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Studies on the Mechanism of Resistance to and Mode of Action of Viomycin in Mycobacterium smegmatis (Mycobacterium smegmatis를 이용한 Viomycin의 내성 및 작용 기전에 관한 연구)

  • 최응칠
    • YAKHAK HOEJI
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    • v.24 no.1
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    • pp.1-10
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    • 1980
  • Viomycin inhibited polypeptide biosynthesis, initiation complex formation and translocation of peptidyl-tRNA on ribosomes derived from a sensitive strain of Mycobacterium smegmatis (R-15), but not significantly on ribosomes from viomycin-resistant mutants(R-31 and R-43). The inhibition of translocation was stronger than that of initiation complex formation in the sensitive strain. The binding of [$^{14}C$] tuberactinomycin O, a viomycin analog, to ribosomal particles was studied by Millipore filter method. The sensitive ribosome exhibited higher affinity for the antibiotic than the resistant ribosomes. The resistance was localized on the large ribosomal subunit in a mutant(R-31), and on the small subunit in another mutant(R-43). The binding of the drug to the sensitive ribosomal subunit was markedly reduced by combination with the resistant pair subunit, and the entire ribosome became resistant to the antibiotic.

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Performances of Current-Waveform Modulated Single-Phase Induction Machine (전류파형을 변조한 단상유도전동기구의 특성에 관한 연구)

  • 황영문;김철우;박용규
    • 전기의세계
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    • v.24 no.1
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    • pp.55-62
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    • 1975
  • A single-phase induction motor with it's stator winding splitted into two series windings, of which the terminals of one winding is switched pulsationally by a thyristor type ON-OFF device so that the motor may operate as a pulsational shaded-pole motor, can modulate current waveforms of it's two series windings. In view of current waveform modulation method, a single-phase single-winding motor operates as a two-phase induction motor with asymmetrical axis windings where the starting torque can be obtained effectively without an auxiliary capacitor attached and it's running speed controlled by shifting phase between current waveforms differently. Equivalent circuit for analysis is modified from a double revolving field equivalent circuit of a single-phase induction motor with asymmetrical windings whose angle is 45.deg.C elet. degrees. Analysis and test results show that ON-OFF action of the pulsational shaded-pole winding has the same effect of a series capacitor, and then at heavy loads this motor operates with a small amonut of the input current than that having the fixed shaded-pole winding.

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Inhibitory effects of extract from the Schizandra chinensis on rat small intestinal ${\alpha}-amylase$ activity and postprandial blood glucose

  • Chae, Hee-Jin;Heo, Ye-Na;Moon, Hae-Yeon
    • 한국생물공학회:학술대회논문집
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    • 2005.10a
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    • pp.821-826
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    • 2005
  • Postprandial hyperglycemia plays an important role in the development of type 2 diabetes and complications associated with the disease such micro-and macro-vascular disease. The present study investigated the effect and action mechanism of a ethanolic extract from the Schizandra chinensis(SC-E) on hypeglycemia in vivo and in vitro. In vitro, SE-E demonstrated a potent inhibitory effects on ${\alpha}-amylase$ activity ($IC_{50}$ : 4 ${\mu}g/ml$). Its inhibition on ${\alpha}-amylase$ was determined to be competitive type. Oral administration of SE-E markedly lowered plasma glucose levels in non-fasted streptozotocin induced diabetic rats (45 mg/kg BW). In addition when it was orally administrated to rats with starch (2g/kg BW), SC-E (50 and 100 mg/kg BW) significantly suppressed the increase of blood glucose levels after starch loading . These results suggest that some edible plants merit further evaluation for clinical usefulness as anti-diabetic drugs.

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Avoidance Behavior of Small Mobile Robots based on the Successive Q-Learning

  • Kim, Min-Soo
    • 제어로봇시스템학회:학술대회논문집
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    • 2001.10a
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    • pp.164.1-164
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    • 2001
  • Q-learning is a recent reinforcement learning algorithm that does not need a modeling of environment and it is a suitable approach to learn behaviors for autonomous agents. But when it is applied to multi-agent learning with many I/O states, it is usually too complex and slow. To overcome this problem in the multi-agent learning system, we propose the successive Q-learning algorithm. Successive Q-learning algorithm divides state-action pairs, which agents can have, into several Q-functions, so it can reduce complexity and calculation amounts. This algorithm is suitable for multi-agent learning in a dynamically changing environment. The proposed successive Q-learning algorithm is applied to the prey-predator problem with the one-prey and two-predators, and its effectiveness is verified from the efficient avoidance ability of the prey agent.

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Improved High Rate Capabilities of Composite Cathodes for Lithium Ion Batteries

  • Lee, Sang-Young;Jeong, Yeon-Uk
    • Journal of the Korean Electrochemical Society
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    • v.11 no.4
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    • pp.309-312
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    • 2008
  • In an attempt to achieve high rate capability of cell, a new composite cathode was prepared by mixing host compounds with MWCNTs and Super P carbon. Because MWCNTs generally have bundle-type morphologies, it is not easy to get completely separated form. Successful dispersion of divided small bundles between the host particles keeps electrochemical contacts among the particles and plays a significant role in the buffer action as a volume-change absorber. Relative amounts and distributions of the additives are important for design of the electrode for high power application of lithium ion batteries.

A study on the Nonlinear Normal Mode Vibration Using Adelphic Integral

  • Huinam Rhee;Kim, Jeong-Soo
    • Journal of Mechanical Science and Technology
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    • v.17 no.12
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    • pp.1922-1927
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    • 2003
  • Nonlinear normal mode (NNM) vibration, in a nonlinear dual mass Hamiltonian system, which has 6$\^$th/ order homogeneous polynomial as a nonlinear term, is studied in this paper. The existence, bifurcation, and the orbital stability of periodic motions are to be studied in the phase space. In order to find the analytic expression of the invariant curves in the Poincare Map, which is a mapping of a phase trajectory onto 2 dimensional surface in 4 dimensional phase space, Whittaker's Adelphic Integral, instead of the direct integration of the equations of motion or the Birkhoff-Gustavson (B-G) canonical transformation, is derived for small value of energy. It is revealed that the integral of motion by Adelphic Integral is essentially consistent with the one obtained from the B-G transformation method. The resulting expression of the invariant curves can be used for analyzing the behavior of NNM vibration in the Poincare Map.

A sensor-based obstacle avoidance for a mobile robot (센서 정보를 이용한 이동 로봇의 충돌 회피)

  • 범희락;조형석
    • 제어로봇시스템학회:학술대회논문집
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    • 1992.10a
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    • pp.7-12
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    • 1992
  • This paper proposes a sensor-based path planning method which utilizes fuzzy logic and neural network for obstacle avoidance of a mobile robot in uncertain environments. In order to acquire the information about the environment around the mobile robot, the ultrasonic sensors mounted on the front of mobile robot are used. The neural network, whose inputs are preprocessed by ultrasonic sensor readings, informs the mobile robot of the situation of environment in which mobile robot is at the present instant. Then, according to the situation class, the fuzzy rules are fired to make a decision on the mobile robot action. In addition, this method can be implemented real time since the number of fuzzy rules used to avoid the obstacle is small. Fuzzy rules are constructed based on the human reasoning and tuned by iterative simulations. The effective of the proposed avoidance method is verified by a series of simulations.

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Friction Reduction Properties of Evaporation Coated Petroleum and Silicone Oil Lubricants (증발 코팅법으로 증착된 광유와 실리콘 오일 윤활제의 마찰 저감 특성)

  • Yoo, Shin Sung;Kim, Dae Eun
    • Journal of the Korean Society for Precision Engineering
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    • v.30 no.8
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    • pp.864-869
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    • 2013
  • As the size of mechanical components decreases, capillary forces and surface tension become increasingly significant. A major problem in maintaining high reliability of these small components is that of large frictional forces due to capillary action and surface tension. Unlike the situation with macro-scale systems, liquid lubrication cannot be used to reduce friction of micro-scale components because of the excessive capillary and drag forces. In this work, the feasibility of using evaporation to coat a thin film of organic lubricant on a solid surface was investigated with the aim of reducing friction. Petroleum and silicone oils were used as lubricants to coat a silicon substrate. It was found that friction could be significantly reduced and, furthermore, that the effectiveness of this method was strongly dependent on the coating conditions.

THE CHARACTERISTICS OF FRETTING WEAR

  • Iwabuchi, Akira
    • Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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    • 1996.05a
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    • pp.1-3
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    • 1996
  • The characteristics of fretting wear are reviewed. Fretting damage depends on slip amplitude and classified into three groups: (1) an annular damage according to Mindlin's analysis at microslip region, (2) strong adhesive deformation without loose wear particles at the intermediate region, and (3) formation of fine oxide particles at the gross slip region. The critical slip amplitude of fretting is the boundary between (2) and (3). The boundary slip amplitude depends on normal load. The wear rate increases and saturates with increasing slip amplitude. But it is constant by considering the critical amplitude. The role of oxide particles are discussed. Three different actions are noted: accelerating wear, preventing wear and insignificant effect. The oxide shows two opposing effect depends on normal load and slip amplitude. This is related to the removal rate from the interface (abrasive action) and compaction rate at the interface to form a protective layer. The effect of oxidation is significant to determine the wear and friction. The diffusion of oxygen is restricted at the small amplitude. As a result, crack formation at the boundary is a predominant damage, related to fretting fatigue damage.

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Fracture Behavior of Reinforced Concrete Beams Repaired by Latex-Modified Concrete (LMC로 보강된 철근콘크리트 보의 파괴거동)

  • 김성환;정원경;김기헌;김동호;윤경구
    • Proceedings of the Korea Concrete Institute Conference
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    • 2003.05a
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    • pp.475-480
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    • 2003
  • Latex modification of concrete provides the material with higher flexural strength. This increase in flexural strength can attribute to the crack-arresting action of polymer in concrete, and also to the bonding they provide between the matrix and aggregates. This experimental study presents the fracture behavior of 12 flexural reinforced concrete beams repaired or strengthened by latex-modified concrete with the main experimental variables such as overlay thickness, strength thickness, and shear reinforcement. The results are as follow: All beam specimens having shear reinforcement were failed by delamination rupture at concrete interface at about 80% of ultimate loading after flexural cracking. All specimens overlayed and strengthened by latex-modified concrete (LMC) showed higher ultimate flexural strength than OPC control specimen, but lower than LMC control specimen. This increase in flexural strength could attribute to the high bonding they provide between the matrix and aggregates. All specimens except two shear unreinforced showed quite similar and consistent displacement behavior. The effect of overlay and strength thickness on the load-displacement relationship were a small at this study.

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