• 한국시뮬레이션학회논문지
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• 제10권4호
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• pp.11-20
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• 2001

In the IMT-2000 networks, the model of micro/pico cell is suggested for transmission of multimedia service. Hence, the efficient method is required for processing of mobile calls in micro/pico cell. In the central urban area, mobile calls may be dynamically increased because of many mobile users. And microcel]/picocell size has small size, handover calls will be more increased. Therefore, many of mobile calls is occurred at a cell in the central urban area, so channel requests for these calls will be increased in the call. In this paper, we propose a scheme, FTC(Fault Tolerant Channel allocation) which is the channel management method for hard handover and new call in a mobile cell of central urban area. When available channels in the cell are consumed, the FTC investigates channel states of neighbor cells in the RNC(Radio Network Controller) or BSC (Base Station Center), and provide available channel for mobile call. The ]no scheme is analyzed and compared with existing channel management method by simulation.

• 전자공학회논문지
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• 제53권5호
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• pp.19-24
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• 2016

LTE-A(Long Term Evolution-Advanced)에서는 비용 효율적 방법으로 급증하는 무선 데이터 서비스를 대처하고 사용자의 QoS(Quality of Service)를 만족시키기 위해 소형셀 향상(SCE:Small Cell Enhancement)에 대한 연구가 활발히 진행되고 있다. 하지만 수많은 소형셀이 밀집하여 불규칙하게 배치되기 때문에 오프로딩 기법이 적용되어야 한다. 본 논문에서는 LTE-Advanced 시스템에서 SCE 위한 새로운 사용자 오프로딩 기법을 제안한다. 제안 기법은 UE(User Equipment)로부터 받은 RSRP(Reference Signal Received Power)를 비교하여 소형셀의 클러스터를 구성한다. 클러스터 내에서 셀의 사용자 수와 간섭 상황을 고려하여 사용자 오프로딩을 적용한다. 모의실험 결과, 제안한 기법에서 소형셀 사용자의 전송률 및 스펙트럼 효율이 향상되어 전체적인 셀 성능이 향상 되는 것을 볼 수 있다.

• 한국정보처리학회논문지
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• 제3권4호
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• pp.947-960
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• 1996

우수한 성능의 ATM 스위칭 시스템 개발을 위한 주요 목표가 셀 손실, 셀지연 및 처리율의 저하를 최소화하는데 있으며, 이러한 목적에 가장 적합한 ATM스위치 소자가 램덤 액세스 메모리 및 제어 논리에 의해 수행되는 공유 버퍼 메모리 스위치(shared buffer memory switch)이다. 이 스위치는 입력 포트의 수가 증가할 수록 VLSI의 제조가 어렵기 때문에 최근의 소용량 및 대용량의 ATM 스위치는 8$\times$8,600 b/s 또는 16$\times$16,150 Mb/s의 단위 스위치를 사용하여 32$\times$32(4.9 Gb/s), 150Mb/s의 스위치를 구현하는 스위치 모듈 방법을 사용하고 있다. 본 논문에서는 단위 공유 버퍼 메모리 스위치의 버퍼 공유에가 위한 전체 메모리 감소 효과를 만족하는 버퍼 용량을 해석적 으로 평가하고, 트래픽 조건에 따른 셀 손실율을 컴퓨터 시뮬레이션한 결과를 제시 하며 또한, 스위치 모듈 방법을 이용하는 소용량 및 대용량 ATM 스위치 마의 특징을 분석,이 결과를 바탕으로 현재 각국에서 연구중인 32$\times$32, 150Mb/s의 스위치 구조를 제시하며, 궁극적으로 위 주요 목표들을 만족하는 소용량 및 대용량의 ATM 스위칭 시 스템을 위한 고속 스위칭 망 구조를 제시한다.

• 한국통신학회논문지
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• 제39B권10호
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• pp.664-673
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• 2014

본 논문은 기지국 간 상하향링크의 할당 비율이 동일하지 않은 비동기식 시분할 듀플렉싱 모드 기반의 이종 네트워크 환경에서 총 전송률을 최대화 하는 전력 할당 방식을 연구한다. 본 논문에서는 매크로 셀 커버리지 안에 같은 자원을 공유하는 소형 셀이 존재하는 이종 네트워크를 고려한다. 각 셀 마다 주어진 Target 수신 신호 대 간섭 및 잡음 비 성능을 만족하면서 각 셀의 전송률의 합을 목적 함수로 가지는 최적화 문제를 정의한다. 이를 통해 최적 해가 존재하기 위한 가시적인 영역을 분석하고 총 전송률을 최대화 할 수 있는 전력 할당 방식을 도출한다. 실험 결과를 통하여 제안한 전력 할당 방식을 사용한 전송 방식이 모든 노드가 최대 허용 전력으로 전송하는 전송 방식보다 더 높은 전송률을 달성함을 확인할 수 있다.

• ETRI Journal
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• 제35권5호
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• pp.775-785
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• 2013

Because of their exclusive features, millimeter wave directive mesh networks can be considered for small cell backhaul support in urban environments. For this purpose, a network of closely spaced stations has been considered with very directive line-of-sight links operating in the 60-GHz band. An attempt is made to evaluate channel response and interference behavior in such a network, taking into account the effect of building blockage. A simple grid of building blocks is considered as the propagation environment, and wave propagation is simulated using 2.5-dimensional (2.5D) ray tracing (2D with ground effect) to calculate the received signal at different nodes in the network. The results are compared with free space predictions and used to evaluate interference at all nodes in the channel and describe certain characteristics of links, such as the delay profile and the correlation length.

• IMMUNE NETWORK
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• 제6권1호
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• pp.1-5
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• 2006

Background: B cell subset has been divided into B-1 cells and B-2 cells. B-1 cells are found most prominently in the peritoneal cavity, as well as constituting a small pro portion of splenic B cells and they are larger and less dense than B-2 cells in morphology. This study was designed to compare the differences in their proliferation and differentiation between B-1 and B-2 cell. Methods: We obtained sorted B-1 cells from peritoneal fluid and B-2 cells from spleens of mice. Secreted IgM was measured by enzyme-linked immunosorbent assay. Entering of S phase in response to LPS-stimuli was measured by proliferative assay. Cell cycle analysis by propidium iodide was performed. p21 expression was assessed by real time PCR. Results: Cell proliferation and cell cycle progression in B-1 and B-2 cells, which did not occur in the absence of LPS, required LPS stimulation. After LPS stimulation, B-1 and B-2 cells were shifted to Sand G2/M phases. p21 expression by resting B-1 cells was higher than that of resting B-2 cells. Conclusion: B-1 cells differ from conventional B-2 cells in proliferation, differentiation and cell cycle.

• Interdisciplinary Bio Central
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• 제5권1호
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• pp.1.1-1.8
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• 2013

High quality publicly-available transcriptomic data representing relationships in gene expression across a diverse set of biological conditions is used as a context network to explore transcriptomics of the CNS. The context network, 18367Hu-matrix, contains pairwise Pearson correlations for 22,215 human genes across18,637 human tissue samples1. To do this, we compute a network derived from biological samples from CNS cells and tissues, calculate clusters of co-expressed genes from this network, and compare the significance of these to clusters derived from the larger 18367Hu-matrix network. Sorting and visualization uses the publicly available software, MetaOmGraph (http://www.metnetdb.org/MetNet_MetaOm-Graph.htm). This identifies genes that characterize particular disease conditions. Specifically, differences in gene expression within and between two designations of glial cancer, astrocytoma and glioblastoma, are evaluated in the context of the broader network. Such gene groups, which we term outlier-networks, tease out abnormally expressed genes and the samples in which this expression occurs. This approach distinguishes 48 subnetworks of outlier genes associated with astrocytoma and glioblastoma. As a case study, we investigate the relationships among the genes of a small astrocytoma-only subnetwork. This astrocytoma-only subnetwork consists of SVEP1, IGF1, CHRNA3, and SPAG6. All of these genes are highly coexpressed in a single sample of anaplastic astrocytoma tumor (grade III) and a sample of juvenile pilocytic astrocytoma. Three of these genes are also associated with nicotine. This data lead us to formulate a testable hypothesis that this astrocytoma outlier-network provides a link between some gliomas/astrocytomas and nicotine.

• IMMUNE NETWORK
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• 제12권6호
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• pp.223-229
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• 2012

Clinical and preclinical in vivo immune cell imaging approaches have been used to study immune cell proliferation, apoptosis and interaction at the microscopic (intra-vital imaging) and macroscopic (whole-body imaging) level by use of ex vivo or in vivo labeling method. A series of imaging techniques ranging from non-radiation based techniques such as optical imaging, MRI, and ultrasound to radiation based CT/nuclear imaging can be used for in vivo immune cell tracking. These imaging modalities highlight the intrinsic behavior of different immune cell populations in physiological context. Fluorescent, radioactive or paramagnetic probes can be used in direct labeling protocols to monitor the specific cell population. Reporter genes can also be used for genetic, indirect labeling protocols to track the fate of a given cell subpopulation in vivo. In this review, we summarized several methods dealing with dendritic cell, macrophage, and T lymphocyte specifically labeled for different macroscopic whole-body imaging techniques both for the study of their physiological function and in the context of immunotherapy to exploit imaging-derived information and immune-based treatments.

• IMMUNE NETWORK
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• 제22권1호
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• pp.9.1-9.23
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• 2022

In the past few decades, biological drugs and small molecule inhibitors targeting inflammatory cytokines, immune cells, and intracellular kinases have become the standard-of-care to treat autoimmune diseases. Inhibition of TNF, IL-6, IL-17, and IL-23 has revolutionized the treatment of autoimmune diseases, such as rheumatoid arthritis, ankylosing spondylitis, and psoriasis. B cell depletion therapy using anti-CD20 mAbs has shown promising results in patients with neuroinflammatory diseases, and inhibition of B cell survival factors is approved for treatment of systemic lupus erythematosus. Targeting co-stimulatory molecules expressed on Ag-presenting cells and T cells is also expected to have therapeutic potential in autoimmune diseases by modulating T cell function. Recently, small molecule kinase inhibitors targeting the JAK family, which is responsible for signal transduction from multiple receptors, have garnered great interest in the field of autoimmune and hematologic diseases. However, there are still unmet medical needs in terms of therapeutic efficacy and safety profiles. Emerging therapies aim to induce immune tolerance without compromising immune function, using advanced molecular engineering techniques.

• IMMUNE NETWORK
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• 제11권5호
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• pp.227-244
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• 2011

MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their target messenger RNAs (mRNAs). Recent studies have clearly demonstrated that miRNAs play critical roles in several biologic processes, including cell cycle, differentiation, cell development, cell growth, and apoptosis and that miRNAs are highly expressed in regulatory T (Treg) cells and a wide range of miRNAs are involved in the regulation of immunity and in the prevention of autoimmunity. It has been increasingly reported that miRNAs are associated with various human diseases like autoimmune disease, skin disease, neurological disease and psychiatric disease. Recently, the identification of miRNAs in skin has added a new dimension in the regulatory network and attracted significant interest in this novel layer of gene regulation. Although miRNA research in the field of dermatology is still relatively new, miRNAs have been the subject of much dermatological interest in skin morphogenesis and in regulating angiogenesis. In addition, miRNAs are moving rapidly center stage as key regulators of neuronal development and function in addition to important contributions to neurodegenerative disorder. Moreover, there is now compelling evidence that dysregulation of miRNA networks is implicated in the development and onset of human neruodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Tourette's syndrome, Down syndrome, depression and schizophrenia. In this review, I briefly summarize the current studies about the roles of miRNAs in various autoimmune diseases, skin diseases, psychoneurological disorders and mental stress.