• BMB Reports
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• v.56 no.12
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• pp.633-644
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• 2023

Epigenetic mechanisms, primarily mediated through histone and DNA modifications, play a pivotal role in orchestrating the functional identity of a cell and its response to environmental cues. Similarly, the spatial arrangement of chromatin within the three-dimensional (3D) nucleus has been recognized as a significant factor influencing genomic function. Investigating the relationship between epigenetic regulation and 3D chromatin structure has revealed correlation and causality between these processes, from the global alignment of average chromatin structure with chromatin marks to the nuanced correlations at smaller scales. This review aims to dissect the biological significance and the interplay between the epigenome and 3D chromatin structure, while also exploring the underlying molecular mechanisms. By synthesizing insights from both experimental and modeling perspectives, we seek to provide a comprehensive understanding of cellular functions.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.28 no.10
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• pp.1193-1201
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• 2004

The effect of equivalence ratio and fuel/air mixing quality on the phase-resolved gas temperatures at different phases of the oscillating pressure cycle was experimentally investigated. An atmospheric pressure, optically accessible and laboratory-scale dump combustor operating on methane with heat release rate of 1.59kW was used. Temperature measurements were made using coherent anti-Stokes Raman spectroscopy (CARS) at several spatial locations fur typical unstable combustion conditions. Analysis was conducted using parameters such as phase-resolved averaged temperature, normalized standard deviation and temperature probability distribution functions (PDFs). Also the probability on the occurrence of high temperature (over 1900K) was investigated to get the information on the perturbation of equivalence ratio and NOx emission characteristics. It was shown that most of temperature histograms exhibit Gaussian profile which has short breadth of temperature fluctuation at equivalence ratio of 0.6, while beta profile was predominant for the cases of other equivalence ratios (${\Phi}$=0.55, 0.50). It was also shown that phase-resolved averaged temperature oscillated in phase with pressure cycle, while normalized standard deviations which represent temporal turbulent intensity of temperature showed nearly constant value around 0.1. The characteristics on the occurrence of high temperature also displayed periodic wave form which was very similar to the pressure signal. And the amplitude of this profile went larger as the fuel/air mixing quality became poorer. These also provided additional information on the perturbation of equivalence ratio at flame as well as NOx emission characteristics.

• 한국연소학회:학술대회논문집
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• 2003.12a
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• pp.103-108
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• 2003

The effect of equivalence ratio and fuel/air mixing quality on the phase-resolved gas temperatures at different phases of the oscillating pressure cycle was experimentally investigated. An atmospheric pressure, optically accessible and laboratory-scale dump combustor operating on methane with heat release rate of 1.59kW was used. Temperature measurements were made using coherent anti-Stokes Raman spectroscopy (CARS) at several spatial locations for typical unstable combustion conditions. Analysis was conducted using parameters such as phase-resolved averaged temperature, normalized standard deviation and temperature probability distribution functions (PDFs). Also the probability on the occurrence of high temperature (over 1900K) was investigated to get the information on the perturbation of equivalence ratio and NOx emission characteristics. It was shown that most of temperature histograms exhibit Gaussian profile which has short breadth of temperature fluctuation at equivalence ratio of 0.6, while beta profile was predominant for the cases of other equivalence ratios (${\Phi}$=0.55, 0.50). The characteristics on the occurrence of high temperature also displayed periodic wave form which is very similar to the pressure signal. And the amplitude of this profile goes larger as the fuel/air mixing quality become poorer. These also provided additional information on the perturbation of equivalence ratio at flame as well as NOx emission characteristics.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.28 no.10
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• pp.1184-1192
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• 2004

Experimental investigations were carried out in an atmospheric pressure, optically accessible and laboratory-scale dump combustor operating on methane gas. The objective of this study was to obtain the phase-resolved gas temperatures at different phases of the oscillating pressure cycle during unstable combustion. CARS temperature measurements were made at several spatial locations under lean premixed conditions to get the information on temperature field within the combustor. Also the effect of incomplete fuel-air mixing on phase-resolved temperature fluctuation was investigated. Results including phase-resolved averaged temperature, normalized standard deviation and temperature probability distribution functions (PDFs) were provided in this paper. Temperature PDFs gave an insight on the flame behavior. And strong correlation between phase-resolved temperature profile and pressure cycle was observed. Results of the phase-resolved high temperature gave an additional information on the perturbation of equivalence ratio at flame as well as the effect of mixing quality on NOx emission characteristics.

• Nuclear Engineering and Technology
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• v.12 no.4
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• pp.267-273
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• 1980

The quasistatic approximation is incorporated in HEXKIN, a 2-group, 2-dimensional reactor kinetics code specially developed for a hexagonal lattice-type reactor. The code allows maximum 15 delayed neutron groups, 279 lattice points, and 500 different driving functions to be able to initiate perturbation at each lattice point. Reactivity feedback due to power-dependent fuel temperature change is also involved. To check the accuracy of the code, a result of numerical experiment is compared with the measurement at the Savannah River Laboratory. The experiment was specifically designed to emphasize delayed neutron holdback. The calculated flux tilts agree with the measured flux tilts within the small uncertainty of the measurements.

• International Journal of Aeronautical and Space Sciences
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• v.7 no.2
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• pp.26-32
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• 2006

This paper targets a direct and quantitative prediction of characteristics of unstable waves in a combustion chamber, which employs the governing equations derived in terms of amplification factors of flow variables. A freshly formulated nonlinear acoustic equation is obtained and the analysis of unsteady waves in a rocket engine is attempted. In the present formalism, perturbation method decomposes the variables into time-averaged part that can be obtained easily and accurately and time-varying part which is assumed to be harmonic. Excluding the use of conventional spatially sinusoidal eigenfunctions, a direct numerical solution of wave equation replaces the initial spatial distribution of standing waves and forms the nonlinear space-averaged terms. Amplification factor is also calculated independently by the time rate of changes of fluctuating variables, and is no longer an explicit function for compulsory representation. Employing only the numerical computation, major assumptions inevitably inherent, and in erroneous manner, in up to date analytical methods could be avoided. With two definitions of amplification factor, 1-D stable wave and 3-D unstable wave are examined, and clearly demonstrated the potentiality of a suggested theoretical-numerical method of combustion instability.

• 한국연소학회:학술대회논문집
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• 2003.12a
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• pp.97-102
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• 2003

Experimental investigations were carried out in an atmospheric pressure, optically accessible and laboratory-scale dump combustor operating on natural gas. The objective of this study is to obtain the phase-resolved gas temperatures at different phases of the oscillating pressure cycle during unstable combustion. CARS temperature measurements were made at several spatial locations under lean premixed conditions to get the information on temperature field within the combustor. Also the effect of incomplete fuel-air mixing on phase-resolved temperature fluctuation was investigated. Results including phase-resolved averaged temperature, normalized standard deviation and temperature probability distribution functions (PDFs) were provided in this paper. Temperature PDFs give an insight on the flame behavior. And strong correlation between phase-resolved temperature profile and pressure cycle was observed. Results of the phase-resolved high temperature give an additional information on the perturbation of equivalence ratio at flame as well as the effect of mixing quality on NOx emission characteristics.

• Structural Engineering and Mechanics
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• v.44 no.4
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• pp.521-538
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• 2012

In this study, the transverse vibrations of an axially moving flexible beams resting on multiple supports are investigated. The time-dependent velocity is assumed to vary harmonically about a constant mean velocity. Simple-simple, fixed-fixed, simple-simple-simple and fixed-simple-fixed boundary conditions are considered. The equation of motion becomes independent from geometry and material properties and boundary conditions, since equation is expressed in terms of dimensionless quantities. Then the equation is obtained by assuming small flexural rigidity. For this case, the fourth order spatial derivative multiplies a small parameter; the mathematical model converts to a boundary layer type of problem. Perturbation techniques (The Method of Multiple Scales and The Method of Matched Asymptotic Expansions) are applied to the equation of motion to obtain approximate analytical solutions. Outer expansion solution is obtained by using MMS (The Method of Multiple Scales) and it is observed that this solution does not satisfy the boundary conditions for moment and incline. In order to eliminate this problem, inner solutions are obtained by employing a second expansion near the both ends of the flexible beam. Then the outer and the inner expansion solutions are combined to obtain composite solution which approximately satisfying all the boundary conditions. Effects of axial speed and flexural rigidity on first and second natural frequency of system are investigated. And obtained results are compared with older studies.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.32 no.10
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• pp.800-809
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• 2008

Scanning Thermal Microscope (SThM) is the tool that can map out temperature or the thermal property distribution with the highest spatial resolution. Since the local temperature or the thermal property of samples is measured from the extremely small heat transferred through the nanoscale tip-sample contact, improving the sensitivity of SThM probe has always been the key issue. In this study, we develop a new design and fabrication process of SThM probe to improve the sensitivity. The fabrication process is optimized so that cantilevers and tips are made of thermally grown silicon dioxide, which has the lowest thermal conductivity among the materials used in MEMS. The new design allows much higher tip so that heat transfer through the air gap between the sample-probe is reduced further. The position of a reflector is located as far away as possible to minimize the thermal perturbation due to the laser. These full $SiO_2$ SThM probes have much higher sensitivity than that of previous ones.

• Nuclear Engineering and Technology
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• v.55 no.6
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• pp.2172-2194
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• 2023

A variational nodal method (VNM) with unstructured-mesh is presented for solving steady-state and dynamic neutron diffusion equations. Orthogonal polynomials are employed for spatial discretization, and the stiffness confinement method (SCM) is implemented for temporal discretization. Coordinate transformation relations are derived to map unstructured triangular nodes to a standard node. Methods for constructing triangular prism space trial functions and identifying unique nodes are elaborated. Additionally, the partitioned matrix (PM) and generalized partitioned matrix (GPM) methods are proposed to accelerate the within-group and power iterations. Neutron diffusion problems with different fuel assembly geometries validate the method. With less than 5 pcm eigenvalue (k_eff) error and 1% relative power error, the accuracy is comparable to reference methods. In addition, a test case based on the kilowatt heat pipe reactor, KRUSTY, is created, simulated, and evaluated to illustrate the method's precision and geometrical flexibility. The Dodds problem with a step transient perturbation proves that the SCM allows for sufficiently accurate power predictions even with a large time-step of approximately 0.1 s. In addition, combining the PM and GPM results in a speedup ratio of 2-3.