• Title/Summary/Keyword: skin properties

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Tuning the Stiffness of Dermal Fibroblast-encapsulating Collagen Gel by Sequential Cross-linking (연속가교를 통한 피부 진피세포 담지 콜라겐 겔의 강도 제어)

  • Jung, Mun-Hee;Shin, Sung Gyu;Lim, Jun Woo;Han, Sa Ra;Kim, Hee-Jin;Jeong, Jae Hyun
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.44 no.1
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    • pp.23-29
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    • 2018
  • In this study, sequential cross-linked collagen gels were successfully prepared with collagen, which is biomaterial, and acrylamide (AAm), which is a synthetic monomer. The elastic moduli (E) of cross-linked collagen gels were increased from 1.5 to 3.0 kPa by varying of AAm concentrations. In addition, human dermal fibroblasts were encapsulated into the porous pores introduced into the gels, and cell growth and behavior were investigated. Increasing E of the gels led to decreases in cell growth rate, while the cellular glycosaminoglycan (GAG) production level was elevated. Overall, the growth and cellular activity of skin cells were influenced by the extracellular matrix properties of the collagen gels. In conclusion, these results will be highly useful for designing reconstructive skins and various tissue engineering researches.

Evaluation of Impact Damage and Residual Compression Strength after Impact of Glass/Epoxy Laminate Composites for Lightweight Bogie Frame induced by Ballast-Flying Phenomena (도상자갈 비산에 의한 경량 대차프레임 적용 유리/에폭시 적층 복합재의 충격손상 및 충격 후 잔류압축강도 평가)

  • Goo, Jun-Sung;Shin, Kwang-Bok;Kim, Jung-Suk
    • Journal of the Korean Society for Railway
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    • v.15 no.2
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    • pp.109-115
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    • 2012
  • In order to evaluate the effect of structural degradation of a GFRP composite bogie frame due to ballast-flying phenomena, the impact test and residual compression test after impact was conducted for glass fiber/epoxy 4-harness satin woven laminate composites applied to skin part of a bogie frame. The impact test was performed using a instrumented impact testing system with energy levels of 5J, 10J, and 20J, and the impactor was designed to have various ballast shapes such as sphere, cube, and cone to consider the ballasted track environments. The residual compression strength was tested to evaluate the degradation of mechanical properties of impact-damaged laminate composites. The results showed that the damage area and the degradation of residual compressive strength after impact for laminate composites was increased with increase of impact energy for all ballast shapes, and was particularly most influenced by ballast shape of cone.

Correlating the Fineness and Residual Gum Content of Degummed Hemp Fibres

  • Beltran, Rafael;Hurren, Christopher J.;Kaynak, Akif;Wang, Xungai
    • Fibers and Polymers
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    • v.3 no.4
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    • pp.129-133
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    • 2002
  • It is well known residual gum exists in degummed or rotted hemp fibers. Gum removal results in improvement in fiber fineness and the properties of the resultant hemp yams. However, it is not known what correlation if any exists between the residual gum content in retted hemp fibers and the fiber fineness, described in terms of fiber width in this paper. This study examined the mean width and coefficient of variation (CV) of fiber width of seventeen chemically rotted hemp samples with reference to residual gum content. The mean and CV of fiber width were obtained from an Optical fiber diameter analyser (OFDA 100). The linear regression analysis results show that the mean fiber width is directly proportional to the residual gum content. A slightly weaker linear correlation also exists between the coefficient of variation of fiber width and the residual gum content. The strong linear co-relation between the mean of fiber width and the residual gum content is a significant outcome, since testing for fiber width using the OFDA is a much simpler and quicker process than testing the residual gum content. Scanning Electron Microscopy (SEM) reinforces the OFDA findings. SEM micrographs show a flat ribbon like fiber cross-section hence the term \"fiber width\" is used instead of fiber diameter. Spectral differences in the untreated dry decorticated skin samples and chemically treated and subsequently carded samples indicate delignification. The peaks at $1370cm^{-1}$, $1325cm^{-1}$, $1733cm^{-1}$, and $1600cm^{-1}$ attributed to lignin in the untreated samples are missing from the spectra of the treated samples. The spectra of the treated samples are more amine-dominated with some of the OH character lost.cter lost.

A New k-$\varepsilon$ Model for Prediction of Transitional Boundary-Layer Under Zero-Pressure Gradient (압력 구배가 없는 평판 천이 경계층 유동을 예측하기 위한 k-$\varepsilon$모형의 개발)

  • Baek, Seong-Gu;Im, Hyo-Jae;Jeong, Myeong-Gyun
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.25 no.3
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    • pp.305-314
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    • 2001
  • A modified model is proposed for calculation of transitional boundary layer flows. In order to develop the eddy viscosity model for the problem, the flow is divided into three regions; namely, pre-transition region, transition region and fully turbulent region. The pre-transition eddy-viscosity is formulated by extending the mixing length concept. In the transition region, the eddy-viscosity model employs two length scales, i.e., pre-transition length scale and turbulent length scale pertaining to the regions upstream and the downstream, respectively, and a universal model of stream-wise intermittency variation is used as a function bridging the pre-transition region and the fully turbulent region. The proposed model is applied to calculate three benchmark cases of the transitional boundary layer flows with different free-stream turbulent intensity (1%∼6%) under zero-pressure gradient. It was found that the profiles of mean velocity and turbulent intensity, local maximum of velocity fluctuations, their locations as well as the stream-wise variation of integral properties such as skin friction, shape factor and maximum velocity fluctuations are very satisfactorily predicted throughout the flow regions.

A Research Trend of Natural Product on Well-Being Industry (웰빙산업에서의 천연물 연구 동향)

  • Kim Ki Ho;Ko Kang Il;Kang En Jung;Yang En Kyung;Park Soo Nam
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.30 no.3 s.47
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    • pp.329-343
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    • 2004
  • Recently, our society has prominently raised the desire to well-being life since not only our economical situations are better than before, but environmental pollution become serious. In well-being trends, the natural or nature-related products are also issued on their usages as bio-/raw materials for our living industries, such as cosmetics, household goods, and so on. Especially, various materials which comes from medicinal plants has been discovered their physiological properties and validated their functions. Thus, they have been subjected to several processes, including extraction, isolation and concentration, and popularly introduced to cosmetic industry. In these reasons, a variety of cosmetic Products using natural materials has been developed, which are focused on whitening, wrinkle improvement, and anti-aging. In this report, we present a brief review of the function and classification of natural products interested in until now, and introduce the natural materials for cosmetics having physiological activities on skin, including Fructan, Acrea extract, Portulaca extract, Licorce extract, Dandelion extract, Ulmus extract, SC-glucan, Arbutin, and Sophora extract.

The Inhibition of Oxidative Stress by Chios Gum Mastic is Associated with Autophagy

  • Lee, Bo-Young;Lee, Kee-Hyun;Kim, In-Ryoung;Kim, Yong-Ho;Park, Hae-Ryoun;Park, Bong-Soo
    • International Journal of Oral Biology
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    • v.39 no.2
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    • pp.65-73
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    • 2014
  • Chios Gum Mastic (CGM) is a natural resin extracted from the leaves of Pistacia lentiscus, a plant endemic to the Greek island of Chios. It has been used by traditional healers, and it has antibacterial, antifungal properties, and therapeutic benefits for the skin. The CGM reduces the formation of dental plaque and bacterial growth in oral saliva, and recent studies have demonstrated the role of antioxidant activity of CGM. Although CGM has been widely investigated, its protective effect against oxidative-damage to keratinocytes, as well as the relationship between CGM and autophagy, has not been investigated. The aim of this study was to assess the protective effect of CGM against $H_2O_2$-induced oxidative stress and to evaluate the autophagic features induced by CGM in human keratinocytes. The pretreatment with CGM significantly reduced apoptosis in $H_2O_2$-exposed HaCaT cells. It promoted the degradation of caspase-3, caspase-8, and caspase-9; and it induced the formation of the processed PARP. The treatment with CGM caused an increase in vesicle formation compared to control group. The level of p62 was reduced and the conversion of LC3-I to LC3-II was increased in CGM treated HaCaT cells. Also, the treatment with CGM increased cleavage of ATG5-ATG12 complex. In summary, CGM helps the cells to survive under stressful conditions by preventing apoptosis and enhancing autophagy. Besides, the present investigation provides evidence to support the antioxidant potential of CGM in vitro and opens up a new horizon for future experiments.

A Study on the Adhesiveness between Polyurethane Sheet for Maxillofacial Prostheses and Autopolymerizing Acrylic Resin in Various Polymerization Methods (다양한 중합방법에 따른 악안면 보철용 폴리우레탄과 자가중합 레진 간의 결합력에 관한 연구)

  • Kim, Doo-Yeol;Cho, In-Ho
    • Journal of Dental Rehabilitation and Applied Science
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    • v.16 no.2
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    • pp.123-132
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    • 2000
  • The field of maxillofacial prosthetics is concerned with the prosthetic reconstruction of missing head and neck tissue. Currently, facial prostheses are usually applied in cases of defects caused by the surgical removal of tumors or congenital defects. While silicone has been most widely used for the reconstruction of missing maxillofacial defects, it does not have ideal physical properties. Therefore, bonding a thin polyurethane sheet to silicone prostheses was recommended. In this case skin adhesives were used for the retention of maxillofacial prostheses. But retention of devices has always been problematic. The contributions of implants can be made to solve these problems. Implants have reduced the need for adhesive use, simplifying cleaning procedures and thus extending the life of the prostheses. For implant-retained prostheses, retentive matrix is necessary to hold attachments and/or magnets. The retentive matrix is usually fabricated with autopolymerizing acrylic resin or visible light- polymerized resin. The purpose of this study was to compare the adhesion-in-peel force of silicone adhesive to autopolymerizing acrylic resin and polyurethane sheet with two different surface textures : pumice polish only or retention groove, and three surface primers : Dow corning 1205 primer or Dow corning S-2260 primer or FactorII A-304 primer, and two polymerization methods : room temperature or dry heat oven. The t-peel bond strength of specimens was determined as described in ASTM Standard D1876-72. The results were statistically analyzed using the ANOVA test, multiple range test and t-test The results were as follows. 1. The t-peel bond strength of A-304 primer was the highest and statistically higher than that of S-2260(p<0.05). 2. The t-peel bond strength of specimens with retention groove was statistically higher than that of specimens polished with pumice(p<0.05). 3. The t-peel bond strength of specimens polymerized in dry heat oven was statistically higher than that of specimens in room temperature(p<0.01).

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Gradient Structures and Surface Composition of Polypropylene/Ethylene-Propylene Rubber Blends (폴리프로필렌/에틸렌-프로필렌 고무 블렌드 경사구조 및 표면조성)

  • Kim, Seog Je;Lee, Sung-Goo;Lee, Jae Heung;Choi, Kil-Yeong
    • Journal of Adhesion and Interface
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    • v.2 no.4
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    • pp.24-31
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    • 2001
  • Polypropylenes(PP) with different melt index values were mixed with ethylene-propylene rubber(EPR) or ethylene-propylene diene monomer rubber(EPDM) and an ethylene copolymer containing carboxylic acid group in a twin screw extruder. Then test specimens were prepared from the pellets of the blends with an injection molding machine. The mechanical properties and morphology of fractured surfaces were measured. Relative peak intensities of carboxylic acid group on the specimen surface were measured with an attennuated total reflection infrared spectrometer (ATR-IR) and compared with each other. The blend specimens were found to have the gradient morphology of rubber domains in PP matrix in the core region and PP skin layer. The blends containing PP of higher melt index showed greater content of ethylene copolymer containing carboxylic acid on the surface when the relative peak intensities of ATR-IR for carboxylic acid were compared. As the melt index values were increased, the decrease tendency in mechanical propeties such as tensile strength and impact strength was more significant for PP/EPR blends than PP/EPDM blends.

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Convergence Study on Preparation of Anti-aging Peptides from Fish Collagen Hydrolysates (콜라겐 단백가수물을 이용한 항노화 펩타이드 제조에 대한 융합 연구)

  • Bae, In Young;Han, Yoo Kyung;Je, Hyun Jeong;Lee, Hyun Jun;Lee, Hyeon Gyu
    • Journal of the Korea Convergence Society
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    • v.11 no.5
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    • pp.61-72
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    • 2020
  • An anti-aging peptide was prepared from fish collagen hydrolysate (FCH) by ultrafiltration (MWCO; 1 kDa) and reversed-phased high performance liquid chromatography (RP-HPLC). Its anti-aging properties were evaluated based on the procollagen-synthesizing and MMP-1-inhibiting activities in Hs68 cells. A potent anti-aging peptide (fraction I-I) increased collagen synthesis by 46% and also inhibited MMP-1 secretion by 77%, compared with unpurified FCH. The amino acid sequence of fraction I-I was identified to be Gly-Arg-Arg-Gly-Asn-Lys (GRRGNK; the repeating Gly-X-Y sequence in collagen), and it had a molecular mass of 686.175 Da. It revealed that the anti-aging activity of GRRGNK was mainly due to skin protective effects. These results demonstrated that fish collagen hydrolysate may be a potential source of anti-aging peptides, which could be utilized in various field, including foods, cosmetics, and pharmaceuticals.

Pullout Characteristics of End Fixed Nails (양단정착형 쏘일네일링의 인발특성)

  • Lee, Bongjik;Kim, Josoon;Lee, Jongkyu
    • Journal of the Korean GEO-environmental Society
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    • v.8 no.4
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    • pp.5-11
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    • 2007
  • In this study, several pullout tests were carried out under various field conditions to evaluate the pullout force of the end fixed nails. Pullout resistance force, displacement and friction force between the grouting and nail were measured in end fixed nails installed in soft rock, weathered rock and weathered soil. Furthermore, the field test were also carried out under the same condition using the conventional type nails. Based on the test results, it is concluded that the end fixed nails showed larger ultimate resistance force compared with conventional types nails, approximately two times in weathered soil and 1.6 times of weathered rock, respectively. The skin friction is also increased in end fixed type about 1.8~3.0 times. Finally, it is concluded in the base of the force transfer properties that using the end fixed nails could decrease the displacement and show a uniform resistance in entire length of nails.

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