Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Ethanol Extract of Perillae Herba Enhances Pentobarbital-Induced Sleep and Non-Rapid Eye Movement (NREM) Sleep through GABAA-ergic Systems

  • Kwon, Yeong Ok (College of Pharmacy, Chungbuk National University) ;
  • Ha, Tae-Woo (College of Pharmacy, Chungbuk National University) ;
  • Oh, Ki-Wan (College of Pharmacy, Chungbuk National University)
  • Received : 2016.11.10
  • Accepted : 2017.01.12
  • Published : 2017.03.31
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Abstract

Perillae Herba has been traditionally used for the sedation in the oriental countries. Therefore, this study was conducted to determine whether Perillae Herba ethanol extract (PHEE) enhances pentobarbital-induced sleeping behaviors in animals. In addition, the possible mechanisms are demonstrated. PHEE (12.5, 25 and 50 mg/kg. p.o.) reduced the locomotor activity in mice. PHEE reduced sleep latency and augmented the total sleep time in pentobarbital (42 mg/kg, i.p.)-induced sleep in mice. Furthermore, the number of sleeping mice treated with sub-hypnotic pentobarbital (28 mg/kg, i.p.) increased. PHEE (50 mg/kg. p.o.) decreased the sleep/wake cycles and wakefulness, and increased total sleeping time and NREM sleep in electroencephalogram (EEG) of rats. In addition, PHEE (0.1, 1.0 and $10{\mu}g/ml$) increased the intracellular $Cl^-$ level through the GABA receptors in the hypothalamus of rats. Moreover, the protein of glutamate decarboxylase (GAD) was overexpressed by PFEE. It was found that PHEE enhanced pentobarbital-induced sleeping behaviors through $GABA_A-ergic$ transmissions.

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References

  1. Pilcher, J. J.; Ginter, D. R.; Sadowsky, B. J. Psychosom. Res. 1997, 42, 583-596. https://doi.org/10.1016/S0022-3999(97)00004-4
  2. Doi, Y.; Minowa, M.; Tango, T. Sleep. 2003, 26, 467-471. https://doi.org/10.1093/sleep/26.4.467
  3. Iliescu, E. A.; Coo, H.; McMurray, M. H. Nephrol. Dial. Transplant. 2003, 18, 126-132. https://doi.org/10.1093/ndt/18.1.126
  4. Phillips, K. D.; Sowell, R. L.; Boyd, M.; Dudgeon, W. D.; Hand, G. A.; Mind-Body Research Group. Qual. Life Res. 2005, 14, 959-170. https://doi.org/10.1007/s11136-004-2574-0
  5. Joanna, M. W.; Stachowicz, K.; Nowak, G.; Pilc, A. The Loss of Glutamate-GABA Harmony in Anxiety Disorders; InTech: USA, 2011, p 24.
  6. Olsen, R. W.; Sieghart, W. Pharmacol. Rev. 2008, 60, 243-260. https://doi.org/10.1124/pr.108.00505
  7. Whiting, P. J. Drug Discov. Today 2003, 8, 445-450. https://doi.org/10.1016/S1359-6446(03)02703-X
  8. Ahn, H. Korean J. Food Preserv. 2006, 13, 703-707.
  9. Honda, G.; Koezuka, Y.; Tabata, M. Chem. Pharm. Bull. 1988, 36, 3153-3155. https://doi.org/10.1248/cpb.36.3153
  10. Yi, L. T.; Li, J.; Geng et, D. J. Ethnopharmacol. 2013, 147, 245-253 https://doi.org/10.1016/j.jep.2013.03.015
  11. Takeda, H.; Tsuji, M.; Inazu, M.; Egashira, T.; Matsumiya, T. Eur. J. Pharmacol. 2002, 449, 261-267. https://doi.org/10.1016/S0014-2999(02)02037-X
  12. Takeda, H.; Tsuji, M.; Miyamoto, J.; Matsumiya, T. Psychopharmacology (Berl) 2002, 164, 233-235. https://doi.org/10.1007/s00213-002-1253-5
  13. Morton, G. J.; Kaiyala, K. J.; Fisher, J. D.; Ogimoto, K.; Schwartz, M. W.; Wisse, B. E. Am. J. Physiol. Endocrinol. Metab. 2011, 300, 392-401. https://doi.org/10.1152/ajpendo.00546.2010
  14. Wolfman, C.; Viola, H.; Marder, M.; Wasowski, C.; Ardenghi, P.; Izquierdo, I.; Paladini, A. C.; Medina, J. H. Eur. J. Pharmacol. 1996, 318, 23-30. https://doi.org/10.1016/S0014-2999(96)00784-4
  15. Sanford, L. D.; Yang, L.; Liu, X.; Tang, X. Brain Res. 2006, 1084, 80-88. https://doi.org/10.1016/j.brainres.2006.02.020
  16. Tokunaga, S.; Takeda, Y.; Niimoto, T.; Nishida, N.; Kubo, T.; Ohno, T.; Matsuura, Y.; Kawahara, Y.; Shinomiya, K.; Kamei, C. Biol. Pharm. Bull. 2007, 30, 363-366,. https://doi.org/10.1248/bpb.30.363
  17. Ma, Y.; Han, H.; Eun, J. S.; Kim, H. C.; Hong, J. T.; Oh, K. W. Biol. Pharm. Bull. 2007, 30, 1748-1753. https://doi.org/10.1248/bpb.30.1748
  18. West, M. R.; Molloy, C. R. Anal. Biochem. 1996, 241, 51-58. https://doi.org/10.1006/abio.1996.0377
  19. Wagner, C.; Vargas, A. P.; Roos, D. H.; Morel, A. F.; Farina, M.; Nogueira, C. W.; Aschner, M.; Rocha, J. B. Arch. Toxicol. 2010, 84, 89-97. https://doi.org/10.1007/s00204-009-0482-3
  20. Fanger, B. O. Anal. Biochem. 1987, 162, 11-17. https://doi.org/10.1016/0003-2697(87)90004-2
  21. Igarashi, M. Miyazaki, Y. Evid. Based Complement. Alternat. Med. 2013, 2013, 1-7.
  22. Ito, N.; Nagai, T.; Oikawa, T.; Yamada, H.; Hanawa, T. Evid. Based Complement. Alternat. Med. 2011, 2011, 1-5.
  23. Hu, H. Z.; Li, Z. W. J. Physiol. 1997, 501( Pt 1), 67-75. https://doi.org/10.1111/j.1469-7793.1997.067bo.x
  24. Mohler, H. J. Recept. Signal Transduct. Res. 2006, 26, 731-740. https://doi.org/10.1080/10799890600920035
  25. Miller, M. A. Front. Neurol. 2015, 6, 1-9.
  26. Liu, Z.; Xu, X. H.; Liu, T. Y.; Hong, Z. Y.; Urade, Y.; Huang, Z. L.; Qu, W. M. CNS Neurosci. Ther. 2012, 18, 623-630. https://doi.org/10.1111/j.1755-5949.2012.00334.x
  27. Mehta, A. K.; Ticku, M. K. Brain Res. Brain Res. Rev. 1999, 29, 196-217. https://doi.org/10.1016/S0165-0173(98)00052-6
  28. Lambert, J. J.; Belelli, D.; Harney, S. C.; Peters, J. A.; Frenguelli, B. G. Brain Res. Brain Res. Rev., 2001, 37, 68-80. https://doi.org/10.1016/S0165-0173(01)00124-2
  29. Choi, J. J.; Kim, Y. S.; Kwon, Y. O.; Yoo, J. H.; Chong, M. S.; Lee, M. K.; Hong, J. T.; Oh, K. W. Nat. Prod. Sci. 2015, 21, 219-225.

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