• The Korean Journal of Physiology and Pharmacology
• /
• v.26 no.6
• /
• pp.415-425
• /
• 2022

Memory formation in the hippocampus is formed and maintained by circadian clock genes during sleep. Sleep deprivation (SD) can lead to memory impairment and neuroinflammation, and there remains no effective pharmacological treatment for these effects. Myricetin (MYR) is a common natural flavonoid that has various pharmacological activities. In this study, we investigated the effects of MYR on memory impairment, neuroinflammation, and neurotrophic factors in sleep-deprived rats. We analyzed SD-induced cognitive and spatial memory, as well as pro-inflammatory cytokine levels during SD. SD model rats were intraperitoneally injected with 10 and 20 mg/kg/day MYR for 14 days. MYR administration significantly ameliorated SD-induced cognitive and spatial memory deficits; it also attenuated the SD-induced inflammatory response associated with nuclear factor kappa B activation in the hippocampus. In addition, MYR enhanced the mRNA expression of brain-derived neurotropic factor (BDNF) in the hippocampus. Our results showed that MYR improved memory impairment by means of anti-inflammatory activity and appropriate regulation of BDNF expression. Our findings suggest that MYR is a potential functional ingredient that protects cognitive function from SD.

• Journal of Ginseng Research
• /
• v.46 no.3
• /
• pp.435-443
• /
• 2022

Background: Post-traumatic stress disorder (PTSD) is a psychiatric disease that develops following exposure to a traumatic event and is a stress-associated mental disorder characterized by an imbalance of neuroinflammation. Korean Red Ginseng (KRG) is the herbal supplement that is known to be involved in a variety of pharmacological activities. We aimed to investigate the effects of KRG on neuroinflammation as a potential mechanism involved in single prolonged stress (SPS) that negatively influences memory formation and consolidation and leads to cognitive and spatial impairment by regulating BDNF signaling, synaptic proteins, and the activation of NF-κB. Methods: We analyzed the cognitive and spatial memory, and inflammatory cytokine levels during the SPS procedure. SPS model rats were injected intraperitoneally with 20, 50, or 100 mg/kg/day KRG for 14 days. Results: KRG administration significantly attenuated the cognitive and spatial memory deficits, as well as the inflammatory reaction in the hippocampus associated with activation of NF-κB in the hippocampus induced by SPS. Moreover, the effects of KRG were equivalent to those exerted by paroxetine. In addition, KRG improved the expression of BDNF mRNA and the synaptic protein PSD-95 in the hippocampus. Taken together, these findings demonstrate that KRG exerts memory-improving actions by regulating anti-inflammatory activities and the NF-κB and neurotrophic pathway. Conclusion: Our findings suggest that KRG is a potential functional ingredient for protecting against memory deficits in mental diseases, such as PTSD.

• The Journal of Korean Medicine
• /
• v.27 no.4
• /
• pp.125-134
• /
• 2006

During the prenatal period, the development of the individual is influenced by a host of environmental factors. Exposure to noise stress during pregnancy was determined to result in the retardation of growth, a reduction in neurogenesis, and an impairment of spatial learning ability in the rat pups. In the present study, we have attempted to characterize the effects of prenatal treatment with Cnidium officinale Makino on spatial memory and neurogenesis in the hippocampus of rat pups born from maternal rats exposed to noise stress during pregnancy. Prenatal treatment with Cnidium officinale Makino was shown to increase neurogenesis and enhanced spatial learning ability in rat pups born from maternal rats exposed to noise stress. In this study, we have determined that prenatal treatment with Cnidium officinale Makino can stimulate spatial development and neurogenesis in the brain of the fetuses exposed to prenatal stresses.

• ETRI Journal
• /
• v.44 no.2
• /
• pp.208-219
• /
• 2022

Crime amount prediction is crucial for optimizing the police patrols' arrangement in each region of a city. First, we analyzed spatiotemporal correlations of the crime data and the relationships between crime and related auxiliary data, including points-of-interest (POI), public service complaints, and demographics. Then, we proposed a crime amount prediction model based on 2D convolution and long short-term memory neural network (2DCONV-LSTM). The proposed model captures the spatiotemporal correlations in the crime data, and the crime-related auxiliary data are used to enhance the regional spatial features. Extensive experiments on real-world datasets are conducted. Results demonstrated that capturing both temporal and spatial correlations in crime data and using auxiliary data to extract regional spatial features improve the prediction performance. In the best case scenario, the proposed model reduces the prediction error by at least 17.8% and 8.2% compared with support vector regression (SVR) and LSTM, respectively. Moreover, excessive auxiliary data reduce model performance because of the presence of redundant information.

• The Journal of Pediatrics of Korean Medicine
• /
• v.25 no.1
• /
• pp.40-48
• /
• 2011

Objectives: The purpose of this study is to evaluate the effect of Gonjadaesungchimjoongbang on spatial learning abilities and memories in ischemic brain injury. Methods: Rats were separated into three groups; (1) Normal, (2) Saline medication after ischemic brain injuries (control), (3) Gonjadaesungchimjoongbang medication after ischemic brain injuries (experiment). Ischemic brain injuries was induced by MCA occlusion and reperfusion. Morris water maze test was conducted for spatial learning and memory tests. Then, the change of BDNF in the hippocampus($7^{th}$, $14^{th}$ day) was examined by immunohistoche- mistry. Results: In Morris water maze test, spatial learning abilities and memory functioning were considerably increased in the experiment group as oppose to control group on $7^{th}$ and $14^{th}$ day(p<0.01). Moreover, immunohistochemistric response of BDNF in the hippocampus indicated that the more increased immune reaction was found in the experiment group as oppose to the control group on $7^{th}$ and $14^{th}$ day. Conclusions: Gonjadaesungchimjoongbang can improve the learning abilities and memories in ischemic brain injury.

• Journal of the Korea Society of Computer and Information
• /
• v.16 no.10
• /
• pp.1-10
• /
• 2011

There are the large overhead of block erase and page write operations in NAND flash memory, though it has low power consumption, cheap prices and a large storage. Due to the physical characteristics of NAND flash memory, overwrite operations are not permitted at the same location, so rewriting operation require after erase operation. it cause performance decrease of NAND flash memory. Using SRAM buffer in traditional NAND flash memory, it can not only reduce effective write operation but also guarantee fast memory access time. In this paper, we proposed the small SRAM buffer management system for reducing overhead of NAND flash memory, that is, erase and write operations. The proposed buffer system in a NAND flash memory consists of two parts, i.e., a fully associative temporal buffer with the small fetching block size and a fully associative spatial buffer with the large fetching block size. The temporal buffer have small fetching blocks that referenced from spatial buffer. When it happen write operations or erase operations in NAND flash memory, the related fetching blocks in temporal buffer include a page or a block are written in NAND flash memory at the same time. The writing and erasing counts in NAND flash memory can be reduced. According to the simulation results, although we have high miss ratios, write and erase operations can be reduced approximatively 58% and 83% respectively. Also the average memory access times are improved about 84% compared with the fully associative buffer with two sizes.

• The Mathematical Education
• /
• v.52 no.1
• /
• pp.19-41
• /
• 2013

What is the foundation of mathematical thinking? Is it logic based symbolic language system? or does it rely more on mental imagery and visuo-spatial abilities? What kind of neural changes happen if someone's mathematical abilities improve through practice? To answer these questions, basic cognitive processes including long term memory, working memory, visuo-spatial perception, number processes are considered through neuropsychological outcomes. Neuronal changes following development and practices are inspected and we can show there are neural networks critical for the mathematical thinking and development: prefrontal-anterior cingulate-parietal network. Through these inquiry, we can infer the answer to our question.

• Journal of Ginseng Research
• /
• v.20 no.2
• /
• pp.139-148
• /
• 1996

This study was designed to examine the effects of red ginseng total saponin and extract on spatial working memory in mice using Morris water maze. Two kinds of red ginseng saponin (No. 1 and No. 2) and three kinds of red ginseng extract (No. 1, No. 2 and No. 3) to have different PD/ PT ratio (No. 1=1.24, No.2=1.47 No.3=2.41) were prepared by mixing the different parts of red ginseng In different ratio. In acute administration of total saponin No. 1 or No. 2, escape time to reach to a hidden platform In a fixed location for training trials was significantly decreased as compared with control group and swimming time in the quadrant that had contained the platform was also significantly increased as compared with control group. In acute treatment of extract No. 1 or 1 No. 2, swimming time in the platformless quadrant was increased dose dependently as compared with control group, especially at dose of 200 mg/kg,bw swimming time was significantly Increased. Oral treatment of extract No. 1 (100 mg/kg, bw) for 7 days produced an increase of swimming time In the platformless quadrant but a decrease of swimming time in No.3-treated group (100 mg/kg, bw). These results show that red ginseng may improve spatial discrimination learning and spatial working memory of mice

• Proceedings of the Optical Society of Korea Conference
• /
• 1989.02a
• /
• pp.99-102
• /
• 1989

Optical implementation of adaptive quadratic associative memory for two-dimensional patterns is described by using holographic lenslet arrays and spatial light modulators. Basic experimental results demonstrating its feasibility are reported.

• Journal of Korea Spatial Information System Society
• /
• v.11 no.2
• /
• pp.79-88
• /
• 2009

The volume of memory to store real-time data stream is varied dynamically. Continuous queries processing the data stream must manage the storage volume dynamically. In previous research, according to current volume of data a general memory manager which allocates and releases memory by a page unit is researched.However, the method frequently executes page allocation and release to store data stream. Moreover, particularly delayed queries can monopolize many of pages because the method directly allocates pages when a query has not enough memory. Focusing on the problems in memory management systems, this research proposes a memory management method which reduces the frequency of allocation and release and uniformly distributes pages for queries. The method can reduce the frequency of allocation and release through allocation based on utilization ratio of pages in each query and prevent memory monopoly through memory allocation which considers query delay.