Synergistic Effects of N-methyl-2-pyrrolidone on Skin Permeation of a Hydrophobic Active Ingredient
![]() |
Lee, Geun-Soo
(R&D Center, Hanbul Cosmetics Co. Ltd)
Lee, Dong-Hwan (R&D Center, Hanbul Cosmetics Co. Ltd) Kim, Kyoung-Bum (R&D Center, Hanbul Cosmetics Co. Ltd) Ko, Hyun-Joo (R&D Center, Hanbul Cosmetics Co. Ltd) Pyo, Hyeong-Bae (R&D Center, Hanbul Cosmetics Co. Ltd) |
1 | H. Sasaki and J. Nakamura, Enhancing effect of pyrrolidone derivates on transdermal drug delivery 1, Int. J. Pharm., 44, 15 (1988). DOI ScienceOn |
2 | H. Sasaki and J. Nakamura, A cute toxicity and skin irritation of pyrrolidone derivates as transdermal penetration enhencer, Chem. Pharm. Bull., 38, 2308 (1990). DOI ScienceOn |
3 | Z. M. Hua, Q. Zhoua, and T. C. Lei, Effects of hydroquinone and its glucoside derivatives on melanogenesis and antioxidation, J. Dermatological Sci., 55(3), 179 (2005). |
4 | D. U. Lee, C. H. Park, S. I. Kang, E. G. Min, Y. H. Han, and C. K. Lee, Isolation of the component transformed into blue pigments by aerobic bacteria in the fruits of gardenia jasminoides, Kor. J. Pharmacogn., 29(3), 204 (1998). |
5 | P. Mura, M. T. Faucci, and P. Corti, Evaluation of hencer from hydrophlic gel formulations, Eur. J. Pharmaceutical Sci., 9, 365 (2000). DOI ScienceOn |
6 | S. Bian, J. S. Kim, and D. D. Kim, In vitro evaluation of patch formulations for topical delivery of gentisic acid in rats, Eur, J. Pharmaceutical Sci., 18, 141 (2003). DOI ScienceOn |
7 | T. K. Ghosh, W. R. Pfister, and S. I. Yum, Tranderma land Topical Drug Delivery Systems, Interpharm Press, Buffalo Grove, U.S.A. (1997). |
8 | A. C. Williams and B. W. Barry, Essential oils as novel human skin penetration enhancers, Int. J. Pharm., 57, R7 (1989). DOI ScienceOn |
9 | K. Yoneto and D. K. Lee, Mechanistic studies of the 1-alkyl-2-pyrrolidones as skin permeation enhancers, J. Pharm Sci., 84, 312 (1995). DOI ScienceOn |
10 | A. Koizumi and Y. Watanabe, Effect of N-methyl-2-pyrrolidone on skin permeation of estradiol, Eur. J. Pharm. Biopharm., 57, 473 (2004). DOI ScienceOn |
11 | N. Kanikkannan, K. Kandimalla, S. S. Lamba, and M. Singh, Structure activity relationship of chemical penetration enhancers in transdermal drug delivery, Cur. Med. Chem., 6, 593 (1999). |
12 | J. L. Zatz, Optimizing skin delivery, Cosmet. Toiletr., 115, 31 (2000). |
13 | H. S. Gwak and I. K. Chun, Effect of vehicles and penetration enhancers on the in vitro percutaneous absorption often oxicam through hairless mouse skin, Int J. Pharm., 236, 57 (2002). DOI ScienceOn |
14 | D. K. Hincha, A. E. Oliver, and J. H. Crowe, Lipid compositon determines the effects of arbutin on the stability of membranes, Biophysical J., 77, 2024 (1999). DOI ScienceOn |
15 | Y. G. Bachhav and V. B. Patravale, Exploring the potential of n-methyl pyrrolidine as a cosurfactant in the microemulsion systems, Int. J. Pharmaceutics, 326, 186 (2006). DOI ScienceOn |
16 | S. Akhter and B. W. Barry, Absorption through human skin of ibrofen and flurbibrofen, J. Pharm. Pharmacol., 37, 27 (1985). DOI |
17 | B. J. Aungst, N. J. Rogers, and E. Shefter, Enhancement of naloxone penetration through human skin in vitro using fatty acids, fatty alcohols, surfactants, sulfoxides and amides, Int. J. Pharm., 33, 225 (1986). DOI ScienceOn |
18 | J. W. Wiechers, Avoiding transdermal cosmetic delivery, Cosmet. Toiletr., 115, 39 (2000). |
19 | S. Magdassi and E. Touitou, Novel Cosmetic Delivery Systems, Marcel Dekker, NewYork, 1 (1999). |
![]() |