• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.1993-1995
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• 2015

Purpose: This analysis was conducted to evaluate the efficacy and safety of irinotecan based regimens as second-line chemotherapy in treating patients with small cell lung cancer. Methods: Clinical studies evaluating the efficacy and safety of irinotecan based regimens as second-line chemotherapy for patients with small cell lung cancer were identified using a predefined search strategy. Pooled response rates (RRs) of treatment were calculated. Results: In irinotecan based regimens as second-line chemotherapy, 4 clinical studies which including 155 patients with small cell lung cancer were considered eligible for inclusion. In all chemotherapy consisted of irinotecan with or without nedaplatin. Pooled analysis suggested that, in all patients, the pooled RR was 27.1% (42/155) in irinotecan based regimens. Nausea, vomiting, diarrhea and myelosuppression were the main side effects. No grade III or IV renal or liver toxicity was observed. No treatment related death occurred with the irinotecan based treatments. Conclusion: This systemic analysis suggests that irinotecan based regimens as second-line chemotherapy are associated with mild response rate and acceptable toxicity for patients with small cell lung cancer.

• 대한약침학회지
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• 제11권2호
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• pp.13-19
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• 2008

Objectives To investigate the therapeutic effects of intravenous cultivated wild ginseng(Panax ginseng C.A. Meyer) pharmacopuncture(CWGP) in treating patients with non-small cell lung cancer(NSCLC). Design Prospective case series. Setting This study was conducted at the East-West Cancer Center of Dunsan Oriental Hospital, Daejeon University. Patients Two non-small cell lung cancer patients. Intervention Two non-small cell lung cancer patients were injected CWGP(20mL/day) mixed with 0.9% normal saline(100mL) intravenously. Each patient received a total of 16 and 9 cycles, respectively. One cycle is composed of 14 days. Outcome Measures The effect of intravenous CWGP was measured by scanning with computed tomography(CT) after every 2 cycle and Positron emission tomography- computed tomography(PET/CT) after every 6 cycles. Response and progression was evaluated using the Response Evaluation Criteria in Solid Tumors(RECIST) Committee classification of complete response(CR), partial response(PR), progressive disease(PD) and stable disease(SD). Results They were treated with intravenous CWGP for 8 and 5 months respectively. time later, each tumor remains stable disease(SD). Conclusion These cases may give us a possibility that intravenous CWGP offers potential benefits for non-small cell lung cancer patients.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4797-4800
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• 2015

Background: This analysis was conducted to evaluate the efficacy and safety of crizotinib based regimens in treating Chinese patients with EML4-ALK positive non-small-cell lung cancer. Materials and Methods: Clinical studies evaluating the efficacy and safety of crizotinib based regimens on response and safety for Chinese patients with EML4-ALK positive non-small-cell lung cancer were identified by using a predefined search strategy. Pooled response rate (RR) of treatment were calculated. Results: In crizotinib based regimens, 3 clinical studies which including 128 Chinese patients with EML4-ALK positive non-small-cell lung cancer and treated with crizotinib based regimen were considered eligible for inclusion. Pooled analysis suggested that, in all patients, the pooled RR was 59.3% (76/128) in crizotinib based regimens. ALT/AST mild visual disturbances, nausea, and vomiting were the main side effects. No treatment related death occurred in these crizotinib based treatments. Conclusions: This pooled analysis suggests that crizotinib based regimens are associated with good response rate and accepted toxicities in treating Chinese patients with EML4-ALK positive non-small-cell lung cancer.

• ETRI Journal
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• 제40권1호
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• pp.51-60
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• 2018

In Long Term Evolution (LTE) cellular networks, the transmit power control (TPC) mechanism consists of two parts: the open loop (OL) and closed loop. Most cellular networks consider OL/TPC because of its simple implementation and low operation cost. The analysis of OL/TPC parameters is essential for efficient resource management from the cellular operator's viewpoint. In this work, the impact of the OL/TPC parameters is investigated for homogeneous small cells and heterogeneous small-cell/macrocell network environments. A mathematical model is derived to compute the transmit power at the user equipment, the received power at the eNodeB, the interference in the network, and the received signal-to-interference ratio. Using the analytical platform, the effects of the OL/TPC parameters on the system performance in LTE networks are investigated. Numerical results show that, in order to achieve the best performance, it is appropriate to choose ${\alpha}_{small}=1$ and $P_{o-small}=-100dBm$ in a homogenous small-cell network. Further, the selections of ${\alpha}_{small}=1$ and $P_{o-small}=-100dBm$ in the small cells and ${\alpha}_{macro}=0.8$ and $P_{o-macro}=-100dBm$ in the macrocells seem to be suitable for heterogeneous network deployment.

• 한국수정란이식학회지
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• 제31권3호
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• pp.307-311
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• 2016

The aim of this study was to compare the appearance rate of vaginal cytology during estrous cycle in small pet bitches. A characteristic features of vaginal cytology during the estrous cycle were the high proportion of superficial cell in proestrus, anuclear cell in estrus, small intermediate cell in diestrus, and small intermediate cell in anestrus, respectively. There were no statistically significant differences of appearance rate of vaginal cytology among small pet bitches in the each phase of estrous cycle. These results indicated that the vaginal cytology was useful method for estimating estrous cycle and optimal breeding time in small pet bitches.

• 인터넷정보학회논문지
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• 제22권5호
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• pp.9-16
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• 2021

Recently, the traffic volume of mobile communications increases rapidly and the small-cell is one of the solutions using two offload schemes, i.e., local IP access (LIPA) and selected IP traffic offload (SIPTO), to reduce the end-to-end delay and amount of mobile data traffic in the core network (CN). However, 3GPP describes the concept of LIPA and SIPTO and there is no decision algorithm to decide the path from source nodes (SNs) to destination nodes (DNs). Therefore, this paper proposes a dynamic mobile data traffic offload scheme using small-cells to decide the path based on the SN and DN, i.e., macro user equipment, small-cell user equipment (SUE), and multimedia server, and type of the mobile data traffic for the real-time and non-real-time. Through analytical models, it is shown that the proposed offload scheme outperforms the conventional small-cell network in terms of the delay of end-to-end mobile data communications and probability of the mobile data traffic in the CN for the heterogeneous networks.

• Tuberculosis and Respiratory Diseases
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• 제48권1호
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• pp.72-77
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• 2000

저자들은 기침과 전신 쇄약감으로 내원하여 기관지내시경에 의한 조직생검에서 편평상피세포암종으로 진단되었으나 수술 후 소세포암종이 편평정상피세포암종과 선암종을 포함한 복합형 소세포암종 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 대한세포병리학회지
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• 제1권1호
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• pp.111-120
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• 1990

Small cell neuroendocrine carcinoma of the uterine cervix is a distinct subtype of cervical cancer that appears analogous to oat cell carcinoma and carcinoid tumors of the lung. It has been assumed to be derived from the neural crest via argyrophilic cells in the normal endocervix. We have recently encountered a case of small cell neuroendocrine carcinoma of the uterine cervix coexisting with adenocarcinoma which was argyrophil negative. A 66-year-old multiparous woman was admitted because of vaginal bleeding for 2 months. Cervicovaginal smear revealed several scattered clusters and sheets of monotonous small cells with some peripheral palisading in the background of hemorrhage and necrosis. Radical hysterectomy specimen revealed an ulcerofungating tumor on endocervical canal which was composed of two components. Major component of the tumor was made up of monomorphic population of small oval-shaped tumor cells arranged in sheets and partly in acinar structures or trabecular fashion. Other component was adenocarcinoma, endocervical well-differentiated type. Argyrophilia was present on the Grimelius stain and immunohistochemical studies revealed diffuse positivity to neuron-specific enolase and carcinoembryonic antigen. Electron microscopic examination showed clusters of small round to oval cells, which had a few well-formed desmosomes and several membrane-bound, dense-core neurosectetory granules.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.491-495
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• 2016

Background: Small B-cell non-Hodgkins lymphoma (NHL) is difficult to be distinguished from non-neoplastic reactive processes using conventional haematoxylin-eosin (HE) staining due to different interpretations among pathologists with diagnosis based on morphologic features. Ancillary examinations such as immunohistochemical (IHC) staining are essential. However, negative or doubtful results are still sometimes obtained due to unsatisfactory tissue processing or IHC technique. The polymerase chain reaction (PCR) as a molecular diagnostic technique is very sensitive and specific. Clonality detection of heavy chain immunoglobulin (IgH) gene rearrangement has been widely used to establish diagnosis of B-cell NHL. Aims: To elaborate interobserver variation in small B-cell NHL diagnosis based on morphologic features only and to confirm sensitivity and specificity of the PCR technique as an ancillary method. Materials and Methods: A toptal of 28 samples of small B cell NHL and suspicious lymphoma were interpreted by 3 pathologists in Sardjito General Hospital based on their morphology only. The reliability of assessment and the coefficient of interobserver agreement were calculated by Fleiss kappa statistics. Interpretation results were confirmed with IHC staining (CD20, CD3, Bcl2). PCR was performed to analyze the clonality of IgH gene rearrangement. Results: Interobserver agreement in morphologic evalution of small B cell NHL and chronic lymphadenitis revealed kappa coefficient 0.69 included in the substantial agreement category. The cases were divided into 3 groups based on morphology and IHC results; lymphoma, reactive process and undetermined group. PCR analysis showed 90% sensitivity and 60% specificity. Conclusions: The present study revealed a substantial agreement among pathologists in small B-cell NHL diagnosis. For difficult cases, PCR is useful as complementary method to morphologic and IHC examinations to establish definitive diagnosis.

• 한국통신학회논문지
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• 제39A권9호
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• pp.548-556
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• 2014

최근 급증하는 데이터 트래픽에 효율적으로 대응하기 위해 매크로 기지국 영역에 매크로 기지국과 같은 주파수를 사용하는 소형 기지국이 공존하는 이종망에 관한 연구가 활발하게 진행 중이다. 이때, 매크로셀로부터 소형셀로의 간섭을 줄이기 위해 시간 영역에서 ABS (Almost Blank Subframe)을 이용한 enhanced Inter-cell Interference Coordination (eICIC) 기법이 제안되어 있다. 그러나 간섭 문제 해결을 위해 데이터를 전송하지 않는 서브프레임들이 발생함으로써 매크로셀 입장에서는 자원 낭비 문제가 발생한다. 본 논문에서는 능동 안테나 시스템 (AAS)과 Genetic Algorithm (GA)을 이용하여 소형 셀 방향으로 안테나 이득을 줄인 매크로 기지국의 3D 섹터 빔을 형성하여 셀간의 간섭신호 세기가 감소 되도록 하고 데이터 전송에 모든 서브프레임을 이용하여 낭비되는 자원이 없도록 한다. LTE -Advanced 시스템 레벨 시뮬레이터를 통해 기존 eICIC 기법과의 성능을 비교 분석하며, 제안된 기법의 성능 향상을 확인한다.