• Journal of Pharmaceutical Investigation
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• 제31권1호
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• pp.1-5
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• 2001

The aggregation behavior of nystatin (NYS) in the presence of pluronic F127, triblock copolymer of poly (ethylene oxide) (PEO) and poly (propylene oxide) (PPO), was measured and correlated with hemolytic activity. Antifungal activity was also studied using Saccharomyces cerevisiae as a model strain. The critical aggregation concentrations (CAC) of the drug were 50.1, 108.0, 134.2, 154.3, and $217.9\;{\mu}M$ at 0.1%, 0.5%, 1.0%, 1.5%, and 2.0% pluronic F127 solution, respectively. The levels of NYS required to start lysis of erythrocytes were about 80, 100, 125, 150, and $200\;{\mu}M$ at 0.1%, 0.5%, 1.0%, 1.5%, and 2.0% pluronic F127 solution, respectively. It was $50\;{\mu}M$ in the absence of the polymer. Minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of NYS-pluronic F127 lyophilizate were same at $3\;{\mu}g/ml$, while MIC and MFC of pure NYS are $3\;{\mu}g/ml$ and $12\;{\mu}g/ml$, respectively. By modulating the aggregation behavior of NYS, pluronic F127 was able to reduce the toxicity of the drug without compromising the MIC and MFC.

• 국제학술발표논문집
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• The 9th International Conference on Construction Engineering and Project Management
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• pp.784-791
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• 2022

Tack coat is a thin layer of asphalt between the existing pavement and asphalt overlay. During construction, insufficient tack coat layering can later cause surface defects such as slippage, shoving, and rutting. This paper proposed a method for tack coat inspection improvement using an unmanned aerial vehicle (UAV) and deep learning neural network for automatic non-uniform assessment of the applied tack coat area. In this method, the drone-captured images are exploited for assessment using a combination of Mask R-CNN and Grey Level Co-occurrence Matrix (GLCM). Mask R-CNN is utilized to detect the tack coat region and segment the region of interest from the surroundings. GLCM is used to analyze the texture of the segmented region and measure the uniformity and non-uniformity of the tack coat on the existing pavements. The results of the field experiment showed both the intersection over union of Mask R-CNN and the non-uniformity measured by GLCM were promising with respect to their accuracy. The proposed method is automatic and cost-efficient, which would be of value to state Departments of Transportation for better management of their work in pavement construction and rehabilitation.

• 한국축산식품학회지
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• 제31권6호
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• pp.858-864
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• 2011

The effect of adding 10% fat substitute (10%F) or 2% plum extract (2%P) on the formation of hydrocarbons and 2-alkyl-cyclobutanones (2-ACBs) in freeze-dried beef patties, irradiated (IR) at 44 kGy, and freeze-dried irradiated cooked beef patties was investigated. Hydrocarbons, such as $C_{16:3}$, $C_{16:2}$, $C_{17:2}$ and $C_{17:1}$, were detected only in irradiated samples and their concentrations were high in the order of 2%P+IR, IR and 10%F+IR. Only irradiated beef samples produced 2-ACBs (2-DCB, 2-TCB, 2-TeCB), and their amounts were high in reverse order. The addition of fat substitute or plum extract did not help in reducing hydrocarbons and 2-ACBs in the freeze-dried irradiated cooked beef. However, the amounts of radiation-induced hydrocarbons and 2-ACBs in all irradiated beef patties even at 44 kGy were too small to be of concern for human consumption.

• 한국지진공학회논문집
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• 제23권2호
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• pp.131-140
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• 2019

Diagonally reinforced concrete coupling beams (DRCBs) have been widely adopted in reinforced concrete (RC) bearing wall systems. DRCBs are known to act as a fuse element dissipating most of seismic energies imparted to the bearing wall systems during earthquakes. Despite such importance of DRCBs, the damage estimation of such components and the corresponding consequences within the knowledge of performance based seismic design framework is not well understood. In this paper, drift-based fragility functions are developed for in-plane loaded DRCBs. Fragility functions are developed to predict the damage and to decide the repair method required for DRCBs subjected to earthquake loading. Thirty-seven experimental results are collected from seventeen published literatures for this effort. Drift-based fragility functions are developed for four damage states of DRCBs subjected to cyclic and monotonic loading associated with minor cracking, severe cracking, onset of strength loss, and significant strength loss. Damage states are defined in a consistent manner. Cumulative distribution functions are fit to the empirical data and evaluated using standard statistical methods.

• 대한원격탐사학회지
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• 제35권1호
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• pp.151-162
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• 2019

Surface temperature has been derived from the MODIS/ASTER airborne simulator (MASTER) mid-wave infrared single channel data using the MODerate resolution atmospheric TRANsmission (MODTRAN) radiative transfer model with input data including the University of Wisconsin (UW) emissivity, the National Centers for Environmental Prediction (NCEP) atmospheric profiles, and solar and line-of-sight geometry. We have selected the study area that covers some surface types such as water, sand, agricultural (vegetated) land, and clouds. Results of the current study show the reasonable geographical distribution of surface temperature over land and water similar to the pattern of the MASTER L2 surface temperature. The thorough quantitative validation of surface temperature retrieved from this study is somehow limited due to the lack of in-situ measurements. One point comparison at the Salton Sea buoy shows that the present estimate is 1.8 K higher than the field data. Further comparison with the MASTER L2 surface temperature over the study area reveals statistically good agreement with mean differences of 4.6 K between two estimates. We further analyze the surface temperature differences between two estimates and find primary factors to be emissivity and atmospheric correction.

• 한국과학교육학회지
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• 제17권4호
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• pp.525-540
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• 1997

The present study tested the hypothesis that maturation of the prefrontal lobes is a crucial factor determining the performance of scientific reasoning tasks, Functions of the prefrontal lobes, such as activating relevant information, sequential planning and monitoring, and inhibiting irrelevant information, are related thinking patterns with scientific reasoning. Therefore, we inferred the idea that the prefrontal lobes play an important role in scientific reasoning. To test the hypothesis. the present study investigated a prefrontal lobe patient's task solving procedures in scientific reasoning tasks and the correlation and regression analysis between a test of prefrontal lobe function and two scientific reasoning tasks, The perseverative errors in the Wisconsin Card Sorting Test(WCST) was used as a measure of the prefrontal lobe function, The Melinark Type Task and the Classroom Test of Scientific Reasoning were used as measures of scientific reasoning abilities. Ages and Group Embedded Figure Test were also used as measures of two alternative hypotheses, general maturation and field independency respectively. The prefrontal lobe patient showed a crucial deficiency in solving scientific reasoning tasks. In the tasks, the patient could not used the reasoning of If... and... then... therefore pattern. In correlation study, the perseveration errors of the WCST showed a significantly negative correlation with two scientific reasoning tasks. Multiple regression study also showed that the perseveration errors measured as a function of the prefrontal lobes have more contribution to scientific reasoning ability than contributions of alternative hypotheses. Therefore, the present study supported the hypothesis that prefrontal lobes play a crucial role in scientific reasoning ability, What function of the prefrontal lobes do play crucial role in scientific reasoning? The present study provided an explanation for the question, which inhibiting ability of the prefrontal lobes is responsible for the scientific reasoning ability, in a part at least. That is, perseverative tendency in task-solving procedures causes a deficiency of an ability to inhibit the wrong information to solve a task. The present study provided a possibility of neuropsychological approach in science education research. The present study also showed an importance of the prefrontal lobe development in the performance of scientific reasoning task.

• 한국재료학회지
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• 제20권5호
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• pp.257-261
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• 2010

A non-volatile resistive random access memory (RRAM) device with a Cr-doped $SrZrO_3/SrRuO_3$ bottom electrode heterostructure was fabricated on $SrTiO_3$ substrates using pulsed laser deposition. During the deposition process, the substrate temperature was $650^{\circ}C$ and the variable ambient oxygen pressure had a range of 50-250 mTorr. The sensitive dependences of the film structure on the processing oxygen pressure are important in controlling the bistable resistive switching of the Cr-doped $SrZrO_3$ film. Therefore, oxygen pressure plays a crucial role in determining electrical properties and film growth characteristics such as various microstructural defects and crystallization. Inside, the microstructure and crystallinity of the Cr-doped $SrZrO_3$ film by oxygen pressure were strong effects on the set, reset switching voltage of the Cr-doped $SrZrO_3$. The bistable switching is related to the defects and controls their number and structure. Therefore, the relation of defects generated and resistive switching behavior by oxygen pressure change will be discussed. We found that deposition conditions and ambient oxygen pressure highly affect the switching behavior. It is suggested that the interface between the top electrode and Cr-doped $SrZrO_3$ perovskite plays an important role in the resistive switching behavior. From I-V characteristics, a typical ON state resistance of $100-200\;{\Omega}$ and a typical OFF state resistance of $1-2\;k{\Omega}$, were observed. These transition metal-doped perovskite thin films can be used for memory device applications due to their high ON/OFF ratio, simple device structure, and non-volatility.

• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2002년도 학술대회지
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• pp.72-77
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• 2002

미국에서는 품질 관리 문제를 해결할 수 있는 아이디어로 지급(Pay) Factor가 사용되어왔으며 현재는 생애주기비용까지 고려한 한층 진보된 지급조정모델 개발에 많은 관심을 가지고 있다. 하지만 이러한 지급조정모델절차의 개발은 품질특성변수 선택의 문제, 품질특성변수의 확률적 분포와 도로 공용성간의 관계 분석의 문제, 그리고 하나의 전체 지급조정모델 개발의 문제 등으로 미 교통부에서 어려움을 가지고 있다. 본 논문에서는 이러한 점을 극복하기 위한 방법론으로 생애주기비용분석을 고려한 몬테카를로 시뮬레이션 접근 방식이 사용되었다. 미 여러 교통부에서 적용 가능한 견본이 될 수 있도록 현 위스콘신 교통국에서 사용중인 도로관리 관련 시스템들에서 데이터를 축출하여 지급조정을 격정하기 위한 분석 절차를 제시하고 이를 근간으로 지급조정모델 결정 지원 시스템을 개발하였으며 민감도 분석을 실행하여 실제 데이터를 사용하여 개발된 지급조정모델의 적정성을 평가하였다. 본 논문에서 사용된 지급조정모델 개발 절차는 한층 정확성을 높인 도로공용성예측모델과 생애주기비용모델을 사용함으로써 실제 프로젝트에 사용 가능할 것으로 판단된다.

• 토지주택연구
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• 제5권2호
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• pp.57-68
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• 2014

도시개발에 따른 외부효과 발생을 최소화하고 개발의 편익을 주변지역으로 확산하고자 하는 사회적 요구가 증가하면서 다양한 협력적 계획방식에 대한 논의가 증가하고 있다. 장기적으로는 협력적 계획을 뒷받침할 수 있는 법규 및 제도정비가 필요한 사항이지만 이에 앞서 미국사례의 협력적 계획이 실행될 수 있는 요소, 절차, 방법론 고찰을 통해 단일 행정구역 뿐만 아니라 여러 지자체에 걸쳐 도시개발이 이루어지는 복합경계신도시 등에 적용 가능한 협력적 계획의 대안과 시사점을 도출하고자 한다. 본 논문에서는 미국 위스콘신주의 사례조사 및 분석을 통해 다음과 같은 시사점을 도출하였다. 먼저 다수 지자체 경계 구역 내 공동계획구역을 설정하여 복합경계신도시 등과 같은 특수지역에 협동계획을 위한 구역 설정이 필요하며, 이를 위한 도시 계획적 수단이 마련되어야 한다. 이와 함께 협력계획의 유연성을 높이기 위해서는 생활권 단위의 계획단위 설정과 커뮤니티 활성화를 위한 제도적 운영체계가 마련되어야 한다. 또한 지역의 성장으로 인하여 발생한 수익은 공동세를 통하여 약정된 비율로 각 지자체에 배분하는 등 소규모 지역에서의 서비스 공유 및 공동세를 운영하는 방안도 협력계획의 실천력을 확보하는 방안이 될 수 있을 것이다. 이와 함께 협력적 거버넌스 구축을 위해서 계획단계에서부터의 이해관계자 참여와 중재인을 통한 갈등관리 방안이 마련되어야 하며, 도시기본계획 수준에서 협력계획의 실행 방안이 마련되어야 한다.

• 자원환경지질
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• 제27권1호
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• pp.93-100
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• 1994

이 연구는 위스컨신주 도어지역의 지하수계에서의 남성분의 이동과 불규칙한 검출에 대한 메카니즘을 규명하였다. 1991년 봄 충진기간 동안에, 세개씩의 수위정(piezometers)을 내장한 두곳의 관측정과 다섯군데의 가정우물에서 수위와 수질의 변화를 측정하였다. 충진현상에 대한 수위의 변화는 지하수의 충진이 약 4일에서 10일 정도 연체되면서 비교적 빠르게 일어남을 보여주며, 이것은 지하수의 충진이 실루리안 돌로마이트 대수층 내에서 높은 수리전도율(K)을 가진 지대를 통해서 일어나고 있음을 지시해준다. 지하수내의 납성분은 미립자에서만 발견되었고, 용융된 상태로는 검출되지 않았다. 그 농도는 0.2에서 $7.1{\mu}g/mg$인데, 이는 지하수내 총 납성분으로는 0.3에서 $4.7{\mu}g/l$이다. 충진사건부터 최대의 미립자가 가정우물까지 이동하는데 걸리는 연체시간은 약 19일에서 22일 이었다. 지하수내에서 납성분이 미립자와 더불어 있으므로, 가정우물 중에서도 높은 수리전도대와 연결된 우물에서만 납성분이 검출되고, 결과적으로 지역적 불규칙성을 유발한다. 또한 우물에서는, 충진사건에 의한 지하수계로의 미립자의 유입량의 변화, 미립자의 이동에 따른 연체현상, 그리고 이동중의 분산 등으로 인해서 납성분의 농도가 채취하는 시간에 따라서 다르게 나타난다.