• 대한수의학회지
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• 제14권1호
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• pp.41-44
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• 1974

The effect of Panax ginseng on the sleeping time of chicken anesthetized with pentobarbital sodium were observed to elucidate the influence of ginseng on the duration of action of barbiturates. The results were as follows: 1. By the oral administration of ginseng powder(0.1~0.6 g/day/head for a week) shortened the sleeping time of very young chicken anesthetized with pentobarbital sodium.

• 여성건강간호학회지
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• 제11권2호
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• pp.163-168
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• 2005

Purpose: This study was to identify the relationship between fatigue and sleep disturbance in adult women so as to provide basic data for developing a women's health promotion program and nursing intervention. Method: A convenience sample of 184 women who visited a Well-baby clinic at P city Maternal child center during October in 2004 was obtained. Data was collected by self-administered questionnaires. Results: The Subjects' mean age was 36.87 years and 70% were employed and had more education than high school. The mean level of fatigue was 56.65, mean sleeping hours were 6.54, and time until falling asleep was 17.58 minutes. Scores of fatigue differed by subject's age, level of education, and menstruation status. In addition, sleeping hours differed by age, occupation status, and income level. There were significant low levels of correlation between fatigue and sleeping hours (r=-.16) and getting up too early (r=-.15). Conclusion: This study concludes that fatigue and sleeping patterns have a significant relationship.

• 약학회지
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• 제23권2호
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• pp.111-118
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• 1979

It was previously reported that cytochrome P$_{450}$ content in liver was increased when Capsicum acetone extract was given chronically to rats. The present study is aimed to investigate the effect of capsaicin, a principal component of red pepper, on the drug metabolizing enzymes in rat liver. Capsaicin (5mg/kg) was given intraperitoneally once a day for seven days and zoxazolamine paralysis time and hexobarbital sleeping time were determined 24 hrs after the last dose of capsaicin. Plasma hexobarbital concentration was also determined five and 15 min after hexobarbital administration to rats. Zoxazolamine paralysis time and hexobarbital sleeping time were shortened by 31.6% and 37.1%, respectively, compared with control group. Plasma hexobarbital concentration was lowered by 26.2% after five min and by 35.2% after 15 min, respectively, compared with control group. However, administration of single dose of capsaicin did not affect the zoxazolamine paralysis time and hexobarbital sleeping time. Microsomal cytochrome P$_{450}$ content and NADPH-cytochrome C reductase activity were increased by 14.6% and 11.6%, respectively in the rats pretreated with capsaicin for seven days, while cytochrome b$_{5}$ content was not changed. These results suggest that treatment with capsaicin for seven days may induce the drug metabolizing enzyme in rat liver.

• Natural Product Sciences
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• 제21권3호
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• pp.219-225
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• 2015

In the previous experiments, we reported that ethanol extract of Gastrodiae Rhizoma, the dried tuber of Gastrodia ElataBlume (Orchidaceae) increased pentobarbital-induced sleeping behaviors. These experiments were undertaken to know whether 4-hydroxybenzaldehyde (4-HBD), is one of the major compounds of Gastrodiae Rhizoma increases pentobarbital-induced sleeping behaviors and changes sleep architectures via activating GABA_A-ergic systems in rodents. 4-HBD decreased locomotor activity in mice. 4-HBD increased total sleep time, and decreased of sleep onset by pentobarbital (28 mg/kg and 40 mg/kg). 4-HBD showed synergistic effects with muscimol (a GABA_A receptor agonist), shortening sleep onset and enhancing sleep time on pentobarbital-induced sleeping behaviors. On the other hand, 4-HBD (200 mg/kg, p.o.) itself significantly inhibited the counts of sleepwake cycles, and prolonged total sleep time and non-rapid eye movement (NREM) in rats. Moreover, 4-HBD increased intracellular Cl⁻ levels in the primary cultured cerebellar cells. The protein levels of glutamic acid decarboxylase (GAD) and GABA_A receptors subunits were over-expressed by 4-HBD. Consequently, these results demonstrate that 4-HBD increased NREM sleep as well as sleeping behaviors via the activation of GABA_A-ergic systems in rodents.

• 정보과학회 논문지
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• 제44권1호
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• pp.63-70
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• 2017

본 논문에서는 확률적 보상과 유효성을 갖고, 매 시간 유효한 arm들의 집합이 변하는 sleeping bandit 문제를 해결하는 다수의 전략들의 집합 ${\Phi}$가 주어졌을 때, 이들을 융합하는 문제를 고려하고, 이 문제를 해결하기 위한 융합 알고리즘 sleepComb(${\Phi}$)를 제안한다. 제안된 알고리즘인 sleepComb(${\Phi}$)는 확률적(stochastic) multi-armed bandit 문제를 해결하는 매개변수 기반 휴리스틱으로 잘 알려진 ${\epsilon}_t$-greedy의 확률적 스위칭 기법을 바탕으로 매 시간 적절한 전략을 선택하는 알고리즘이다. 시퀀스 {${\epsilon}_t$}와 전략들에 대한 적절한 조건이 주어졌을 때, 알고리즘 sleepComb(${\Phi}$)는 sleeping bandit 문제에 대해 적절히 정의된 "best" 전략으로 수렴한다. 실험을 통해 이 알고리즘이 "best" 전략으로 수렴한다는 사실을 확인하고, 기존의 다른 융합 알고리즘보다 "best" 전략으로 더 빠르게 수렴함과 "best" 전략을 선택하는 비율이 더 높음을 보인다.

• 한국보건간호학회지
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• 제6권1호
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• pp.25-31
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• 1992

The purpose of this study was to investigate the relationship between perceived stress and exercise and sleeping of high school girls. For the survey, 1829 respondents were randomly selected from Seoul and local area. The survey was conducted from the 1st to the 14th of June, 1991 by the use of questionnaires made·after a pilot study. For the analysis, descriptive statistics were used by calculating frequencies, percentages and mean scores. t-test, ANOVA and Pearson's correlation coefficient were employed to test the differences and the statistical significance. The results of this study are summarized as follows: (1) 'There was no significant difference in stress level between the subjects who took exercise and who didn't take exercise. (2) Significant positive correlation was revealed between stress level and sleeping time. It means that a increase in stress level brought on increased sleeping time. (3) Residential makes the significant differences in terms of stress level. The stress level of Seoul students(3.0l) showed higher than that of local students(2.65). The results of the study lead us to the suggestion that, for the high school girls, the health education for stress management must be required. In addition, adolescents welfare work would be reached by supporting the group activity and sufficient leisure facilities.

• Natural Product Sciences
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• 제23권1호
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• pp.53-60
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• 2017

Perillae Herba has been traditionally used for the sedation in the oriental countries. Therefore, this study was conducted to determine whether Perillae Herba ethanol extract (PHEE) enhances pentobarbital-induced sleeping behaviors in animals. In addition, the possible mechanisms are demonstrated. PHEE (12.5, 25 and 50 mg/kg. p.o.) reduced the locomotor activity in mice. PHEE reduced sleep latency and augmented the total sleep time in pentobarbital (42 mg/kg, i.p.)-induced sleep in mice. Furthermore, the number of sleeping mice treated with sub-hypnotic pentobarbital (28 mg/kg, i.p.) increased. PHEE (50 mg/kg. p.o.) decreased the sleep/wake cycles and wakefulness, and increased total sleeping time and NREM sleep in electroencephalogram (EEG) of rats. In addition, PHEE (0.1, 1.0 and $10{\mu}g/ml$) increased the intracellular $Cl^-$ level through the GABA receptors in the hypothalamus of rats. Moreover, the protein of glutamate decarboxylase (GAD) was overexpressed by PFEE. It was found that PHEE enhanced pentobarbital-induced sleeping behaviors through $GABA_A-ergic$ transmissions.

• Advances in Traditional Medicine
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• 제6권3호
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• pp.208-214
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• 2006

In this study the Ayurvedic formulation Dasamularista was studied for its preliminary pharmacological properties using laboratory mice. Dasamularista showed a decrease in food intake and stool formation, while the water content of stool and water intake was higher and the volume of the urine was less. Dasamularista in a slight extent reduced the intestinal motility. This constipating effect was further supported by the significant anti-diarrhoeal property of the formulation in castor oil induced dairrhoea. The tested formulation markedly increased the latent period of diarrhoea and reduced the purging index value. Dasamularista did not alter the acetic acid induced abdominal writhing. Significant reduction on the onset of sleeping time and increased duration of sleep was observed in pentobarbital induced sleeping time test.

• 인터넷정보학회논문지
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• 제8권1호
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• pp.33-45
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• 2007

본 논문에서는 개폐상태를 알릴 수 있는 스위치나 센서들을 이용하여, 수면자의 수면상태를 인식할 뿐 아니라 올바른 수면상태로 제어할 수 있는 수면제어 및 원격모니터링 시스템을 제안하였고, 이 시스템을 헬스케어 수면매트에 실제 적용한 예를 보였다. 제안한 시스템은 센서를 이용한 수면상태 감지부, 센싱데이터 검출 및 송수신부, 수면상태 제어 및 모니터링부로 구성되었다. 시스템 구축을 위해 먼저, 수면상태 감지부는 접촉 방식의 개폐형식의 스위치센서를 사용하였다. 둘째, 센싱데이터 검출 및 송수신부는 임베디드 보드를 자체 개발하였으며, 실시간 데이터 추출과 수면상태 제어 및 모니터링부와는 소켓 기반의 통신이 지원된다. 그리고 세 번째 수면상태 제어 및 모니터링부에서는 입력된 센서 ID와 센싱된 데이터를 기반으로 올바른 수면자세의 유도 및 전반적인 수행상태 정보를 모니터링 하도록 하였다. 마지막으로 이들 서비스 모듈 및 그들 간의 통신구현은 실시간 객체지향형 모델인 TMO 스키마와 이들 간의 실시간 통신을 위해 분산 미들웨어로서 TMOSM을 이용하였다.

• 보건교육건강증진학회지
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• 제24권2호
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• pp.63-75
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• 2007

Purpose: The research was performed to provide basic information and bring importance to people's attention based upon seizing relation between employees's life patterns and health conditions in their daily lives. Method: This study was done from October 9th, 2006 to 27th and targeted on people who work more than 1 year in Seoul and Kyung-gi area including 700 people; 350 of males, 350 of females. In the experiment, there are 8 measurable variables which are weight, smoking, drinking, exercise, sleeping, having breakfast, regular time for meal and having snack. The survey questionnaire used THI. The collected data was analyzed using t-test, one way ANOVA, Pearson correlation coefficient and Multiple regression with SPSS/PC. Results: 1) It showed different data based on general traits such as gender, age, marriage, job and working time. 2) It also displayed different data in physical, mental and total health conditions depending on general traits. 3) The rate of symptom appeal was noticeably low as the body condition is in a good shape. 4) It exhibited that the variables for the rate of symptom appeal was negatively related to both male and female. 5) The variables affected to health conditions were age, exercise, having snack, sleeping, time for meal and smoking for male and weight, sleeping and time for meal for female. Conclusion: It is shown that if a person has a good life patterns in his/her daily life, he/she has a low rate of symptom appeal, which means he/she has better both physical and mental conditions.