• Journal of Preventive Medicine and Public Health
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• 제36권1호
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• pp.11-23
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• 2003

Objectives : The 1990s has seen advances in the conceptualization of self-perceived health status which has important roles for individual health and the quality of life. Many types of standardized questionnaires have been developed with the current wide use of SF-36, NHP, andEuroQol. However, the outcomes of these tools may be different with regard to regional, cultural and emotional backgrounds. The purpose of this study was to trial the development of a Korean Health Profile (KHP 1.0) to measure the self-perceived health stati of Koreans. Methods : The KHP 1.0 was designed on the basis of the Medical Outcome Study Form 36 (SF-36), the Nottingham Health Profile (NHP), and the EuroQOL. It was composed of 9 scales; physical functioning, role limitation-physical, pain, general health, energy, social isolation, sleep, role limitation-emotional, and e-motional health. Self-reported chronic disease conditions, and the Zung's Self-Rating Depression Scale (SDS), were also checked for the evaluation of clinical validity. This study was conducted, from December 2000 to January 2001, on 800 middle-aged parents, with four high school students, with 100 retest sets being conducted two weeks later. From the 800 subjects there were 588 complete responses (effective response 73.5%). The reliability of the test-retest results, and the factor analysis on the validity of the KHP 1.0 components, were evaluated using the SPSS (ver 10.0) software. Results : The reliability of the KHP 1.0 was good with Cronbach's alpha (>0.6), test-retest correlation coefficients (>0.5), but with no significant differences from the paired t-test. From the psychometric validity tests, the 9 scales of the KHP 1.0 were divided into two components; physical and mental, and trimmed to the established model with 55% of the total variance, with the exception of role limitation-emotional. The clinical validity on the basis of the comparison for the four characteristic groups; healthy, physical conditions only, mental conditions only, and physical and mental conditions were also good. Conclusions : The KHP 1.0 appears to be a valid measurement tool of self-perceived health stati of Koreans, although there are limitations, i.e. sample size was too small, a limited number of middle-aged subjects, and it was based on unconfirmed diagnoses, etc. Therefore, further study is required to standardize the assessment.

• Clinical and Experimental Pediatrics
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• 제48권9호
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• pp.935-938
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• 2005

목 적 : 소아 비만은 동맥 경화에 따른 성인 심혈관 질환의 독립적인 위험인자이다. 저자들은 비만 소아들을 대상으로, 동맥경화증의 조기 병변인 경동맥 내막중막 두께가 정상아들에 비해 증가되어 있는지를 확인해 보고자 본 연구를 시행하였다. 방 법 : 총 32명을 대상으로 하였는데, 체질량지수가 연령, 성별 표준치의 85 백분위수 이상인 21명의 비만아/과체중아들을 비만군으로 하였고, 85 백분위수 미만이었던 11명을 정상 대조군으로 하였다. 모든 대상 소아들에서 만성 질환력과 약물 투여력이 없었다. 연령, 성별, 신장, 체중, 수축기/이완기 혈압 등이 조사되었고, 초음파를 통해 경동맥 내막중막 두께가 측정되었다. 19명의 비만아군 환아들에서 혈청 포도당, 간 transaminase 수치, 콜레스테롤 수치 등이 검사되었다. 결 과 : 비만아군의 경동맥 내막중막 두께가 대조군에 비해 증가되어 보였으나 유의한 차이를 보이지는 않았다(0.42 vs. 0.40, P=0.0592). 단순선형회귀분석 결과 체질량지수를 포함하여 경동맥 내막중막 두께의 변화를 통계적으로 의미있게 설명해 주는 변수는 없었으나, 체질량지수가 유의성에 근접하였다(P=0.0585). 결 론 : 소아들을 대상으로 경동맥 내막중막 두께 측정이 연구된 것은 저자들이 조사한 바로는 국내에서 본 연구가 시초의 것으로 생각된다. 통계적 유의성에 근접하였으나 조사 대상수의 부족으로 비만아에서 경동맥 내막중막 두께의 상승이나 체질량지수와의 의미있는 연관성을 증명해 내지는 못하였다. 향후 보다 많은 비만 소아들을 포함한 연구가 후속되어야 할 것으로 판단된다.

• 대한불안의학회지
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• 제7권2호
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• pp.92-100
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• 2011

Objectives : The aim of this study was to investigate Post Traumatic Stress Disorder (PTSD)-related symptom severity, level of functional impairment and personality profiles between full-blown PTSD, partial PTSD and non-PTSD groups among 59 adolescent survivals from the Incheon fire disaster. Method : Using Short Screening Scale for DSM-IV PTSD, victims of the disaster were assigned to a full-blown PTSD group (n=18), a partial PTSD (n=22), or a non-PTSD group (n=19). Assessments included the Beck Depression Inventory (BDI), the State-Trait Anxiety Inventory (STAI), the Impact of Event Scales (IES), the McBride's Degree of General Labor Loss, and the Korean Version of Temperament and Character Inventory (K-TCI). Results : Significantly severe PTSD symptoms (F=4.832, df=2, p<.05) and functional impairment (F=12.144, df=2, p<.01) were demonstrated by PTSD groups as compared to the non-PTSD group. Interestingly, full and partial PTSD did not differ in these comparisons. Similarly, the subtypes of PTSD did not differ with respect to personality profiles using the K-TCI ; however, personality profiles were sharply differentiated between the PTSD and non-PTSD group. Conclusion : Although high subject homogeneity and small sample size may limit the results of this study, the present results highlight the possibility of the underestimation as well as the insufficient, treatment and compensation of partial vs full PTSD.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7657-7661
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• 2013

Background: This study concerns uptake and results of colorectal cancer (CRC) screening of government servant as part of the Health Screening Program that was conducted in Brunei Darussalam in 2009. Materials and Methods: Government servants above the age of 40 or with family history of CRC were screened with a single fecal occult blood test (FIT, immunohistochemistry). Among 11,576 eligible subjects, 7,360 (66.9%) returned their specimen. Subjects with positive family history of CRC (n=329) or polyps (n=135) were advised to attend clinics to arrange screening. All the subjects with positive FIT (n=142, 1.9%) were referred to the endoscopy unit for counselling for screening colonoscopy. Results: Overall only 17.7% of eligible subjects attended for screening; 54.9% (n=79/142) of positive FIT, 8.8% (n=29/329) of positive family history of CRC and none with history of polyps (n=0/135). Of these, only 54 patients (50.5%) agreed for colonoscopy, 52 (48.6%) declined as they were asymptomatic, and one was not offered (0.9%) due to his very young age. On screening colonoscopy, 12.9% (n=7) had advanced lesions including a sigmoid carcinoma in situ and six advanced polyps. The other findings included non advanced polyps (n=21), diverticular (n=11) and hemorrhoids (n=26). One patient who missed his screening colonoscopy appointment re-presented two years later and was diagnosed with advanced right sided CRC. All the advanced lesions were detected in patients with positive FIT, giving a yield of 20.5% for advanced lesions including cancers in the 5.1% FIT positive subjects. Conclusions: Our study showed screening for CRC even with a single FIT was effective. However, the uptake rate was poor with just over half of the patients agreeing to screening colonoscopy. Measures to increase public awareness are important. Since one limitation of our study was the relatively small sample size, larger studies should be conduced in future.

• 기술사
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• 제20권3호
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• pp.15-25
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• 1987

Statistical control charts are useful tools to monitor and control the manufacturing processes and are widely used in most Korean industries. Many Korean companies, however, do not always obtain desired results from the traditional control charts by Shewhart such as the X-chart, X-chart, X-chart, etc. This is partly because the quality charterstics of the process are not distributed normally but are skewed due to the intermittent production, small lot size, etc. In Shewhart X-chart, which is the most widely used one in Korea, such skewed distributions make the plots to be inclined below or above the central line or outside the control limits although no assignable causes can be found. To overcome such shortcomings in nonnormally distributed processes, a distribution-free type of confidence interval can be used, which should be based on order statistics. This thesis is concerned with the design of control chart based on a sample median which is easy to use in practical situation and therefore properties for nonnormal distributions may be easily analyzed. Control limits and central lines are given for tile more famous nonnormal distributions, such as Gamma, Beta, Lognormal, Weibull, Pareto, Truncated-normal distributions. Robustness of the proposed median control chart is compared with that of the X-chart, the former tends to be superior to the latter as the probability distribution of the process becomes more skewed. The average run length to detect the assignable cause is also compared when the process has a Normal or a Gamma distribution for which the properties of X are easy to verify, the proposed chart is slightly worse than the X-chart for the normally distributed product but much better for Gamma-distributed products. Average Run Lengths of the other distributions are also computed. To use the proposed control chart, the probability distribution of the process should be known or estimated. If it is not possible, the results of comparison of the robustness force us to use the proposed median control chart based on a normal distribution. To estimate the distribution of the process, Sturge's formula is used to graph the histogram and the method of probability plotting, $X^2$-goodness of fit test and Kolmogorov-Smirnov test, are discussed with real case examples. A comparison of the propose4 median chart and the X chart was also performed with these examples and the median chart turned out to be superior to the X-chart.

• 박물관보존과학
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• 제2권
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• pp.57-68
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• 2000

청주 사뇌사지에서 출토된 청동기 12점에 대한 과학 분석을 실시하였다. 이들 각 시료의 금속조직에 나타난 결정 입자의 형태, 크기, 분포와 관련하여 검토한 결과 식기류, 제기류, 타명기류로 나타났는데 성분조성에 따른 분류 결과와도 일치하였다. 식기류는 주로 단조품으로서 성분조성비는 Cu:Sn:Pb≃8:2:0, 제기류는 주조품으로서 Cu:Sn:Pb≃7:1:2, 타명기류는 Cu:Sn:Pb≃85:10:5/9:1:0이었다. 즉, 원료의 배합비는 제품의 용도 및 제작방볍과 밀접한 관계가 있다는 것을 알 수 있었다. Cu와 상관계수가 높은 원소는 Co, Fe, As이었는데 이는 Cu 광물에 불순물로 함께 분포한다는 것을 의미하며 As 함량은 식기류, 제기류, 타명기류 순으로 증가한다는 것을 알 수 있었다. 또한 납 함유량이 높은 청동기 3점의 납동위원소비를 분석하고 원료의 산지를 추정한 결과 일본·중국산 납을 사용한 것으로 나타났다. 땜납의 성분조성은 Cu:Sn:Pb≃83:12:5이었으며 Pb의 결정이 작고 고르게 분포하고 있었다.

• Bulletin of the Korean Chemical Society
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• 제32권8호
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• pp.2648-2656
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• 2011

A simple HPLC-DAD method was developed and validated to determine B group vitamin content (thiamine, riboflavin, nicotinamide, pantothenic acid, pyridoxine and folic acid) in supplemented food samples, i.e., infant formula, cereal, low-calorie food, a multi-vitamin pill and a vitamin drink. In this study, the most significant advantages were simultaneous determination of the six B group vitamins in various food matrices and a small number of sample treatment steps that required only an organic solvent, acetonitrile. Moreover, this method prevents reduction of column durability, because the mobile phase does not contain ion-pairing reagents. Analytes were separated on a Develosil RPAQUEOUS $C_{30}$ (4.6 mm ${\times}$ 250 mm, 5 ${\mu}M$ particle size) column with a gradient elution of acetonitrile and 20 mM phosphate buffer (pH 3.0) at a flow rate between 0.8 and 1.0 mL/min. Detection was performed at 275 nm, except for that of pantothenic acid (205 nm). The calibration curves for all six vitamins showed good linearity with correlation coefficients ($r^2$) higher than 0.995. The developed method was validated with respect to linearity, intra- and inter-day accuracy and precision, limit of quantification (LOQ), recovery and stability. The method showed good precision and accuracy, with intra- and inter-assay coefficients of variation less than 15% at all concentrations. The recovery was carried out according to the standard addition procedure, with yields ranging from 89.8 to 104.4%. This method was successfully applied to the determination of vitamin B groups in supplemented food products.

• 한국병원경영학회지
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• 제13권4호
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• pp.1-26
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• 2008

This study examines the statistical relationship between medical specialists and managerial performance, using regression analysis with the number of medical specialists per 100 beds as the independent variable and the managerial performance index as the dependent variable. Managerial performance index incorporated the number of out-patients per specialist, the number of in-patients per specialist, the volume of revenue per specialist, the number of beds per specialist, and the average length of stay. To compare different groups of hospitals, dummy variable was applied to five groups of hospitals according to size: 100-299 beds, 300-599 beds, 600-899 beds, 900-1199 beds, and more than 1200 beds. The data consisted of 181 general hospitals with more than 100 beds, which included 28 public hospitals, 73 corporate hospitals, 64 university hospitals and 16 private hospitals. Of those, 87 hospitals were located in big cities and 94 hospitals in medium to small cities. This study used hospitals from the Korean Hospital Association, and data published in 2004. The collected data sample was analyzed using the SPSSWIN 12.0 version, and the study hypothesis was tested using regression analysis. The findings of this study are summarized as follows: Hypothesis 1 predicting a negative effect of the number of medical specialists on the number of out-patients per specialist was supported with statistical significance. The analysis of dummy variable showed causality in all the hospital groups larger than the group of 100-299 beds. Hypothesis 2 predicting a negative effect of the number of medical specialists on the number of in-patients per specialist was supported with statistical significance. The analysis of dummy variable showed causality in the hospital group of 300-599 beds when compared to the group of 100-299 beds. Hypothesis 3 predicting a negative effect of the number of medical specialists on the volume of revenue per specialist was not supported. However, the analysis of dummy variable showed that the volume of revenue per specialist increased in the hospital groups of 600-899 beds, 900-1199 beds, and over 1200 beds, when compared to the group of 100-299 beds. Hypothesis 4 predicting a negative effect of the number of medical specialists on the average length of stay was supported with statistical significance. The analysis of dummy variable showed causality in the hospital group of 300-599 beds, when compared to the group of 100-299 beds. Results of this study show that the number of the medical specialists per 100 beds is an important factor in hospital managerial performance. Most hospitals have tried to retain as many medical specialists as possible to keep the number of patients stable, to ensure adequate revenue, and to maintain efficient managerial performance. Especially, the big hospitals with greater number of beds and medical specialists have shown greater revenue per medical specialist despite the smaller number of patients per medical specialist. Findings of this study explains why hospitals in Korea are getting bigger.

• 한국임상약학회지
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• 제17권1호
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• pp.6-12
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• 2007

지난 20 여 년 간 서구 선진사회에서는 식사장애(Eating disorder) 중에서 신경성 폭식증(Bulimia nervosa)의 발병률이 급격히 상승하였고, 우리나라는 특히 젊은 여성층에서 발병률이 빠르게 상승하고 있다. 치료약물로는 주로 항우울제가 선택되지만, 치료효과가 미흡한 바, 항경련제인 topiramate가 효과가 있다는 보고들이 있어 이를 신경성 폭식증치료에 적극 사용할 수 있는가에 관심이 고조되었다. 본 연구는 topiramate가 지닌 신경성 폭식증 치료효과에 대한 최신 지견을 얻고자, 1990년부터 2006년 사이 MEDLINE과, 한국의학논문데이터베이스에 등재된 국내외 자료를 binge eating disorder, bulimia nervosa, topiramate라는 3개의 주요어휘로 검색하여 추출한 자료중에서, 대조군이 사용된 무작위 배정, 이중맹검 임상연구 및 치험사례 만을 선별하여 임상적유용성을 평가하였다. 국외 임상연구 및 치험사례에 따르면, topiramate가 신경성 폭식증에 수반되는 유해한 증상의 발생빈도를 경감시키는데 유효함을 나타내었다. 국내에는 아직 topiramate의 신경성 폭식증 치료효과를 검증한 체계화된 임상연구나 치험사례가 보고된 바 없었다. 피험자의 규모가 작다는 한계에도 불구하고, 일일 투여량 25 mg로 시작하여 점차 증량후 최대 600 mg까지 투여한 국외의 연구결과는, topiramate가 신경성 폭식증 치료에 유효한 결과를 보인다고 사료되므로, 국내 신경성 폭식증 임상치료와 연구에 반영되기를 기대한다.

• Tuberculosis and Respiratory Diseases
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• 제79권3호
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• pp.165-178
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• 2016

Background: Although recent metagenomic approaches have characterized the distinguished microbial compositions in airways of asthmatics, these results did not reach a consensus due to the small sample size, non-standardization of specimens and medication status. We conducted a metagenomics approach by using terminal restriction fragment length polymorphism (T-RFLP) analysis of the induced whole sputum representing both the cellular and fluid phases in a relative large number of steroid $na{\ddot{i}}ve$ asthmatics. Methods: Induced whole sputum samples obtained from 36 healthy subjects and 89 steroid-$na{\ddot{i}}ve$ asthma patients were analyzed through T-RFLP analysis. Results: In contrast to previous reports about microbiota in the asthmatic airways, the diversity of microbial composition was not significantly different between the controls and asthma patients (p=0.937). In an analysis of similarities, the global R-value showed a statistically significant difference but a very low separation (0.148, p=0.002). The dissimilarity in the bacterial communities between groups was 28.74%, and operational taxonomic units (OTUs) contributing to this difference were as follows: OTU 789 (Lachnospiraceae), 517 (Comamonadaceae, Acetobacteraceae, and Chloroplast), 633 (Prevotella), 645 (Actinobacteria and Propionibacterium acnes), 607 (Lactobacillus buchneri, Lactobacillus otakiensis, Lactobacillus sunkii, and Rhodobacteraceae), and 661 (Acinetobacter, Pseudomonas, and Leptotrichiaceae), and they were significantly more prevalent in the sputum of asthma patients than in the sputum of the controls. Conclusion: Before starting anti-asthmatic treatment, the microbiota in the whole sputum of patients with asthma showed a marginal difference from the microbiota in the whole sputum of the controls.