• 한국지능시스템학회논문지
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• 제15권1호
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• pp.104-109
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• 2005

컨텍스트 인식은 유비쿼터스 컴퓨팅 환경에서 사용자의 주변환경과 상태에 따라 양질의 서비스를 제공할 수 있는 중요한 요소이다. 컨텍스트 인식을 위한 정보 수집 도구로는 이동이 편리한 소형 모바일 장치와 그 안에 내장된 모바일 에이전트를 이용하고 있다. 현재 모바일 에이전트는 각 사용자의 컨텍스트 정보를 수집하고 인식하는데 많은 시간과 비용이 소모되고 있다. 이에 모바일 에이전트의 부하를 줄이고, 빠른 시간내에 사용자의 컨텍스트 정보 인식을 위한 구조에 대한 연구가 필요하다. 본 논문에서는 모바일 에이전트에 협력적 필터링 기법과 P2P 에이전트를 혼합한 P2P 모바일 에이전트 구조를 제안한다. 제안한 구조는 동일 지역내에서 각 사용자의 컨텍스트 정보를 분석하고, 비슷한 선호도를 갖는 사용자들로 그룹핑하며, 그룹핑된 사용자는 P2P 모바일 에이전트를 이용하여 정보를 공유한다. 또한 이 구조는 사용자들의 행위와 서비스를 지속적으로 관찰 및 학습하여 새로운 상관 관계를 측정하도록 하였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2005년도 학술대회 논문집 정보 및 제어부문
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• pp.38-40
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• 2005

Microdrive with high precision and light mass enough to install on mouse head was fabricated for recording the reliable signal of neuron cell to understand the brain study. The proposed microdrive has three H-form PZT actuators and its guide structure. The microdrive operation principle is based on the well known inchworm principle. The synchronization of three PZT actuators is able to produce the linear motion along the guide structure. Our proposed microdrive has a precise accuracy of about 100nm and a long stroke of about 5mm. The electrode which is used for the recording of the action potential of the neuron cell was fixed at one of PZT actuators. The proposed microdrive was suited to acquisition of signals from in vivo extra-cellular single-unit recoding. On the condition of the anesthetized mouse, the single-unit signals could be recorded by using the proposed microdrive. In addition, applying the PZT microdrive to an alert mouse, we try to implant it on a mouse brain skull to explore single neuron firing.

• 동서간호학연구지
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• 제26권1호
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• pp.28-38
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• 2020

Purpose: The aim of this study was to provide information on the extent and variations of elderly residents' nursing care needs, and provision of nursing care across long term care facilities. Methods: A nationwide survey was conducted on nurse managers from 1,041 long term care facilities, by e-mail or fax, from August 16 to September 30 in 2017. A self-reported questionnaire consisting of 5 domains was used to collect data. Results: Facilities with more than 30 residents were more likely to need skilled nursing services and to obtain the nursing staff such as a registered nurse and a nurse's aide. Awareness and satisfaction of hospital-based home nursing care was high in all facilities. In addition, there are some differences in nurse managers' perceptions of the level of healthcare resources and required action by facility size. Nurse managers of senior congregate housings were more likely to have considerable difficulty in dealing with healthcare needs of residents and recognizing the healthcare resource shortage. A majority of nurse managers agreed on the need to employ a registered nurse. Conclusion: This study confirmed that it is essential to increase nurse staffing level and to reform the long term care insurance for enhancing the accessibility of healthcare services, especially for the residents in small long term care facilities. There is also a need to provide diverse education and training opportunities for nursing staff working in long term care facilities.

• 한국응급구조학회지
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• 제6권1호
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• pp.87-102
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• 2002

Injury has now replaced disease as the biggest single cause of death in children after their first birthday. Each day child dies from preventable, unintentional injury and the medical cost of these injury is increasing remarkably. It is necessary to develope injury prevention models to explain, predict, manage, evaluate and analyze the information about accident. The purpose of this paper is, firstly, to investigate parent's actions regarding safety measures at home and secondly, to identify the influencing factors of parents' safety behaviors. The selection of such factors is guided by the theoretical framework of the Pender's Health Promotion Model. Method ; The questionnaire was developed on the basis of other investigations, through pilot testing, peer review, and review by field health workers. The questionnaire was completed by 231 mothers of young children. Data was collected between April and May 2002. Variable Use of three different domains of safety behavior, safety habits, supervision and perception of safety devices, were listed. Mothers were self reported on internal locus of control, mother & child relationships, and marital intimacy. Also the elements of the Health Promotion Model: perceived benefit, barrier, threat, and self-efficacy, were surveyed. Results & discussion The results indicate that most parents take considerable action to reduce household hazards. The constructs derived from the Model were statistically significant differences for a small part of the variables on parental behavior to reduce hazards in the home, such as age, education, economic status, self-efficacy, perceived benefit, internal locus of control. Future studies ought to include social influences, such as expectations, perceived norms, knowledge, and child-related variables, relevant to parental safety measures in their home.

• BMB Reports
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• 제35권1호
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• pp.116-126
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• 2002

Nitric oxide (NO), synthesized from L-arginine by NO synthases, is a small, lipophilic, diffusible, highly reactive molecule with dichotomous regulatory roles in many biological events under physiological and pathological conditions. NO can promote apoptosis (pro-apoptosis) in some cells, whereas it inhibits apoptosis (anti-apoptosis) in other cells. This complexity is a consequence of the rate of NO production and the interaction with biological molecules such as metal ion, thiol, protein tyrosine, and reactive oxygen species. Long-lasting overproduction of NO acts as a pro-apoptotic modulator, activating caspase family proteases through the release of mitochondrial cytochrome c into cytosol, up-regulation of the p53 expression, and alterations in the expression of apoptosis-associated proteins, including the Bcl-2 family. However, low or physiological concentrations of NO prevent cells from apoptosis that is induced by the trophic factor withdrawal, Fas, $TNF{\alpha}$/ActD, and LPS. The anti-apoptotic mechanism is understood on the basis of gene transcription of protective proteins. These include: heat shock protein, hemeoxygenase, or cyclooxygenase-2 and direct inhibition of the apoptotic executive effectors caspase family protease by S-nitrosylation of the cysteine thiol group in their catalytic site in a cell specific way. Our current understanding of the mechanisms by which NO exerts both pro- and anti-apototic action is discussed in this review article.

• 복식
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• 제56권8호
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• pp.15-34
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• 2006

Knit wear was industrialized, diversified, specialized and was made into high-class and it is including knitted cloth and small product for fashion as well as cardigan, sweater, and jacket etc. unlike past recognition only with underwear and inner wear. To consider elasticity to be the best strength of knit wear, middle-aged women that form change is serious are wearing knit wear as clothes for going out, and this may be regarded as clothes action to be conscious of form than vogue. Thus, in this study, this researcher tried to suggest solution scheme through the development of design of knit wear to supplement the form defect of middle-aged women. This researcher tried to develop the design of knit wear to supplement the form defect of middle-aged women, after examining the theoretical background of knit wear, the bodily and mental feature of middle-aged women. Internal and external knit wear brand that middle-aged women prefer as the scheme for solving the problematic form of middle-aged women with knit wear. As the result first, to see the present situation of inland production enterprise of knit wear, almost all the brand companies are concentrating energies on widening age class. Second, middle-aged women become far off from the form which is regarded ideal form in modern society. Third, result that this researcher examined the brand of knit wear of middle-aged women is as follows : MORADO, Cartknit, Escalier. And, in foreign knit wear brand, ST John, Missoni, ESCADA. Fourth, as the result that this researcher did work manufacture for the supplement of form defect of middle-aged women, it has practical and active side, and off-time has high-class and elegant refined beauty.

• 대한기계학회논문집
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• 제8권5호
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• pp.488-497
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• 1984

본 연구에서는 Fig.1과 같은 조립용 손목을 개발하였는데, 유연성의 구조는 RCC의 원리를 이용하고, 감지성은 Hi-Thand에서 채택한 스트레인 게이지 방식을 적용 하였다. 이 조립용 손목의 성능실험은 조립될 부품간의 틈새율, 부품의 길이 그리고 오차의 크기에 따라 수행하였으며, 조립시 스트레인 게이지로부터 측정되는 반력들은 D.E.Whitney의 조립이론식을 적용하여 구한 이론치와 비교하여 보았다. 반력을 측정 하는 궁극적인 목적은 이 측정치를 이용하여 귀환제어함으로써 초기오차를 수정하는 것이기 때문에 귀환제어를 어떻게 하느냐에 따라 조립시 생기는 반력이나 조립시간이 달라진다. 따라서 귀환제어를 위한 제어 알고리즘을 개발하였고 조립시 발생하는 반 력을 컴퓨터 시뮬레이션을 통하여 구해서 귀환제어 시키지 않을시 즉 수정적 방법에 의해서 조립할때에 발생하는 힘과를 비교 분석하였다.

• 생약학회지
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• 제31권2호
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• pp.130-141
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• 2000

The dried roots of Rehmannia glutinosa (RG) have been used in the traditional medicine for treatment of diabetes, fever and dysuria, etc. In order to investigate the quality evaluation of the dried roots of RG, we conducted the physico-chemical and biological evaluation method. The amount of catalpol from commercial samples is very diverse about $0.00{\sim}3.89%$ by using HPLC method, because it is easily decomposed by processing of RG. So, we should try to identify the correlation with the contents of catalpol and biological activities of RG. We chose 3 samples which were a wide difference of catalpol contents between each sample (Sample-I; 3.4%, Sample-II; 2.8%, Sample-III; 0.05%). Sample-I and Sample-II were found to be more effective than Sample-III on the DPPH free radical scavenging effect and inhibitory effect on $H_2O_2-catalyzed$ lipid peroxidation in rat liver in vitro. And, Sample-I and Sample-II exhibited more significant effects than Sample-III on accelerating actions of the small and large intestinal transport, and diuretic action in mice. So, it is suggested that the quantitative determination of catalpol should be required for the tandardization of the dried roots of RG.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1119-1122
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• 2016

Background: Punica granatum (PG) has been demonstrated to possess antitumor effects on various types of cancer cells. In this study, we determined antiproliferative properties of a seed extract of PG (PSE) from Iran in different human cancer cells. Materials and Methods: A methanolic extract of pomegranate seeds was prepared. Total phenolic content (TPC) and total flavonoid content (TFC) were assessed by colorimetric assays. Antioxidant activity was determined with reference to DPPH radical scavenging activity. The cytotoxicity of different doses of PSE (0, 5, 20, 100, 250, 500, $1000{\mu}g/ml$) was evaluated by MTT assays with A549 (lung non small cell carcinoma), MCF-7 (breast adenocarcinoma), SKOV3 (ovarian cancer cells), and PC-3 (prostate adenocarcinoma) cells. Results: Significant (P<0.01) or very significant (P<0.0001) differences were observed in comparison to negative controls at all tested doses ($5-1000{\mu}g/ml$). In all studied cancer cells, PSE reduced the cell viability to values below 23%, even at the lowest doses. In all cases, IC50 was determined at doses below $5{\mu}g/ml$. In this regard, SKOV3 ovarian cancer cells were the most responsive to antiproliferative effects of PSE with a maximum mean growth inhibition of 86.8% vs. 82.8%, 81.4% and 80.0% in MCF-7, PC-3 and A549 cells, respectively. Conclusions: Low doses of PSE exert potent antiproliferative effects on different human cancer cells SKOV3 ovarian cancer cells as most and A549 cells ar least responsive regarding cytotoxic effects. However, the mechanisms of action need to be addressed.

• Archives of Pharmacal Research
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• 제26권4호
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• pp.264-269
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• 2003

5-Aminosalicylic acid (5-ASA) is an active ingredient of therapeutic agents used for Crohn s disease and ulcerative colitis. Because it is absorbed rapidly and extensively in the upper intestine, delivery of the agent specifically to the colon is necessary. We selected taurine as a colon-specific promoiety and designed 5-aminosalicyltaurine (5-ASA-Tau) as a new colon-specific prodrug of 5-aminosalicylic acid (5-ASA). It was expected that introduction of taurine would restrict the absorption of the prodrug and show additive effect to the anti-inflammatory action of 5-ASA after hydrolysis. 5-ASA-Tau was prepared in good yield by a simple synthetic route. The apparent partition coefficient of 5-ASA-Tau in 1-octanol/pH 6.8 phosphate buffer or $CHCl_3$/pH 6.8 phosphate buffer was 0.10 or 0.18, respectively, at $37^{\circ}C$. To determine the chemical and biochemical stability in the upper intestinal environment, 5-ASA-Tau was incubated in pH 1.2 and 6.8 buffer solutions, and with the homogenates of tissue and contents of stomach or small intestine of rats at $37^{\circ}C$. 5-ASA was not detected from any of the incubation medium with no change in the concentration of 5-ASA-Tau. On incubation of 5-ASA-Tau with the cecal and colonic contents of rats, the fraction of the dose released as 5-ASA was 45% and 20%, respectively, in 8 h. Considering low partition coefficient and stability in the upper intestine, 5-ASA-Tau might be nonabsorbable and stable in the upper intestine. After oral administration, it would be delivered to the colon in intact form and release 5-ASA and taurine. These results suggested 5-ASA-Tau as a promising colon-specific prodrug of 5-ASA.