• Journal of Powder Materials
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• v.28 no.2
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• pp.110-119
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• 2021

In this study, the high-temperature oxidation properties of austenitic 316L stainless steel manufactured by laser powder bed fusion (LPBF) is investigated and compared with conventional 316L manufactured by hot rolling (HR). The initial microstructure of LPBF-SS316L exhibits a molten pool ~100 ㎛ in size and grains grown along the building direction. Isotropic grains (~35 ㎛) are detected in the HR-SS316L. In high-temperature oxidation tests performed at 700℃ and 900℃, LPBF-SS316L demonstrates slightly superior high-temperature oxidation resistance compared to HR-SS316L. After the initial oxidation at 700℃, shown as an increase in weight, almost no further oxidation is observed for both materials. At 900℃, the oxidation weight displays a parabolic trend and both materials exhibit similar behavior. However, at 1100℃, LPBF-SS316L oxidizes in a parabolic manner, but HR-SS316L shows a breakaway oxidation behavior. The oxide layers of LPBF-SS316L and HR-SS316L are mainly composed of Cr₂O₃, Fe-based oxides, and spinel phases. In LPBF-SS316L, a uniform Cr depletion region is observed, whereas a Cr depletion region appears at the grain boundary in HR-SS316L. It is evident from the results that the microstructure and the high-temperature oxidation characteristics and behavior are related.

• Molecules and Cells
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• v.45 no.12
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• pp.935-949
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• 2022

Liver cancer has a high prevalence, with majority of the cases presenting as hepatocellular carcinoma (HCC). The prognosis of metastatic HCC has hardly improved over the past decade, highlighting the necessity for liver cancer research. Studies have reported the ability of the KiSS1 gene to inhibit the growth or metastasis of liver cancer, but contradictory research results are also emerging. We, therefore, sought to investigate the effects of KiSS1 on growth and migration in human HCC cells. HepG2 human HCC cells were infected with lentivirus particles containing KiSS1. The overexpression of KiSS1 resulted in an increased proliferation rate of HCC cells. Quantitative polymerase chain reaction and immunoblotting revealed increased Akt activity, and downregulation of the G1/S phase cell cycle inhibitors. A significant increase in tumor spheroid formation with upregulation of β-catenin and CD133 was also observed. KiSS1 overexpression promoted the migratory, invasive ability, and metastatic capacity of the hepatocarcinoma cell line, and these effects were associated with changes in the expressions of epithelial mesenchymal transition (EMT)- related genes such as E-cadherin, N-cadherin, and slug. KiSS1 overexpression also resulted in dramatically increased tumor growth in the xenograft mouse model, and upregulation of proliferating cell nuclear antigen (PCNA) and Ki-67 in the HCC tumors. Furthermore, KiSS1 increased the angiogenic capacity by upregulation of the vascular endothelial growth factor A (VEGF-A) and CD31. Based on these observations, we infer that KiSS1 not only induces HCC proliferation, but also increases the metastatic potential by increasing the migratory ability and angiogenic capacity.

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.136-136
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• 2023

우리나라의 강우 특성은 하절기에 집중되어 있으며 최근 이상강우와 기상이변에 따른 집중호우 발생으로 여를철 탁수 문제 발생 빈도가 높아지고 있는 추세이다. 과거 '02년 태풍 루사', '03년 태풍 매미', '06년 에위니아'부터 20년 마이삭, 하이선과 같은 태풍 및 장마에 의해 탁수 유입이 급증되어 수중 탁도가 높아지며 저수지 탁수 문제가 발생하였다. 특히 우리나라 경우 하천 및 저수지에서 물 사용량의 대부분을 이용하고 있기에 탁수 문제가 장기화 될 시 댐 하류 지역의 농업, 공업, 수생태 등 사회적, 비용적, 환경적 문제를 발생시킨다. 이러한 문제를 파악, 대응을 위한 탁수 모의에 대한 연구가 활발히 진행되고 있다. 탁수를 모의하기 위해서는 유량, 수온, SS, 탁도 데이터가 필요하며 이를 위해 국가측정망에서 하천 및 댐 저수지 내 SS를 측정하여 탁수를 측정 하고 있다. 하지만 현재 측정의 경우 채수를 통한 점단위의 측정으로 데이터 해상도가 낮다는 한계점이 있다. 이러한 데이터 취득의 한계로 기존 조사를 통한 탁도-SS 관계식을 통해 탁수를 예측하고 있으나 과거 2003년 이후 자료를 바탕으로 산정된 식으로 불확도가 존재한다. 탁수 모의 정확도 개선을 위한 데이터 해상도 및 탁도-SS 관계식 문제를 해결 하기 위해 기존 데이터 분석을 통한 미계측 기간에 대한 보간을 필요로 하며 현장 계측을 통한 탁도, SS 자료를 취득하여 탁도-SS 관계식을 최신화 할 필요가 있다. 따라서, 본 연구에서는 탁도를 측정 센서 YSI와 SS 측정센서 레이저부유사측정기(LISST: Laser In-Situ Scattering and Transmissometry)를 활용하여 자료를 취득하고 탁도-SS 산정식을 최신화 하였다. 또한 기존 국가 수질 측정망 데이터 및 기상 자료 데이터를 취득하여 데이터 분석을 통해 미계측 기간에 대한 데이터를 보간하여 탁수 모의 입력자료를 개선하였고 이를 기반으로 탁수 모의 정확도를 개선하고자 하였다.

• The Journal of Korean Obstetrics and Gynecology
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• v.22 no.1
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• pp.95-109
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• 2009

Purpose: This study was performed to determine the inhibitory effect of Sihosogansangagambang (SS) on melanin synthesis in B16F10 melanoma cells (B16F10). Methods: The inhibitory effects of Sihosogansangagambang on melanin synthesis were used by in vitro assay. To elucidate inhibitory effects of SS on melanin synthesis, we determined the melanin release in B16F10. And to investigate the mechanism of inhibitory effect of SS, we assessed the gene expression of tyrosinase, TRP-1, TRP-2 and ERK-1 in B16F10. Results: 1. SS decreased the release of melanin in B16F10 melanoma cells. 2. SS inhibited mushroom tyrosinase activity in vitro. 3. SS decreased the expression of tyrosinase, TRP-2 in B16F10 melanoma cells, but did not decreased the expression of TRP-1 in B16F10 melanoma cells. 4. SS decreased the expression of ERK-1 in B16F10 melanoma cells. Conclusion: From these results, it may be suggested that SS is possesed of the antimelanogenetic effects.

• Journal of Life Science
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• v.18 no.11
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• pp.1499-1506
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• 2008

To examine antitumor activity of the edible plant Zanthoxylum schinifolium, the cytotoxic effect of various organic solvent extracts of its stems on human acute leukemia Jurkat T cells was investigated. Among these extracts such as methanol extract (SS-7), methylene chloride extract (SS-8), ethyl acetate extract (SS-9), n-butanol extract (SS-10), and residual fraction (SL-11), SS-8 exhibited the most cytotoxic activity against Jurkat T cells. The methylene chloride extract (SS-8) possessed the apoptogenic activity capable of inducing sub-G1 peak along with apoptotic DNA fragmentation in Jurkat T cells. Western blot analysis revealed that SS-8 induced apoptosis via mitochondrial cytochrome c release into cytoplasm, subsequent activation of caspase-9 and caspase-3, and cleavage of PARP, which could be blocked by overexpression of Bcl-xL. Jurkat T cell clone I2.1 $FADD^{-/-}$) and Jurkat T cell clone I9.2 (caspase-$8^{-/-}$ were as sensitive as was the wild-type Jurkat T cell clone A3 to the cytotoxic effect of SS-8, suggesting no contribution of Fas/FasL system to the SS-8-mediated apoptosis. The GC-MS analysis of SS-8 showed that it was composed of 16 ingredients including 9,12-octadecanoic acid (18.62%), 2,4-dihydro-5-methyl-4- (1-methylethylidene)- 2-(4-nitrophenyl)-3H- pyrazol-3-one (14.97%), hexadecanoic acid (14.23%), (z,z)-6,9-pentadecadien- 1-ol (13.73%), 5,6-dimethoxy-2-methyl benzofuran (10.95%), and 4-methoxy-2-methylcinnamic acid (5.38%). These results demonstrate that the methylene chloride extract of the stems of Z. schinifolium can induce apoptotic cell death in Jurkat T cells via intrinsic mitochondria-dependent caspase cascade regulated by Bcl-xL without involvement of the Fas/FasL system.

• Journal of Korean Society of Environmental Engineers
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• v.32 no.4
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• pp.325-332
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• 2010

This study was conducted with the experiment of solubilisation of excess sludge by microbubble ozone process. To improve ozone contact efficiency, microbubble ozones which its diameter were the avearge 30 ${\mu}m$, microbubble size less than 40 ${\mu}m$ occupied about over 90% of all. In treating sludge using microbubble ozones, in case microbubble ozones are injected at microbubble ozone dosage of 0.34 g $O_3/g$ SS or less regardless of sludge concentration, microbubble ozone consumption rate was found to be 100% with no emission of waste ozones. In treating sludges by each concentration, in case the initial SS concentration of sludge is set to 6,447 mg/L, 5,557 mg/L, 3,180 mg/L, 1,092 mg/L and 515 mg/L, the amount of removed SS tended to increase with increase in initial SS concentration for the same microbubble ozone dosage, and treatment of sludge with high initial SS concentration was effective in raising the oxidation efficiency of microbubble ozones. On the other hand, as a result of reviewing acid, alkali and microbubble ozone treatment as composite treatment of sludge, use of acid treatment for the pre-treatment of microbubble ozone was more effective than alkali treatment, and in case of treatment at microbubble ozone dosage 0.05g $O_3/g$ SS with the concentration of sulfuric acid infused in the sludge, the amount of removed SS, 153.9 g, was 1.9 times more than 81.2 g the amount of single treatment of microbubble ozone.

• Journal of the Korea Organic Resources Recycling Association
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• v.32 no.1
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• pp.39-47
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• 2024

In this study, LiDAR-detective black material is synthesized by recycling silicon sludge (SS) that is generated from semiconductor manufacturing process, and its recognition is confirmed using two types of LiDAR sensors (MEMS and Rotating LiDAR). In detail, metal impurities on the surface of SS is removed, followed by coating of titanium dioxide (TiO₂) and subsequent chemical reduction to obtain SS-derived black TiO₂ (SS/bTiO₂) material. As-prepared SS/bTiO₂ is mixed with transparent paint to prepare hydrophilic black paints and applied to a glass substrate using a spray gun. SS/bTiO₂-based paint shows similar blackness (L^*=15.7) compared to commercial carbon black-based paint, and remarkable NIR reflectance (26.5R%, 905nm). Furthermore, MEMS and Rotating LiDAR have successfully detected the SS/bTiO₂-based paint. This is attributed to the occurrence of high reflection of light at the interface between the black TiO₂ and the silicon sludge according to the Fresnel's reflection principle. Hence, the new application field to effectively recycle silicon sludge generated in the semiconductor manufacturing process has been presented.

• Journal of Nutrition and Health
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• v.57 no.2
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• pp.196-210
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• 2024

Purpose: This study investigated the anti-obesity effects of a combination of Syzygium aromaticum L. and Sorbus commixta Hedl. (SS) in vitro and in vivo. Methods: The extracts of Syzygium aromaticum extract (SA) and Sorbus commixta extract (SC) were prepared individually using distilled water. They were mixed in a 1:2 ratio for use in the experiment. To assess the anti-obesity potential of SS in vitro, we examined cell proliferation, cellular triglyceride (TG), and total cholesterol (TC) levels, as well as lipogenesis and β-oxidation in 3T3-L1 cells. To confirm its anti-obesity potential in vivo, C57BL/6J mice were fed a 60% high-fat diet (HFD) to induce obesity. SA alone, SC alone, and their combination compound, SS (at a dosage of 200 mg/kg) were orally administered for 6 weeks. Thereafter, to conduct a comparative evaluation, serum analysis, western blotting of liver tissues, and histopathological analysis were performed. Results: Both SS200 and SS400 significantly inhibited the cellular TG and TC contents in the 3T3-L1 cells. Furthermore, treatment of the cells with SS (at a dose 200 and 400 ㎍/mL) also led to a noticeable regulation of key lipogenic and β-oxidation factors. Treatment of obese mice with SS resulted in a greater reduction in serum leptin and TG levels compared to treatment with the individual compounds (SA and SC). Furthermore, activation of AMP-activated protein kinase α by SS treatment resulted in the suppression of sterol regulatory element-binding proteins (SREBP)-1, leading to the inhibition of acetyl-CoA carboxylase (ACC) expression. Conclusion: Our results suggest that SS may have the potential to prevent obesity through a reduction in the TG and TC levels and regulation of lipogenesis and β-oxidation.

• Proceedings of the Korea Institutes of Information Security and Cryptology Conference
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• 2002.11a
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• pp.352-355
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• 2002

QoSS(Quality of Security Service)는 보안을 단순한 성능 장애 요소의 관점에서 벗어나 QoS(Quality of Service)의 관점에서 효율적인 네트워크 관리 도구로서 사용하기 위해 등장한 개념이다. QoSS는 보안 서비스들이 적용되는 상황에 따라, 또는 사용자의 요구사항에 따라 다양한 수준으로 제공 가능하다는 가변 보안의 개념에 기초하고 있다. 이를 통해 사용자에게는 제공되는 서비스들에 대한 만족도를 향상시키고, 서비스 제공자 측면에서는 자원의 가용성을 향상시키는 효과를 달성 할 수 있다. 본 논문에서는 이러한 QoSS의 전반적인 구성 요소들을 간략히 소개하고, 차세대 네트워크 보안 서비스의 구축 시 QoSS의 적응 절차와 적용 시 고려해야 할 사항에 대해서 제안한다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 1999.05a
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• pp.243-247
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• 1999

For the purpose of LAN or data transmission line design with high speed and reliability using power lines, in this paper, we present CSK/SS-DS signal transmission characteristics simulations with changing channel characteristics due to impedance fluctuation. And we also simulated the signal transmissions with a strong impulsive burst noise and with a gaussian random noise. We introduce a simple channel equalization filtering method that solves the synchronization problem of CSK/SS-DS with fluctuating channel characteristics or low S/N ratio.