• 한국항해항만학회지
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• 제41권5호
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• pp.345-352
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• 2017

Recently, a new port reserves deep water depth for safe navigation and mooring, following the trend of larger ship building. Larger port facilities include long and huge breakwaters, and mainly adopt vertical type considering low construction cost. A vertical breakwater creates stem waves combining inclined incident waves and reflected waves, and this causes maneuvering difficulty to the passing vessels, and erosion of shoreline with additional damages to berthing facilities. Thus, in this study, the researchers have investigated the response of stem waves at the vertical breakwater near the entrance channel and applied numerical models, which are commonly used for the analysis of wave response at the harbor design. The basic equation composing models here adopted both the linear parabolic approximation adding the nonlinear dispersion relationship and nonlinear parabolic approximation adding a linear dispersion relationship. To analyze the applicability of both models, the research compared the numerical results with the existing hydraulic model results. The gap of serial breakwaters and aligned angles caused more complicated stem wave generation and secondary stem wave was found through the breakwater gap. Those analyzed results should be applied to ship handling simulation studies at the approaching channels, along with the mooring test.

• International Journal of Ocean System Engineering
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• 제3권3호
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• pp.152-157
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• 2013

This study, a new concept design of the stem and aims to determine the suitability of various carbon/PEEK composite designs for artificial hip joints. Shear stress tested with alternative materials of the Ti-based stem for artificial hip joints. In addition, FEA is conducted according to the fiber ply orientation and the load condition for carbon/PEEK composites. The stem shape of two types was designed through the shape normal of the femur. Multidirectional load cases were used for each FEA model. In the case of general shape, the results show that the stress of ply orientation case II was lower than for cases I and III. On the other hand, in the case of the curved shape, ply orientation case I was lowest. In the case of the Ti stem, the stress of the curved shape was 18% lower than the general shape.

• 한국수학교육학회지시리즈D:수학교육연구
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• 제24권3호
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• pp.137-173
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• 2021

Research and national standards, such as the Next Generation Science Standards (NGSS) in the United States, promote the development and implementation of K-12 interdisciplinary curricula integrating the disciplines of science, technology, engineering, mathematics, and computer science (STEM+CS). However, little research has explored how teachers provide epistemic support in interdisciplinary contexts or the factors that inform teachers' epistemic support in STEM+CS activities. The goal of this paper is to articulate how interdisciplinary instruction complicates epistemic knowledge and resources needed for teachers' instructional decision-making. Toward these ends, this paper builds upon existing models of teachers' instructional decision-making in individual STEM+CS disciplines to highlight specific challenges and opportunities of interdisciplinary approaches on classroom epistemic supports. First, we offer considerations as to how teachers can provide epistemic support for students to engage in disciplinary practices across mathematics, science, engineering, and computer science. We then support these considerations using examples from our studies in elementary classrooms using integrated STEM+CS curriculum materials. We focus on an elementary school context, as elementary teachers necessarily integrate disciplines as part of their teaching practice when enacting NGSS-aligned curricula. Further, we argue that as STEM+CS interdisciplinary curricula in the form of NGSS-aligned, project-based units become more prevalent in elementary settings, careful attention and support needs to be given to help teachers not only engage their students in disciplinary practices across STEM+CS disciplines, but also to understand why and how these disciplinary practices should be used. Implications include recommendations for the design of professional learning experiences and curriculum materials.

• BMB Reports
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• 제47권8호
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• pp.439-444
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• 2014

Inhibition of an increase of osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays an important role in the mobilization of osteoclast precursors within bone marrow (BM). However, the actual therapeutic impact of AMD3100 in osteoporosis has not yet been ascertained. Here we demonstrate the therapeutic effect of AMD3100 in the treatment of ovariectomy-induced osteoporosis in mice. We found that treatment with AMD3100 resulted in direct induction of release of SDF-1 from BM to blood and mobilization of hematopoietic stem/progenitor cells (HSPCs) in an osteoporosis model. AMD3100 prevented bone density loss after ovariectomy by mobilization of HSPCs, suggesting a therapeutic strategy to reduce the number of osteoclasts on bone surfaces. These findings support the hypothesis that treatment with AMD3100 can result in efficient mobilization of HSPCs into blood through direct blockade of the SDF-1/CXCR4 interaction in BM and can be considered as a potential new therapeutic intervention for osteoporosis.

• 한국임상수의학회지
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• 제28권1호
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• pp.57-62
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• 2011

The shortage of transplantable kidneys has many efforts to regenerate bioartificial kidneys using transgenic animals and diverse kinds of scaffolds which are important tools for cell seeding. However, there are many limitations for clinical applications so far. Recently, decellularized bioscaffolds using animal organs come into spotlight because of its many superior advantages. In current study, we produced decellularized kidney bioscaffolds of pig which is an attractive animal as a clinical model for human. We decellularized pig kidneys with 1% SDS detergent solution using peristaltic pump systems for 12h. After decellularization process, the kidney bioscaffolds preserved intact 3D morphology including glomerular structure and almost DNA from pig was entirely removed. In addition, this process could preserve micro vascular network which is necessary for cell survival. Although, additional studies for recellularization and transplantation should be required, the decellular vascularized kidney bioscaffolds might have many potentials for kidney regeneration.

• 대한기계학회논문집B
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• 제37권7호
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• pp.703-708
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• 2013

고관절 전치환술은 대퇴골두와 비구 부분이 손상되어 제 기능을 하지 못하였을 때, 인공 고관절로 대체하는 수술로서 인체에는 많은 양의 절개를 필요로 하며 장기간의 회복시간과 재활시간을 필요로 한다. 최소침습술은 환자에게 흉터와 근육절개를 최소화하고, 회복시간을 단축하여 미관상 흉터가 적어 가장 선호되는 수술 방법이다. 이 논문에서는 최소침습술이 가능한 메커니컬 스템(Mechanical stem)을 기어의 원리를 이용하여 개발하였다. 재치환술을 할 경우에는 스템 전체를 교체할 필요 없이 일부 부품만을 교체하여 수술 시간을 단축할 수 있도록 설계하였으며, 아크릴 소재로 모형을 제작하여 작동에 문제가 없는 것을 확인하였다. 3D Bio-CAD 모델링 기법을 통하여 메커니컬 스템의 기하학적 모델링을 하였다. 실험 대상자의 고관절 부위는 컴퓨터 단층촬영 영상데이터를 기반으로 3차원 재구축을 하였고, 가상 시술 환경 조건에서 몸무게보다 더 과중한 하중을 적용하여 메커니컬 스템의 안전성을 유한요소해석으로 확인하였다.

• 대한의생명과학회지
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• 제13권4호
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• pp.273-278
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• 2007

Stem cells have been the subject of increasing scientific interest because of their utility in numerous biomedical applications. Stem cells are capable of renewing themselves; that is, they can be continuously cultured in an undifferentiated state, giving rise to more specialized cells of the human body. Therefore, stem cells are an important new tools for developing unique, in vitro model systems to test drugs and chemicals and a potential to predict or anticipate toxicity in humans. In the present study, in vitro cultured F3 immortalized human neural stem cell line and in vivo adult Sprague Dawley rats was used to evaluate the cytotoxicity of anticancer drug paclitaxel. In vitro apoptotic activity of paclitaxel was evaluated in F3 cell line by a MTT assay and DAPI test. The cell death was induced with the treatment of 20 nM paclitaxel and chromatin degradation was detected by DAPI staining, which was analyzed by fluorescent microscope. In vivo studies, we also observed nestin immunoreactivity on subventricular zone, which is stem cell rich region in the adult brain of the SD rat. Immunofluorescent staining result shows that pixel intensities of nestin were decreased in a dose dependent manner. These results suggest that paclitaxel is able to induce cytotoxic activity both in F3 neural stem cell line and neural stem cell in SD rat brain.

• 한국기후변화학회지
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• 제8권4호
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• pp.415-424
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• 2017

This study was conducted to estimate carbon stocks of Pinus densiflora with drawing volume of trees in each tree height and DBH applying the suitable stem taper equation and tree specific carbon emission factors, using collected growth data from all over the country. Information on distribution area, tree age, tree number per hectare, tree volume and volume stocks were obtained from the $5^{th}$ National Forest Inventory (2006~2010) and Statistical yearbook of forest (2016), and method provided in IPCC GPG was applied to estimate carbon stock and uptake. Performance in predicting stem diameter at a specific point along a stem in Pinus densiflora by applying Kozak's model, $d=a_{1}DBH^{a_2}a_3^{DBH}X^{b_{1}Z^2+b_2ln(Z+0.001)+b_3\sqrt{Z}+b_4e^z+b_5(\frac{DBH}{H})}$, which is well known equation in stem taper estimation, was evaluated with validations statistics, Fitness Index, Bias and Standard Error of Bias. Consequently, Kozak's model turned out to be suitable in all validations statistics. Stem volume table of P. densiflora was derived by applying Kozak's model and carbon stock tables in each tree height and DBH were developed with country-specific carbon emission factors ($WD=0.445t/m^3$, BEF = 1.445, R = 0.255) of P. densiflora. As the results of analysis in carbon uptake for each province, the values were high with Gangwon-do $9.4tCO_2/ha/yr$, Gyeongsandnam-do and Gyeonggi-do $8.7tCO_2/ha/yr$, Chungcheongnam-do $7.9tCO_2/ha/yr$ and Gyeongsangbuk-do $7.8tCO_2/ha/yr$ in order, and Jeju-do was the lowest with $6.8tC/ha/yr$. Total carbon stocks of P. densiflora were 127,677 thousands tC which is 25.5% compared with total percentage of forest and carbon stock per hectare (ha) was $84.5tC/ha/yr$ and $7.8tCO_2/ha/yr$, respectively.

• 한국항해학회지
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• 제17권1호
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• pp.37-48
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• 1993

When the vessel is running at the very low Froude numbers, the free-surface is difficult to be disturbed, wave-making is negligible, and the double -model velocity potential gives a very good approximation for calculating the velocity distribution just outside the boundary layer. If the speed of incident flow is gradually increased, the most perceptible change is the rise of the flow surface at stem. With further increase in speed, the nature of the flow at the bow changes completely, The flow ahead of the bow becomes more distrubed, the rise at the stem to stagnation height disappear, and the first wave crest, of less than the stagnation height, appears a small distance downstream from the stem. The present study is concerned with a small region of this flow, mainly in the bow region. The present investigation is primarily an experimental study of the flow in the bow region of s ship model, and it is undertaken in order to investigated systematically, the effect of bow geometry on this flow. The long-range objective is to use these results to guide the development of a mathematical model for predicting the flow about a ship's bow.

• 한국해안해양공학회지
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• 제2권1호
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• pp.51-57
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• 1990

수심변화가 완만하고 흐름이 없는 곳을 파가 전파할 때 겪게되는 침수, 굴절 및 회절현상의 해석에는 3차 Stokes파 이론에 의한 선형, 비선형, 포물형 방정식이 이용되며, 여기서는 바닥마찰과 바람의 영향은 고려하지 않는다. 이 포물형 방정식으로 암초가 있는 경우에 대해 수치해석을 수행하여 기존의 실험치와 비교 검토하였고, 회절과 굴절효과의 중요성을 고찰했다. 천해파의 특성변화 해석에는 Boussinesq방정식에 기초한 포물형 방정식이 이용된다. 흐름이 없는 경우에 방파제를 따라 전파하는 Cnoidal파의 회절현상을 수심이 변하고 입사각이 변하는 경우에 대해 수치해석을 하여 Stem wave의 특성에 대해 논의하였다.