• Journal of Life Science
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• v.26 no.8
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• pp.983-989
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• 2016

All cells composing of our body undergo their destiny such as proliferation, differentiation, necrosis, apoptosis and senescence depending on their circumstance with time. The errors occurring in these processes develop several aberrations in phenotypes including cancer, inflammation, aging and diseases. New strategy and approach are required to screen anti-aging compounds derived from natural products. Therefore, here we explain the target proteins to play a key role in aging mechanism. In the first place, matrix metalloproteinases (MMPs) are involved in metastasis, chronic inflammation and skin aging as an aging marker. In particular, histone deacetylases (HDACs) give a great attention to aging researchers who try to extend the life span of animal model. In addition, we describe the signaling pathway related to senescence which p53, IGF-1 and SIRT1 play an important role in. Furthermore, autophagy is involved in the signaling pathway associated with aging. Several new compounds modulating the signaling pathway of senescence are introduced in this review. Here, we try to provide a new insight in the molecular basis for the aging mechanism and development of aging marker. In addition, the compounds introduced here could be available for pharmaceutical applications for the prevention and the treatment of diseases related to aging.

• Journal of the Korean Recycled Construction Resources Institute
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• v.3 no.2
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• pp.109-114
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• 2015

Recently, numerous studies were dedicated on the HVFA concrete using high volume CCPs. In initial studies, main topics are dependent on material properties of HVFA concrete, but several studies were dedicated on the structural behavior of HVFA concrete such as elasticity modulus, stress-strain relationship and structural behavior nowadays. Therefore, in this paper, on the basis of recent studies on the structural behavior, 2 large-scale test members were manufactured with 7.5m span length and fly ash replacement ratio 50%, concrete compressive strength 50MPa in order to apply to the practical structure and evaluate possibility of application. From the test results, although there were small differences between test results and existing research results on the stress-strain relationship, the application to practical structure is not hard. In flexural test, as the produced pattern of displacement and strain were similar to those of general concrete without fly ash, the difference between 50% fly ash concrete and general concrete is very small. And the concrete shear strength obtained by test was similar to that of design code, so existing design code will be also able to apply.

• Smart Structures and Systems
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• v.14 no.2
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• pp.209-224
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• 2014

With more and more built long-term structural health monitoring (SHM) systems, it has been considered to apply monitored data to learn the reliability of bridges. In this paper, based on a long-term SHM system, especially in which the sensors were embedded from the beginning of the construction of the bridge, a method to calculate the localized reliability around an embedded sensor is recommended and implemented. In the reliability analysis, the probability distribution of loading can be the statistics of stress transferred from the monitored strain which covered the effects of both the live and dead loads directly, and it means that the mean value and deviation of loads are fully derived from the monitored data. The probability distribution of resistance may be the statistics of strength of the material of the bridge accordingly. With five years' monitored strains, the localized reliabilities around the monitoring sensors of a bridge were computed by the method. Further, the monitored stresses are classified into two time segments in one year period to count the loading probability distribution according to the local climate conditions, which helps us to learn the reliability in different time segments and their evolvement trends. The results show that reliabilities and their evolvement trends in different parts of the bridge are different though they are all reliable yet. The method recommended in this paper is feasible to learn the localized reliabilities revealed from monitored data of a long-term SHM system of bridges, which would help bridge engineers and managers to decide a bridge inspection or maintenance strategy.

• Korean Institute of Interior Design Journal
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• v.24 no.5
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• pp.108-116
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• 2015

This study intends to research the spatial characteristics of Asian interim housing that accommodates sufferers pro tempore after disasters. The scope of this research covers the interim spaces used for housing people after natural disasters that occurred in Asia for the past fifteen years. Within this scope, literature review was conducted as the basis to derive the characteristics and environmental elements of interim housing, which provided the criteria to compare and evaluate cases of interim housing along with characteristic elements required of interim housing found in previous studies. According to literature review, interim housing can be classified by life-span, region, economy, climate, type, number of household, square measure, residential cost, structure/material, and service life. Within the scope of the present research, literature review showed a total of twenty-eight cases of interim housing in fifteen countries revealing a high rate of disaster occurrence in the subtropic and tropic climate of Southeast Asia. A great percentage of interim housing was used for long-term stay of over a year. The structure of interim housing varied from lightweight steel, wooden, masonry, membrane, to traditional structure and the type were divided into temporary shelter, transitional housing, temporary housing, and permanent housing. Followed by literature review, the characteristics required of post-disaster interim housing were analyzed based on previous research and case studies. The characteristics of interim housing can be divided into environmental, technological, and socio-cultural ones. Sub-characterical items according to such division include amenity, health, surroundings, structure, convenience, eco-friendliness, safety, communication, and locality. As a result of evaluation, most items met the required characteristics of interim housing, while technological characteristics such as structure and convenience varied with the types of interim housing and appeared even unnecessary in some cases. According to analysis, amenity is maintained through the structural and material characteristics of interim housing and is also facilitated by increasing number of infrastructure such as educational, sanitary, and convenience facilities provided by the governmental and organizational bodies. It is expected that this study will be utilized as preliminary data for follow-up studies that improve the environment of post-disaster interim housing suitable for domestic circumstances in environmental, technological, and socio-cultural respects.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.17 no.3
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• pp.110-118
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• 2003

Spacer dampers maintain the constant gaps between each conductor in a bundle conductor-transmission line, and are installed at proper intervals to keep a line from all sorts of damages derived from the vibration energy caused by mechanical or electrical external factors. It is most important to embody a technology which considers difficulties of maintenance and repair, and has optimum elements in order to prevent accidents such as destruction by fire or the snapping of a wire by the effect of vibration phenomenon coming from transmission lint In the resent thesis, therefore, the analysis of vibratory characteristics of spacer damper is set up by analytical methods such as the analysis of conductor motion's governing equation, the equation of spacer damper's motion, spacer damper-fastened wire's motion in a span and the numerical analysis of finite difference method. Furthermore, the installation distance between spacer dampers was scrutinized by simulations of various vibration phenomena which change at any time as actual conditions do, and hereafter difference method. Furthermore, the installation distance between spacer dampers was scrutinized by simulations of various vibration phenomena which change at any time as actual conditions do, and hereafter we will be able to analyze all kinds of vibration phenomena coming from a boltless spacer damper with 6 bundle conductor for 765kV transmission line based on new analytical methods.

• Journal of the Korea institute for structural maintenance and inspection
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• v.15 no.1
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• pp.67-76
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• 2011

The use of glass-fiber-reinforced polymer (GFRP) bars in reinforced concrete (RC) structures has emerged as an alternative to traditional RC due to the corrosion of steel in aggressive environments. Although the number of analytical and experimental studies on RC beams with GFRP reinforcement has increased in recent decades, it is still lower than the number of such studies related to steel RC structures. This paper presents the experimental moment deflection relations of GFRP reinforced beam which are spliced. Test variables were different reinforcement ratio and cover thickness of GFRP rebars. Seven concrete beams reinforced with steel GFRP re-Bars were tested. All the specimens had a span of 4000mm, provided with 12.7mm nominal diameter steel and GFRP rebars. All test specimens were tested under 2-point loads so that the spliced region be subject to constant moment. The experimental results show that the ultimate moment capacity of beam increasing of the reinforcement ratio. Failure mode of these specimens was sensitively vary according to the reinforcement ratio. The change of beam effective depth, which was caused by cover thickness variation, controlled the maximum strength and deflection because of cover spalling in tension face.

• Journal of Information Management
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• v.30 no.4
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• pp.39-60
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• 1999

Digital library research has attracted much attention. While many research projects are funded by government agencies and national and international bodies, some are run by specific academic and research institutions and libraries. While some digital library projects, such as the ELINOR project in the UK, the first two phases of the eLib(Electronic Libraries) programme in the UK, and the first phase of the DLI(Digital Library Initiative) in the USA, are now over, a number of other projects are currently under-way in different parts of the world. Beginning with the definitions and characteristics of digital libraries proposed by various researchers, this paper provides brief accounts of some major digital library projects that are currently in progress, or are just completed, in different parts of the world. There follows a review of digital library research under 16 major headings. Literature for this review has been identified through a search on the LISA CD-ROM database and a Dialog search on library and information science databases, and the resulting output has been supplemented by a scan of the various Issues of D-Lib Magazine and Ariadne, and the Web sites of various organizations and institutions engaged in digital library research. The review indicates that we have learned a lot through digital library research within a short span of time. However, a number of issues are yet to be resolved. The paper ends with an indication of the research issues that need to be addressed and resolved in the near future in order to bring the digital library from the researcher's laboratory to the real life environment.

• Journal of Embryo Transfer
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• v.32 no.3
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• pp.73-79
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• 2017

Transplantation is considered to be a very useful approach to improve human welfare and to prolong life-span. Heterologous organ transplantation using pig organs which are similar to human beings and easy to make mass-production has known as one of the alternatives. To ensure potential usage of the pig organ for transplantation application, it is essentially required to generate transgenic pig modifying immuno-related genes. Previously, we reported production of heterozygous ${\alpha}1,3$-galactosyltransferase (GalT) knock-out and human membrane cofactor protein (MCP) expressing pig ($GalT^{-MCP/+}$), which is enforced for suppression of hyperacute and acute immunological rejection. In this study, we reported generation of homozygous pig ($GalT^{-MCP/-MCP}$) by crossbreeding $GalT^{-MCP/+}$ pigs. Two female founders gave birth to six of $GalT^{-MCP/-MCP}$, and seven $GalT^{-MCP/+}$ pigs. We performed quantitative real-time PCR, western blot, and flow cytometry analyses to confirm GalT and MCP expression. We showed that fibroblasts of the $GalT^{-MCP/-MCP}$ pig do not express GalT and its product Gal antigen, while efficiently express MCP. We also showed no expression of GalT, otherwise expression of MCP at heart, kidney, liver and pancreas of transgenic pig. Taken together, we suggest that the $GalT^{-MCP/-MCP}$ pig is a useful candidate to apply xenotransplantation study.

• Journal of Bio-Environment Control
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• v.9 no.2
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• pp.120-126
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• 2000

The quality of oak mushoom(Lentinus edodes(Berk) Sing) is sensitively affected by environmental factors, especially moisture by the rain during the growing period. To protect mushrooms from being wet, plastic-covered facilities with side openings are mostly being used. However, the indoor temperature and humidity f the facility without roof opening become higher due to its poor ventilation, and consequently reduce the productivity and quality as well. In this study, we analyzed the ventilation rates and indoor temperatures of improved facilities as affected by the area of roof opening and shading rate by the model. The indoor temperature decreased by more than 2.5$^{\circ}C$ as the shading rate increased from 50% to 90%, and especially the effect of wind speed on indoor temperature was significantly great under as low as 50% of shading rate. The ventilation rate became higher under wind speed of 1~2m.s-1 regardless of the shading rate. As the wind speed increased from 0m.s-1 to 2m.s-1, the indoor temperature decreased by more than 2.$0^{\circ}C$. Moreover, the indoor temperature became lower with increasing roof opening ratio, but showed no significant differences at more than 50% of roof opening ratio. At lower shading rate, the indoor temperature sensitively decreased with increasing area of roof opening. Additionally, we obtained the higher ventilation performance with the area of roof opening more or less equal to side opening, regardless of the wind speed and shading rate.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.2
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• pp.116-122
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• 2017

The environmental lighting of a city advances its landscape standards and the city's touristic value because the lighting can help improve the city's safety and security as well as its esthetic value. The types of parks in cities vary in size and function and should be reflected carefully in lighting planning to gain the best effect. The importance of city lighting has been increased in recent years due to the expanded span of urban night life. Lighting systems around rivers and coastal waterfronts in cities play an important role not only in their functional aspects, such as safety and security, but also in boosting the city's identities. This paper performed comparison analysis among Tsim Sha Tsui Promenade in Hong Kong, Fukuoka Nakagawa Park in Japan, and the walking path in Hamdeok Beach in Jeju City, Korea. According to the evaluation, Hong Kong is excellent in 8 evaluation criteria for park lighting so that the city shows its superior installation and management. Fukuoka is also good by being analyzed as 'fair' in 5 criteria. Finally, Jeju is judged as inferior overall by showing 'poor' in several criteria. The paper shows how they differ in their environment lighting characteristics and aims to suggest stable lighting planning strategies for seaside parks in Jeju so the citizens and visitors of Jeju can enjoy the beautiful sceneries and nighttime activities.