• Biomolecules & Therapeutics
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• v.23 no.4
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• pp.367-373
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• 2015

Cordyceps species including Cordyceps bassiana are a notable anti-cancer dietary supplement. Previously, we identified several compounds with anti-cancer activity from the butanol fraction (Cb-BF) of Cordyceps bassiana. To expand the structural value of Cb-BF-derived anti-cancer drugs, we employed various chemical moieties to produce a novel Cb-BF-derived chemical derivative, KTH-13-amine-monophenyl [4-isopropyl-2-(1-phenylethyl) aniline (KTH-13-AMP)], which we tested for anti-cancer activity. KTH-13-AMP suppressed the proliferation of MDA-MB-231, HeLa, and C6 glioma cells. KTH-13-AMP also dose-dependently induced morphological changes in C6 glioma cells and time-dependently increased the level of early apoptotic cells stained with annexin V-FITC. Furthermore, the levels of the active full-length forms of caspase-3 and caspase-9 were increased. In contrast, the levels of total forms of caspases-3, caspase-8, caspase-9, and Bcl-2 were decreased in KTH-13-AMP treated-cells. We also confirmed that the phosphorylation of STAT3, Src, and PI3K/p85, which is linked to cell survival, was diminished by treatment with KTH-13-AMP. Therefore, these results strongly suggest that this compound can be used to guide the development of an anti-cancer drug or serve as a lead compound in forming another strong anti-proliferative agent.

• Journal of Digital Convergence
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• v.17 no.6
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• pp.297-305
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• 2019

The purpose of this study was to examine resilience and empathy on the relation between humanity and friendship of the early adolescents using structural equation modeling. The subjects were total 332 students of the 5th and 6th grade in elementary school and 1st and 2nd grade in junior school. The data were collected by means of the self-report questionnaire. The results of this study were as follows: Firstly, the direct effect of humanity on resilience, empathy, and friendship was found. Resilience also influence friendship directly, but empathy did not affect friendship. Secondly, humanity had influence on friendship partially mediated by resilience, but not mediated by empathy. This result shows that resilience was better mediated between humanity and friendship than empathy. Additionally, sex differences were found on empathy, but the differences were not found on resilience. The results revealed that the adolescents who scored high on humanity were better at friendship and when the higher humanity score was, the higher level of resilience was found, and this had an indirect effect on friendship quality.

• Journal of Industrial Convergence
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• v.19 no.5
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• pp.129-137
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• 2021

The present study attempted to identify how the knowledge and risk perception of nursing students regarding COVID-19 impact COVID-19 preventive behaviors. This study collected data from May 1st to September 20th, 2021, using a self-reported questionnaire targeting 184 nursing students. The collected data were analyzed using Independent t-test, One-way ANOVA, and Multiple regression. The research results indicated that the knowledge(r=.15, p=.019) and risk perception(r=.13, p=.036) of nursing students regarding COVID-19 had a positive correlation with COVID-19 preventive behaviors. The factor that impacted the COVID-19 preventive behaviors of the subjects was COVID-19 knowledge, which had an explanatory power of 4%. Therefore, it is necessary to develop an educational intervention program that enables nursing students to obtain the correct knowledge regarding COVID-19 and improves preventive behaviors.

• Journal of Digital Convergence
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• v.18 no.12
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• pp.401-412
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• 2020

This study was to determine differences and relations in nursing students' clinical practice stress and clinical competence by gender role identity. The study made a questionnaire survey of 450 nursing students of 2 colleges in J city, Gyeongnam, from June 1st to 30th, 2020. Data from 417 sheets were finally analyzed with descriptive statistics, χ2test, t-test, ANOVA, Scheffe test, correlation and hierarchial regression analysis. The analysis found that most of the participants belonged to undifferentiated type(34.3%) in gender role identity. Clinical competence showed significantly different(F=20.98, p<.001), but clinical practice stress showed no significant difference depending on that identity(F=1.56, p=.199). Clinical competence had positive correlations with the index of masculinity(r=.397, p<.001) or the index of feminity(r=.325, p<.001), but had no with clinical practice stress(r=.061, p=.217). Gender role identity turned out to be a factor that would significantly influence clinical competence(F=6.67, p<.001). These findings suggest that gender role identity of nursing students should be confirmed prior to clinical practice education and, thereon, interventions for clinical competence improvement should be developed.

• The Journal of the Convergence on Culture Technology
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• v.7 no.3
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• pp.509-515
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• 2021

This study analyzes the efficient floor layout plan of classrooms for securing evacuation stability in school in case of fire by using the Pathfinder simulation program. Efficient evacuation methods and safety were evaluated by analyzing REST (Required Safe Egress Time) according to the allocation of personnel by floor targeting a high school 5-story building equipped with a ramp and stairs. The current status of personnel assignments exceeded the Required Safe Egress Time(RSET), resulting in a problem with evacuation safety. When students were placed on the 3rd, 4th, and 5th floors, the result was that the time exceeded RSET the most. When students were placed on the 1st, 2nd, and 3rd floors, the result was that they completed evacuation in the shortest time, less than RSET. In the current state, when evacuation was guided by designating an evacuation exit depending on the location, the result of shortening RSET was obtained. As a result, it is effective to put the students on the lower floors when placing students in high-rise school buildings in terms of evacuation safety, and in the preliminary training, it is required to designate evacuation exits so that they can use the nearest exit for each location in case of a fire. As a future research project, additional research is needed on the RSET when a fire occurs in a specific location according to whether the automatic fire door at that location is opened or closed.

• The Journal of the Convergence on Culture Technology
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• v.8 no.1
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• pp.39-49
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• 2022

Early childhood teachers are teachers who take care of and raise infants or children and play a role in providing various care. The purpose of this study is to investigate the correlation between how the positive psychological capital of early childhood teachers affects the behavioral attitude of early childhood teachers through job stress in the COVID-19 situation. This study was conducted through an online survey from October 1st to October 14th, 2021, targeting 220 kindergarten teachers and daycare center teachers. Except for 20 questionnaires such as omission of records, a total of 200 questionnaires were used for the final analysis. As a result of hypothesis verification, first, it was found that self-efficacy and hope among positive psychological capital had an effect on lowering work stress. Second, among positive psychological capital, hope and optimism were found to have an effect on lowering parents' stress. Third, it was found that work stress had a positive effect on turnover intention but a negative effect on loyalty. On the other hand, it was found that parent stress had a positive effect on both turnover intention and loyalty. Based on the results of this study, it is expected that it can be used as basic policy data to help lower the turnover intention of early childhood teachers in the situation of COVID-19.

• Journal of Internet of Things and Convergence
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• v.8 no.2
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• pp.13-24
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• 2022

In order to explore the context of fraudulent claims and the measures for preventing them targeting the long-term care institutions for the elderly, which is increasing every year in Korea, this study conducted the text mining analysis using the media report articles. The media report articles were collected from the news big data analysis system called 'BIG KINDS' for about 15 years from July 2008 when the Long-Term Care Insurance for the Elderly took effect, to February 28^th 2022. During this period of time, total 2,627 articles were collected under keywords like 'elderly care+fraudulent claims' and 'long-term care+fraudulent claims', and among them, total 946 articles were selected after excluding overlapped articles. In the results of the text mining analysis in this study, first, the top 10 keywords mentioned in the highest frequency in every section(July 1^st 2008-February 28^th 2022) were shown in the order of long-term care institution for the elderly, fraudulent claims, National Health Insurance Service, Long-Term Care Insurance for the Elderly, long-term care benefits(expenses), elderly care facilities, The Ministry of Health & Welfare, the elderly, report, and reward(payment). Second, in the results of the N-gram analysis, they were shown in the order of long-term care benefits(expenses) and fraudulent claims, fraudulent claims and long-care institution for the elderly, falsehood and fraudulent claims, report and reward(payment), and long-term care institution for the elderly and report. Third, the analysis of TF-IDF was similar to the results of the frequency analysis while the rankings of report, reward(payment), and increase moved up. Based on such results of the analysis above, this study presented the future direction for the prevention of fraudulent claims of long-term care institutions for the elderly.

• Journal of Industrial Convergence
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• v.19 no.6
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• pp.73-79
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• 2021

The purpose of this study was to find out how the importance and satisfaction of social commerce selection factors perceived by social commerce users differ, and how social commerce selection factors affect repurchase intention. A survey was conducted for 17 days from September 1st to September 17th, 2021, and 316 copies were used for empirical analysis. As a result of the analysis, the selection factors of social commerce were divided into six factors: safety, convenience, economy, informativity, collectivity, and SNS relevance. IPA results were in the order of convenience in the first quadrant, relevance and informativity in the second quadrant SNS, collectivity in the third quadrant, stability in the fourth quadrant, and economy. In the relationship between social commerce selection factors and repurchase intention, convenience, economy, safety, and information among social commerce selection factors were found to have a significant influence on repurchase intention. As a result of this study, it was confirmed that if existing social commerce was important at an affordable price, convenience is more important for non-face-to-face commerce in the COVID-19 situation. It is considered important to have a system that can continuously identify and preemptively respond to users' shopping trends through IPA.

• The Mathematical Education
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• v.60 no.4
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• pp.467-491
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• 2021

This study is a study on the coding mathematics curriculum that converges elementary and middle school mathematics and information subjects and a minimum coding game-based education method for this. For the past 3 years, the coding mathematics curriculum and educational methods to effectively operate the curriculum were studied by applying them to 6th graders of elementary school and 1st graders of middle school. As a result of the first year of research, the coding mathematics curriculum was modified to a coding environment including the mathematical concept of a three-dimensional coordinate space, and the three-dimensional object was improved to be output as a real 3D print. As a result of the 2nd year study, it was improved so that even low-level students can build buildings by introducing different level commands for each component of the building so that self-directed learning is possible. As a result of the 3rd year study, a teaching-learning strategy based on a minimal coding game was designed to induce an increase in the level of computational thinking, and evaluation and feedback for diagnosing computational thinking were developed. Educational methods to promote self-directed learning and computing thinking ability, and researched coding mathematics curriculum are meaningful for the research and practice of the convergence education of school mathematics and informatics.

• The Journal of the Convergence on Culture Technology
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• v.8 no.3
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• pp.143-148
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• 2022

The subject of this paper is the practical examples of technoculture that critically thinks network technology, a strong material foundation in the era of data capitalism in the 21st century, and appropriates its socio-cultural metaphor as an artistic potential. In order to analyze its alternatives and the meaning of cultural politics, this paper examines the properties and influence of data capitalism after the 2008 global financial crisis, and the cultural and artistic context formed by its reaction. The first case considered in this paper, Furtherfield's workshop, provided a useful example of how citizens can participate in social change through learning and education in which art and technology are interrelated. The second case, Greek hackerspace HSGR, developed network technology as a tool to overcome the crisis by proposing a new progressive cultural commons due to Greece's financial crisis caused by the global financial crisis and a decrease in the state's creative support. The third case, Paolo Cirio's project, promoted a critical citizenship towards the state and community systems as dominant types of social governance. These technoculture cases can be evaluated as efforts to combine and rediscover progressive political ideology and its artistic realization tradition in the context of cultural politics, paying attention to the possibility of signifying practices of network technology that dominates the contemporary economic system.