• Environmental Mutagens and Carcinogens
• /
• v.26 no.2
• /
• pp.35-40
• /
• 2006

Background: Inorganic arsenic is a human carcinogen that can target the liver, but its carcinogenic mechanisms are still unknown. Inorganic arsenic induces a spectrum of tumors including hepatocellular carcinoma in mice. Methods: Pregnant C3H mice were supplied with drinking water containing 50 ppm sodium arsenite during their pregnancy. The protein expression profile in the liver of 0.5-day-old. male offsprings exposed transplacentally to sodium arsenite was analyzed using protein 2D gel electrophoresis followed by mass spectrometry (MALDI-TOF). Results: Expression of proteins such as hydroxymethylglutaryl-CoA synthase mitochondrial precursor (HMG-CoA synthase), ${\beta}$-actin (cytoplasmic 1) and apolipoprotein A-IV precursor (Apo-AIV) were induced in mouse liver by sodium arsenite, while uricase (urate oxidase), guanine nucleotidebinding protein beta subunit 2-like 1 (RACK1) and fructose-bisphosphate aldolase B (Aldolase 2) were down-regulated. Summary: Expression of proteins that have been implicated in carcinogenesis, such as HMG-CoA, ${\beta}$-actin, and RACK1, was regulated in the liver of mice transplacentally exposed to inorganic arsenic.

• Journal of Sensor Science and Technology
• /
• v.24 no.3
• /
• pp.169-174
• /
• 2015

In this study, we developed a system to detect the various defects in the metallic objects using the phenomenon that the defects cause the changes of the natural resonant frequencies. Our system consists of a FFT Amp, an Auto Impact Hammer, a Hammer controller and a PC. Auto Impact Hammer creates vibrations in the metallic objects when tapped on the surface. These vibrational signals are converted to the voltage signals by an acceleration sensor attached to the metallic part surface. These analog voltage signals were fed into an ADC (analog-digital converter) and an FFT (fast fourier transform) conversion in the FFT Amp to obtain the digital data in the frequency domain. Labview graphical program was used to process the digital data from th FFT amp to display the spectrum. We compared those spectra with the standard spectrum to find the shifts in the resonant frequencies of the metal parts, and thus detecting the defects. We used PCB's acceleration sensor and TI's TMS320F28335 DSP (digital signal processor) to obtain the resolution of 2.93 Hz and to analyze the frequencies up to 44 kHz.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• v.42
• /
• pp.26.1-26.6
• /
• 2020

Background: Orofacial clefts (OFCs) comprise a wide range of malformations, including cleft lip, cleft palate, and cleft lip with cleft palate, which can vary in terms of etiology, severity, and disease burden. Objective(s): This study aimed to evaluate the correlation between various risk factors and orofacial cleft disorder spectrum in newborns. Study design: A total of 323 cases and 400 controls were enrolled in this study and evaluated in terms of the maternal history of abortion or miscarriage, child's sex, maternal and paternal age, maternal history of systemic disease, history of medication therapy during pregnancy, birth order, consanguineous marriage, and complications during pregnancy. Results: Analysis of the results suggested that consanguineous marriage, a maternal history of abortion/miscarriage, and complications during pregnancy could potentially increase the risk of OFCs in children (P < 0.05). However, the analyses revealed that the other variables could not potentially increase the risk of OFCs (P > 0.05). Conclusion(s): Multiple cofactors may simultaneously contribute to the formation of such abnormalities; therefore, a comprehensive, multidisciplinary care program is necessary to ensure a successful pregnancy period and the birth of a healthy newborn.

• Journal of the Earthquake Engineering Society of Korea
• /
• v.20 no.6
• /
• pp.379-389
• /
• 2016

This study intends to evaluate the conservativeness of the fixed-base analysis as compared to the soil-structure interaction (SSI) analysis for the seismically isolated model of a nuclear power plant in Korea. To that goal, the boundary reaction method (BRM), combining frequency-domain and time-domain analyses in a twofold process, is adopted for the SSI analysis considering the nonlinearity of the seismic base isolation. The program KIESSI-3D is used for computing the reaction forces in the frequency domain and the program MIDAS/Civil is applied for the nonlinear time-domain analysis. The BRM numerical model is verified by comparing the results of the frequency-domain analysis and time-domain analysis for the soil-structure system with an equivalent linear base isolation model. Moreover, the displacement response of the base isolation and the horizontal response at the top of the structure obtained by the nonlinear SSI analysis using BRM are compared with those obtained by the fixed-base analysis. The comparison reveals that the fixed-base analysis provides conservative peak deformation for the base isolation but is not particularly conservative in term of the floor response spectrum of the superstructure.

• Journal of the Earthquake Engineering Society of Korea
• /
• v.11 no.5
• /
• pp.33-47
• /
• 2007

In a practical engineering, the equivalent static analysis (E.S.A) and the response spectrum analysis (R.S.A) are generally used for the seismic analysis. The base shears obtained from the E.S.A are invariable no matter how the principal axes of building structures are specified on an analysis program while those from the R.S.A are variable. Accordingly, the designed member size may be changed by how an engineer specify the principal axes of a structure when the R.S.A is used. Moreover, the base shears in the normal direction to the excitation axis are sometimes produced even when an engineer performs a response spectrum analysis in only one direction. This tendency makes the base shear, which is used to calculate the scale-up factor, relatively small. Therefore the scale-up factor becomes larger and it results in uneconomical member sizes. To overcome these disadvantages of the R.S.A, an alternative has been proposed in this study. Three types of example structures were adapted in this study, i.e. bi-direction symmetric structure, one-direction antisymmetric structure and bi-direction antisymmetric structure. The seismic analyses were performed by rotating the principal axes of the example structures with respect to the global coordinate system. The design member forces calculated with the scale-up factor used in the practice were compared with those obtained by using the scale-up factor proposed in this study. It can be seen from this study that the proposed method for the scale-up factor can provide reliable and economical results regardless of the orientation of the principal axes of the structures.

• Korean Journal of Applied Biomechanics
• /
• v.18 no.4
• /
• pp.49-57
• /
• 2008

The purpose of this study was to determine the effects of 12-week elastic resistance exercise for the elderly on the magnitude of frequency and variability of ground reaction force signals. To this aim, total 12 elderly women aged in their 70 were participated in this study and asked to do a 12-week elastic resistance exercise program. FFT(fast Fourier Transform) was used to analyze the frequency domain analysis of the ground reaction forces's signals and an accumulative PSD (power spectrum density) normalized by support phase of walking was calculated to reconstruct the certain signals. To estimate the gait stability between the before and after exercise, values of variability were determined in a coefficient of variance. The magnitude of frequency and variability analysis for media-lateral signal revealed significantly less after exercise (p<.05). In contrast, variability of this signal's frequency that have used to evaluate the local stability during walking exhibited significantly greater after exercise(p<.05). In summary, magnitude frequency and variability of media-lateral ground reaction force's signal were significantly changed after a 12-week elastic resistance exercise.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.10 no.2
• /
• pp.380-385
• /
• 2006

In this paper, a program that can be utilized to measure and analyze radio propagation characteristics is developed. This program is able to control the measurement instruments including spectrum analyzer through GPIB interface and analyze the measured data to yield mean excess delay and RMS delay spread. The measured path loss can be compared with theoretical value in free space or inside a tunnel. The measured and analyzed results can also be presented in the forms of graphs. As these tasks can be conducted on the spot of the measurements, this program is very helpful in performing and verifying the measurements immediately. In this thesis radio propagation characteristics with frequency bands of 2.45 and 5.8GHz in subway tunnels are measured by using the program. Path loss and delay spread in subway tunnel is measured and compared according to the form of antenna beam and LOS(Line of Sight) and N-LOS(Non-Line of Sight).

• Phonetics and Speech Sciences
• /
• v.6 no.2
• /
• pp.73-79
• /
• 2014

Alveolar fricative sounds /s/ and /s'/ are learned last for normal children in the speech development process for Koreans. These are especially difficult to articulate for hearing-impaired children often causing articulation errors. The acoustic phonetic evaluation uses testing tools to provide indirect and object information. These objective resources can be compared with standardized resources on speech when interpreting the results of a test. However, most previous studies in Korea did not consider acoustic studies that used the spectrum moment values of hearing-impaired children. Therefore, this study was conducted to compare the characteristics of hearing-impaired children's pronunciation of fricative sounds using spectrum moment values. For this purpose, the study selected a total of 10 hearing-impaired children (5 boys and 5 girls) currently in 3rd or 5th grade and attending one of the elementary schools in Seoul or Gyeonggi-do. For the selection process, their age, type of hearing aid, implantation of hearing aid (CI) before two years of age, hearing capacity (dB) before and after wearing the hearing aid, duration of speech rehabilitation, and time of learning alveolar fricative sounds were all considered. Also, 10 normal children (5 boys and 5 girls) were selected among 3rd or 5th grade students attending one of the elementary schools in Seoul or Gyeonggi-do. The subjects were asked to read the carrier sentence, "I say _______," including a list of 12 meaningless syllables composed of CV and VCV syllables, including alveolar fricative sounds /s/ and /s'/ and vowels /a/, /i/, and /u/. The recorded resources were processed through the Time-frequency Analysis Software Program to measure M1 (mean), M2 (variance), M3 (skewness), and M4 (kurtosis) of the fricative noise. No significant differences were found when comparing spectrum threshold values in the acoustic phonetic characteristics of hearing-impaired children and normal children in alveolar fricative sound pronunciation according to vowels /a/, /i/, and /u/, alveolar fricative sounds /s/ and /s'/, and syllable structure (CV, VCV) other than, for M3 in the comparison of groups according to disability. In the comparison of syllable structures, there were statistically significant differences in M1, M2, M3, and M4 with clinical significance. However, there was no significant difference in results when comparing the alveolar fricative sounds according to the vowels.

• Horticultural Science & Technology
• /
• v.30 no.6
• /
• pp.673-679
• /
• 2012

This study was conducted to examine the effect of artificial light source and photoperiod on the growth of leaf lettuce (Lactuca sativa L.) 'Seonhong Jeokchukmyeon' in a closed-type plant production system. Seedlings were grown under 3 light sources, fluorescent lamp (FL, Philips Co. Ltd., the Netherlands), WL #1 (Hepas Co. Ltd., Korea), and WL #2 (FC Poibe Co., Ltd., Korea), each with 3 photoperiods, 12/12, 18/6, and 24/0 (Light/Dark). An irradiance spectrum analysis showed that FL has various peaks in the 400-700 nm range, while WL #1 and WL #2 have only one monochromatic peak at 450 and 550 nm, respectively. The greatest plant height, fresh and dry weights were obtained in the 24/0 (Light/Dark) photoperiod. The 24/0 (Light/Dark) photoperiod treatment promoted vegetative growth of the leaf area. Length of the longest root, number of leaves, fresh weight, and total anthocyanin contents were greater in FL than in either WL #1 or #2. The greatest chlorophyll fluorescence (Fv/Fm) was found in the 12/12 (Light/Dark) photoperiod with FL treatment. The energy use efficiency of the LED increased by about 35-46% as compared to FL. Results suggest a possibility of LED being used as a substitute light source for fluorescent lamp for lettuce cultivation in a plant factory system.

• Journal of Aerospace System Engineering
• /
• v.9 no.2
• /
• pp.51-56
• /
• 2015

In the vibration test, Most of the test specifications is standardized methods of sinusoidal excitation. However, in accordance with the ability of the test equipment progress and developments of electronic technology, methods of random vibration test is standardized in the MIL standard. Therefore, in this study, we tried to analyze Missile Guidance Structure using a finite element analysis with ABAQUS 6.13 that is commercial program. First, Random response analysis is analyzed. Following analyzing the results, we wanted to find the model that is lightweight and resonance does not occur.