• 대한약침학회지
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• 제20권3호
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• pp.227-229
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• 2017

Fibrosis of skeletal muscle following acupuncture is an iatrogenic disorder. The present case illustrates a patient with a unilateral fibrotic formation on a thumb muscle after acupuncture injection therapy with red sage. The patient in the present case was a counter-terrorism police officer with right-handedness; he noted a palpable nodule three months after injection therapy at his left first dorsal interosseous in which the acupuncture point LI4 (He Gu) is located. He also found a reduction in the strength of his left pinch grip that noticeably affected his left handgun marksmanship. However, being ambidextrous in single-hand pistol shooting is an essential requirement for counter-terrorism police officers. Based on the patient's medical history and claims, no underlying disease or trauma was found to be associated with his current complaint. During physical examination, a fibrotic formation in his left first dorsal interosseous muscle was visualized by using diagnostic ultrasound; also, as confirmed with dynamometry, the strength of his left pinch grip was significantly lower than that of the right counterpart. Because acupuncture injection therapy has three components, antiseptic practices, the mechanical action of syringe insertion, and the pharmacological effect of the sterile herb extract, any one of the components may have contributed to the present adverse event. The first dorsal interosseous muscle is small in dimension and rather vascular; thus, it is not an ideal site for intramuscular injection. When a clinician needs to treat a patient by performing acupuncture at the LI4 acupoint and injecting a herbal extract simultaneously, the clinician should only mechanically stimulate the LI4 acupoint while injecting the herbal medicine into the LI14 (Bi Noe) acupoint on the same meridian, the LI14 acupoint being located in the distal portion of the deltoid muscle and being fairly close to the universally agreed upon site on the upper arm for safe administration of an injection.

• 한국해양바이오학회지
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• 제1권4호
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• pp.243-251
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• 2006

Dideoxypetrosynol A, a polyacetylene from the marine sponge Petrosia sp., is known to exhibit significant selective cytotoxic activity against a small panel of human tumor cell lines, however, the mechanisms of which are poorly understood. In the present study, it was investigated the further possible mechanisms by which dideoxytetrosynol A exerts its anti-proliferative action in cultured human leukemia cell line U937. We observed that the proliferation-inhibitory effect of dideoxypetrosynol A was due to the induction of G1 arrest of the cell cycle and apoptosis, which effects were associated with up-regulation of cyclin D1 and down-regulation of cyclin E without any change in cyclin-dependent-kinases (Cdks) expression. Dideoxypetrosynol A markedly induced the levels of Cdk inhibitor p16/INK4a expression. Furthermore, down-regulation of phosphorylation of retinoblastoma protein (pRB) by this compound was associated with enhanced binding of pRB and the transcription factor E2F-1. The increase in apoptosis was associated with a dose-dependent up-regulation in pro-apoptotic Bax expression and activation of caspase-3 and caspase-9. Dideoxytetrosynol A decreased the levels of cyclooxygenase (COX)-2 mRNA and protein expression without significant changes in the levels of COX-1, which was correlated with a decrease in prostaglandin E2 (PGE2) synthesis. Furthermore, dideoxytetrosynol A treatment markedly inhibited the activity of telomerase, and the expression of human telomerase reverse transcriptase (hTERT), a main determinant of the telomerase enzymatic activity, was progressively down-regulated by dideoxytetrosynol A treatment in a dose-dependent fashion. Taken together, these findings provide important new insights into the possible molecular mechanisms of the anti-cancer activity of dideoxytetrosynol A.

• 한국식품과학회지
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• 제31권2호
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• pp.535-539
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• 1999

콩은 항에스트로젠효과와 항암효과를 가지는 것으로 나타나 최근 많은 관심의 대상이 되고 있다. 콩의 전립선암과 유방암 억제 기작으로 항에스트로젠 효과와 항안드로젠 효과가 보고되었지만 다른 조직에서 발현되는 항암활성 특히 화학적으로 유도되는 발암의 억제기작에 대해서는 아직 분명히 밝혀진 바가 없다. 본 연구에서는 콩이 생식기관이외에도 항암활성을 나타내리라 가정하고 그 기작을 규명하고자 하였다. 콩의 메탄올추추출물의 산가수분해물은 생쥐의 폐에서 항암효소계인 quinone reductase의 활성을 유의적으로 증가시켰으며 신장과 소장에서 1상효소계의 지표효소인 arylhydrocarbon hydroxylase효소활성을 억제하는 것으로 나타났다. 따라서 메탄올 추출물에 배당체로 존재하는 화합물이 산처리에 의하여 유리형으로 전환되면서 화학적 발암을 억제하는 활성을 획득하는 것으로 추정된다. 한편 benzo(a)pyrene으로 위암과 폐암을 유발시켰을 때, 콩추출물 첨가 식이는 폐암 발생을 현저히 낮추는 것으로 확인되었다. 이렇듯 화학적발암에 대한 콩 추출물의 방어효과는 약물대사효소계의 조절과 관련이 있는 것으로 추정된다.

• 한국지반신소재학회논문집
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• 제8권1호
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• pp.53-59
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• 2009

본 연구에서는 변형된 동결-융해 시험장치를 이용하여 동상민감성흙의 동결-융해 과정시 지반공학적 특성을 평가하였다. 흙시료의 정상상태에서 동상이 발생되는 양은 전체 동상량의 70~80% 정도로 정상상태의 동상이 일어나기 위한 열흐름 조건을 제안하였다. 즉, 동결시 동결전선에서 순열흐름을 0으로 하기 위해서 열적 경계조건을 변화시키는 방법이다. 제안된 방법으로 변형된 동결-융해 시험의 결과에 대하여 적합성을 평가하였다. 또한, 동상 발현중 제안된 방법을 적용 결과, 장기적인 동상현상을 제시하였으나, 장기적 동상은 매우 작은 동상량이 나타나기 때문에 공학적 요소에서는 무시할 수 있는 동상으로 판단하였다.

• 한국직업건강간호학회지
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• 제24권4호
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• pp.381-391
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• 2015

Purpose: The purpose of this study was to describe the intervention model development of health promotion for women workers working in the traditional marketplace, using community capacity building framework. Methods: Need assessment of the target population, work-related environment investigation, social network group building, and setting health management in the marketplace were performed. Then the interventions including cardiovascular health, musculoskeletal health, and psychological health were conducted. The results were evaluated using NCEP-ATP III(National Cholesterol Education Program's Adult Treatment Panel III), OWAS, and CES-D. Results: It was found that the intervention program for the vulnerable group in marketplace was appropriate, promoting the improvement of metabolic syndrome and the reduction of pain complaints. Therefore, the intervention framework for health promotion of women workers in the marketplace was developed. Work-related environment assessment also was included in the framework development. Several community capacity building strategies, including developing community resources and promoting partnership, making small social network group, and promoting program participation. Conclusion: It is suggested that occupational health nurses and professionals consider the appropriateness of intervention framework development after identifying the needs of women workers' work-related environmental problems.

• 해양환경안전학회지
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• 제10권1호
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• pp.29-33
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• 2004

지금까지의 강구조설계에서는 일반적인 탄성좌굴개념을 적용하고 있다. 왜냐하면 현재까지의 실적선의 데이터와 경험적인 방법에 의해 도출된 여러 가지 룰에 의한 데이터가 상당히 신뢰할만한 정도를 갖고 있기 때문이라고 판단하기 때문이다. 그러나, 최근들어 판두께가 박판인 고장력강재가 선체에 폭넓게 사용되어지면서 탄성좌굴발생 시점이 빨라졌으며 이에따른 탄소성거동을 정확히 예측할 필요성이 대두되고 있다. 이에 본 연구에서는 선체의 이중저 판넬구조에서 압축하중을 받을때의 실제판부재의 주변지지조건을 네가지로 이성화하여 해석하였으며, 이때 실제 필연적으로 존재하게 되는 열가공에 의한 비대칭형 초기처짐을 적용하였고, 비선형해석기법으로서는 Arc-length method를 적용하였고 해석코드는 범용유한요소법 소프트웨어로 잘 알려진 ANSYS를 사용하였다.

• 해양환경안전학회지
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• 제19권1호
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• pp.52-58
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• 2013

선박의 운항에 소요되는 운항비는 선박의 종류, 크기, 속력, 항행구역 등에 따라 다를 수 있지만, 연료비가 차지하는 비율은 50~60 %에 달하는 것으로 알려져 있다. 최근 국제 유가의 상승으로 인한 선박 운용비를 절감하기 위하여 중소형 선박에서도 저질연료유의 사용이 검토되고 있는 추세이다. 더 나아가 해운선사들은 연료소모량을 줄이기 위한 방법으로 감속운항을 취하고 있다. 따라서, 본 연구에서는 실선을 이용하여 해상에서의 선속대비 주기관의 연료소모량을 계측하고, 부하에 따른 전진계수 대비 속력과 연료소모량의 관계를 통해 상용연속출력보다 낮은 주기관 부하의 70 % 영역이 최적의 운항조건이라고 제안하였다.

• Nuclear Engineering and Technology
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• 제27권3호
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• pp.336-343
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• 1995

적응제어의 한 방식인 자기동조제어(STR) 방식이 비선형 노심 모델의 출력 조정에 적용된다. 적응제어는 비선형, 시변 및 확률(Stochastic) 시스템을 위한 준최적 제어기를 설계하기 위한 적절한 제어 방식이다. 제어계통은 미지의 시변 파라메타를 갖는 3차 선형 모델에 기초한다. 파라메타는 가변 망각계수를 도입한 늑장 최소자승법에 의하여 매시간(Time Step) 순환적으로 평가된다. 평가된 파라메타를 이용하여 한 스텝 먼저 냉자재 평균온도가 예측되고 이 예측된 값과 Setpoint 값과의 차이를 최소화함은 물론, 제어봉의 움직임을 막고자 가중(Weighted) One-step-ahead 제어기가 설계된다. 또한 적분동작이 첨가되어 정상상태 에러가 제거된다. 넓은 운전영역을 포괄하는 비선형 PWR 모델이 원자로 출력 조정을 위한 본 제어기를 시뮬레이션하는데 이용되었다. 시뮬레이션 결과로부터 본 제어기의 성능이 우수한 것으로 판명되었다.

• Animal cells and systems
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• 제4권3호
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• pp.273-278
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• 2000

Transforming growth factor-$\beta$ (IGF-$\beta$)s are multifunctional small polypeptides synthesized in most cell types. TGF-$\beta$ exerts pivotal effects on both bone formation and resorption. In addition, increasing lines of evidence implicate TGF-$\beta$ as a potential coupling factor between these two processes during bone remodeling. In the present study, the expression form and the activation mechanism of latent-TGF-$\beta$ were investigated using specific antibodies for each isoform. TGF-$\beta$s were observed to be synthesized and accumulated in a large amount in cultured osteoblastic cells. The estimated molecular weights of intracellular TGF-$\beta$2 and -$\beta$3 were 49 and 55 kDa, respectively. Based on proteolytic digestion study and immunofluorescence observation, these precursor forms seemed to be accumulated in distinct intracellular compartments. To examine whether the internal pool of TGF-$\beta$ was possiblely regulated by external signals, their biological activites were examined in a conditioned media of this cell. Although the intact conditioned media did not contain detectable TGF-$\beta$ activity, heat-treatment or acid-activation of the conditioned media revealed significant TGF-$\beta$ activity. Furthermore, in the presence of estrogen, this activity was dramatically diminished. It is known that activation of latent TGF-$\beta$ can be achieved by different chemical and enzymatic treatments, or by incubation with certain cell types. This extracellular activation was suggested as a key step in the regulation of TGF-$\beta$ activity. In addition to these extracellular activation, this study suggests that the synthesis and intracellular processing are important regulation steps for TGF-$\beta$ action. In addition, this regulation Is specific for TGF-$\beta$ type 2, because the change was not observed in TGF-$\beta$3 in osteoblastic cell line.

• 한국임상수의학회지
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• 제22권3호
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• pp.220-227
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• 2005

Although ketamine has been used in the field of anesthetic medicine for its safety and favourable respiratory effects, the cardiovascular effects of ketamine is still controversial. To clarify the action and mechanism of ketamine upon cardiovascular system, arterial blood pressure, tension of aortic ring, left ventricular developed pressure and heart rate were measured in rats, Ketamine produced two types of effects on arterial blood pressure in anesthetized rats; monophasic effect (blood pressure lowering) and biphasic effect (initial transient blood pressure increasing following sustained lowering), The ketamine-induced lowering of aterial blood pressure showed a concentration-dependent manner, inhibited by the pretreament of $MgCl_2$ and potentiated by the pretreatment of $CaCl_2$. The ketamine-induced lowering of aterial blood pressure was suppressed by the pretreatment of nifedipine, verapamil or lidocaine. In phenylephrine-precontracted endothelium intact (+E) aortic rings, ketamine sometimes caused a small enhancement of contraction ($112.5{\pm}3.6{\%}$). However, in many experiments, ketamine produced a concentration-dependent relaxation in +E aortic rings precontracted with either phenylephrine or KCl. Ketamine-induced relaxation was significantly greater in KCl-precontracted strips than phenylephrine-precontracted strips. In phenylephrine-precontracted +E aortic rings, the ketamine-induced vasorelaxation was not suppressed by endothelium removal or by the pretreatment of a nitric oxide synthase inhibitors, L-$N^G$-nitro-arginine and a guanylate cyclase inhibitors, methylene blue, suggesting that the ketamine-induced vasorelaxation is not dependent on the endothelial function. In addition, ketamine elicited an increase in left ventricular developed pressure in perfused hearts accompanied by decrease in heart rate. These results suggest that ketamine could evoke a hypotension due to vasorelaxation and decrease in heart rate in rats. The inhibitory effect of cardiovascular system might be associated with modulation of $Ca^{2+}$ homeostasis.