• Investigative Magnetic Resonance Imaging
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• 제1권1호
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• pp.130-134
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• 1997

목적: 역동적 자기공명영상에서 위암의 조영증강양상을 분석하여, 병변의 평가에 조영증강검사의 필요성을 규명하고자 하였다. 대상 및 방법: 병리조직학적으로 증명된 12명의 환자를 대상으로 하였다. 1.0T 자기공명영상장치를 이용하였고, FLASH T1 강조영상기법으로 조영제 주입전, 30초 후, 60초 후, 90초 후에 각각 횡단스캔을 얻었다. 검사 전 환자에게 1리터의 물을 마시게 하였고 장진경제인 Buscopan을 근육주사 하였다. 각 시기에서 병변의 신호 대 잡음비를 측정하였고, 병변과 췌장, 병변과 위장내 물과의 신호차이 대 잡음비를 측정하였다. 또한 각 시기의 영상에서 병변의 두으러짐을 0-3등급으로 나누어 두 명의 방사선과 의사가 합의하에 평가하였다. 결과: 병변의 신호 대 잡음비는 조영증강 전, 조영증강 후 30초, 60초, 90초의 시간경과에 따라 점차 증가하였다(38.7,42.5,57.4,65.7). 병변과 췌장과의 신호차이 대 잡음비는 10.5, 9.33, 9.99, 10.66으로 유의하게 증가하였다. 병변과 위장내 물과의 신호차이 대 잡음비도 1.24, 25.01, 39.30, 45.89로 유의하게 증가하였다. 그러나 정성적 분석에서는 조영 전 영상이 조영 후 영상에 비하여 병변의 두드러짐이 컸다(평균등급:2.8, 1.8, 1.6, 1.5). 병변의 신호강도는 조영증강 후 90초 지연영상에서 가장 높은 신호강도를 보여 병변의 위강쪽은 뚜렷하게 보였다. 그러나 병변과 위 주위 지방조직의 신호강도 차이가 줄어들어 전체적으로는 조영증강 전 영상에서 조영증강 후 영상보다 병변이 분명하게 보였다. 결론: 위암의 역동적 자기공명영상의 조영 전 영상에서 조영 후 영상보다 병변이 분명하게 보이므로 조영증강은 필요 없다고 생각된다.

• 사상체질의학회지
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• 제19권3호
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• pp.270-276
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• 2007

1. Objectives We introduced a case of postoperation stomach cancer patient with metastasis to peritoneum and colon who suffered from repetitive diarrhea and abdominal pain. 2. Methods Stomach cancet is the most common cancer in Korea. Eventhough the 5-year survival rate of stomach cancer is increasing recently, metastasized stomach cancer does not show good prognosis, especially when the surgical operation is not applicable. After partial resection of stomach, most of patients experienced gastrointestinal disorders like dyspepsia, reduced meal size, abdominal discomfort, loose stool, and constipation. 3. Results and Conclusions Taeumjowi-tang, a Sasang Constitutional Medicine, improved the diarrhea and abdominal pain.

• 성인간호학회지
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• 제24권6호
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• pp.588-596
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• 2012

Purpose: The purpose of this study was to identify factors that influence depression in stomach cancer patients receiving chemotherapy at outpatient clinic. Methods: A cross-sectional design was used. Ninety two subjects diagnosed with stomach cancer and receiving chemotherapy agreed to participated in the study. Subjects completed a survey which included questions about depression, symptom experience, social support and self-efficacy. Results: The level of depression was $13.45{\pm}6.92$. Reported depression differed according to patient's perceived health status. Depression was significantly correlated with symptom experience, social support and self-efficacy. The most important factor related to depression was symptom experience, followed by social support and self-efficacy. These three factors could explain about 47% of depression in stomach cancer patients receiving chemotherapy. Conclusion: Although the level of depression in stomach cancer patients receiving chemotherapy was relatively low, 34.8% of patients reported to have depression. It is important to apply nursing intervention including screening of depression level in stomach cancer patients receiving chemotherapy that focused on symptom experience and to consider about social support and self-efficacy at outpatient clinic.

• Journal of the Korean Data and Information Science Society
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• 제21권6호
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• pp.1253-1261
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• 2010

본 연구는 국민건강보험공단의 건강검진데이터, 자격 및 보험료, 그리고 진료비 데이터를 활용하여 위암 발생 예측모형을 개발하고자 하였다. 모형개발에는 데이터마이닝 방법론에 의한 로지스틱 회귀모형을 활용하였으며, 모형개발은 남성, 여성 그리고 전체에 대해 각각 개발하여 각 모형에서 위암 발생 결정요인의 차이를 비교하였다. 그 결과 위암 발견 예측에 가장 큰 영향을 미치는 특성은 수검자의 연령이었고, 다음으로 음주, 가족병력 (암) 순으로 나타났다. 남자가 여자보다 위암 발견 가능성이 다소 높은 것으로 나타났으며, 남성의 경우는 연령, 여성의 경우는 음주유무가 위암 발생에 많은 영향을 미치는 것을 확인 할 수 있었다.

• 대한한방내과학회지
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• 제26권2호
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• pp.333-340
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• 2005

Background: Cancer reseach is done in earnest world-wide, because cancer is one of most threatening diseases to humans. Orostachyos Herba is a widely used herb that has long been in use in Korea as an anti-inflammatory and anti-cancer therapy. The purpose of this study is to verify any anti-cancer effects on stomach and liver cancer in vitro. Materials & Methods: AGS and KATO III stomach cancer cells and Hep3B and HepG2 liver cancer cells, all obtained from Korean Cell Line Bank, were used. The boiled extract of Orostachyos Herba(20 and 40 microliters) were injected into cultures and observed at 0 hours, and at 24-hour intervals up to 96 hours. The destruction of stomach and liver cancer cells was measured through Trypan blue exclusion testing. The suppression on viability of stomach and liver cancer cells was observed, and anti-cancer mechanisms was examined by analyzing the cell cycle. Results: In morphologic change, AGS, KATO III, HepG2 and Hep3B showed some of the withdrawn and floating appearance that is typical in cellular imparment. AGS, KATO III, HepG2 and Hep3B showed more destruction of stomach cancer cells in each test group than in the control group to a statistically significant degree. Analysis of the cell cycle after introduction of Orostachyos Herba showed very little inhibition of divisions of all cell lines. Conclusions: This experiment suggests that Orostachyos Herba has some anti-tumor effects on stomach and liver cancer cells. Progressive research on Orostachyos Herba and it's anti-tumor effects will be needed to determine its practicability as a cancer treatment.

• Journal of Nutrition and Health
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• 제35권3호
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• pp.380-393
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• 2002

The purpose of this study was to investigate the lift-style and eating behavior of stomach cancer patients in the Daegu and Kyungpook area, and to collect basic data for nutrition education designed to prevent stomach cancer in this community. The subjects of the study were 102 patients who were recently diagnosed as having stomach cancer at the Kyungpook National University Hospital. The control subjects were 105 persons who did not have any gastrointestinal disease, and included patients from the Department of Orthopedic Surgery and healthy volunteers. The survey, which covered the personal characteristics and eating behavior of the subjects, was conducted by individual interviews using questionnaires. It was found that the stomach cancer patients (case group) had experienced a significantly higher level of stress in their daily lives than the control group. A significantly higher proportion of the case group subjects recognized their personality as pessimistic, and had family histories of cancer, compared with the control group subjects. The cancer patients had higher preferences for salty and hot tasting foods, and tended to ingest meals faster without enough chewing, compared with the control subjects. The level of nutritional knowledge of the case group was lower than the control group, and there was a positive correlation between subjects' nutritional knowledge scores and nutritional attitude scores. Subjects' estimates of their food intake frequencies during the decade before the cancer was diagnosed revealed that the case group consumed significantly higher amounts of pickled fish, soybean paste soup and stew, cooked vegetables, beef and pork, charcoal broiled meat and alcohol, while consuming significantly lower amounts of green tea than the control group. In summary, the results of the study suggest that the stress of daily life, a family history of cancer, and a pessimistic personality might be the risk factors for the development of stomach cancer. Dietary factors which were suspected as risk factors for stomach cancer in the present study included strong preferences to salty and hot lasting foods, poor eating habits, and frequent consumption of pickled fish, soybean paste soup, cooked vegetables, beef and pork, charcoal broiled meat and alcohol. A high consumption of green tea seemed to be a protective factor against stomach cancer. The results of the study appear to provide useful data for nutritional education focussed on the prevention on stomach rancor in local residents.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.661-665
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• 2016

Background: Stomach cancer is the fifth most common cancer and the third leading cause of death among cancers throughout the world. Therefore, stomach cancer outcomes can affect health systems at the national and international levels. Although stomach cancer mortality and incidence rates have decreased in developed countries, these indicators have a raising trend in East Asian developing countries, particularity in Iran. In this study, we aimed to determine the time trend of age-standardized rates of stomach cancer in different districts of Iran from 2000 to 2010. Materials and Methods: Cases of cancer were registered using a pathology-based system during 2000-2007 and with a population-based system since 2008 in Iran. In this study, we collected information about the incidence of stomach cancer during a 10 year period for 31 provinces and 376 districts, with a total of 49,917 cases. We employed two statistical approaches (a random effects and a random effects Markov model) for modeling the incidence of stomach cancer in different districts of Iran during the studied period. Results: The random effects model showed that the incidence rate of stomach cancer among males and females had an increasing trend and it increased by 2.38 and 0.87 persons every year, respectively. However, after adjusting for previous responses, the random effects Markov model showed an increasing rate of 1.53 and 0.75 for males and females, respectively. Conclusions: This study revealed that there are significant differences between different areas of Iran in terms of age-standardized incidence rates of stomach cancer. Our study suggests that a random effects Markov model can adjust for effects of previous responses.

• 대한한방내과학회지
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• 제22권4호
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• pp.579-587
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• 2001

The efficacy of Sagunja-tang and Sagunja-tang plus Mylabris phalerata against the human stomach cancer was examined and molecular biological fight of its actions was studied. In the efficacy test of anti-stomach cancer cells growth using the MTT assay, administration of Sagunja-tang resulted in no significant change of stomach cancer cells growth, with the control group. Administration of Sagunja-tang plus Mylabris phalerata resulted in a decrease of stomach cancer cells growth in proportion to the concentration of mylabris phalerata and time, which was significantly different from the control group(significance recognized when p<0.05). In the test using the apoptosis assay, administration of Sagunja-tang showed an increase in apoptosis of human stomach cancer cells, with no significant difference from the control group. Administrating Sagunja-tang plus Mylabris phalerata showed an increase in apoptosis of stomach cancer cells in proportion to the concentration of mylabris phalerata and time, which was significantly different from the control group(significance recognized when p<0.05). In the test using the quantitative RT-PCR to examine stomach cancer cells growth and revelation of apoptosis related genes, administrating Sagunja-tang plus Mylabris phalerata resulted in a decrease of Bcl-2, an anti-apoptosis gene, in proportiong to concentration. No significant change was examined in the revelation of CDK1, Cdc2, Cyclin D1, PCNA, c-myc, which are genes related to the stomach cancer cells growth, and Bax, Bel-XL, the genes related to apoptosis, and p53. Referring to the results above, Sagunja-tang plus Mylabris phalerata may be considered to have an anti-growth efficacy against human stomach cancer cells, and an inducement efficacy. Therefore, it can be clinically implemented in the human stomach cancer.

• 종양간호연구
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• 제5권1호
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• pp.52-62
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• 2005

Purpose: This study was to analyze the research trend centering on the theses to cancer nursing research in digestive system released in Korea. Method: The researcher collected the academic degrees and theses published on the book of the academic soceity from January 1993 to August, 2004, and examined 38 domestic papers of cancer nursing research in digestive system. Results: 1) As for the subject, the results were : patients with stomach cancer 25(66%), colon cancer 4(11%), rectal cancer 3(8%), and others(taxi drivers 2, family of cancer patents. 2) As for the research designs the result were : quantitative studies were 33(87%), and qualitative studies were 9(23%). 3) As for key concepts of survey, the results were : life patterns of patients with rectal cancer, oral intake of stomach cancer patients, fatigue of stomach cancer patients undergoing chemotherapy, nursing needs when discharging from hospital after operation with gastrectomy, and so on. 4) As for the comparative studies, the results were : risk factors between colorectal patients and general population, early symptom and risk factors between stomach cancer patients and general population, and risk factors between stomach cancer and patients with gastritis. 5) As for main concepts of correlational studies, the results were : quality of life, health belief, fatigue, health promotion behavior, social support, straitanxiety. 6) The treatment of experimental research, the results were : information services, arc reflex massage, acupressure, educational program for discharge, 7)As for the qualitative studies, in terms of subjects, stomach cancer patients were 2, spouse of patients with stomach cancer was 1, rectal cancer patients were 2. In the theme of the qualitative studies, the results were: experience of family of patients with stomach cancer, experience of long term survival of patients with rectal cancer, experience of disease process of rectal cancer patiens. 8) As for the used instrument in studies, the results were : Strait-anxiety Scale by Spielberger, Nausea and Vomiting Scale by Rhodes, Social support by Tae and Lee, Health belief by Champion, Becker, and Moon. QOL by NCCN, Roh, Pdilla, Kwon, Revised Fatigue Scale by Piper, Health Locus of Control by Wallston and Wallston, Uncertainty Scale by Mishel. Conclusions: More research needs to be encouraged in various subject of cancer patients in digestive system. More nonexperimental and experimental researches should be conducted for the establishment of the basis of practical and theoretical framework and the providing good quality of care for cancer patients.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.717-723
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• 2014

Background: This study was carried out to investigate the interaction of p53 codon 72 polymorphism, dietary and tobacco habits with reference to risk of stomach cancer in Mizoram, India. A total of 105 histologically confirmed stomach cancer cases and 210 age, sex and ethnicity matched healthy population controls were included in this study. Materials and Methods: The p53 codon 72 polymorphism was detected by PCR-RFLP and sequencing. H. pylori infection status was determined by ELISA. Information on various dietary and tobacco related habits was recorded with a standard questionnaire. Results: This study revealed that overall, the Pro/Pro genotype was significantly associated with a higher risk of stomach cancer (OR, 2.54; 95%CI, 1.01-6.40) as compared to the Arg/Arg genotype. In gender stratified analysis, the Pro/Pro genotype showed higher risk (OR, 7.50; 95%CI, 1.20-47.0) than the Arg/Arg genotype among females. Similarly, the Pro/Pro genotype demonstrated higher risk of stomach cancer (OR, 6.30; 95%CI, 1.41-28.2) among older people (>60 years). However, no such associations were observed in males and in individuals <60 years of age. Smoke dried fish and preserved meat (smoke dried/sun dried) consumers were at increased risk of stomach cancer (OR, 4.85; 95%CI, 1.91-12.3 and OR, 4.22; 95%CI, 1.46-12.2 respectively) as compared to non-consumers. Significant gene-environment interactions exist in terms of p53 codon 72 polymorphism and stomach cancer in Mizoram. Tobacco smokers with Pro/Pro and Arg/Pro genotypes were at higher risk of stomach cancer (OR, 16.2; 95%CI, 1.72-153.4 and OR, 9.45; 95%CI, 1.09-81.7 respectively) than the non-smokers Arg/Arg genotype carriers. The combination of tuibur user and Arg/Pro genotype also demonstrated an elevated risk association (OR, 4.76; 95%CI, 1.40-16.21). Conclusions: In conclusion, this study revealed that p53 codon 72 polymorphism and dietary and tobacco habit interactions influence stomach cancer development in Mizoram, India.