• Tuberculosis and Respiratory Diseases
• /
• 제45권5호
• /
• pp.975-983
• /
• 1998

연구배경: 3p는 종양억제유전자의 존재가 강력히 의심되는 염색체의 부위로 폐암을 비롯한 여러 암에서 변이가 관찰되고 있다. 본 연구에서는 한국인의 비소세포폐암을 대상으로 3p의 4부위의 microsatellite locus에 대한 PCR-LOH를 시행하여 deletion의 빈도를 관찰하고 그 임상적 의의를 알아보고자 하였다. 방 법: 3p의 3부위의 CA repeat [D3S1228 (3p14.1-14.3), D3S1067 (3p14.3-21.1), D3S1029 (3p21.1-21.3)] 및 1부위의 tetra repeat [D3S1537 (3p22-24.2)] 의 microsatellite를 대상으로 PCR을 시행한 후 polyacrylamide gel에서 전기영동 후 X-ray film에 현상하였다. 정상 폐의 DNA의 PCR product와 폐암 DNA의 PCR product의 band를 비교하여 LOH가 있는 경우를 관찰하였다. 결 과: 62명의 비소세포폐암환자 중 59명에서 informative case이었고 이중 31명 (52.5%)에서 PCR-LOH를 보여 3p의 deletion이 있음을 관찰하였다. 3p deletion의 유무에 따라 환자의 흡연력, 병기 및 병리소견의 차이(squamous cell carcinoma : 55%, adenocarcinoma : 47%)를 관찰할 수 없었다. 또한 3p deletion의 유무는 비소세포폐암환자의 생존기간에도 영향을 주지 못 했으며 squamous cell carcinoma 및 adenocarcinoma로 나눈 군에서도 생존기간에 차이가 없었다. 결 론: 본 연구의 결과로 3p deletion은 한국인의 비소세포폐암 환자에서 많이 관찰되어 중요 역할을 하고 있으나 임상적인 특정과의 연관성은 관찰할 수 없었다.

• 보건교육건강증진학회지
• /
• 제19권2호
• /
• pp.139-154
• /
• 2002

This study was conducted to examine to causes and symptoms of stress and factors influencing stress management of workers in beauty shops. 811 people who were working in the shops located in Daegu City and Kyungbuk Province were selected as subjects of this study. Data were collected from April 10, 2000 to July 10, 2000. The results of this study can be summarized as follows. According to general characteristics of the respondents, female was 90.8%. 42.1 % of them was in their twenties and 73.7% of them did not marry. 57.5% of the respondents grew up in big cities and 41.1% had no religion. 63.6% was graduated from junior colleges. 44.6% of them worked for below I year and 33.9% earned below four hundred and ninety thousand won per month. 55.8% of them was satisfied with their work aptitude, while 34.2% was not satisfied with it. In the case of satisfaction level with working environment, ‘common level’ was 46.3%, while 12.8% of them was unsatisfied with it. In the case of stress level by factors of stress related to working, male was higher (9.34 $\pm$ 2.38 points). Those who grew up in towns or villages and those who belonged to the middle class showed high stress level. Those who married and those who graduated from high school also displayed high stress level. It also appeared that monthly income influenced the stress level related to working.. The extent of stress level influencing physical causes appeared in order of health condition, education level, sex, satisfaction level with work aptitude, economic status, and working hours. The extent of stress level influencing whole organizational level appeared in order of satisfaction level with work aptitude, working hours, education level, health condition, and sex. The extent of stress factors influencing depressed feeling of stress symptom appeared in order of working hours, sex, amount of smoking, absence due to stress, age, health condition, and education level. The extent of influencing factors on active stress management appeared in order of satisfaction level with work aptitude, health condition, size of the shop, drinking, sex, and the number of day off. The extent of influencing factors on avoidable stress management appeared in order of age, absence due to stress, drinking, health condition, and sex.

• 한국환경보건학회지
• /
• 제34권4호
• /
• pp.261-270
• /
• 2008

Adjusted water fluoridation has been disputed because of its various effects on human health. Previous studies have been concerned with the difference in bone mineral density (BMD) between water fluoridated (WF) and none water fluoridated (NWF) districts. The aim of this study is to examine whether water fluoridation affects BMD. BMD was measured by dual energy X-ray absorptiometry (DXA). 386 adults(174 males and 212 females) in Ansan (WF) district and 399 adults (176 males and 223 females) in Sihwa (NWF) district, participated in this study. The Ansan and Sihwa districts are similar in residential environment and living class. The relationship between serum fluoride concentration and BMD was also examined by analysis of the serum fluoride concentrations from 402 inhabitants of the Ansan district. In females, the BMD of subjects living in Ansan ($0.457{\pm}0.008$) was a little higher than that of Sihwa subjects ($0.446{\pm}0.008$), although it is not significant, after adjusting for BMI, physical activity level, educational achievement, smoking volume, menopause status, and number of births. However, the BMD of Ansan subjects ($0.532{\pm}0.020$) in their forties was statistically higher than that of Sihwa (0.498{\pm}0.019). No relationship was found in males. In residential periods, there was significant difference (Ansan $0.467{\pm}0.013$, Sihwa $0.434{\pm}0.012$, p=0.0125) in the BMD between females of two districts, particularly in the group of over 6 year long-term inhabitants. On the contrary, there was no remarkable difference in males from the two districts. Serum fluoride concentrations in females were associated with BMD, especially in the age group of forties (p=0.0457). No relationship was observed in the male group. Analysis of adult BMD over the age of 20 in a water fluoridated and a none water fluoridated district, confirms more or less a higher BMD in the water fluoridated (WF) district, especially for females. It is assumed that the difference between two districts came somewhat from the effect of water fluoridation.

• Nutrition Research and Practice
• /
• 제12권3호
• /
• pp.258-264
• /
• 2018

BACKGROUND/OBJECTIVES: Diet quality scores or indices, based on dietary guidelines, are used to summarize dietary intake into a single numeric variable. The aim of this study was to examine the association between the modified diet quality index for Koreans (DQI-K) and mortality among Health Examinees-Gem (HEXA-G) study participants. SUBJECTS/METHODS: The DQI-K was modified from the original diet quality index. A total of 134,547 participants (45,207 men and 89,340 women) from the HEXA-G study (2004 and 2013) were included. The DQI-K is based on eight components: 1) daily protein intake, 2) percent of energy from fat, 3) percent of energy from saturated fat, 4) daily cholesterol intake, 5) daily whole-grain intake, 6) daily fruit intake, 7) daily vegetable intake, and 8) daily sodium intake. The association between all-cause mortality and the DQI-K was examined using Cox proportional hazard regression models. Hazard ratios and confidence intervals were estimated after adjusting for age, gender, income, smoking status, alcohol drinking, body mass index, and total energy intake. RESULTS: The total DQI-K score was calculated by summing the scores of the eight components (range 0-9). In the multivariable adjusted models, with good diet quality (score 0-4) as a reference, poor diet quality (score 5-9) was associated with an increased risk of all-cause mortality (hazard ratios = 1.23, 95% confidence intervals = 1.06-1.43). Moreover, a one-unit increase in DQI-K score resulted in a 6% higher mortality risk. CONCLUSIONS: A poor diet quality DQI-K score was associated with an increased risk of mortality. The DQI-K in the present study may be used to assess the diet quality of Korean adults.

• 한국산학기술학회논문지
• /
• 제14권3호
• /
• pp.1283-1293
• /
• 2013

본 연구의 목적은 성별에 따른 한국 청소년의 건강행태, 정신건강과 인터넷 중독 정도를 비교하여 파악하고, 건강행태와 정신건강의 인터넷 중독과의 관련성을 파악하기 위함이다. 본 연구는 질병관리본부가 실시한 "청소년 건강행태 온라인조사(2010)"의 원시자료를 사용하였으며, 총 조사대상자 73,238명 중, 남학생 38,391명과 여학생 34,847명이 분석에 이용되었다. 연구결과, 남학생의 인터넷 중독 고위험군의 비율은 3.9%(1,512명)였으며, 여학생은 1.9%(684명)로 조사되었고, 인터넷 중독의 잠재적 위험군의 비율은 남학생 13.6%(5,225명), 여학생 9.6%(3,401명)으로 나타났다. 건강행태, 정신건강 및 인터넷 중독의 모든 변수에서 성별에 따른 유의한 차이가 있는 것으로 나타났다. 남학생과 여학생 모두 흡연 경험, 습관적 약물 사용경험, 주관적 건강상태, 스트레스, 우울, 자살생각, 행복감, 수면 충족감이 인터넷 중독 발생에 유의한 영향을 미치는 것으로 파악되었는데, 여학생은 남학생에 비해 정신건강 관련 요인이 인터넷 중독과의 관련성이 높았고, 남학생은 여학생보다 건강행태 관련요인이 인터넷 중독 위험에 미치는 영향력이 큰 것으로 나타났다. 그러므로 한국 청소년의 인터넷 중독 예방을 위한 간호 중재는 이와 관련 있는 건강행태와 정신건강 향상을 위한 전략을 포함하고, 성별에 따른 차이를 고려하여, 계획하고 적용하여야 할 것이다.

• 한국학교보건학회지
• /
• 제8권1호
• /
• pp.117-131
• /
• 1995

The purpose of this study is to grasp the nature of health behavior to pactice in order to keep and improve the optimal health in the current status of the cancer patients. The subjects were 21 cancer patients, who knew about their disease for themselves, could communicate without mental disease history, and could understand the purpose of this study and cooperate, in a university hospital in Seoul. The data were collected by direct interview from July 15 to Oct. 17, 1994. The interview took about 1~2hours per one time for each paitent by unstructural and open questions. And they were classified into some similar contents on the basis of the phenomenological analysis and categorized. The analyzed results are as follows: 1) In the daily life before and after diagnosis as cancer patients, they were categorized into 6 areas-the state of movement, sleeping, nutrition and diet, society and economy, drinking and somking, and recognition of their health. 2) In the experience of health behavior of cancer patents, they were categorized into 7 areas-the state of movement, sleeping, nutrition and diet, society and economy, drinking and smoking, recognition of their health, and psychology etc. According to the analyzed results of daily life before diagnosis as cancer patients, it turned out that they didn't recognize the problems for their health habit and made their disease state bad by irresolute characteristics which hesitated to practice rightly, renunciation, and irresponsibility and so on, even if they had much interests in their health and were motivated. Therefore, it is necessary to recognize and have an individual-centric interests in order to change the pattern of life for optimal health state to some extent. In the health behavior of cancer patients, it turned out that they had interests in the state of nutrition and diet the most. Even though they experienced the change of serious nutritive state due to the bad gastroenteric trouble by anticancer treatment, they were trying to have a regular eating habit refraining from irritant food and use folk remedies or healthy food temperating the taste food thoroughly, they also showed the sensitive response for nutrition. In addition, they appeared to use the traditional medical treatment or the folk remedies very seriously without abuse. In consideration of it, it is desirable to use them together with the modern medical treatment intercomplementarily and necessary to look into the types for cancer patients and their benefits.

• 대한한방내과학회지
• /
• 제22권3호
• /
• pp.299-307
• /
• 2001

Objectives: Fatigue is a common symptom experienced by many people who visit Oriental medical clinics or hospital. However, there has been little study about the fatigue in the Oriental medical academic world. For this reason, we attempted to investigate the present status of fatigue of outpatients, and its relation with Health Practice Index(HPI). Methods: The subjects were 63 outpatients who visited the Tonification Clinic in Kyunghee Oriental Medical Center between January 1, 2001 and July 31, 2001. Their chief complaint was fatigue and they did not have any physical or mental problem. They were given a questionnaire which included questions reflecting general characteristics, fatigue degree and health habits. We measured degree of fatigue by Chalder scale et al. Health habits were investigated about 5 articles out of 'Breslow 7 Health habits'. Results: Among the subjects, 48 people(76.2%) were considered as 'fatigue patients' by the Chalder scale. Of this 48 fatigue patients, 27 people(56.3%) had manifested fatigue for more than 6 months. The average of scale II for all the patients was 14.05, which indicates moderate degree of fatigue. They complained fatigue, drowsiness and general weakness, dryness and discomfort of the eyes, headache, shoulder pain and neck stiffness, dizziness, heat in the upper part of the body, and poor concentration. There were no differences in degree of fatigue according to Health habits including exercise or not, smoking or not, the frequency of drinking, hours of sleeping, and body mass index. Conclusions: Many people complain fatigue symptom. Therefore doctors should have more interest in fatigue and care. This study can provide standards of prognosis of fatigue patients. Also prospective studies are needed to find relationship between health habits and fatigue degree.

• Journal of Preventive Medicine and Public Health
• /
• 제33권4호
• /
• pp.459-468
• /
• 2000

Objectives : To investigate the association between BMI and Mortality. Methods : This study was based on the analysis and assembly of the 'Kangwha Cohort Study', previously conducted by the Department of Preventive Medicine, Yonsei University. A total of 2,696 males and 3,595 females were followed for almost ten years and ten months from March 1985 to January 1996, a total of whom 2,420 died during this period. The Cox's proportional hazards regression model was used to analyze this data. Results : We found a U-shaped relationship between BMI and mortality among the aged men in the Kangwha cohort. The hazard ratio of dying was adjusted for age, marital status, occupation, self cognitive health level, chronic disease, smoking, and alcohol frequency, then sorted by body mass index into the following groups; less than 10.5, 18.5 to less than 21.0, 21.0 to less than 23.5, 23.5 to less than 26.0 and greater than or equal to 26. The corresponding ratios for men were 1.81(1.50-2.19, 95%CI), 1.31(1.14-1.51, 95%CI), 1.0(referent), 1.05(0.87-1.26, 95%CI) and 1.39(1.09-1.76, 95%CI), respectively. And for women, 1.46(1.19-1.78), 1.12(0.95-1.31, 95%CI), 1.0(referent), 1.00(0.84-1.20, 95%CI) and 1.09(0.89-1.34, 95%CI), respectively. Conclusions : The risk of death among aged men in Kangwha increased in the under and overweight groups. The relationship between BMl and mortality has been well studied in Western populations, but little is known about the association between BMI and mortality in our country. So, on the basis of this study, it is apparent that more studies of the relationship between BMI and mortality will be needed for future work.

• 생명과학회지
• /
• 제18권4호
• /
• pp.580-584
• /
• 2008

본 연구에서는 손상된 DNA를 수복하는 중요한 효소로 알려진 $O^6-methylguanine-DNA$ methyltransferase (MGMT)발현의 의미를 비소세포폐암종에서 면역조직화학 염색법으로 알아보고자 하였다. 동아대학교 의료원에서 2001년부터 2004년까지 외과적으로 적출한 폐암종 조직 중 비소세포암종으로 진단된 74예를 연구대상으로 하였다. 면역염색 결과, MGMT 발현은 총 74예 중 49예(66.2%)에서 양성을 보였으며, 25예(33.8%)에서 단백 소실을 보였다. 조직학적 유형에 따른 결과를 살펴보면, 편평세포암종은 8/39예(20.5%)에서 단백 소실이 보였고, 샘암종은 17/35예(48.6%)에서 단백 소실이 관찰되어 통계적으로 유의한 차이가 관찰되었다(p=0.021). 하지만 나이, 성별, 흡연유무, 종양 크기, T 병기 및 림프절 전이에 따른 유의한 차이는 관찰되지 않았다(p>0.05). MGMT 단백 발현 소실은 특히 promoter 메틸화와 연관되어 종양에서 관찰된다고 알려져 있으므로, 향후 연구에서는 비소세포폐암종의 MGMT 단백 소실에 대한 임상적 의의를 밝히기 위하여 promoter 메틸화 연구가 추가적으로 수행되어져야 될 것으로 사료된다.

• 한국산학기술학회논문지
• /
• 제17권9호
• /
• pp.447-457
• /
• 2016

본 연구는 기숙사 생활을 하는 대학생과 비기숙사 생활을 하는 대학생의 스트레스 증상과 건강증진행위와의 관계를 파악하기 위하여 시도되었다. 기숙사 생활 대학생 313명, 비기숙사 생활 대학생 281명을 대상으로 설문조사를 하였다. 자료는 2015년 10월 21일부터 11월 20일까지 수집하였다. 자료의 분석은 기술적 통계, 피어슨 상관회귀분석 및 다중회귀분석을 이용하였다. 기숙사 생활 대학생의 건강증진행위가 남녀 모두 비기숙사 생활 대학생보다 높게 나타났다. 기숙사 생활 대학생의 경우 흡연 및 음주여부는 건강증진행위에 영향을 미쳤으며, 비기숙사 생활 대학생의 경우 학업성취도와 건강상태가 건강증진행위에 영향을 미쳤다. 기숙사 생활 대학생의 경우에 우울, 불안, 정서적 분노가, 비기숙사 생활 대학생의 경우에는 인식력 장애, 우울, 정서적 분노가 건강증진행위에 통계적으로 유의한 역 상관관계를 보였다. 다중회귀분석 결과, 기숙사 생활 대학생의 경우 건강증진행위에 영향을 미치는 요인은 우울, 정서적 분노 및 불안이었으며 설명력은 67%였으며, 비기숙사 생활 대학생의 경우에는 우울과 정서적 분노가 영향을 미쳤으며 설명력은 63%였다. 본 연구의 결과를 토대로 대학생들에 대한 적합한 건강증진행위 프로그램의 개발이 필요하다고 제안한다.