• Advances in Traditional Medicine
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• 제3권3호
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• pp.123-128
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• 2003

Stephania hernandifolia belonging to the family Menispermaceae is the biggest storehouse of diphenylbisbenzylisoquinoline (DBBI) alkaloids. Exhaustive chemical processing of the bulb of S. hernandifolia by the application of modern separation techniques yielded a DBBI alkaloid which was identified as cycleanine using spectroscopic methods (UV, IR, $^1HNMR$. $^{13}CNMR$, Mass). Cycleanine showed significant anti-inflammatory activity against carrageenin induced paw oedema, comparable to that produced by diclofenac sodium, used as standard drug. It exhibited potent analgesic effects against chemical and thermal noxious stimuli. It was also found to possess anticonvulsive activity in the strychnine induced convulsion model.

• Bulletin of the Korean Chemical Society
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• 제34권2호
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• pp.367-373
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• 2013

The ruthenium(II) ferrocenyl heterocyclic thiosemicarbazone complexes of the type $[RuCl(CO)(EPh_3)]_2L$ (where E = P/As; L = binucleating monobasic tridendate thiosemicarbazone ligand) have been investigated. Strutural features were determined by analytical and spectral techniques. Binding of these complexes with CT-DNA by absorption spectral study indicates that the ruthenium(II) complexes form adducts with DNA and has intrinsic binding constant in the range of $3.3{\times}10^4-1.2{\times}10^5M^{-1}$. The complexes exhibit a remarkable DNA cleavage activity with CT-DNA in the presence of hydrogen oxide and the cleavage activity depends on dosage.

• Archives of Pharmacal Research
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• 제22권6호
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• pp.642-645
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• 1999

In a bioassay-guided search for anti-allergic compounds from higher plants of Korea, poly-methoxyflavones, 3',4',5,6,7,8-hexamethoxyflavone (I), 5-hydroxy-3',4',6,7,8-pentamethoxyflavone (II) and 3',4',5,7,8-pentamethoxyflavone (III) have been isolated from the immature peels of Citrus unshiu. Structures of these compounds were elucidated on the basis of spectroscopic techniques. Compounds I and II inhibited dose-dependent histamine release from the rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE.

• Natural Product Sciences
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• 제13권2호
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• pp.140-143
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• 2007

Investigation of the chloroform soluble fraction of the red alga Liagora farinosa, collected from Hurghada at the Red Sea resulted in the isolation of three compounds; a nucleoside (thymidine) and two glycosides (methyl-${\beta}$-D-xylopyranoside and glycerol-2-${\alpha}$-D-glucopyranoside). The structures of the isolated compounds were established on the basis of different spectroscopic techniques as well as comparison with the previously published data. This is the first report for the isolation of the three compounds fron red algae; moreover, the compounds were examined for their antioxidant activity and showed variable activity.

• Natural Product Sciences
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• 제16권1호
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• pp.15-19
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• 2010

A new 2,7'-cyclolignan named lonicerinol (1) along with eight known lignans, (-)-epipinoresinol (2), (-)-pinoresinol (3), $9{\alpha}$-hydroxypinoresinol (4), 7R,8S-dihydrodehydrodiconiferyl alcohol (5), ($\pm$)-neo-olivil (6), (+)-isolariciresinol (7), 3-methoxy-8,4'-oxyneoligna-3',4,7,9,9'-pentol (8), and (-)-pinoresinol 4-O-glucoside (9), were isolated from the caulis of Lonicera japonica THUNB. (Caprifoliaceae). All of these constituents except for (-)-pinoresinol (3) and $9{\alpha}$-hydroxypinoresinol (4) are reported for the first time from the genus Lonicera. The structures and absolute configurations of these compounds were determined on the basis of spectroscopic analysis, including CD and 1D- and 2D-NMR techniques and chemical methods.

• Natural Product Sciences
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• 제4권4호
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• pp.257-262
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• 1998

The extract of the aerial parts of Fumaria bastardii Bor. afforded 12 alkaloids belonging to the skeletally six different groups of the isoquinoline alkaloids. In this publication, the isolation and identification of protopine (1), corydaldine (2), oxyhydrastinine (3), (-)-fumaritine (4), (+)-fumariline (5), (-)-O-methylfumarophycine (12), (+)-bicuculline (10), $(-)-{\beta}-hydrastine$ (7), (-)-corlumine (11), (+)-tetrahydropalmatine (8), (-)-stylopine (6), and (+)-juziphine (9) are described. Their structures have been determined by using extensive spectroscopic techniques. This is the first report of the occurrence of these alkaloids in Fumaria bastardii of Turkish origin.

• Natural Product Sciences
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• 제4권3호
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• pp.170-173
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• 1998

A new derivative of allo-inositol has been isolated from the aerial parts of Stocksia brahuica and named as brahol (1). The structure of 1 was elucidated with the help of extensive 2D-NMR spectroscopic techniques and identified as 5-O-methyl-allo-inositol. The structure was reconfirmed by acetate derivative (2).

• Bulletin of the Korean Chemical Society
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• 제20권9호
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• pp.1049-1055
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• 1999

Electrochemical oxidation of silicon (p-type Si(100)) at room temperature in ethylene glycol and in aqueous solutions has been performed by applying constant low current densities for the preparation of thin SiO2 layers. In-situ ac impedance spectroscopic methods have been employed to characterize the interfaces of electrolyte/oxide/semiconductor and to estimate the thickness of the oxide layer. The thicknesses of SiO2 layers calculated from the capacitive impedance were in the range of 25-100Å depending on the experimental conditions. The anodic polarization resistance parallel with the oxide layer capacitance increased continuously to a very large value in ethylene glycol solution. However, it decreased above 4 V in aqueous solutions, where oxygen evolved through the oxidation of water. Interstitially dissolved oxygen molecules in SiO2 layer at above the oxygen evolution potential were expected to facilitate the formation of SiO2 at the interfaces. Thin SiO2 films grew efficiently at a controlled rate during the application of low anodization currents in aqueous solutions.

• Bulletin of the Korean Chemical Society
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• 제18권6호
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• pp.579-584
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• 1997

A series of ferrocene-containing chelating bidentate nitrogen ligands (1 & 2) and polyazamacrocycles (3 & 4) were prepared in high yields from the reaction of ferrocenecarboxaldehydes with corresponding diamines under various catalytic and stoichiometric reaction conditions. The stoichiometric condensation to form Schiff bases required the presence of MgSO₄in the reaction mixture as a water-absorbent. Employment of cyclic diamines such as 1,2-diaminocyclohexane and p-phenylenediamine in the reaction with 1,1'-ferrocenedicarboxaldehyde resulted in the formation of polymers in stead of the expected macrocycles. All these compounds were characterized by microanalytical and spectroscopic techniques. In one case, the structure of 3a was confirmed by X-ray crystallography.

• Journal of Microbiology and Biotechnology
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• 제29권10호
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• pp.1603-1606
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• 2019

Sortase A (SrtA), a type of transpeptidase responsible for anchoring surface proteins to the peptidoglycan cell wall, is important in the virulence of gram-positive bacteria. Three compounds were isolated from marine-derived Streptomyces sp. MBTH32 using various chromatography techniques. The structures of these compounds were determined based on spectroscopic data and comparisons with previously reported data. Among the metabolites tested, lumichrome showed strong inhibitory activity against Staphylococcus aureus SrtA without affecting cell viability. The results of cell clumping activity assessment suggest the potential for using this compound to treat S. aureus infection by inhibiting SrtA activity.