• 분석과학
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• 제26권4호
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• pp.221-227
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• 2013

LC-MS/MS를 이용하여 인체 혈장 중 ginsenoside Rg1의 신속하고 정확한 분석법을 개발하고 이 분석법에 대한 검증을 수행하였다. 혈장 분석을 위하여 internal standard인 digoxin을 첨가한 후 acetone과 methanol용액 (80:20)으로 전처리하고, 그 상층액을 진공농축 한 후, LC-MS/MS로 분석하였다. 최적 크로마토그래피 분석은 0.1% formic acid 첨가된 water와 methanol을 이동상으로 하여 Agilent Eclipse XDB-C18 column ($4.6{\times}150mm$, $5{\mu}m$)을 이용하여 0.9 mL/min의 유속으로 gradient mode로 수행하였다. 혈장 중 ginsenoside Rg1의 표준 검량선은 1~500 ng/mL의 농도 범위에서 우수한 직선성($r^2=0.9995$)을 보였으며, 일내, 일간 정밀성은 변동계수 7.53% 이하, 정확성은 98.28% 이상이었다. 결과적으로 본 분석법은 ginsenoside Rg1의 약동학 연구에 적용되기에 충분한 감도와 특이성, 직선성, 정밀성 및 정확성을 가지고 있음을 확인하였다.

• Radiation Oncology Journal
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• 제19권3호
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• pp.287-292
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• 2001

목적 : 본 연구에서는 골반부위 방사선치료 환자중 직장암 환자에서 고정기구로 사용한 air-vacuum cushion의 조사면의 변화에 따른 고정기구의 유용성을 후향적으로 분석하였다. 대상 및 방법 : 충남대학교병원 치료방사선과에서 1998년 8월부터 1999년 8월까지 직장암으로 방사선치료를 받은 20명의 환자를 대상으로 하였다. 환자들은 모두 복와위 자세로 치료를 받았고 대조군 10명과 실험군 10명으로 각각 나누어서 연구를 실행하였다. 전체 치료과정중 EPID를 이용하여 후면조사면은 x축(right-left), y축(cranio-caudal)에 대한 영상을 얻었고, 측면조사면은 z축(anterior-posterior), y축(cranio-caudal)에 대한 영상을 얻었다. 전체 치료과정 중 얻은 영상들을 모의치료시 촬영한 기준필름과 matching 기법을 이용하여 오차를 측정하였다. 통계적 유의성 확인은 t-검정법을 사용하였다. 결과 : 대조군에서 10명 환자의 후면 조사영역의 경우 x축, y축에 대한 평균이동값은 각각 0.02 mm, 0.78 mm이었고 계통오차과 우연오차의 표준편차값은 각각 2.13 mm, 2.40 mm와 1.46 mm, 1.51 mm이었다. 측면조사면에서 z축, y축에 대한 평균이동값은 각각 2.96 mm, 0.47 mm이었고 계통오차와 우연오차의 표준편차는 각각 3.69 mm, 1.96 mm와 2.79 mm, 1.48 mm이었다. 실험군 10명 환자의 후면 조사면에서 x축, y축에 대한 평균이동값은 각각 -0.33 mm, 0.81 mm이었고 계통오차과 우연오차에 대한 표준편차는 각각 1.71 mm, 3.08 mm와 1.40 mm, 1.88 mm이었다. 측면조사면에서 z축, y축에 대한 평균이동값은 각각 2.98 mm, 0.74 mm이었고 계통오차과 우연오차에 대한 표준편차는 각각 4.75 mm, 2.65 mm와 2.69 mm, 1.86 mm이었다. 본 연구에서는 대조군과 실험군간의 조사면에 대한 평균 이동값과 우연오차는 거의 일치하였으나 계통오차는 실험군에서 다소 큰 경향을 보였다. 후면조사면과 측면조사면에서 air-vacuum cushion에 의한 조사면 변화의 통계적 유의성이 없었다. 결론 : 직장암 환자의 방사선 치료시 고정기구로 사용한 air-vacuum cushion의 사용이 방사선치료의 정확도에 이익을 주지 않는 것으로 생각된다.

• 한국실내디자인학회논문집
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• 제34호
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• pp.86-95
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• 2002

In the 1950’s, after modernistic hospital is begun to build in our country, there were much changes in hospital construction plan such as function, scale, operation, technology for 40 years so far. Interest about 'Healing environment furtherance' which is one of basic function of hospital within these change is continued. Specially, concept about furtherance of healing environment limited in ward department in the early time is applied to hospital space magnificently whole coming at present. Entrance of hospital and change of Lobby may speak as the representative example. This interest about practically use of lobby is rising gradually. Lobby adds to existed concept of space to the importance revaluated. The first purpose of this study is to investigates main entrance and lobby of representative hospital in our country and to search change and present condition. The second purpose is hereupon to present necessary objective standard with direction of lobby plan in general hospital forward though this.

• Journal of Gastric Cancer
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• 제23권1호
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• pp.107-145
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• 2023

The first edition of 'A Standardized Pathology Report for Gastric Cancer' was initiated by the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists and published 17 years ago. Since then, significant advances have been made in the pathologic diagnosis, molecular genetics, and management of gastric cancer (GC). To reflect those changes, a committee for publishing a second edition of the report was formed within the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists. This second edition consists of two parts: standard data elements and conditional data elements. The standard data elements contain the basic pathologic findings and items necessary to predict the prognosis of GC patients, and they are adequate for routine surgical pathology service. Other diagnostic and prognostic factors relevant to adjuvant therapy, including molecular biomarkers, are classified as conditional data elements to allow each pathologist to selectively choose items appropriate to the environment in their institution. We trust that the standardized pathology report will be helpful for GC diagnosis and facilitate large-scale multidisciplinary collaborative studies.

• 한국병원경영학회지
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• 제6권3호
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• pp.109-129
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• 2001

The purpose of this study was the acquisition of the optimum scale of the apportionment of standard & high-class bed for the maximum profit representative of the desire of customers in a General Hospital with 1,100 beds located in Seoul. This investigation was proceeded by the analysis of the result of the simulation with the survey of both the patients' needs for bed and the degree of the medical service by the grade of the ward. And finally the consequence was obtained as follows: 1. The result of the investigation of the inpatients' preference for the grade of ward classes shows that a private ward reflected 4.3 percent, a semi-private ward 1.7 percent, a three-bed ward 0.1 percent, and a ward with six beds 93.9 percent each other. 2. A questionnaire poll was paralleled of service terms of a medical doctor and a nurse by ward class, the data were used for the standard of the allotment of labor cost by the ward class. The poll shows that the service tenn of a medical doctor and a nurse based on a ward with six beds by ward class showed 1.7 times in internal medicine and 1.9 times in surgery at a private ward; 1.4 times in internal medicine and 1.7 times in surgery at a semi-private room; and 1.2 times both in internal medicine and in surgery at a three-bed ward 3. The resultant findings revealed the most profit per bed and per patient in a private ward. However, an analysis of profit with a standard of unit area by ward class represented a higher profit in both the internal medicine and the surgery semi-private ward than other ward classes. 4. The result of the analysis through simulation based on the data of the prime cost per the ward class proved the optimum scale of the distribution of beds by class as follows: sixteen beds of the internal medicine and twenty three beds of the surgery in the private ward; two hundreds and two of the internal medicine and one hundred and ninety eight of the surgery in the semi-private room; three of both the internal medicine and the surgery each other in the three-bed ward; one hundred and ninety eight of the internal medicine and two hundred and fifty two of the surgery in the ward with six beds. The result of this research exhibits that the income and expenditure of the hospital could be improved by changing parts of wards into private ones(containing the maximum profit per a unit of width) in case the scale of the number of beds is reset with the consideration of the profit per the unit width. In the near future it's strongly expected that the research for the more scientific standard of the allotment of labour cost by ward class and for definition of the optimum scale of the number of beds that actualize the maximum profit with the change of the three elements of the prime cost: cost of materials; labor costs; management expenses.

• 한국병원경영학회지
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• 제16권4호
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• pp.35-66
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• 2011

This study analyzed efficiency by utilizing DEA analytical technique centering on materials for 2009 of 20 major university hospitals in capital area. Input variables were utilized professor & full-time doctor, resident, nurse & number of bed hospitals. Output variables were analyzed by dividing number of annual outpatients & number of annual inpatients, and annually total outpatient profit & inpatient profit into a model of the standard for number of patients and the standard for medical profit. DEA analysis was elicited efficiency score by applying CCR, BCC, BFG, scale profit, and SE model. Through t-test after eliciting efficiency score, the implications were suggested by comparing efficiency between DMU in Seoul and DMU in capital area, by comparing between high-class general hospitals and general hospitals, and by comparing between high-class general hospitals in Seoul and 5 big hospitals. As a result of analysis, the major university hospitals in capital area showed high efficiency as a whole close to "1," but indicated low efficiency relatively in CCR field. Thus, the expansion in scale within capital area was indicated to reach the limit. Second, in a model of analyzing the standard for number of patients, the medical institutions, which are being operated efficiently, were indicated to be 10 DMUs. In the standard for medical profit, 12 DMUs were analyzed to be operated efficiently. Third, the efficiency in general hospital was higher than high-class general hospital. Thus, the efficiency of operation was indicated to be more important than scale. Also, large high-class hospitals(big 5) where are located in downtown Seoul showed the higher efficiency than other general high-class general hospitals, but were indicating very low efficiency in some DMUs. Fourth, as a result of generalizing and evaluating the number of patients and the medical profit, the efficient DMU was indicated to be more when analyzing on the basis of medical profit than the standard for number of patients. Thus, major university hospitals in capital area were indicated to make more effort for section in medical profit. Based on the analytical results of efficiency, a strategy for reinforcing efficiency in inefficient DMU was indicated to be needed a strategy of creating customers for promoting number of patients and a strategy for making operation efficient for increasing profitability.

• 간호행정학회지
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• 제9권1호
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• pp.63-73
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• 2003

Purpose : The purpose of this study is to analyze the comparison of organizational climate and job satisfaction of nurses between a secondary hospital and a tertiary hospital. Method : The subjects of this study were 50 nurses who were working in a secondary hospital and 50 working in a tertiary hospital. The data was collected by self-reporting questionnaires. The data were analysed using frequency, percentage, mean, standard deviation, t-test, ANOVA, Pearson's correlation coefficient, regression analysis. Result : 1) There was no statistical significance of the difference of organizational climate between a secondary hospital and a tertiary hospital. However, there was a statistical significance of the difference of job satisfaction. 2) In the organizational climate, there was a significant difference by income in a secondary hospital, and by position in a tertiary center. 3) In the job satisfaction, there was significant differences by age, marriage, position, and duration of working in a secondary hospital, otherwise. there was no significant difference in a tertiary hospital. 4) There was significant positive correlation between organizational climate and job satisfaction. Organizational climate significantly affected job satisfaction. Conclusion : It is suggested that the nursing organizational effectiveness program should be developed with reflecting on organizational characteristics that the nurses perceived.

• Journal of Hospice and Palliative Care
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• 제11권4호
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• pp.206-212
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• 2008

목적: 호스피스 완화의료 전문인력을 위한 기본단계 교육과정으로 개발된 표준교육 프로그램 시범교육의 결과를 평가하기 위함 방법: 표준교육 프로그램을 개발하기 위하여 미국의 Education in Palliative and End-of-life Care (EPEC)교육을 벤치마킹하여 국내 실정에 맞게 수정 보완하였다. 표준교육 프로그램은 총 19개의 세부 주제로 구성하였으며, 강의와 쌍방향식 강의, 소그룹 토론, 역할극 등의 다양한 교육방법을 적용하도록 설계하였다. 개발한 표준교육 프로그램의 내용과 교육방법의 타당성을 검증하기 위하여 3개 주제를 선택하여 호스피스 고위과정을 수료한 23명을 대상으로 시범교육을 실시하였다. 결과: 표준교육 프로그램 시범교육 대상자들은 피교육자 중심의 교육방법과 현장에서 활용할 수 있는 교육 내용에 대하여 만족하였으며, 강의를 위주로 하는 기존의 교육보다 효과적인 교육이라고 평가하였다. 결론: 표준교육 프로그램 시범교육은 그 효과가 긍정적이었으며 호스피스 완화의료 교육의 표준화와 교육 방법의 발전에 기여할 것으로 기대된다. 앞으로 표준교육 프로그램을 성공적으로 실행하기 위해서는 교육자 (Trainer)를 위한 교육이 실행되어야한다.

• 대한임상검사과학회지
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• 제51권2호
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• pp.164-170
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• 2019

5종류의 수송배지를 흡수 및 배출 능력, 생존 효율, 회수율을 CLSI (Clinical and Laboratory Standards Institute) M40-A2의 Swab elution method (Quantitative) 기준으로 평가하였다. 액체배지가 반유동 배지보다 3가지 평가에서 대부분 우수한 결과값을 보여주었다. Flocked swab이 standard swab 형태보다 균의 흡수 및 배출의 능력 또한 우수하였다. 생존 효율에 대한 평가 결과는 액체배지(S4)가 가장 우수한 결과값을 보였다. 성장이 좋지 않은 S. pneumoniae는 액체배지(S4, S5)에서 생존효율과 회수율이 높았다. 균 회수율 평가 결과는 S. pyogenes는 모든 배지에서 CLSI 기준에 적합하였다. S. pneumoniae는 반유동 배지(S2, S3)에서 부적합하였고, 나머지 배지는 모두 기준에 적합하였다. H. influenzae는 반유동 배지(S1, S3)에서 부적합하였고, 반유동 배지(S2), 액체배지(S4, S5)에서 기준에 적합하였다. 호흡기 질환을 유발하는 S. pneumonia, H. influenzae의 생존 능력은 대부분의 배지에서 좋지 않았다. P. aeruginosa는 실온에서 과성장이 관찰되었다. 액체배지와 flocked swab의 조합이 3가지 평가 방법에서 가장 뛰어난 결과를 평가를 통해 확인하였다.

• Journal of Trauma and Injury
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• 제30권2호
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• pp.63-65
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• 2017

Standard open procedures for resection of the first rib in thoracic outlet syndrome can prove to be quite difficult with extensive incisions. A minimal invasive procedure can also be painstaking, but provides an attractive alternative to the more radical open procedures. We report the details of the technique with direct video footage of the procedure performed in a 41-year-old man with thoracic outlet syndrome done entirely by thoracoscopic methods.