Archives of Pharmacal Research
- Volume 22 Issue 6
- /
- Pages.642-645
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- 1999
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Anti-allergic Components from the Peels of Citrus nushiu
- Kim, Dae-Keun (College of Pharmacy, Woosuk University) ;
- Lee, Ki-Taek (College of Pharmacy, Woosuk University) ;
-
Eun, Jae-Soon
(College of Pharmacy, Woosuk University)
;
- Zee, Ok-Pyo (College of Pharmacy, Sung Kyun Kwan University) ;
-
Lim, Jong-Pil
(College of Pharmacy, Woosuk University)
;
- Eum, Sang-Sup (College of Pharmacy, Woosuk University) ;
- Kim, Sang-Hyun (College of Pharmacy, Woosuk University) ;
- Shin, Tae-Yong (College of Pharmacy, Woosuk University)
- Published : 1999.12.01
Abstract
In a bioassay-guided search for anti-allergic compounds from higher plants of Korea, poly-methoxyflavones, 3',4',5,6,7,8-hexamethoxyflavone (I), 5-hydroxy-3',4',6,7,8-pentamethoxyflavone (II) and 3',4',5,7,8-pentamethoxyflavone (III) have been isolated from the immature peels of Citrus unshiu. Structures of these compounds were elucidated on the basis of spectroscopic techniques. Compounds I and II inhibited dose-dependent histamine release from the rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE.
Keywords
- Anti-allergic effect;
- Citrus unshiu;
- 3',4',5,6,7,8-Hexamethoxyflavone;
- 5-Hydroxy-3',4',6,7,8-pentamethoxyflavone;
- Compound 48/80;
- Anti-DNP IgE