.19. p<.01). including the social support. These findings suggest that social support was very important for seniors. and that we have to develop approaches to decrease stress according to the student grade for nursing education process.

• Journal of the Korea Institute of Military Science and Technology
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• v.21 no.2
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• pp.246-254
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• 2018

Psychological stress and physical fatigue, such as anxiety, fear, sleep disturbance, etc., caused by exposure to the war, can lead to post-traumatic stress syndrome(PTSD) or war syndrome. The military has also prepared for drug use to minimize war syndrome and preserve combat strength. However, efforts to prevent war syndrome are still lacking. This study was conducted to identify biomarkers that can track psychophysiological changes. Psychophysiological changes associated with PTSD can be divided into four main categories. The four categories are behavioral changes, changes in brain cognition, neuroimmunological changes, and changes in innate immunity. This study suggest that biomarker profile can be made by the distance moved and the anxiety-like behavior in the open field for behavior category, brain BDNF levels in the brain cognition category, serum corticosterone in the neuroimmunology category, and inflammatory cytokine levels in the innate immunity category.