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http://dx.doi.org/10.4283/JKMS.2006.16.1.107

Preparation of Magnetite Nanoparticles Encapsulated with Biodegradable Polymer (PLGA)  

Lee, Ho-Seok (Department of Chemical Engineering, Konyang University)
Choung, Il-Yeop (Department of Chemical Engineering, Konyang University)
Song, Ki-Chang (Department of Chemical Engineering, Konyang University)
Ahn, Yang-Kyu (Department of Chemistry, Konyang university)
Choi, Eun-Chung (Department of Opthalmic Optics, Konyang University)
Publication Information
Journal of the Korean Magnetics Society / v.16, no.1, 2006 , pp. 107-110 More about this Journal
Abstract
Magnetite nanoparticles encapsulated with biodegradable polymer [poly(D,L-lactide-co-glycoiide), PLGA] were prepared by an emulsification-diffusion method. To investigate the effect of type of organic solvents on the mean particle sizes of obtained composite particles, different organic solvents [ethyl acetate (EA), propylene carbonate (PC) and acetone (ACE)] were used with a stabilizer [didodecyl dimethyl ammonium bromide (DMAB)]. The particle size of nanoparticles was observed by the dynamic light scattering method. When EA and PC as partially water-soluble solvents were used, small composite nanoparticles below 80nm were obtained, while large composite nanoparticles above 330nm were prepared for ACE as a fully water-soluble solvent.
Keywords
magnetitee/PLCA composite particles; emulsification-diffusion method; organic solvents; particle size;
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