• Title/Summary/Keyword: stability of membrane

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Stability and drug release properties of liposomes containing cytarabine as a drug carrier

  • Kim, Chong-Kook;Park, Dong-Kyu
    • Archives of Pharmacal Research
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    • v.10 no.2
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    • pp.75-79
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    • 1987
  • Liposomes were studied as a drug delivery system. Multilamellar vesicles, small unilamellar vesicles and large unilamellar vesicles containing cytarabine were prepared using egg yolk lecithin and cholesterol. Large unilamellar vesicles showed the highest encapsulation efficiency of all and their encapsulation efficiency increased as the buffer volume decreased. Cholesterol increased the stability of liposomal drug products as drug carriers and reduced the permeability of drug across the liposomal membrane. The release rate of cytarabine increased with incubation temperature and decreased with cholesterol incorporation in liposomal membrane. The release mechanism of cytarabine from large unilamellar vesicles in vitro was chiefly due to simple diffusion across the liposomal membrane rather than liposomal rupture.

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Aerodynamic stability analysis of geometrically nonlinear orthotropic membrane structure with hyperbolic paraboloid in sag direction

  • Xu, Yun-ping;Zheng, Zhou-lian;Liu, Chang-jiang;Wu, Kui;Song, Wei-ju
    • Wind and Structures
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    • v.26 no.6
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    • pp.355-367
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    • 2018
  • This paper studies the aerodynamic stability of a tensioned, geometrically nonlinear orthotropic membrane structure with hyperbolic paraboloid in sag direction. Considering flow separation, the wind field around membrane structure is simulated as the superposition of a uniform flow and a continuous vortex layer. By the potential flow theory in fluid mechanics and the thin airfoil theory in aerodynamics, aerodynamic pressure acting on membrane surface can be determined. And based on the large amplitude theory of membrane and D'Alembert's principle, interaction governing equations of wind-structure are established. Then, under the circumstance of single-mode response, the Bubnov-Galerkin approximate method is applied to transform the complicated interaction governing equations into a system of second-order nonlinear differential equation with constant coefficients. Through judging the frequency characteristic of the system characteristic equation, the critical velocity of divergence instability is determined. Different parameter analysis shows that the orthotropy, geometrical nonlinearity and scantling of structure is significant for preventing destructive aerodynamic instability in membrane structures. Compared to the model without considering flow separation, it's basically consistent about the divergence instability regularities in the flow separation model.

Gas Permeation and Steam Stability of Ga Salt Doped Silica Membrane by Chemical Vapor Deposition (CVD 법으로 제조한 실리카 막의 Ga 염 첨가에 따른 스팀안정성 및 기체투과특성)

  • Ryu, Seung Hee;Lee, Yong Taek
    • Membrane Journal
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    • v.22 no.6
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    • pp.424-434
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    • 2012
  • In this study, a ceramic membrane was prepared by CVD. Tube type alpha alumina support was used for substrate and added the Ga salt in intermediate layer. Synthesized method was counter diffusion CVD method at $650^{\circ}C$ with tetramethylorthosilane (TMOS). Gas permeation was measured at $600^{\circ}C$ using single-component $H_2$, $N_2$, $CO_2$ and $CH_4$. During the steam treatment, $H_2/N_2$ permselectivity of non-Ga silica membrane was decreased 926 to 829 at $600^{\circ}C$. On the other hand $H_2/N_2$ permselectivity of added Ga silica membrane was stable 910 to 904 at $600^{\circ}C$. These results show that the metal-doped membranes improved steam stability for gas separation.

Preparation and Characterization of SPAES/SPVdF-co-HFP Blending Membranes for Polymer Electrolyte Membrane Fuel Cells (고분자 전해질 연료전지용 술폰화된 폴리(아릴렌 이써 설폰)/SPVdF-co-HFP 브렌딩 멤브레인의 제조 및 특성 분석)

  • PARK, CHUL JIN;KIM, AE RHAN;YOO, DONG JIN
    • Transactions of the Korean hydrogen and new energy society
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    • v.30 no.3
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    • pp.227-236
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    • 2019
  • In this work, preparation and characterizations of hybrid membranes containing sulfonated poly(arylene ether sulfone) (SPES) and sulfonated poly(vinylidene fluoride-co-hexafluoropropylene) (SPVdF-co-HFP) (20, 30 or 40 wt%) were carried out. The structure of hybrid membranes was confirmed using X-ray diffraction (XRD) analysis and the Fourier transform infrared (FT-IR) spectroscopy. The prepared SPAES/SPVdF-30 membrane exhibits higher ionic conductivity of 68.9 mS/cm at $90^{\circ}C$ and 100% RH. Besides, the other studies showed that the hybrid membrane has good oxidation stability, thermal stability, and mechanical stability. Thus, we believe that the prepared hybrid membrane is suitable for the development of membranes for fuel cell applications.

Effects of Vitamin E supplement and Perilla oil on the Cytochrome P-450 contents and Fatty acid composition in Rat Hepatocarcinogenesis

  • Kim, Sookhee;Oum, Jungin;Choi, Haymie
    • Culinary science and hospitality research
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    • v.4
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    • pp.129-146
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    • 1998
  • The effects of vitamin E supplement on 15%(w/w diet) perilla or corn oils were studied in rat hepatocellular chemical carcinogenesis induced by modified Solt & Farber model, which consists of 20mg/kg body weight diethylintrosamine(DEN) injection, 3 weeks feeding of 0.02%2-acetylaminofluorene(2-AAF) and partial hepatectomy. The area of placental glutathione S-transferase(GST-P) positive foci tended to be smaller in perilla oil group had lower thiobarbituric acid reactive substances(TBARS) CONTENT. Fatty acid compositions in microsomal membrane were reflected by dietary fatty acid compositions, and not affected by carcinogen treatment or vitamin E supplement. By vitamin E supplement, linolenic acid contents of perilla oil group were much increased. By carcinogen treatment, membrane stability decreased significantly in corn oil, but maintained in perilla oil groups Vitamin E supplemental effect was noticed only in the corn-carcinogen group. Perilla oil may prevent hepatocarcinogenesis by maintaining membrane stability and by reducing cytochrome P-450 content. Vitamin E supplement did not seem to have the effect on hepatocarcinogenesis, but prevented lipid peroxidation, reduced cytochrome P-450 content and maintained membrane stability.

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Sectional Analysis of Sheet Metal Stamping Processes Using Bending Energy Augmented Membrane Element and Continuous Contact Treatment (굽힘 에너지가 보강된 박막 요소와 연속 접촉 처리를 이용한 스탬핑 공정의 단면 해석)

  • 윤정환;김종봉;양동열;유동진;한수식
    • Journal of the Korean Society for Precision Engineering
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    • v.15 no.4
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    • pp.58-67
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    • 1998
  • A sectional analysis of sheet metal forming process with an arbitrary tool shape is proposed in the present work. To improve the numerical convergence in the conventional membrane sectional analysis, the Bending Energy Augmented Membrane (BEAM) elements had been developed. The BEAM elements particularly improve the stability and convergence of the finite element method for the case of deep drawing. In this work, the FERGUBON spline (C$^2$-continuous) was used to fit the deformed mesh to smooth the given curves and calculate the local curvature of the deformed sheet. The fittings of the deformed sheet and tool surface profile ensure the stability and the convergence of the finite element analysis of highly nonlinear stamping processes. A center floor section and front fender section are analyzed to show the accuracy and robustness of the approach. The results obtained by the proposed approach are compared with the available experimental data.

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Separation of Organic Liquid Mixtures using Plasma Membrane (플라즈마 멤브레인을 이용한 유기용매 혼합을 분리)

  • 김성오;박복기;김두석;박진교;이덕출
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 1999.05a
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    • pp.642-644
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    • 1999
  • We have prepared the plasma-polymerized membrane for pervaporation of organic-liquid mixtures by the plasma polymerization technique. Plasma polymerization techniques were utilized in the development of hydrophilic composite membranes having high hydrogen ion permeability and excellent dimensional stability. To develop an organic liquid permselective Membrane, suppressing membrane swearing as well as enhancing the solubility difference is impotant. the objectives of the present study are to disign a suitable membrane for an organic-mixture system by the control of the plasma-polymer solubility.

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Effective Water Treatment Process by Hollow Fiber MF Membranes; VAS(Vibrating & Stripping by Air ) Process (에너지절약형 VSA MF Membrane 수처리 시스템)

  • 김정학
    • Proceedings of the Membrane Society of Korea Conference
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    • 1999.10a
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    • pp.93-116
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    • 1999
  • MF membrane element was specially designed for water purification and VSA process which can solve the fouling problem. Especially VSA process is developed for the SK Chemicals' asymmetric microfiltration hollow fiber membranes. In case of outside-to-in filtration process, MF membrane element showed the excellent flux stability caused by cleaning ability of VSA process . Simultaneous back-washing with VSA consideratbly enhances cleaning efficiency. From the result the possibility of the replacement of chemical coagulation and sand filtration process with newly developed VSA process was revealed.

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EFFECTIVE WATER TREATMENT PROCESS BY HOLLOW FIBER MEMBRANES : VAS (VIBRATING & STRIPPING BY AIR) PROCESS

  • Kim, Jeong-Hak
    • Proceedings of the Membrane Society of Korea Conference
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    • 1999.07a
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    • pp.63-66
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    • 1999
  • MF membrane element was specially designed for water purification and VSA process which can solve the fouling problem. Especially VSA process is developed for the SK Chemical's asymmetric microfiltration hollow fiber membranes. In case of outside-to-in filtration process, MF membrane element showed the excellent flux stability caused by cleaning ability of VSA process. Simultaneous back- washing with VSA considerably enhances cleaning efficiency. Form the result, the possibility of the replacement of chemical coagulation and sand filtration process with newly developed VSA process was revealed.

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