• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2001.11b
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• pp.3-6
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• 2001

In common globular proteins, the native form is in its most stable state. However, the native form of inhibitory serpins (serine protease inhibitors) and some viral membrane fusion proteins is in a metastable state. Metastability in these proteins is critical to their biological functions. Our previous studies revealed that unusual interactions, such as side-chain overpacking, buried polar groups, surface hydrophobic pockets, and internal cavities are the structural basis of the native metastability. To understand the mechanism by which these structural defects regulate protein functions, cavity-filling mutations of a 1-antitrypsin, a prototype serpin, were characterized. Increasing conformational stability is correlated with decreasing inhibitory activity. Moreover, the activity loss appears to correlate with the decrease in the rate of the conformational switch during complex formation with a target protease. We also increased the stability of a 1-antitrypsin greatly via combining various stabilizing single amino acid substitutions that were distributed throughout the molecule. The results showed that a substantial increase of stability, over 13 kcal/mol, affected the inhibitory activity with a correlation of 11% activity loss per kcal/mol. The results strongly suggest that the native metastability of proteins is indeed a structural design that regulates protein functions and that the native strain of a 1-antitrypsin distributed throughout the molecule regulates the inhibitory function in a concerted manner.

• Journal of Information Science Theory and Practice
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• v.8 no.2
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• pp.68-78
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• 2020

This study is a preliminary study to develop an evaluation framework necessary for evaluating the DataON platform. The first objective is to examine expert perceptions of the level of DataON platform construction. The second objective is to evaluate the importance, stability, and usability of DataON platform features over OpenAIRE features. The third objective is to derive weights from the evaluation perspective for future DataON platform evaluation. The fourth objective is to examine the preferences of experts in each evaluation perspective and to derive unbiased evaluation criteria. This study used a survey method for potential stakeholders of the DataON platform. The survey included 12 professionals with at least 10 years of experience in the field. The 57 overall functions and services were measured at 3.1 out of 5 for importance. Stability was -0.07 point and usability was measured as -0.05 point. The 42 features and services scored 3.04 points in importance. Stability was -0.58 points and usability was -0.51 points. In particular, the stability and usability scores of the 42 functions and services provided as of 2018 were higher than the total functions were, which is attributed to the stable and user-friendly improvement after development. In terms of the weight of the evaluation point, the collection quality has the highest weight of 27%. Interface usability is then weighted 22%. Subsequently, service quality is weighted 19%, and finally system performance efficiency and user feedback solicitation are equally weighted 16%.

• Electrical & Electronic Materials
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• v.14 no.12
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• pp.3-6
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• 2001

In common globular proteins, the native form is n its most stable state. However, the native form of inhibitory serpins (serine protease inhibitors) and some viral membrane fusion proteins is in a metastable state. Metastability in these proteins is critical to their biological functions. Our previous studies revealed that unusual interactions, such as side-chain overpacking, buried polar groups, surface hydrophobic pockets, ad internal cavities are the structural basis of the native metastability. To understand the mechanism by which these structural defects regulate protein functions, cavity-filling mutations of $\alpha$1-antitrypsin, a prototype serpin, were characterized. Increasing conformational stability is correlated with decreasing inhibitory activity. Moreover, the activity loss appears to correlate with the decrease in the rate of the conformational switch during complex formation with a target protease. We also increased the stability of $\alpha$1-antitrypsin greatly via combining various stabilizing single amino acid substitutions that were distributed throughout the molecule. The results showed that a substantial increase of stability, over 13 kcal/mol, affected the inhibitory activity with a correlation of 11% activity loss per kcal/mol. The results strongly suggest that the native metastability of proteins is indeed a structural design that regulates protein functions and that the native strain of $\alpha$1-antitrypsin distributed throughout the molecule regulates the inhibitory function in a concerted manner.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2001.11a
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• pp.3-6
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• 2001

In common globular proteins, the native form is in its most stable state. However, the native form of inhibitory serpins (serine protease inhibitors) and some viral membrane fusion proteins is in a metastable state. Metastability in these Proteins is critical to their biological functions. Our previous studies revealed that unusual interactions, such as side-chain overpacking, buried polar groups, surface hydrophobic pockets, and internal cavities are the structural basis of the native metastability. To understand the mechanism by which these structural defects regulate protein functions, cavity-filling mutations of ${\alpha}$1-antitrypsin, a prototype serpin, were characterized. Increasing conformational stability is correlated with decreasing inhibitory activity. Moreover, the activity loss appears to correlate with the decrease in the rate of the conformational switch during complex formation with a target protease. We also increased the stability of ${\alpha}$1-antitrypsin greatly via combining various stabilizing single amino acid substitutions that were distributed throughout the molecule. The results showed that a substantial increase of stability, over 13 kcal/mol, affected the inhibitory activity with a correlation of 11% activity loss per kcal/mol. The results strongly suggest that the native metastability of proteins is indeed a structural design that regulates protein functions and that the native strain of e 1-antitrypsin distributed throughout the molecule regulates the inhibitory function in a concerted manner.

• Journal of the Korean Society for Precision Engineering
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• v.22 no.4
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• pp.128-135
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• 2005

Overhead crane systems consist of trolley, girder, rope, objects, trolley motor, girder motor, and hoist motor. The dynamic system of these systems becomes a nonlinear state equations. These equations are obtained by the nonlinear equations of motion which are derived from transfer functions of driving motors and equations of motion for objects. From these state equations, Lyapunov functions of overhead crane systems are derived from integral method. These functions secure stability of autonomous overhead crane systems. Also constraint equations of driving motors of trolley, girder, and hoist are derived from these functions. From the results of computer simulation, it is founded that overhead crane systems is secure.

• KIEE International Transactions on Power Engineering
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• v.4A no.3
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• pp.134-140
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• 2004

This paper presents an improved group of energy functions reflecting generator damping effects for multi-machine power systems by using Center of Inertia (COI) formulation as an extension of the previous work. Since rotor angles at the Stable Equilibrium Point (SEP) of post-fault systems are generally calculated in COI, system transient energy can be found without assumption of infinite or slack bus, which is a crucial drawback of the absolute rotor angle frame approach. The developed energy functions have a structure preserving property with which it is very flexible to incorporate various models of power system components, especially various load and generator models. The proposed damping-reflected energy functions are applied to the Potential Energy Boundary Surface (PEBS) method, one of the direct methods. Numerical simulation of WSCC 9-bus shows that conservativeness of the PEBS method can be considerably reduced.

• Proceedings of the KSR Conference
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• 2011.10a
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• pp.188-194
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• 2011

The purpose of this paper is to explain the implementation method in order to enhance stability and reliability of embedded system. In this research, Texas Instrument (TI)'s TMS570 MCU(Micro Controller Unit) is used to satisfy the standard of stability that is IEC 61508. IEC 61508 suggest SIL(Safety Integrity Level) from 1 to 4 and TMS570 is satisfied SIL3. Also, TMS570 can provide several stability functions can be used in realtime system. To use such functions, this paper suggest the solution about the defect that can be used in realtime system. In basic way TMR(Triple Modular Redundancy) suggested in addition to explain about the way to improve safety and reliability. Also this paper will suggest the method that reinforce the stability of calculation by using multiplex voter and memory.

• 제어로봇시스템학회:학술대회논문집
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• 1994.10a
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• pp.518-521
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• 1994

Most of the theorems of nonlinear stability is based on the Lyapunov stability theory. The Lyapunov function method is most well-known and provides precise and rigorous theoretical backgrounds. However, the conventional approach to direct stability analysis has been performed without taking account of damping effects. For accurate stability analysis of nonlinear systems, the damping effects should be considered. This paper presents a new method to derive a group of Lyapunov functions to reflect the damping effects by considering the integral relationships of the system governing equations.

• The korean journal of orthodontics
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• v.19 no.2
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• pp.109-120
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• 1989

We tend to consider only static occlusion such as molar relationship, canine key, and interdigitation at finishing stage. Of course, this static occlusion is important for post-orthodontic stability. But we should remember that mandible is always on the move during its various functions. If no pressure or too much pressure is put on during its functions, untoward tooth movement could occur. And tooth mobility, periodontitis, wear facet, bruxism, and far worse temporomandibular disorder could occur. After many studies have been done on what is a desirable occlusal scheme to strengthen post-orthodontic stability, today, "mutually protective occlusion" is recommended. If an orthodontist does not have understanding about this occlusal scheme during orthodontic treatment, the following conditions will be resulted after orthodontic treatment. I. Centric discrepancy 1. centric prematurity 2. sunday bite 3. molar fulcrum II. Eccentric discrepancy 1. posterior interference 2. anterior interference If we have deep understanding about these discrepancies that can happen after orthodontic treatment and their causes, corrections, and especially preventions against them, post-orthodontic stability could be strengthened and further temporomandibular disorder could be prevented.

• Journal of Korean Society of Steel Construction
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• v.8 no.3 s.28
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• pp.55-65
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• 1996

For stability analysis of stifened rectangular thin plates with various boundary conditions, Ritz method is presented. An energy method is especially useful in those cases where a rigorous solution of the diferential eqution is unknown or where we have a plate reinforced by stiffeners and it is required to find only an approximate value of the critical load. The strain energy due to the plate bending and the work done by the in-plane forces are taken into account in order to apply the principle of the minimum potential energy. The buckling mode shapes of flexural beams with various boundary conditions are derived, and shape functions consistent with the given boundary conditions in the two orthogonal directions are chosen from those displacement functions of beams. The matrix equations for stability of stiffened rectangular thin plates are determined from the stationary condition of the total potential energy. Numerical example for stability behaviors of horizontally and vertically stiffened plates subjected to uniform compression, bending and shear loadings are presented and the obtained results are compared with other researchers' results.