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An Overview of Fish-borne Nematodiases among Returned Travelers for Recent 25 Years- Unexpected Diseases Sometimes Far Away from the Origin

  • Eiras, Jorge Costa;Pavanelli, Gilberto Cezar;Takemoto, Ricardo Massato;Nawa, Yukifumi
    • Parasites, Hosts and Diseases
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    • v.56 no.3
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    • pp.215-227
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    • 2018
  • Along with globalization of traveling and trading, fish-borne nematodiases seems to be increasing in number. However, apart from occasional and sporadic case reports or mini-reviews of particular diseases in particular countries, an overview of fish-borne nematodiasis among travelers have never been performed. In this review, we gathered fish-borne nematodiasis among travelers for recent 25 years by an extensive global literature survey using appropriate keywords, e.g. travelers diseases, human infection, anisakiasis, gnathostomiasis, capillariasis, sushi, sashimi, ceviche, Gnathostoma, Pseudoterranova, Anisakis, Capillaria, etc., as well as various combinations of these key words. The Internet search engines PubMed, Medline, Google and Googler Scholar were used as much as possible, and the references of every paper were checked in order to identify useful and reliable publications. The results showed unexpectedly high incidence of gnathostomiasis and low incidence of anisakidosis. The different incidence values of the infection with several fish-borne zoonotic nematode species are discussed, as well as some epidemiological aspects of the infections. The difficulties of differential diagnosis in non-endemic countries are emphasized. It is concluded that travelers must avoid risky behaviors which can lead to infection and that physicians and health authorities must advice travelers on the risks of eating behaviors during travel.

Functional Diversity of Cysteine Residues in Proteins and Unique Features of Catalytic Redox-active Cysteines in Thiol Oxidoreductases

  • Fomenko, Dmitri E.;Marino, Stefano M.;Gladyshev, Vadim N.
    • Molecules and Cells
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    • v.26 no.3
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    • pp.228-235
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    • 2008
  • Thiol-dependent redox systems are involved in regulation of diverse biological processes, such as response to stress, signal transduction, and protein folding. The thiol-based redox control is provided by mechanistically similar, but structurally distinct families of enzymes known as thiol oxidoreductases. Many such enzymes have been characterized, but identities and functions of the entire sets of thiol oxidoreductases in organisms are not known. Extreme sequence and structural divergence makes identification of these proteins difficult. Thiol oxidoreductases contain a redox-active cysteine residue, or its functional analog selenocysteine, in their active sites. Here, we describe computational methods for in silico prediction of thiol oxidoreductases in nucleotide and protein sequence databases and identification of their redox-active cysteines. We discuss different functional categories of cysteine residues, describe methods for discrimination between catalytic and noncatalytic and between redox and non-redox cysteine residues and highlight unique properties of the redox-active cysteines based on evolutionary conservation, secondary and three-dimensional structures, and sporadic replacement of cysteines with catalytically superior selenocysteine residues.

Establishment of reverse transcription polymerase chain reaction for detection of Getah virus infection in livestock

  • Lee, Seung Heon;Yang, Dong-Kun;Kim, Ha-Hyun;Choi, Sung-Suk;Cho, In-Soo
    • Korean Journal of Veterinary Research
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    • v.57 no.1
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    • pp.37-42
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    • 2017
  • Getah virus (GETV) infection causes sporadic outbreaks of mild febrile illness in horses and reproductive failure in pigs. In this study, we established a reverse transcription polymerase chain reaction (RT-PCR) method to detect GETV from suspected virus-infected samples. The reaction conditions were optimized and validated by using RNA extracted from GETV propagated in cell culture. A GETV-specific GED4 primer set was designed and used to amplify a 177 bp DNA fragment from a highly conserved region of the E1 glycoprotein gene in the GETV genome. RT-PCR performed with this primer set revealed high sensitivity and specificity. In the sensitivity test, the GED4 primer set detected GETV RNA at the level of $10^{2.0}\;TCID_{50}/mL$. In the specificity test, the GED4 primer set amplified only a single band of PCR product on the GETV RNA template, without non-specific amplification, and exhibited no cross-reactivity with other viral RNAs. These results suggest that this newly established RT-PCR method is useful for accurate identification of GETV infection in animals.

PPARγ Physiology and Pathology in Gastrointestinal Epithelial Cells

  • Thompson, E. Aubrey
    • Molecules and Cells
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    • v.24 no.2
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    • pp.167-176
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    • 2007
  • Peroxisome proliferator-activated receptor-gamma ($PPAR{\gamma}$) is expressed at very high levels in the gastrointestinal epithelium. Many of the functions of $PPAR{\gamma}$ in gastrointestinal epithelial cells have been elucidated in recent years, and a pattern is emerging which suggests that this receptor plays an important role in gastrointestinal physiology. There is also strong evidence that $PPAR{\gamma}$ is a colon cancer suppressor in pre-clinical rodent models of sporadic colon cancer, and there is considerable interest in exploitation of $PPAR{\gamma}$ agonists as prophylactic or chemopreventive agents in colon cancer. Studies in mice and in human colon cancer cell lines suggest several mechanisms that might account for the tumor suppressive effects of $PPAR{\gamma}$ agonists, although it is not in all cases clear whether these effects are altogether mediated by $PPAR{\gamma}$. Conversely, several reports suggest that $PPAR{\gamma}$ agonists may promote colon cancer under certain circumstances. This possibility warrants considerable attention since several million individuals with type II diabetes are currently taking $PPAR{\gamma}$ agonists. This review will focus on recent data related to four critical questions: what is the physiological function of $PPAR{\gamma}$ in gastrointestinal epithelial cells; how does $PPAR{\gamma}$ suppress colon carcinogenesis; is $PPAR{\gamma}$ a tumor promoter; and what is the future of $PPAR{\gamma}$ in colon cancer prevention?

In Silico Signature Prediction Modeling in Cytolethal Distending Toxin-Producing Escherichia coli Strains

  • Javadi, Maryam;Oloomi, Mana;Bouzari, Saeid
    • Genomics & Informatics
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    • v.15 no.2
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    • pp.69-80
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    • 2017
  • In this study, cytolethal distending toxin (CDT) producer isolates genome were compared with genome of pathogenic and commensal Escherichia coli strains. Conserved genomic signatures among different types of CDT producer E. coli strains were assessed. It was shown that they could be used as biomarkers for research purposes and clinical diagnosis by polymerase chain reaction, or in vaccine development. cdt genes and several other genetic biomarkers were identified as signature sequences in CDT producer strains. The identified signatures include several individual phage proteins (holins, nucleases, and terminases, and transferases) and multiple members of different protein families (the lambda family, phage-integrase family, phage-tail tape protein family, putative membrane proteins, regulatory proteins, restriction-modification system proteins, tail fiber-assembly proteins, base plate-assembly proteins, and other prophage tail-related proteins). In this study, a sporadic phylogenic pattern was demonstrated in the CDT-producing strains. In conclusion, conserved signature proteins in a wide range of pathogenic bacterial strains can potentially be used in modern vaccine-design strategies.

Cognitive dysfunctions in individuals with diabetes mellitus

  • Kim, Hye-Geum
    • Journal of Yeungnam Medical Science
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    • v.36 no.3
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    • pp.183-191
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    • 2019
  • Some patients with type 1 and type 2 diabetes mellitus (DM) present with cognitive dysfunctions. The pathophysiology underlying this complication is not well understood. Type 1 DM has been associated with a decrease in the speed of information processing, psychomotor efficiency, attention, mental flexibility, and visual perception. Longitudinal epidemiological studies of type 1 DM have indicated that chronic hyperglycemia and microvascular disease, rather than repeated severe hypoglycemia, are associated with the pathogenesis of DM-related cognitive dysfunction. However, severe hypoglycemic episodes may contribute to cognitive dysfunction in high-risk patients with DM. Type 2 DM has been associated with memory deficits, decreased psychomotor speed, and reduced frontal lobe/executive function. In type 2 DM, chronic hyperglycemia, long duration of DM, presence of vascular risk factors (e.g., hypertension and obesity), and microvascular and macrovascular complications are associated with the increased risk of developing cognitive dysfunction. The pathophysiology of cognitive dysfunction in individuals with DM include the following: (1) role of hyperglycemia, (2) role of vascular disease, (3) role of hypoglycemia, and (4) role of insulin resistance and amyloid. Recently, some investigators have proposed that type 3 DM is correlated to sporadic Alzheimer's disease. The molecular and biochemical consequences of insulin and insulin-like growth factor resistance in the brain compromise neuronal survival, energy production, gene expression, plasticity, and white matter integrity. If patients claim that their performance is worsening or if they ask about the effects of DM on functioning, screening and assessment are recommended.

The Relation between Sandy Shore Distribution and Basic Rock in the East Coast of the Korean Peninsula (한반도 동해안의 모래해안 발달과 암석 분포 사이의 상관성)

  • Kim, Young-Rae
    • Journal of The Geomorphological Association of Korea
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    • v.25 no.4
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    • pp.21-35
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    • 2018
  • The distribution and size of sandy beaches along eastern Korea has a close relationship with the presence of granite rocks. In general, elongated and wide beaches with abundant sands are likely to develop along the coasts where granitic basic rocks comprise the dominant geology or where a large amount of sands are supplied by streams from inland granitic rocks. Small sandy beaches, in contrast, appear in non-granitic rocks (i.e., under sedimentary and/or metamorphic geology). Hence, large beaches are observed continuously along the shore of Gangwon-do, of which coasts consist predominantly of granitic geology. Such continuity declines from Samcheok city to Pohang city. The rock of Gyeonbuk-do is commonly known as sedimentary, deposited between the late Triassic and the early Tertiary Periods. Because few sands are supplied from the upstream areas, sandy beaches unlikely develop along the coasts of the province, only showing a sporadic, discontinuous distribution under Bulguksa granite, granitic gneiss, and some volcanic rocks. Erosion was rarely observed in the beaches where granitic rocks are distributed, whereas merely five beaches seemed to have undergone some level of erosion in non-granitic regions. This is presumably because a larger amount of sands than that which had been eroded away was replenished in areas under granitic geology, while under non-granitic geology having a deficit in sands, no large sandy beaches had formed at first.

Synchronous Carotid Body and Glomus Jugulare Tumors : A Case Report and Review of Literature

  • Md Atikur Rahman;Tejas Venkataram;Riad Habib;Nwoshin Jahan;Farid Raihan;Shamsul Alam;Ehsan Mahmood;Giuseppe E Umana;Bipin Chaurasia
    • Journal of Korean Neurosurgical Society
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    • v.67 no.1
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    • pp.122-129
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    • 2024
  • Paragangliomas are rare neuroendocrine tumors that are usually benign in nature. They may be either familial or sporadic in their occurrence. Numerous neuroendocrine tumors are collectively included under the umbrella of paragangliomas. Among them, carotid body tumors and glomus jugulare tumors are extremely rare. Thus, we present a rare case of 29-year-old male who was admitted with hearing difficulties and tinnitus in the left ear, with swelling on the left side of the neck. Based on clinical and radiological findings, a diagnosis of left-sided glomus jugulare with carotid body tumor was made. The patient underwent a two-stage surgery with an interval of approximately 2 months. Histopathology revealed a paraganglioma. Herein, we present the clinical features, imaging findings, management, and a brief review of literature on the classification, evaluation, and management of carotid body and glomus jugulare tumors. Paraganglioma is a slow-growing tumor. The synchronous occurrence of carotid body and glomus jugulare tumors is infrequent. Microsurgical resection remains the primary treatment modality. Therefore, our patient underwent two-stage surgery. The rarity of occurrence and the proximity and adherence to vital neurovascular structures have resulted in the treatment of paragangliomas remaining a challenge.

A Study on Stabilization of Underwater TAS Winch System Deploy/Recover Operation Performance (수중용 TAS윈치 전개/회수 성능 안정화 방안에 관한 연구)

  • Chang, Ho-Seong;Cho, Kyu-Lyong;Hwang, Jae-Gyo;Lee, Sang-Yong;Kim, Yong-Tae
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.6
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    • pp.472-482
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    • 2019
  • This paper describes the stabilization of underwater TAS winch system Deploy/Recover operation performance. TAS winch installed on the stern of submarine performs to deploy/recover sensor, towing cable and rope tail which is deployed from the stern and separated from submarine itself. Also TAS winch provides transmission path of power to the sensor and data transmitting/receiving path which data are acquired from underwater environment like sound, depth and temperature. At the step of TAS winch evaluation test, sporadic standstill and rotating speed oscillation phenomenon were occurred. Winch motor provides the available torque to deploy/recover TAS and root cause analysis to the winch motor was done to find exact reason to sporadic malfunction. When winch motor was disassembled, eccentricity of rotor, slip-ring and the other composition part for winch motor were found. These might cause magnetic field distortion. To make TAS winch system more stable and block magnetic field distortion, this paper suggests methods to enhance fixing status installed in winch motor. For reliable data acquisition for TAS winch operation, the deploy/recover function of the improved type of TAS winch was verified in LBTS making similar condition with sea status. At the end of stage, improved type of TAS winch was tested on some functions not only deploy/recover function, but sustainability of TAS operation on specific velocity, steering angle of submarine in the sea trial. Improved type of TAS winch was verified in accordance with design requirement. Also, validity of suggested methods were verified by the sea trial.

Performance Impact of Large File Transfer on Web Proxy Caching: A Case Study in a High Bandwidth Campus Network Environment

  • Kim, Hyun-Chul;Lee, Dong-Man;Chon, Kil-Nam;Jang, Beak-Cheol;Kwon, Tae-Kyoung;Choi, Yang-Hee
    • Journal of Communications and Networks
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    • v.12 no.1
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    • pp.52-66
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    • 2010
  • Since large objects consume substantial resources, web proxy caching incurs a fundamental trade-off between performance (i.e., hit-ratio and latency) and overhead (i.e., resource usage), in terms of caching and relaying large objects to users. This paper investigates how and to what extent the current dedicated-server based web proxy caching scheme is affected by large file transfers in a high bandwidth campus network environment. We use a series of trace-based performance analyses and profiling of various resource components in our experimental squid proxy cache server. Large file transfers often overwhelm our cache server. This causes a bottleneck in a web network, by saturating the network bandwidth of the cache server. Due to the requests for large objects, response times required for delivery of concurrently requested small objects increase, by a factor as high as a few million, in the worst cases. We argue that this cache bandwidth bottleneck problem is due to the fundamental limitations of the current centralized web proxy caching model that scales poorly when there are a limited amount of dedicated resources. This is a serious threat to the viability of the current web proxy caching model, particularly in a high bandwidth access network, since it leads to sporadic disconnections of the downstream access network from the global web network. We propose a peer-to-peer cooperative web caching scheme to address the cache bandwidth bottleneck problem. We show that it performs the task of caching and delivery of large objects in an efficient and cost-effective manner, without generating significant overheads for participating peers.