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Does periosteum promote chondrogenesis? A comparison of free periosteal and perichondrial grafts in the regeneration of ear cartilage

  • Yoo, Hyokyung;Yoon, Taekeun;Bae, Hahn-Sol;Kang, Min-Suk;Kim, Byung Jun
    • Archives of Craniofacial Surgery
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    • v.22 no.5
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    • pp.260-267
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    • 2021
  • Background: Elastic ear cartilage is a good source of tissue for support or augmentation in plastic and reconstructive surgery. However, the amount of ear cartilage is limited and excessive use of cartilage can cause deformation of the auricular framework. This animal study investigated the potential of periosteal chondrogenesis in an ear cartilage defect model. Methods: Twelve New Zealand white rabbits were used in the present study. Four ear cartilage defects were created in both ears of each rabbit, between the central artery and marginal veins. The defects were covered with perichondrium (group 1), periosteum taken from the calvarium (group 2), or periosteum taken from the tibia (group 3). No coverage was performed in a control group (group 4). All animals were sacrificed 6 weeks later, and the ratio of neo-cartilage to defect size was measured. Results: Significant chondrogenesis occurred only in group 1 (cartilage regeneration ratio: mean±standard deviation, 0.97±0.60), whereas the cartilage regeneration ratio was substantially lower in group 2 (0.10±0.11), group 3 (0.08±0.09), and group 4 (0.08±0.14) (p= 0.004). Instead of chondrogenesis, osteogenesis was observed in the periosteal graft groups. No statistically significant differences were found in the amount of osteogenesis or chondrogenesis between groups 2 and 3. Group 4 showed fibrous tissue accumulation in the defect area. Conclusion: Periosteal grafts showed weak chondrogenic potential in an ear cartilage defect model of rabbits; instead, they exhibited osteogenesis, irrespective of their embryological origin.

Automated Applying Greybox Fuzzing to C/C++ Library Using Unit Test (유닛테스트를 활용한 c/c++ 라이브러리 그레이박스 퍼징 적용 자동화)

  • Jang, Joon Un;Kim, Huy Kang
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.29 no.4
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    • pp.807-819
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    • 2019
  • Greybox fuzzing is known as an effective method to discover unknown security flaws reside in software and has been actively researched today. However, most of greybox fuzzing tools require an executable file. Because of this, a library, which cannot be executed by itself requires an additional executable file for greybox fuzzing. Generating such an executable file is challengeable because it requires both understanding of the library and fuzzing. In this research, we suggest the approach to generate an executable file automatically for a library and implement this approach as a tool based on the LLVM framework. This tool shows that executable files and seed files can be generated automatically by static/dynamic analysis of a unit test in the target project. A generated executable file is compatible with various greybox fuzzers like AFL because it has a common interface for greybox fuzzers. We show the performance of this tool as code coverage and discovered unknown security bugs using generated executable files and seed files from open source projects through this tool.

Advanced medical devices and regulatory innovations in new health technology assessments (의료기기 발전과 신의료기술평가 규제혁신)

  • Lee, You Kyoung
    • Journal of the Korean Medical Association
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    • v.61 no.12
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    • pp.702-705
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    • 2018
  • Advances in technology lead to advances in medical devices, and these advances have the positive effect of creating opportunities for beneficial developments in healthcare, such as innovating traditional healthcare processes or expanding opportunities for diagnosing and treating diseases. Nonetheless, device developers, suppliers, users, insurers, and patients all face the challenge of balancing patient safety and health effectiveness with a reasonable profit. In Korea, the New Health Technology Assessment system aims to introduce safe and effective health technology, but this is only effective for the entry of devices onto the healthcare market. This system is not enough for creating a healthy ecosystem in which high-quality technologies and devices survive in the market and naturally exit from the market if not successful. The nation must not lag in the rapid development of medical devices, but the concomitant requirement for patient safety is like two rabbits moving in different directions. There is not enough time to resolve each source of uncertainty for both developers and users. The early adoption of health technologies, including medical devices, offers new opportunities for treatment and diagnosis, but also poses unexpected health risks. Thus, we need to design a plan to generate scientific evidence related to medical devices after they introduced into practice. Additionally, regarding the use of individual medical devices, we believe that the creation of a healthy ecosystem for medical devices by implementing medical device surveillance culture is a way to manage the opportunities and risks of the early introduction of innovative medical devices.

Analytical Study on Software Static/Dynamic Verification Methods for Deriving Enhancement of the Software Reliability Test of Weapon System (무기체계 소프트웨어 신뢰성 시험 개선점 도출을 위한 소프트웨어 정적/동적 검증 분석 사례연구)

  • Park, Jihyun;Choi, Byoungju
    • KIPS Transactions on Software and Data Engineering
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    • v.8 no.7
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    • pp.265-274
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    • 2019
  • The reliability test performed when developing the weapon system software is classified into static test and dynamic test. In static test, checking the coding rules, vulnerabilities and source code metric are performed without executing the software. In dynamic test, its functions are verified by executing the actual software based on requirements and the code coverage is measured. The purpose of this static/dynamic test is to find out defects that exist in the software. However, there still exist defects that can't be detected only by the current reliability test on the weapon system software. In this paper, whether defects that may occur in the software can be detected by static test and dynamic test of the current reliability test on the weapon system is analyzed through experiments. As a result, we provide guidance on improving the reliability test of weapon system software, especially the dynamic test.

Influence of plant on distribution of an endangered butterfly, Leptalina unicolor (Bremer & Grey, 1853), in restored riverside areas along the Geum River

  • Choi, Jong-Yun;Kim, Seong-Ki;Back, You-Hyune;Jeon, Ju-A;Kim, Jeong-Cheol;Yun, Jong-Hak
    • Journal of Ecology and Environment
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    • v.43 no.3
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    • pp.314-319
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    • 2019
  • Background: The dramatic worldwide decline in the butterfly species Leptalina unicolor (Bremer & Grey) is largely the result of continuous habitat decline and disturbance by humans. The discovery of a narrow habitat in riverside wetlands utilized by L. unicolor raises the hope that such restricted key areas could be rather easily protected. Results: Here, we explain the environmental variables and habitat characteristics that primarily influence the distribution of L. unicolor discovered at the riverside areas along the Geum River. L. unicolor larvae were found at 9 of 13 study sites, and their abundance was strongly positively correlated with plant biomass. Our investigation showed that among four plant species (Miscanthus sinensis, Spodiopogon cotulifer, Setaria viridis, and Imperata cylindrica), L. unicolor larvae were the most abundant on the leaves of M. sinensis. They were not abundant on the leaves of S. cotulifer, S. viridis, or I. cylindrica. Interestingly, the number of L. unicolor larvae was positively correlated with the coverage area ($m^2$) of M. sinensis (F = 41.7, $r^2=0.74$, P < 0.0001). Conclusions: It appears that water (e.g., wetlands, ponds, and watersides) located along the riverside areas along the Geum River is important for the constant maintenance and conservation of L. unicolor. This is based on the habitat characteristics (water preference) of M. sinensis, which is used as a habitat by L. unicolor larvae. However, the waterside is dry and terrestrialization is in progress owing to the decreased water levels and water supply caused by an opened weir. Hereafter, this area will likely require management to secure a stable habitat for L. unicolor.

A Out-of-Bounds Read Vulnerability Detection Method Based on Binary Static Analysis (바이너리 정적 분석 기반 Out-of-Bounds Read 취약점 유형 탐지 연구)

  • Yoo, Dong-Min;Jin, Wen-Hui;Oh, Heekuck
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.31 no.4
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    • pp.687-699
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    • 2021
  • When a vulnerability occurs in a program, it is documented and published through CVE. However, some vulnerabilities do not disclose the details of the vulnerability and in many cases the source code is not published. In the absence of such information, in order to find a vulnerability, you must find the vulnerability at the binary level. This paper aims to find out-of-bounds read vulnerability that occur very frequently among vulnerability. In this paper, we design a memory area using memory access information appearing in binary code. Out-of-bounds Read vulnerability is detected through the designed memory structure. The proposed tool showed better in code coverage and detection efficiency than the existing tools.

A Comparative Content Analysis of Newspapers in Three Countries-Korea, China and Japan-on the 60th Anniversary of the Historical Event, 8.15 Independence Day (한.중.일 3국 신문의 8.15 보도 비교 분석)

  • Seo, Ra-Mi;Jung, Jae-Min
    • Korean journal of communication and information
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    • v.37
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    • pp.237-269
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    • 2007
  • This study examined how newspapers covered the 60th anniversary of the historical event, 8 15 Independence Day. Specifically, five newspapers from three countries were content-analyzed to see differences, if any, based on country level and political ideology of the newspaper. The findings showed that Japanese newspapers yielded less amount of coverage than those of Korea and China. The newspapers of Korea and China used straight news format, while Japanese newspapers used opinion news format. In terms of information source, Korean newspapers and Chinese newspapers mainly relied on the information from the government, while Japanese newspapers took the information from citizen. The difference also revealed that Korean newspapers focused on domestic situation frame and the other countries more emphasized past memory of the War times. Consequently, the three countries showed clearly different perspectives on the same historical event. These distinctions were caused from national interest rather than political ideology of the newspaper.

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Development of a fatty acids database using the Korea National Health and Nutrition Examination Survey data (국민건강영양조사 자료를 이용한 지방산 데이터베이스 구축)

  • Yoon, Mi Ock;Kim, Kirang;Hwang, Ji-Yun;Lee, Hyun Sook;Son, Tae Young;Moon, Hyun-Kyung;Shim, Jae Eun
    • Journal of Nutrition and Health
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    • v.47 no.6
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    • pp.435-442
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    • 2014
  • Purpose: The objective of this study was to develop a fatty acid database (DB) for estimation of intake levels of fatty acids in the Korean population, using data from the Korea National Health and Nutrition Survey (KNHANES). Methods: Analytical values of fatty acids in foods were collected from food composition tables of national institutions (National Fisheries Research & Development Institute, Rural Development Administration), Japan Ministry of Education, Culture, Sports, Science and Technology, US Department of Agriculture, and journal articles that previously reported analytical fatty acid content of some Korean foods. The coverage of fatty acids was C14:0, C16:0, C18:0, C18:1, C18:2 n-6, C18:3 n-3, C20:5 n-3 (EPA), C22:6 n-3 (DHA), SFA, MUFA, and PUFA (n-3, n-6, n-9). The fatty acids DB covered a total of 5,144 food items used in the KNHANES nutrition survey. The food items were preferentially filled with analytical values of the collected data source. An analytical value for each food item was selected based on the priority criteria and the quality evaluation of data sources. Missing values were replaced with calculated or imputed values using the analytical values of similar food items from the data source. Results: A total of 1,545 analytical values, 2,589 calculated values, and 1,010 imputed values were included in the fatty acid DB. The developed fatty acid DB was applied to 2,112 food items available for 2011 KNHANES data. Mean intake levels of total fatty acids and saturated fatty acids were 40.3 g/day and 13.2 g/day, respectively. The estimation of total fatty acid intake was 84.3% (men 83.2%, women 86.0%) of daily total fat intake. Conclusion: This newly developed fatty acid DB would be helpful in determining the association of fatty acids intake and related health concerns in the Korean population.

Current Conditions and Problems of Entertainers and Politicians' SNS-based News Reports on Internet Newspapers (국내 인터넷신문의 유명인 SNS 활용 기사의 현황과 문제점)

  • Kwak, Sun-hye;Yu, Hong-Sik;Lee, Jeongbae
    • The Journal of the Korea Contents Association
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    • v.22 no.4
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    • pp.159-171
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    • 2022
  • This study examined the problem of utilizing celebrity SNS in online news, which have increased by an average of 745 every year since 2010, reaching about 10,000 in 2021. 40 online newspapers were selected and 202,730 news articles produced by these newspapers in July 2021 were analyzed. As a result, 1.27% (2,582) of all articles were found to be using celebrity SNS as a source. This indicates that on average, online newspapers produce 2.08 celebrity SNS-utilized articles per day and 64.7 articles per month. Specifically, entertainer SNS (53.7%) was used the most compared to SNS of politician(39.8%) and influencer(6.5%). Instagram(69.1%, 57.1%) was utilized the most for entertainer and influencer and this were mostly related to personal information. On the other hand, Facebook(70.4%) was cited the most for politician, mostly related to opinions on social/political issues. The average length of SNS-based articles was 536 characters. The problem with news articles utilizing SNS is that most articles simply copy the SNS content without additional coverage(88.4%), and 14% of the articles did not disclose the exact source. Implication of the research on 40 online news agency is discussed.

A Study on the Psychological State of the Security Subjects of National Guard (공경호원의 경호대상자 심리상태 인지)

  • Kim, Haw-Su;Kang, Min-Wan;Jo, Sung-Gu
    • Korean Security Journal
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    • no.31
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    • pp.73-100
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    • 2012
  • Republic of Korea for the last 2012 nuclear security summit in Seoul in three days from March 26, has held great success. This industry watchers at home and abroad through professional meetings and private organizations to promote global nuclear security was intended to draw, for the preparation of this event the most important one of the things that should be addressed at the meeting was over the top guard. The national guard of heads of state and nationally significant as the important issues should be dealt with. So who is responsible for national security summit national guard for a successful guard against participants should have a higher understanding, these stories ever to be dealt with important security subjects is the psychological state of cognition. This study is currently a source of honor to escort the psychological state of subjects, and whether the search as I looked at cognition. Qualitative research methods to conduct research in-depth interview technique was used for one of the transcribed data analysis program, a non-quantitative data were analyzed using NVivo 8. As a result of this study, analysis of the problem compared with the usual methods 39 (72.2%), fine-grained observation and 15 (27.7%), through the media how cognition 41 (73.2%), marginal help of 15 (26.7%) were. The usual comparison with how honored Issue sources to detect security of those words and actions and facial expressions, etc. Security of subjects over the state of mind cognition that he, detailed observation of the national guard to security subjects the psychological state of cognition which are pre-Thorough Information subjects that can have all the information about security and the state can be obtained by saying that. Media coverage through a cognitive approach national guard of the media coverage to understand the security subjects of the political situation to understand the prerequisite that were marginal for help through the cognitive approach of security subjects surrounding the execution of security workers, Secretary in charge of protocol and security, and be propagated through the selection techniques to be utilized was that.

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