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http://dx.doi.org/10.9766/KIMST.2018.21.2.246

Biomarkers for Combat-Related Stress and Fatigue-Mitigating Drugs Discovery  

Koo, Hyojin (Department of Basic Science, Air Force Academy)
Kim, Chang Yul (Department of Occupational Health, Catholic University of Daegu)
Kim, Yeonkyung (Department of Occupational Health, Catholic University of Daegu)
Sin, So Jung (Department of Occupational Health, Catholic University of Daegu)
Cheon, Kicheol (The 5th Research and Development Institute, Agency for Defense Development)
Kim, Dongsoo (Department of Basic Science, Air Force Academy)
Publication Information
Journal of the Korea Institute of Military Science and Technology / v.21, no.2, 2018 , pp. 246-254 More about this Journal
Abstract
Psychological stress and physical fatigue, such as anxiety, fear, sleep disturbance, etc., caused by exposure to the war, can lead to post-traumatic stress syndrome(PTSD) or war syndrome. The military has also prepared for drug use to minimize war syndrome and preserve combat strength. However, efforts to prevent war syndrome are still lacking. This study was conducted to identify biomarkers that can track psychophysiological changes. Psychophysiological changes associated with PTSD can be divided into four main categories. The four categories are behavioral changes, changes in brain cognition, neuroimmunological changes, and changes in innate immunity. This study suggest that biomarker profile can be made by the distance moved and the anxiety-like behavior in the open field for behavior category, brain BDNF levels in the brain cognition category, serum corticosterone in the neuroimmunology category, and inflammatory cytokine levels in the innate immunity category.
Keywords
Stress; Fatigue; Biomarker; Combat-Related PTSD; Animal Model; Drug;
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Times Cited By KSCI : 1  (Citation Analysis)
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