• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.2
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• pp.310-318
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• 2010

Dioscorea bulbifera is one of the traditional medicinal herb. It commonly used in the treatment of hematemesis, epistaxis, tuberculous cervical lymphadenitis, laryngitis, acute infectious disease in East Asia. In the present study, we have demonstrated the anti-inflammatory effects of Dioscorea bulbifera MeOH extract (DBME) in macrophage cell line. To investigate mechanism of the anti-inflammatory activity, we examined the effects of the lipopolysaccaride (LPS)-induced production of nitric oxide (NO), prostaglandin $E_2$ ($PGE_2$), pro-inflammatory cytokines and expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), p-inhibitory ${\kappa}B{\alpha}$ (p-$I{\kappa}B{\alpha}$), and nuclear factor-${\kappa}B$ (NF-${\kappa}B$) in a murine macrophage cell line RAW 264.7. The RAW 264.7 cells were cultured in DMEM + serum medium for 24 hrs. After serum starvation for 24 hrs, the cells were treated with DBME 0.03, 0.10, 0.30 mg/$m{\ell}$ for 1 h, followed by stimulation with LPS (1 ${\mu}g/m{\ell}$) for activation of immune response. After treatment, cell viability was measured by MTT assay, and NO production was monitored by measuring the nitrite content in culture medium. The protein band of iNOS, COX-2, p-$I{\kappa}B{\alpha}$, and NF-${\kappa}B$ was determined by immunoblot analysis and levels of cytokine were analyzed by sandwich immunoassays. There were three experimental groups: carrageenan, DBME 0.3, 1.0 g/kg. Rats were administrated either carrageenan (40% PEG) or carrageenan + DBME (0.3, 1.0 g/kg body weight) for 4 days (p.o.). To induce acute paw edema, rats were injected 1% carrageenan (100 ${\mu}{\ell}$/rat, dissolved in sterilized saline). The effect of DBME in the carrageenan-induced rat paw edema. As results, DBME has an inhibitory effect on the production of NO, PGE2, TNF-${\alpha}$, IL-$1{\beta}$ and IL-6 and on the expression of iNOS, COX-2, p-$I{\kappa}B{\alpha}$ and translocation of NF-${\kappa}B$ to nuclear from cytosol. In addition, DBME effectively inhibited the increases of paw edema induced by carrageenan treatment in vivo. These results suggest that DBME can inhibit production of pro-inflammatory mediators and might be a useful source for treatment of acute inflammatory disease.

• The Korean Journal of Nuclear Medicine
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• v.29 no.1
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• pp.54-60
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• 1995

Medical Internal Radiation Dose(MIRD) schema was developed for calculating the absorbed dose from the administered radiopharmaceuticals. With the biological distribution data and the physical properties of the radionuclide we can estimate the absorbed dose by the MIRD schema. For the thyroid cancer patients received $^{131}I$ therapy, the absorbed dose to the bone marrow is the limiting factor to the administered dose, and the duration of admission is deter-mined by the retained activity in the whole body. To monitor the whole body radioactivity, we used Eberline Smart 200 system using ionization chamber as a detector. With the time activity curve of the whole body, total body residence time was obtained. From the ICRP publication 53, the residence times of the source organs, such as kidney, urinary bladder content and stomach, were used to calculate the absorbed doses of the target organs, such as stomach, red marrow, bladder wall and remaineder total body. In 8 thyroid cancer patients with 175 mci of $^{131}I$ administered orally, the mean absorbed dose in the bladder wall was 375.1, in the stomach 285.1, red marrow 25.4 and total body 22.4 rad respectively. For the monitoring of the large administered activity, this method seemed to be quite useful.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.40 no.3
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• pp.398-405
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• 1995

In termperate zone planting rice at different date subjects the crop to different climatic condition. This study aimed at comparison of the change in source-sink relationship of the Japonica(J) and that of Indica Japonica(I$\times$J) type rice cultivars caused by shift of heading date. Two J-and two I$\times$J-type cultivars were made to head on Aug. 16, Aug. 26 and Sep. 5. Percent grain fertility was not changed in response to shift of heading date. Ripening patterns of 4 rice cultivars were similar to sigmoid curve type but when the heading date was delayed to Sep. 5, the form is changed to log type of curve. In J-type, physiological maturity was delayed about 5 day when headed at Sep. 5, in compare to headed at Aug. 16 and Aug. 26. However ripening was continued about 10 days when the diurnal, nocturnal and minimum temperature was above 17, 12$^{\circ}C$ and about 3~8$^{\circ}C$. In I$\times$J hybrid, real ripening was continued when the diurnal, nocturnal and minimum temperature was over 20, 17$^{\circ}C$, but if the minimum temperature was downed bellow 1$0^{\circ}C$, it was impossible. Simulated photosynthetic amount based on photosynthetic ability, temperature, leaf area and day length was varied according to changes in heading date and it was decreased seriously if the minimum temperature was fall down bellow 4$^{\circ}C$ in field, that's why decrease in photosynthetic ability and aging. The temperature range of optimum ripening was 21~26$^{\circ}C$, if there is nothing hindering factor.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.56 no.1
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• pp.57-63
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• 2011

Changes in food preferences and dietary habits of Korean prone to decrease consumption of the traditional energy source, rice. The exceeding condition of rice production in Korea is now not only impacting on the profit structure of farmers but also threatening food security. Although there have been several efforts to increase rice consumption rate, by developing various processed foods using rice flour, grain hardness of rice has been the most significant limiting factor. In this study, we addressed the suitability of the Namil(SA)-flo1, a mutant rice line has floury endosperm, in terms of producing rice flour by using dry-milling method, which is lower cost and more eco-friendly than other available methods such as wet-milling. Rice flour of the Namil(SA)-flo1 exhibited superior physico-chemical characteristics to any other check varieties including the wild type, Namil, in terms of distribution of granule sizes and content of damaged starch.

• Journal of KIISE:Computing Practices and Letters
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• v.5 no.4
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• pp.467-478
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• 1999

실시간 태스크의 최악 실행시간을 예측할 때 과예측이 발생하는 원인은, 첫째 프로그램의 동적인 최악 실행 행태를 정적으로 분석하는 것이 근본적으로 어렵기 때문이며, 둘째 최근의 RISC 형태 프로세서에 포함되어 있는 파이프라인 실행 구조와 캐쉬 등이 그러한 정적 분석을 더욱 어렵게 만들기 때문이다. 그런데 기존의 연구에서는 각각의 과예측 원인을 해결하기 위한 방법에 대해서만 언급하고 있을 뿐 분석의 정확도에서 각 원인이 차지하는 비중에 대해서는 언급하고 있지 않다. 이에 본 연구에서는 최악 실행시간 예측시 과예측을 유발하는 원인들, 즉 분석 요소들의 영향을 정량적으로 조사함으로써 기존의 최악 실행시간 분석 기법들이 보완해야 할 방향을 제시하고자 한다. 본 연구에서는 실험이 특정 분석 기법에 의존하지 않도록 하기 위하여 시뮬레이션 방법에 기반한다. 이를 위해 분석 요소별 스위치가 포함된 MIPS R3000 프로세서를 위한 시뮬레이터를 구현하였는데, 각 스위치는 해당 분석 요소에 대한 분석의 정확도 수준을 결정한다. 모든 스위치 조합에 대해서 시뮬레이션을 반복 수행한 다음 분산 분석을 수행하여 어떤 분석 요소가 가장 큰 영향을 끼치는지 고찰한다.Abstract Existing analysis techniques for estimating the worst case execution time (WCET) of real-time tasks still suffer from significant overestimation due to two types of overestimation sources. First, it is unavoidably difficult to predict dynamic behavior of programs statically. Second, pipelined execution and caching found in recent RISC-style processors even more complicate such a prediction. Although these overestimation sources have been attacked in many existing analysis techniques, we cannot find in the literature any description about questions like which one is most important. Thus, in this paper, we quantitatively analyze the impacts of overestimation sources on the accuracy of the worst case timing analysis. Using the results, we can identify dominant overestimation sources that should be analyzed more accurately to get tighter WCET estimations. To make our method independent of any existing analysis techniques, we use simulation based methodology. We have implemented a MIPS R3000 simulator equipped with several switches, each of which determines the accuracy level of the timing analysis for the corresponding overestimation source. After repeating simulation for all of the switch combinations, we perform the variance analysis and study which factor has the largest impact on the accuracy of the predicted WCETs.

• Journal of KIISE:Computing Practices and Letters
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• v.10 no.2
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• pp.174-188
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• 2004

In the life environment changed with not only the quality and the price of the products but also the material abundance, it is the most crucial factor for the strategy of product sales to investigate consumer's sensibility and preference degree. In this perspective, it is necessary to design and merchandise the products in cope with each consumer's sensibility and needs as well as its functional aspects. In this paper, we propose the Fashion Design Recommender Agent System (FDRAS-pro) for textile design applying collaborative filtering personalization technique as one of the methods of material development centered on consumer's sensibility and preference. For a collaborative filtering system based on textile, Representative-Attribute Neighborhood is adopted to determine the number or neighbors that will be used for preferences estimation. Pearson's Correlation Coefficient is used to calculate similarity weights among users. We build a database founded on the sensibility adjectives to develop textile designs by extracting the representative sensibility adjectives from users' sensibility and preferences about textile designs. FDRAS-pro recommends textile designs to a customer who has a similar propensity about textile. To investigate the sensibility and emotion according to the effect of design factors, fertile designs were analyzed in terms of 9 design factors, such as, motif source, motif-background ratio, motif variation, motif interpretation, motif arrangement, motif articulation, hue contrast, value contrast, chroma contrast. Finally, we plan to conduct empirical applications to verify the adequacy and the validity of our system.

• Ecology and Resilient Infrastructure
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• v.6 no.4
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• pp.191-199
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• 2019

Road development is considered an important factor in invasion and dispersion of ailen plants by damaging the natural ecosystems and connecting the detached landscapes into long tubular structures. In this study, vegetation survey was carried out according to the topographical characteristics of cut slope, fill slope, and flat land at the construction site in order to understand the effect of road developemt on the change of the floristic composition of ailen plants. Road developement projects caused a lot of changes in annual and biennial alien plants because of continuous disturbances. Changes in species composition of alien plants decreased in the cut slope. On the other hand, the ailen palnts of the fill slope increased. The increase or decrease alien plants on flat land were identified depending on where it occurred, and no major trend was found. The cause of these change was driven by unintentionally introduced alien plants. In particular, the cut slope with a high occurence of unintentional ailen plants should not be used as a source of high-risk alien plants such as ecosystem disturbances. Since the transplanted species were intentionally planted by the landscape plan, it was possible to identify colonies from early stages and spread to the nearby flat land. Therefore, in order to minimize the impact of road slope vegetation on the surrounding ecosystem during and after road construction, it is suggested to plant high viability plants in the landscape design during the environmental impact assessment consultation.

• Microbiology and Biotechnology Letters
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• v.31 no.2
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• pp.95-102
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• 2003

Microalgae are a diverse group of photosynthetic organisms and abundant in every ecosystem in the biosphere. They are common in aqueous environments including marine, brackish and fresh waters and in some habitats that lack eukaryotic life such as some hot springs and highly alkaline lakes. Microalgal biotechnology that is focused on the microalgae-based production of a variety of useful materials such as pharmaceutical comfounds, health foods, natural pigments, and biofuels is considered as an important discipline with the development of biotechnology. In addition, the mass cultivation of microalgae can also contribute to improving the environmental quality by reducing the concentration of $CO_2$ which is one of major gases lead to global warming. Consequently, it seems that the microalgae can be used as an efficient, renewable, environmentally friendly source of high-value biomaterials such as chemicals, pigments, energy, etc. and the microalgal biotechnology will most likely represent a larger portion of modern biotechnology.

• Journal of Life Science
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• v.20 no.6
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• pp.922-928
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• 2010

This study was carried out to develop safe and novel anticoagulation agents from oriental medicinal herbs. From 33 medicinal herbs, 40 different ethanol extracts were prepared according to place of origin or extraction parts, and anticoagulation activities were evaluated by determination of thrombin time (TT), prothrombin time (PT) and activated partial thromboplastin time (aPTT). The average water content and average extraction ratio for the medicinal herbs were $6.85{\pm}2.26%$ and $5.27{\pm}4.25%$, respectively. Evaluation of TT at various concentrations of the extract led to the selection of Mucuna birdwoodiana, Prunus armeniaca, Cacalia ainsliaeiflora, Cinnamonum aromaticum, and Rhus javanica Linneas potent antithrombosis medicinal herbs. Evaluation of PT and aPTT showed that the extracts of R.javanica Linne, M. birdwoodiana, and P. armeniaca have strong anticoagulation activities. Determination of hemolytic activities of 40 different ethanol extracts against human red blood cells, however, showed that only M. birdwoodiana, C. ainsliaeiflora, C. aromaticum, and R. javanica Linnehas strong anticoagulation activity without hemolytic activity at a concentration of 500 mg/ml. Our results suggest that oriental medicinal herbs, which are under a mass-production system, have potentialas a safe and novel source of anticoagulants, as well being a thrombin-specific and coagulation factor-specific inhibitor.

• Journal of Life Science
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• v.30 no.7
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• pp.634-639
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• 2020

Starfish are a potential source of marine materials, but their unique odor can limit application. Our previous work suggested that brittle star Ophioplocus japonicus extract could be more effective as a cosmetic material by reducing its odor through a roasting process. However, the biological properties of heat-treated Ophioplocus japonicus extract (HOJE) remain poorly understood. We here examined the anti-inflammatory potential of HOJE in lipopolysaccharide (LPS)-induced RAW 264.7 cells. HOJE significantly inhibits LPS-stimulated nitric oxide (NO) production without affecting cell viability in a dose-dependent manner and suppresses LPS-induced expression of inducible nitric oxide synthases (iNOS) and pro-inflammatory cytokines such as interleukin-6 and -1β. Furthermore, treatment of pyrrolidine dithiocarbamate to inhibit nuclear factor kappa B (NF-κB) signaling accelerated the inhibitory effect of HOJE on NO production, and the translocation of NF-κB p65 from the cytosol to the nucleus was attenuated by HOJE. These results show that HOJE ameliorates inflammation partly through NF-κB signaling which consequently suggests that it has anti-inflammatory potential.