• Journal of Mechanical Science and Technology
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• 제17권6호
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• pp.825-835
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• 2003

Previous studies have demonstrated the importance of joint angle errors mainly due to skin artifact and measurement errors during gait analysis. Joint angle errors lead to unreliable kinematics and kinetic analyses in the investigation of human motion. The purpose of this paper is to present the Joint Averaging Coordinate System (JACS) method for human gait analysis. The JACS method is based on the concept of statistical data reduction of anatomically referenced marker data. Since markers are not attached to rigid bodies, different marker combinations lead to slightly different predictions of joint angles. These different combinations can be averaged in order to provide a "best" estimate of joint angle. Results of a gait analysis are presented using clinically meaningful terminology to provide better communication with clinical personal. In order to verify the developed JACS method, a simple three-dimensional knee joint contact model was developed, employing an absolute coordinate system without using any kinematics constraint in which thigh and shank segments can be derived independently. In the experimental data recovery, the separation and penetration distance of the knee joint is supposed to be zero during one gait cycle if there are no errors in the experimental data. Using the JACS method, the separation and penetration error was reduced compared to well-developed existing methods such as ACRS and Spoor & Veldpaus method. The separation and penetration distance ranged up to 15 mm and 12 mm using the Spoor & Veldpaus and ACRS method, respectively, compared to 9 mm using JACS method. Statistical methods like the JACS can be applied in conjunction with existing techniques that reduce systematic errors in marker location, leading to an improved assessment of human gait.

• Journal of Pharmaceutical Investigation
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• 제33권2호
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• pp.129-133
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• 2003

In order to evaluate the effects of vehicles and penetration enhancers on skin permeation of apomorphine, the skin permeation rates of apomorphine from vehicles of different composition were determined using Franz diffusion cells fitted with excised rat skins. Solubility of apomorphine in various solvents was investigated to select a vehicle suitable for the percutaneous absorption of apomorphine. The solvents used were propylene glycol (PG), $Transcutol^{\circledR},\;Labrasol^{\circledR},\;Labrafac hydro WL^{\circledR},\;Labrafil WL 2609 BS^{\circledR}$ and isopropyl alcohol. Even though permeation rates of apomorphine from each vehicle were low $(0.008-0.36\;{\mu}g/cm^2/hr)$, the combination of PG and $Labrafac^{\circledR}$ increased it significantly. The permeation rates of apomorphine from $PG/Labrafac^{\circledR}$ mixtures increased as the volume fraction of PG in the mixture increased. The maximum permeation rate of $18\;{\mu}g/cm^2/hr$ was achieved at 30% of PG, which decreased with further increase of PG fraction. A series of fatty acids, alcohols and monoterpenes were employed as penetration enhancers. Incorporation of each enhancer in the $PG/Labrafac^{\circledR}$ (30:70) mixture at the level of 10% improved the skin permeation significantly. The highest permeation rate, $117\;{\mu}g/cm^2/hr$, was attained with myristic acid.

• Biomolecules & Therapeutics
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• 제22권1호
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• pp.73-77
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• 2014

The purpose of this study was to examine the effect of stabilization of retinyl palmitate (RP) on its skin permeation and distribution profiles. Skin permeation and distribution study were performed using Franz diffusion cells along with rat dorsal skin, and the effect of drug concentration and the addition of pectin on skin deposition profiles of RP was observed. The skin distribution of RP increased in a concentration dependent manner and the formulations containing 0.5 and 1 mg of pectin demonstrated significantly increased RP distributions in the epidermis. Furthermore, it was found that skin distribution of RP could be further improved by combined use of pectin and ascorbyl palmitate (AP), due largely to their anti-oxidative effect. These results clearly demonstrate that the skin deposition properties of RP can be improved by stabilizing RP with pectin. Therefore, it is strongly suggested that pectin could be used in the pharmaceutical and cosmetic formulations as an efficient stabilizing agent and as skin penetration modulator.

• Journal of Pharmaceutical Investigation
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• 제38권2호
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• pp.87-92
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• 2008

Wood vinegar is well known as a softening agent affecting on the stratum corneum that is easy to penetrate into the skin. In this study, we prepared mixed ursolic acid hydrogel with wood vinegar(1, 2, 5%) as a penetration enhancer. The accumulation of ursolic acid in the skin from hydrogels was evaluated in vitro hairless mouse skin and skin moisturizing effect of them was evaluated using the corneometer and the tewermeter. And the role of stratum corneum as a protective barrier was evaluated as well. The hydrogels were retained about 40% of water retention capacity 2hrs and had better effect on the stripped skin than full-thickness skin. The accumulation of ursolic acid through stripped skin from hydrogels with wood vinegar was not change compared to normal skin, which indicated the action site of wood vinegar and the accumulation site of ursolic acid would be stratum corneum. From these result, we could find wood vinegar seems to be a good enhancer for active materials with anti-wrinkle and anti aging effect such as ursolic acid, and can be a developed topical delivery system maintaining excellent water retention capacity.

• 한국지반공학회지:지반
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• 제14권5호
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• pp.163-172
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• 1998

말뚝의 지지력 거동을 연구하기 위하여 말뚝 제작시 다수의 변형률계를 설치한 2본의 말뚝들에 대하여 항타시에 그리고 항타후 소정의 시간이 경과된 시점에 동재하시험과 정재하시험을 몇 차례 수행하였다. 콘관입저항값 그리고 표준관입저항값과 말뚝의 단위 주면마찰력과의 관계를 규명하기 위해 재하시험전에 시험지반에 대하여 론관입시험과 표준관입시험도 실시하였다. 지지력과 두부침하량 관계를 살펴보면, 0.055D(D: 직경)의 두부침하량에서 전체지지력이 극한에 도달하였고, 이 때에 주면마찰력은 극한간에 도달했으나, 선단지지력은 계속 증가하는 것으로 나타났다. 말뚝의 지지력은 항타후 시간이 경과함에 따라 자연대수함수로 증가하였으며, 지지력 성분중 주면마찰력 성분이 항타한 후 40일 경과한 시점에 초기값의 4.6배 정도로 현저하게 증가하였다. 지지력 거동에 대한 시간경과의 영향을 보면, 시험말뚝들은 초기항타시에는 선단지지말뚝으로 거동하다가 시간이 경과하면서 주면마찰 말뚝으로 거동이 변화되었음을 관찰할 수 있었다. 단위 주면마찰력은, 토질분류에 따라 다르지만, 콘관입저항칼(q.)과 표준관입저항값(N)과 일정한 관계를 갖는 것으로 나타났으며, 관계상수는 현재 국내에서 사용하고 있는 간보다 큰 것으로 나타났다.

• 대한화장품학회지
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• 제36권2호
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• pp.115-120
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• 2010

피부에서 표피를 통한 물질의 수송은 피부의 여러 가지 보호 작용으로 인해 경피 흡수가 쉽게 이루어지지 않아 결과적으로 생리 활성 성분이 그 효과를 발휘하는 진피층까지 도달하기 어렵다. 본 연구는 피부에서 매우 낮은 농도가 투과되는 친수도가 높은 약물(알부틴)의 경피흡수를 촉진하는 화학적 촉진제의 in vitro 흡수 양상에 대한 연구이다. 화학적 촉진제로 N-methyl-2-pyrrolidone (NMP)을, 경피흡수장치는 Franz diffusion cell을 사용하였다. NMP는 약물의 경피흡수에 상당히 영향을 준다는 것을 알 수 있었다. NMP는 피부 지질층의 유동성에 영향을 주지 않고 약물의 보조흡수제로 작용하여 알부틴의 경피흡수촉진비율을 약 1.3~1.5배 증가 시켰지만 지연 시간의 변화는 없었다. 따라서 NMP는 친수성 생리활성 물질의 효과적인 화학적 경피흡수 촉진제로 작용하였으며, 향후 화장품 제형 및 약물전달체계에 응용이 기대된다.

• 한국지반공학회논문집
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• 제35권8호
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• pp.17-30
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• 2019

실제 시공된 말뚝들의 재하시험 자료 및 매입 PHC말뚝의 설계 자료로부터 전체지지력에 대한 주면마찰력의 분담율인 SRF를 분석하였다. 현장에서 시험 시공된 말뚝의 SRF는 말뚝의 종류, 상대근입길이, 지반의 종류, 재하시험의 종류에 상관없이 42~99%이었다. 매입 PHC말뚝에 대한 설계 자료에서 구한 SRF는 말뚝의 직경, 상대근입길이에 상관없이 풍화암에 소켓된 경우 20~53%의 범위에 분포하였다. 사용말뚝으로 실제 시공된 매입 PHC말뚝에서 재항타 동재하시험 자료로부터 구한 SRF는 말뚝의 직경, 상대근입길이, 지반의 종류에 상관없이 4~83%의 범위에 분산되어 분포하였다. 사용말뚝에서 SRF가 낮은 수준으로 나타나는 이유는 매입 PHC말뚝의 주면고정액의 충전이 제대로 이루어지지 않은 채 시공된 현황으로 볼 수 있었으며 따라서 주면고정액의 시공관리에서 시급하게 개선해야 할 현황이었다. 풍화암에 소켓된 매입 PHC말뚝의 설계에서 사용하고 있는 극한지지력 산정공식으로 계산한 주면마찰력의 SRF는 실제 현장 시공 말뚝의 SRF보다 평균적으로 2.2배 정도로 낮은 수준으로 평가되었다. 이는 설계에서 사용하고 있는 산정공식에 의한 극한주면마찰력이 매우 낮은 수준으로 계산되기 때문이다. 따라서 SRF를 만족시킬 수 있는 새로운 주면마찰력 산정공식의 제안 필요성이 있는 것으로 판단된다.

• Medical Lasers
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• 제10권3호
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• pp.181-184
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• 2021

Scars can cause great psychological stress among patients. Currently, there are numerous topical agents, laser and surgical treatments available for skin rejuvenation and scar minimization. Laser-assisted drug delivery (LADD) is a treatment method that increases drug delivery by stimulating the skin physically and chemically to enhance the penetration of topical agents. This is one of the areas of great interest in the treatment of various skin diseases in addition to its use for cosmetic purposes. In particular, LADD is relatively non-invasive and has advantages in terms of accessibility and stability. Poly-L-lactic acid (PLLA) is a collagen stimulator known to gradually restore skin volume by inducing inflammation and fibroplasia. Herein, we report a case of treatment of an atrophic scar with fractional carbon dioxide laser-assisted PLLA delivery.

• Journal of Pharmaceutical Investigation
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• 제38권6호
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• pp.357-363
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• 2008

Penetration rate of large molecule through skin is very low due to the barrier effect of stratum corneum. Novel microneedle treatment device with roll was designed for transdermal delivery of large molecular drugs such as vaccine and protein drugs. The permeation rates of FITC labelled bovine serum albumin (FITC-BSA) as a model protein were determined using modified Franz diffusion cell and hairless mouse skin which were treated by hydrogel or solution containing FITC-BSA. Fluorescent spectrophotometer was used to analyze the concentration of FITC-BSA. Microscope using fluorescent filter was used to capture the image and location of FITC-BSA in the skin. We confirmed that permeation rate of BSA was increased with the treatment by microneedle and was increased by the increasing frequency of treatment. Furthermore, the permeation rate observed from hydrogel treated skin was significantly higher than that from solution treated skin.

• 한국응용과학기술학회지
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• 제28권2호
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• pp.170-177
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• 2011

Transdermal drug delivery(TDS) offers many important advantages. For instance, it is easy and painless, it protects the active compound from gastric enzymes, and it avoids the hepatic first-pass effect. Also, it is simple to terminate the therapy if any adverse or undesired effect occurs. But skin is a natural barrier, and only a few drugs can penetrate the skin easily and in sufficient quantities to be effective. Therefore, in recent years, numerous studies have been conducted in the area of penetration enhancement. The most commonly used transdermal system is the skin patch using various types of technologies. Compared with other method of dosage, it is possible to use for a long term. It is also possible to stop the drug dosage are stopped if the drug dosage lead to side effect. Polysaccharide, such as xanthan gum and algin were selected as base materials of TDS. Also, these polymers were characterized in terms of enhancers and drug contents. Among these polysaccharide, the permeation rate of Paroxetine such as lipophilic drug was the fastest in xanthan gum matrix in vitro. We used glycerin, PEG400 and PEG800 as enhancers. Since dermis has more water content(hydration) than the stratum corneum, skin permeation rate at steady state was highly influenced when PEG400 was more effective for lipophilic drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate.