• Journal of the Society of Cosmetic Scientists of Korea
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• v.36 no.1
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• pp.17-32
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• 2010

This review shows the design and the development of new $CO_2$-soluble hydrocarbon copolymers which can be used as effective stabilizers for successful dispersion polymerizations of bio-compatible materials in supercritical carbon dioxide ($scCO_2$). The basic concepts of supercritical fluid including its solvent properties and applications in polymer synthesis are described. We report the facile synthesis of highly soluble hydrocarbon based copolymers, prepared with good control via controlled free radical polymerization from readily accessible and commercially available monomers. The phase behaviour of these materials was monitored in pure $CO_2$ to investigate how the molecular weights and the composition of the copolymers affect their solubility in $CO_2$. Their activity as a stabilizer was then tested in dispersion polymerization of N-vinyl pyrrolidone in $CO_2$ at various reaction conditions to identify the key parameters required for a successful dispersion stabilization of growing PVP particles. Some prospective potentials of this research which can be applied in developing new polymer materials in an environmentally-friendly fashion for use in cosmetics are also discussed.

• KSBB Journal
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• v.26 no.3
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• pp.217-222
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• 2011

Itraconazole is a triazole antifungal agent to inhibit most fungal pathogens. To improve the oral absorption and dissolution of poorly water-soluble itraconazole, microsponge system composed of $Eudragit^{(R)}$ E100 and polyvinyl alcohol(PVA) formulated by quasi-emulsion solvent diffusion method, and its physicochemical properties and pharmacokinetic parameters of itraconazole were studied. The microsponge of itraconazole were discrete free flowing micro sized particles with perforated orange peel like morphology as visualized by scanning electron microscope (SEM). Results showed that the drug loading efficiency, production yield, and particle size of itraconazole microsponge were affected by drug to polymer ratio, the volume of internal phase containing methylene chloride, stirring rate and the concentration of PVA used. Also, the results showed that the dissolution rate of itraconazole from the microsponges was affected by drug to polymer ratio. In other words, the release rate of itraconazole from microsponges was increased from at least 27.43% to 64.72% after 2 h. The kinetics of dissolution mechanism showed that the dissolution data followed Korsmeyer-Peppas model. Therefore, these results suggest that microsponge system can be useful for the oral delivery of itraconazole by manipulating the release profile.

• Polymer(Korea)
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• v.33 no.4
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• pp.389-395
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• 2009

To develop the carrier of hydrophobic antifungal agents based on low molecular weight water-soluble chitosan (LMWSC), LMWSC was chemically modified with deoxycholic acid (DA) which is one of the bile acid as a hydrophobic group. The nanoparticles (WSCDA) using DA conjugated LMWSC were characterized using dynamic light scattering (DLS) and transmittance electron microscope (TEM). The particle size of WSCDA ranged from 250 to 350 nm and increased with the number of DA substitution. The loaded itraconazole as an antifungal agent WSCDA nanoparticles (WSCDA-ITCN) were prepared by solvent evaporation method. The drug content and the loading efficiency were investigated approximately $9{\sim}10%$ and $61{\sim}68%$ by UV spectrophotometer, respectively. The release of drug from nanoparticles was slow and showed sustained release characteristics. Based on the results of release study that the higher DA contents in WSCDA, the slower the releasing rate, the WSCDA-ITCN could be used as an excellent antifungal agent.

• Polymer(Korea)
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• v.24 no.5
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• pp.728-735
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• 2000

Fentanyl-loaded biodegradable poly(L-lactide-co-glycolide) (75 : 25 by mole ratio of lactide to glycolide, PLGA) microspheres (MSs) were prepared to study the possibility for long-acting local anesthesia. We developed the fentanyl base (FB, slightly water-soluble)-loaded PLGA MSs by means of conventional O/W solvent evaporation method. The size of MSs was in the range of 10~150 ${\mu}{\textrm}{m}$. The morphology of MSs was characterized by SEM, and the in vitro release amounts of FB were analyzed by HPLC. The lowest porous cross-sectional morphology and the highest encapsulation efficiency were obtained by using gelatin as an emulsifier. The influences of several preparation parameters, such as emulsifier types, molecular weights and concentrations of PLGA, and initial drug loading amount, etc., have been observed in the release patterns of FB. The release of FB in vitro was more prolonged over 25 days, with close to zero-order pattern by controlling the preparation parameters. We also investigated the physicochemical properties of FB-loaded PLGA MSs by X-ray diffraction and differential scanning calorimeter.

• Advances in materials Research
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• v.1 no.2
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• pp.161-168
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• 2012

Nanoflake composite multi core-shell $SrFe_{12}O_{19}/Fe_3O_4$/PEG/Polypyrrole was synthesized by in situ polymerization method. In this paper, the fabrication of $SrFe_{12}O_{19}$ nanoflake is as first core by solgel method. Then fabricated a shell layer from magnetic nanoparticles of $Fe_3O_4$, which synthesized by coprecipitation technique, onto the $SrFe_{12}O_{19}$ nanoflake. Polyethylene glycol (PEG) as a polymer layer and as second shell was coated onto the before core-shell. Than core-shell $SrFe_{12}O_{19}/Fe_3O_4$/PEG was used as template for the preparation of $SrFe_{12}O_{19}/Fe_3O_4$/PEG/Polypyrrole composite. Final composite has a conductive property among $4.23{\times}10^{-2}Scm^{-1}$ and magnetic property about $M_s$=2.99 emu/g. Also final composite in soluble at organic solvent such as DMF and DMSO and has a flake structure. Conductivity and magnetic property respectively determine by four-probe instrument and vibrant sample magnetometer (VSM), morphology and article size determined by FE-SEM, TEM and XRD.

• Polymer(Korea)
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• v.27 no.5
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• pp.405-412
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• 2003

Poly(vinyl alcohol) (PVA) and N-(2-hydroxy)propyl-3-trimethylammonium chitosan chloride (HTCC), a water soluble chitosan derivative synthesized by the reaction of quaternary ammonium compound with chitosan, were blended using water as a solvent and the PVA/HTCC blend films with various compositions were prepared by solution casting method. The miscibility between the two polymers and the thermal properties of the blend films were investigated using FT-IR, DSC, DMA, and TGA. Single glass transition temperatures and single melting temperatures of the blend films along with the strong and clear film state for the whole composition of blending ratios suggest the miscibility between PVA and HTCC. The PVA/HTCC blend films with HTCC content of 1% and greater showed excellent antimicrobial activity.

• Journal of the Korean Magnetics Society
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• v.16 no.1
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• pp.107-110
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• 2006

Magnetite nanoparticles encapsulated with biodegradable polymer [poly(D,L-lactide-co-glycoiide), PLGA] were prepared by an emulsification-diffusion method. To investigate the effect of type of organic solvents on the mean particle sizes of obtained composite particles, different organic solvents [ethyl acetate (EA), propylene carbonate (PC) and acetone (ACE)] were used with a stabilizer [didodecyl dimethyl ammonium bromide (DMAB)]. The particle size of nanoparticles was observed by the dynamic light scattering method. When EA and PC as partially water-soluble solvents were used, small composite nanoparticles below 80nm were obtained, while large composite nanoparticles above 330nm were prepared for ACE as a fully water-soluble solvent.

• Textile Coloration and Finishing
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• v.2 no.4
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• pp.245-250
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• 1990

Copolyspiroacetals were synthesized by interfacial polycondensation from 3, 9-bis(4-hydroxyphenyl)-2, 4, 8, 10-tetraoxaspiroundecane(SAB) and 4, 4'-biphenol(BP) with sebacoyl chloride. These copolymers were soluble in polar solvent such as phenol/tetrachloroethane and sulfuric acid, and exibited good thermal stability. But they did not exhibit thermotropic mesophases. The structures of spiroacetal moiety were observed by computer-aided-modeling that had two types of conformational isomers and not linear and/or not planar conformations.

• Journal of Powder Materials
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• v.30 no.1
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• pp.47-52
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• 2023

The purpose of this study is to develop and evaluate amorphous spray-dried microparticles (SDM) containing levosulpiride to increase its solubility. SDM are prepared via solvent evaporation using polyvinylpyrrolidone (PVP) as the water-soluble polymer and Cremophor RH40 as the surfactant. The SDM is prepared by varying the amounts of PVP and Cremophor RH40, and its physicochemical properties, solubility, and dissolution are confirmed. All levosulpiride-loaded SDMs converted the crystalline drug into an amorphous form, significantly improving drug solubility and dissolution compared with the drug alone. SDM consisting of drug/PVP/Cremophor RH40 in a weight ratio of 5:10:3, with increased solubility (720 ± 36 vs. 1822 ± 51 ㎍/mL) and dissolution rate (10.3 ± 2.2 vs. 92.6 ± 6.0%) compared with drug alone, shows potential as a commercial drug for improved oral bioavailability of levosulpiride.

• Applied Chemistry for Engineering
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• v.10 no.4
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• pp.581-585
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• 1999

The surface treated hydroxypropyl methylcellulose(HPMC) which could adjust the soluble time was synthesized when 40 wt % glyoxal solution and $KH_2PO_4$ were sprayed and reacted. And also, the solution dynamic at different ratios of two adding agents were identified If the surface of HPMC was treated with only glyoxal, the dispersion characteristics at different ratios of two adding agents were identified If the surface of HPMC was treated with only glyoxal, the dispersion was observed in the neutral solution and the viscosity was increased after directly dissolved as the solution become alkali condition. But the fine-powder type of HPMC which reacted with glyoxal and $KH_2PO_4$ was dispersed regardless of pH of solution and observed that it was dissolved and its viscosity increased after elapsing some time. With increasing amount of glyoxal and $KH_2PO_4$, the soluble time was delayed. The reaction condition was about 60 min at $75{\sim}85^{\circ}C$. Especially, the removal process of organic solvent after reaction was not required due to reaction under water solution without organic during glyoxal and $KH_2PO_4$ treatment. And also, the HPMC which could adjust the soluble rate in water or organic solvent by changing the degree of substitution of HPMC was synthesized.