• 대한한방내과학회지
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• 제38권3호
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• pp.401-407
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• 2017

Objective: This study reports on a treatment case of Soojeom-san plus Jeungmiyijin-tang (SJJI) on gastroesophageal reflux disease with hiatal hernia. Method: We considered a male patient suffering from gastroesophageal reflux disease with hiatal hernia because of blood stasis and damp-heat of the spleen and stomach pattern and prescribed SJJI. The progress was evaluated using the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) score, and the visual analogue scale for abdominal pain, sore stomach, and other symptoms. Results: The patient's symptoms, which included abdominal pain, sore stomach, dyspepsia, anorexia, insomnia, etc., almost disappeared. Conclusion: SJJI can be used for patients who have a chronic condition of gastroesophageal reflux disease with hiatal hernia because of blood stasis and a pattern of damp-heat of the spleen and stomach.

• 동의생리병리학회지
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• 제21권2호
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• pp.532-538
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• 2007

In order to establish the standard symptoms in men and women and highly frequent symptoms(HFS) of Phlegm(痰) Blood Stasis(血於) Cold(寒) Heat(熱) Dryness(濕) pathogenesis(病機), 969 questionnaires were analyzed through Cronbach alpha value and Pearson's correlative efficient. The Cronbach ${\alpha}$ value of each pathogensesis was Phlegm(0.83500)${\cdot}$Cold(0.823272)${\cdot}$Heat(0.816344)${\cdot}$Dampness(0.760292)${\cdot}$Blood Stasis(0.692551)${\cdot}$Dryness(0.672783) respectively. Through this study of frequency number of symptoms, followings were found that the physiological differences of men and women made some differences of main symptoms in each pathogenesis, and the differences of several clinical symptoms in a pathogenesis were resulted from the difference of specimens between textbook and this study.

• 대한한의진단학회지
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• 제22권1호
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• pp.33-44
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• 2018

Objectives This study aimed to perform a cross-cultural translation of 5 kinds of pattern identification questionnaires from Korean to English: questionnaires for seven emotions, fatigue and malaise, phlegm, food retention, and blood stasis. Methods We followed the strict guideline on the cross-cultural translation of healthcare evaluation tool. Total five stages of study were conducted. First, translations of two individual translators. Second, synthesizing of the two results. Third, two back translations from synthesized version to Korean. Fourth, expert committee reviewed with the original version, synthesized version, back translated versions to make a pre-final version. Last, with the pre-final version, 5 Americans evaluated face validity of the pre-final version. We made a final version after the above-mentioned 5 stages. Result and conclusion International versions of the 5 kinds of pattern identification questionnaires were completed. We can expect this versions are widly used for clinical usage and following academical researches.

• 동의생리병리학회지
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• 제25권2호
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• pp.176-184
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• 2011

Modern treatment of diabetes with hypoglycemic agents have been resulted the Pathological changes. Therefore, the pattern identifications of Korean traditional medicine also have to change. The aim of this study is to learn about the recent change of the pattern identifications on diabetes mellitus. Chinese traditional medicine is more free than us in medical activities because of the combination of Western and Eastern medical treatment and so there has been much published studies. Therefore, 35 papers that were searched from 2003 to 2010 in China by the keyword '糖尿' & '消渴' through the date base system of Kisti & Cnki were selected and analyzed. 35 review papers were composed of 28 observing academically and 7 clinical research studies. The combination of Western and Eastern Medical treatment has been effective than Western Medical treatment alone and the stasis(瘀血) acted as an important etiology on Diabetes mellitus. In the treatment of diabetes the stasis should be considered consistently from the onset.

• 대한예방한의학회지
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• 제23권2호
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• pp.91-99
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• 2019

Objectives : The aim of this study was to examine the reference value of biomarker serum amyloid p (SAP) to diagnose blood stasis objectively. Methods : Pubmed-Medline, Cochrane library, EMBASE were searched using the key words 'SAP' and 'serum amyloid p' in June 2018. Original articles of human adults that published in English, studies that recruited from the clinical research settings or well defined population based cohorts were only included. Results : A total of 12 studies were selected to extract the reference value of SAP. It was between 8.5 ng/mL (0.0085 mg/L) to 57.5 mg/L. Although the disease varied, most of them showed elevated SAP levels in the disease group (1.1-1.5 times). Conclusions : This study is meaningful in that it summarizes the results of previous researches of SAP, which has the potential to be diagnostic index of blood stasis.

• 동의생리병리학회지
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• 제22권1호
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• pp.13-24
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• 2008

This Chapter mentioned Terror and Palpitation due to Fright(驚悸) and Hemorrhagic disease(血證). Terror and Palpitation due to FrightAcctually Terror(驚) is different from Palpitation(悸). Terror(驚) is one of the seven emotions. But in this case, It refer to the Palpitation and the uneasiness of mind due to one's hearing a strange sound of seeing a strange. Tremulous Pulse can be appear. So Terror(驚) is caused by Exopathic Factors(外因) and belongs to Excess syndrome(實證). Palpitaion(悸) is the sensation of plamus, palpitation and unrest not because of being frightened. It is usurally caused by the deficiency of Ki(氣) and blood(血). So Deep, Thready and weak pulse can be appear. So Palpitaion(悸) is caused by Endopathic Factors and belongs to Deficiency Syndrome. In this Chapter, Terror and Palpitation due to Fright(驚悸) treat with the Kyeji-ke-jakyak-ka-chokchil-moryu-yongkol-kuyuk-tang(桂枝去芍藥加蜀漆牡蠣龍骨救逆湯) and Banha-mahwang-hwan(半夏麻黃丸). There are two type in Hemorrhagic disease(血證). One is bleeding(出血) and another is blood stasis(瘀血). The contents which relate with the Hemorrhagic disease(血證) are Hematemisis(吐血), Rhinorrhagia, Hemafecia(下血). In hemorrhage pathological mechanisms, there are two mechanisms. One is that Fire and Heat(火熱) pressure blood. Another is that cold and deficiency(虛寒) disable Ki(氣) from keeping blood flowing within vessels. Blood stasis(瘀血) can be called Extravasated Blood(惡血), Coagulated Blood, Blood retention(蓄血,積血), Dead Blood(死血) and Emaciation due to Blood disorder(乾血). It refer to a morbid state of unsmooth circulation and blood stagnancy often resulting from Ki(氣) stagnation, Ki(氣) deficiency and accumulation of pathogenic coldness. The symptom of Blood stasis are 'Fullness sensation in the chest, Lip Flaccidity, Cyonotic Tongue and Dryness of Mouth'. And the man who have Blood stasis, want to rinse his mouth with the water, but he can't drink the water because there isn't interior Heat of Excess Type. The symptom of Cyonotic Tongue(舌靑) had influence on diagnosing Blood stasis(瘀血) in offspring.

• Korean Journal of Radiology
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• 제24권7호
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• pp.647-659
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• 2023

Objective: The study was conducted to investigate the effect of correct occlusion of the left atrial appendage (LAA) on intracardiac blood flow and thrombus formation in patients with atrial fibrillation (AF) using four-dimensional (4D) flow magnetic resonance imaging (MRI) and three-dimensional (3D)-printed phantoms. Materials and Methods: Three life-sized 3D-printed left atrium (LA) phantoms, including a pre-occlusion (i.e., before the occlusion procedure) model and correctly and incorrectly occluded post-procedural models, were constructed based on cardiac computed tomography images from an 86-year-old male with long-standing persistent AF. A custom-made closed-loop flow circuit was set up, and pulsatile simulated pulmonary venous flow was delivered by a pump. 4D flow MRI was performed using a 3T scanner, and the images were analyzed using MATLAB-based software (R2020b; Mathworks). Flow metrics associated with blood stasis and thrombogenicity, such as the volume of stasis defined by the velocity threshold ($\left|\vec{V}\right|$ < 3 cm/s), surface-and-time-averaged wall shear stress (WSS), and endothelial cell activation potential (ECAP), were analyzed and compared among the three LA phantom models. Results: Different spatial distributions, orientations, and magnitudes of LA flow were directly visualized within the three LA phantoms using 4D flow MRI. The time-averaged volume and its ratio to the corresponding entire volume of LA flow stasis were consistently reduced in the correctly occluded model (70.82 mL and 39.0%, respectively), followed by the incorrectly occluded (73.17 mL and 39.0%, respectively) and pre-occlusion (79.11 mL and 39.7%, respectively) models. The surfaceand-time-averaged WSS and ECAP were also lowest in the correctly occluded model (0.048 Pa and 4.004 Pa^-1, respectively), followed by the incorrectly occluded (0.059 Pa and 4.792 Pa^-1, respectively) and pre-occlusion (0.072 Pa and 5.861 Pa^-1, respectively) models. Conclusion: These findings suggest that a correctly occluded LAA leads to the greatest reduction in LA flow stasis and thrombogenicity, presenting a tentative procedural goal to maximize clinical benefits in patients with AF.

• 생약학회지
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• 제21권2호
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• pp.126-129
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• 1990

Platelet anti-aggregating activities were evaluated with three combined crude drug preparations which have been used for 'eahyul'-one of the pathological concept in oriental medicine presumably concerning blood stasis or stagnant syndrome. The water extract of each combined preparation and each component plant was tested for their effects against ADP, arachidonic acid (AA) or collagen induced rat platelet aggregations. Mild inhibitory activities were observed with all the three tested preparations, Kaechibokryung-Hwan, Dangkqijakyak-San and Ohnkyung-Tang, and the component plants which are included in at least two of the above preparations.

• 대한한의학회지
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• 제23권2호
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• pp.151-163
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• 2002

Traditionally, the Leech (Hirudo) has been used for the treatment of cerebral vascular diseases, cardiovascular diseases, women's diseases, etc. In Chinese medicine, usually Chinese medical doctors use Whitmania pigra Whitman among several species in their clinics. Because it was considered as toxic animal medicine according to related books, they used it in a parched form with Talcum powder, and this is the most general type for medication. Nowadays, however, many clinical doctors regard it as secure, so they tend to use it naturally in a capsule, in large quantities, and more frequently. We have no doubt that it is useful for diseases connected with blood stasis, especially including pulmonary diseases and allergic diseases, so we urge that many Korean oriental medical doctors use it practically in their clinics.

• 대한한방소아과학회지
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• 제13권1호
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• pp.1-16
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• 1999

A literature study was progressed for oriental medical diagnosis and treatment for Jianwang(健忘) : forgetfulness(amnesia). In orental medicine, the reason of Jianwang(健忘) was congenital insufficiency(稟賦不足), meditational excessiveness(思慮過多), deficiency of heart(心虛), phlegm retention(痰飮), deficiency of kidney(腎裏), breakdown of the normal physiological coordination between the heart and the kidney(心腎不交), blood stasis(瘀血). The method of medical treatment was invigorating vital energy and enriching the blood(大補氣血), invigorating the heart and nourishing blood(補心養血), dissipating phlegm and relieving mental stress(化痰寧神), regulating the spleen corresponds to earth(理脾土), invigorating the heart and the kidney(補心腎), reinforcing the liver and the kidney(培肝腎), promoting blood circulation to remove blood stasis(活血祛瘀) and etc. Herbal medication was followed as those method. The prescription was commonly used as Guibitang(歸脾湯), Insuksan(仁熟散), Chunwangbosimdan(天王補心丹), Susunghwan(壽星丸), Samjohwan(蔘棗丸) and etc.