Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
권호 표지
DOI QR코드

DOI QR Code

Two Cases of Non-Small Cell Lung Cancer Treated with Intravenous Cultivated Wild Ginseng Pharmacopuncture

산삼약침 혈맥주입을 시행한 비소세포성폐암 환자 2례

  • Bang, Sun-Hwi (East-West Cancer Center, Dunsan Korean Medicine Hospital, Daejeon University) ;
  • Kwon, Ki-Rok (Department of Acupuncture & Moxibustion, College of Korean Medicine, Sangji University) ;
  • Yoo, Hwa-Seung (East-West Cancer Center, Dunsan Korean Medicine Hospital, Daejeon University)
  • 방선휘 (대전대학교 한의과대학 둔산한방병원 동서암센터) ;
  • 귄기록 (상지대학교 한의과대학 침구학교실) ;
  • 유화승 (대전대학교 한의과대학 둔산한방병원 동서암센터)
  • Published : 2008.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives To investigate the therapeutic effects of intravenous cultivated wild ginseng(Panax ginseng C.A. Meyer) pharmacopuncture(CWGP) in treating patients with non-small cell lung cancer(NSCLC). Design Prospective case series. Setting This study was conducted at the East-West Cancer Center of Dunsan Oriental Hospital, Daejeon University. Patients Two non-small cell lung cancer patients. Intervention Two non-small cell lung cancer patients were injected CWGP(20mL/day) mixed with 0.9% normal saline(100mL) intravenously. Each patient received a total of 16 and 9 cycles, respectively. One cycle is composed of 14 days. Outcome Measures The effect of intravenous CWGP was measured by scanning with computed tomography(CT) after every 2 cycle and Positron emission tomography- computed tomography(PET/CT) after every 6 cycles. Response and progression was evaluated using the Response Evaluation Criteria in Solid Tumors(RECIST) Committee classification of complete response(CR), partial response(PR), progressive disease(PD) and stable disease(SD). Results They were treated with intravenous CWGP for 8 and 5 months respectively. time later, each tumor remains stable disease(SD). Conclusion These cases may give us a possibility that intravenous CWGP offers potential benefits for non-small cell lung cancer patients.

Keywords

References

  1. 제 98차 대한 결핵 및 호흡기학회 춘계학술대회. 2004;11-21
  2. 신순식, 김경철, 최영현, 이용태, 엄현섭, 김창식. 산삼 감정기준의 객관성. 東義韓醫硏. 2001;107-114
  3. 대한약침학회. 약침요법 시술 지침서. 대한약침학회.1999:13-14, 112-118, 138-203
  4. 이종영, 조병준, 권기록, 강대인. 혈맥에 대한 문헌적고찰. 대한약침학회지. 8(3).2005;11-20 https://doi.org/10.3831/KPI.2005.8.3.011
  5. 권기록, 조아라, 이선구. 정맥주입용 산양산삼 증류약침이의 급성, 아급성 독성 실험 및 Sarcoma-180 항암효과에 관한 실험적 연구. 대한약침학회지. 6(2).2003;7-27 https://doi.org/10.3831/KPI.2003.6.2.007
  6. 권기록. 정맥주입용 산삼약침이 인체에 미치는 영향에 관한 임상적 연구. 대한약침학회지. 7(1).2004;15-26
  7. 박봉기, 조종관, 권기록, 유화승. 6개월간 산삼약침 요법을 시행 받은 IIIB기 편평세포폐암 환자에 대한 증례보고. 대한약침학회지. 10(3).2007;143-147 https://doi.org/10.3831/KPI.2007.10.3.143
  8. 안용찬. 비소세포성폐암에 있어서 방사선치료의 역할. 제 98차 대한결핵 및 호흡기학회 춘계학술대회 2004;22-25
  9. 박재갑, 박착일, 김노경. 종양학. 서울:일조각. 2003:304
  10. 김명훈, 박희선, 강현모, 장필순, 이연선, 안진영, 권선중, 정성수, 김주옥, 김선영. 제4병기 비소세포폐암의 예후인자. 대한결핵 및 호흡기학회. 2002;53:380
  11. 북경중의학원 편. 중의학 임상병리. 서울:성보사. 1983:572
  12. 강락원, 홍현우, 신우진, 김지윤, 김재연, 이성도, 최영현, 감철우, 박동일. 길경 수용액 추출물에 의한 인체 폐암세포의 성장억제 기전 연구. 2004년 대한한방내과학회 춘계학술대회. 2004;62-72
  13. 안창범, 임춘우, 윤현민, 박수진, 최영현. 약침용 봉독성분 melittin의 영향에 의한 인체 폐암세포의 apoptosis 유도. 대한침구학회지. 20(5).2003;93-106
  14. 김정근, 김종원, 배한호, 조충식, 박형선. 폐암으로 진단 받은 환자의 호흡곤란과 해수 호전 1례. 2005년 대한한방내과학회 추계학술회. 2005;255-261
  15. 곽정진, 이강녕, 최장원, 이영수, 김희철, 김종석. 비폐양허형 폐암횐자 1례에 대한 임상적 고찰. 대한한방내과학회지. 23(3).2002;486-496
  16. 김재연, 김지윤, 김기탁, 이성도, 감철우, 박동일. 폐암환자 1례에 대한 임상적 고찰. 대한한방내과학회지. 23(3).2005;144-152
  17. Chen MW, Yang L, Ni L, Huang C. The effects of 20(R)-Rg3 on lung carcinoma A549 cell line and endogenous VEGF secreted by tumor cells. Sichuan Da Xue Xue Bao Yi Xue Ban. 2006;37(1):60-62
  18. Chen MW, Ni L, Zhao XG, Niu XY. The inhibition of 20(R)-ginsenoside Rg3 on the expressions of angiogenesis factors proteins in human lung adenocarcinoma cell line A549 and HUVEC304 cell. Zhongguo Zhong Yao Za Zhi. 2005;30(5)357-360
  19. Lu P, Su W, Miao ZH, Niu HR, Liu J, Hua QL. Effect and mechanism of ginsenoside Rg3 on postoperative life span of patients with non-small cell lung cancer. Chin J Integr Med. 2008;Jan 25.(ahead of print) https://doi.org/10.1007/s11655-007-9002
  20. Yoo HS, Cho JH, Son CG, Lee YW, Cho CK, The effects of HangAmDan onAntimetastasis and preventing relapses, administered to 69 cancer patients. Korean J. Oriental Int. Med. 2002;23(2):165-173
  21. Lee NH, Yoon DH, Yoo HS, Cho JH, Son CG, Lee YW. Changes of Serum VEGF, bFGF levels and platelet counts in 100 cancer patients treated with HangAmDan(HAD). Korean J. Orient. Int. Med. 2005;26(4):753-760

Cited by

  1. A case report of monitoring PSA level changes in two prostate cancer patients treated with Mountain Ginseng Pharmacopuncture and Sweet Bee Venom along with western anticancer therapy vol.14, pp.4, 2011, https://doi.org/10.3831/KPI.2011.14.4.081
  2. Case of Remission of Progressive Breast Cancer Treated by Capecitabine with Integrative Medicine Therapy vol.19, pp.1, 2014, https://doi.org/10.15432/JKTO.2014.19.1.43
  3. The Effect of Gamisoyo-san Intravenous Pharmacopuncture on Restoration of Liver Function after Partial Hepatectomy in SD Rat vol.36, pp.1, 2015, https://doi.org/10.13048/jkm.15003
  4. Preliminary Study to Develop the Instrument of Oriental Medical Evaluation for Lung Cancer vol.36, pp.3, 2015, https://doi.org/10.13048/jkm.15019
  5. Mountain Ginseng Pharmacopuncture Treatment on Three Amyotrophic Lateral Sclerosis Patients vol.13, pp.4, 2010, https://doi.org/10.3831/KPI.2010.13.4.119
  6. Advanced Cancer Cases Treated With Cultivated Wild Ginseng Phamacopuncture vol.3, pp.2, 2010, https://doi.org/10.1016/S2005-2901(10)60022-2
  7. Proposal of Self Targeting Therapy of Mountain Ginseng Pharmacopuncture vol.14, pp.2, 2011, https://doi.org/10.3831/KPI.2011.14.2.075
  8. A 4-Week, Repeated, Intravenous Dose, Toxicity Test of Mountain Ginseng Pharmacopuncture in Sprague-Dawley Rats vol.17, pp.4, 2014, https://doi.org/10.3831/KPI.2014.17.034
  9. Intravenous Single-dose Toxicity of Mountain Ginseng Pharmacopuncture in Sprague-Dawley Rats vol.17, pp.3, 2014, https://doi.org/10.3831/KPI.2014.17.026
  10. The Clinical Study about Qualitative and Quantitative Characteristics of Acupuncture Sensation According to the Type of Pharmacopuncture: Study about BUM Pharmacopuncture, Mountain Ginseng Pharmacopuncture and Sciatica No. 5 Pharmacopuncture vol.30, pp.5, 2013, https://doi.org/10.13045/acupunct.2013043
  11. Case Series of Non-small Cell Lung Cancer Treated With Mountain Ginseng Pharmacopuncture vol.4, pp.1, 2011, https://doi.org/10.1016/S2005-2901(11)60008-3
  12. A Case Report for Lung Cancer Patient Showing Remission Treated with Cultivated Wild Ginseng Pharmacopuncture vol.14, pp.4, 2011, https://doi.org/10.3831/KPI.2011.14.4.033
  13. Systematic Review of Case Reports about Korean Medicine for Lung Cancer vol.39, pp.4, 2018, https://doi.org/10.13048/jkm.18041