• Archives of Pharmacal Research
• /
• 제27권7호
• /
• pp.738-741
• /
• 2004

Three lignans isolated from the roots of A. koreanum (Araliaceae), namely eleutheroside E(1), tortoside A(2), and hemiariensin(4), were evaluated for their ability to inhibit NFAT transcription factor. Of these compounds, compound 4, possessing a diarylbutane skeleton, exhibited potent inhibitory activity against NFAT transcription factor (($IC_{50}$ ： 36.3${\pm}2.5{\mu}\textrm{M}$). However, the activities of 1 (($IC_{50}$：＞500 11M) and 2 (($IC_{50}$： 136.1 ${\pm}9.4\mu\textrm{M}$), which possess bisaryldioxabicy-clooctane skeletons, were lower. As the lignan derivatives of the same skeletons, hinokinin (5) and (-)-yatein (6) with diarylbutane skeletons and(＋)-syringaresinol (3) with a bisaryldioxabicy-clooctane skeleton were also studied for their inhibitory effects on NFAT transcription factor.

• Structural Engineering and Mechanics
• /
• 제83권3호
• /
• pp.305-326
• /
• 2022

To realize the recycling utilization of waste concrete and alleviate the shortage of resources, 11 specimens of steel reinforced recycled concrete (SRRC) filled circular steel tube columns were designed and manufactured in this study, and the cyclic loading tests on the specimens of columns were also carried out respectively. The hysteretic curves, skeleton curves and performance indicators of columns were obtained and analysed in detail. Besides, the finite element model of columns was established through OpenSees software, which considered the adverse effect of recycled coarse aggregate (RA) replacement rates and the constraint effect of circular steel tube on internal RAC. The numerical calculation curves of columns are in good agreement with the experimental curves, which shows that the numerical model is relatively reasonable. On this basis, a series of nonlinear parameters analysis on the hysteretic behaviors of columns were also investigated. The results are as follows: When the replacement rates of RA increases from 0 to 100%, the peak loads of columns decreases by 7.78% and the ductility decreases slightly. With the increase of axial compression ratio, the bearing capacity of columns increases first and then decreases, but the ductility of columns decreases rapidly. Increasing the wall thickness of circular steel tube is very profitable to improve the bearing capacity and ductility of columns. When the section steel ratio increases from 5.54% to 9.99%, although the bearing capacity of columns is improved, it has no obvious contribution to improve the ductility of columns. With the decrease of shear span ratio, the bearing capacity of columns increases obviously, but the ductility decreases, and the failure mode of columns develops into brittle shear failure. Therefore, in the engineering design of columns, the situation of small shear span ratio (i.e., short columns) should be avoided as far as possible. Based on this, the calculation model on the skeleton curves of columns was established by the theoretical analysis and fitting method, so as to determine the main characteristic points in the model. The effectiveness of skeleton curve model is verified by comparing with the test skeleton curves.

• 한국지반공학회논문집
• /
• 제22권10호
• /
• pp.173-181
• /
• 2006

본 논문에서는 정적 및 액상화와 같은 동적하중을 받는 흙의 거동해석을 위한 두 개의 활성면을 가진 구성모델을 제안하였다. 이 모델은 두 개의 활성면에 기초하고 있으며, 첫번째면은 회전하는 최대전단면을 나타내며 두 번째면은 고정된 수평면을 나타낸다. 이와 같은 두 개의 활성면을 이용하여 본 모델은 초기의 다른 응력상태하에 있는 시료의 직접단순전단시에 발생하는 주응력회전현상을 모델링할 수 있다. 제안된 모델은 초기의 응력비에 관계없이 평균유효응력이 동일할 경우에 유사한 거동을 보이는 흙의 실내실험결과를 묘사할 수 있다 그리고, 배수시 반복 직접단순전단으로 발생하는 흙의 거동 즉 제하시에 나타나는 체적감소 및 대변형에서 발생하는 체적팽창을 묘사할 수 있다. 비배수시의 흙의 정적 및 동적 거동은 배수거동에서 흙 골격사이에 존재하는 물의 구속력을 고려함으로써 해석하였다. 본 모델의 구성관계식은 응력-물의 상관관계를 동시에 묘사할 수 있는 FLAC을 이용하여 구현하였다. 배수 직접단순전단 시험을 이용한 Fraser River Sand의 실험결과를 이용하여 모델을 먼저 검증하였으며, 동일한 입력변수를 이용한 Fraser River Sand 비배수 거동의 예측치와 실험치를 비교하여 검증하였다.

• Structural Engineering and Mechanics
• /
• 제27권6호
• /
• pp.697-711
• /
• 2007

Though extensive research has been carried out for the ultimate strength of steel reinforced concrete (SRC) members under static and cyclic load, there was only limited information on the applied analysis models. Modeling of the inelastic response of SRC members can be accomplished by using a microcosmic model. However, generally used microcosmic model, which usually contains a group of parameters, is too complicated to apply in the nonlinear structural computation for large whole buildings. The intent of this paper is to develop an effective modeling approach for the reliable prediction of the inelastic response of SRC columns. Firstly, five SRC columns were tested under cyclic static load and constant axial force. Based on the experimental results, normalized trilinear skeleton curves were then put forward. Theoretical equation of normalizing point (ultimate strength point) was built up according to the load-bearing mechanism of RC columns and verified by the 5 specimens in this test and 14 SRC columns from parallel tests. Since no obvious strength deterioration and pinch effect were observed from the load-displacement curve, hysteresis rule considering only stiffness degradation was proposed through regression analysis. Compared with the experimental results, the applied analysis model is so reasonable to capture the overall cyclic response of SRC columns that it can be easily used in both static and dynamic analysis of the whole SRC structural systems.

• 한국마린엔지니어링학회:학술대회논문집
• /
• 한국마린엔지니어링학회 2011년도 후기공동학술대회 논문집
• /
• pp.97-98
• /
• 2011

This paper is about the study of a new exo-skeleton device applying a gravity compensator. The exo-skeleton devices is to reduce the external torque applied to the human body joint for the purpose of helping the disabled, reducing heavy payload for industry workers or military soldiers. Most of the exoskeleton devices are actuated by the motors, but motors are limited in energy such that a short durability is always a big problem. In this paper, an exoskeleton device using a new gravity compensator based on a torsion bar is proposed to reduce the torque load applied to human body joints. The exoskeleton device is designed for the lower body of human. Analyses on the torsion bar spring and link of the exoskeleton device using FEM method were performed. To reduce the applied torque to the human joint, a torsion bar gravity compensator is applied to the exoskeleton. The effect of the torsion bar compensator for the exoskeleton device was verified through load test using developed test equipment.

• Journal of Yeungnam Medical Science
• /
• 제8권1호
• /
• pp.32-41
• /
• 1991

비호흡 장애 아동에서 인두편도의 절제가 치조안면골격에 미치는 영향을 연구하기 위해 비호흡 장애 아동 24명의 인두편도 절제전과 절제 1년후의 두부방사선 계측사진과 정상교합 아동의 1년전과 후의 두부방사선 계측사진을 비교분석함으로 다음과 같은 결과를 얻었다. 1. Cranial base variables 두 group간에 유의차가 나타나지 않았다. 2. Craniofacial variables 실험군에서 1년간 성장경향을 보면 Brachyfacial pattern으로 변했지만 대조군에서의 변화는 특정한 경향이 발견되지 않았다. 3. Maxillary variables 실험군에서 1년간 palatal plane의 경사가 평탄해졌고 그 외의 항목에서는 유의차가 발견되지 않았다. 4. Mandibular variables 두 group간에 1년간 성장량의 유의치는 mandibular plane angle과 gonial angle에서 나타났고 특히 실험군에서 감소가 일어났다. 5. Facial height variables 실험군에서 1년간 성장 변화가 하악골의 수평성장회전을 일으켰다. 전항목에서 통계적인 유의차를 나타냈다.

• 한국자동차공학회논문집
• /
• 제15권3호
• /
• pp.166-173
• /
• 2007

A numerical study was conducted to have the effect of $CO_2$ addition to fuel on the chemical reaction mechanism with the change of the initial concentration of $CO_2$ and the axial velocity gradient. From this study, it was found that there were two serious effects of $CO_2$ addition on a non-premixed flame ; a diluent effect by the reactive species reduction and chemical effect of the breakdown of $CO_2$ by the third-body collision and thermal dissociation. Especially, the chemical effect was serious at the lower velocity gradient of the axial flow. It was certain that the mole fraction profile of $CO_2$ was deflected and CO was increased with the initial concentration of $CO_2$. It was also ascertained that the breakdown of $CO_2$ would cause the increasing of CO mole fraction at the reaction region. It was also found that the addition of $CO_2$ did not alter the basic skeleton of $H_2-O_2$ reaction mechanism, but contributed to the formation and destruction of hydrocarbon products such as HCO. The conversion of CO was also suppressed and $CO_2$ played a role of a dilution in the reaction zone at the higher axial velocity gradient.

• 천문학회보
• /
• 제38권2호
• /
• pp.58.1-58.1
• /
• 2013

The main idea of the Alcock-Paczynski (AP) test is that, if we use a wrong distance-redshift relation to infer the shape of a spherical object in the Universe, this object may look non-spherical. To probe the cosmic expansion history through the AP test, the key point is to find something which is known as spherical in the Universe. We propose two possible ways applying the AP test to the large scale structure (LSS): 1) Based on the observed galaxies or quasars, one built up the beta-skeleton tracing the LSS, and investigating the inhomogeneity of the connections; 2) One reconstructs the smoothed density-contrast gradient field based on LSS observations, and investigating the inhomogeneity of the gradient vectors. Compared with some existed methods probing AP effect through 2-point correlation function, galaxy pairs, or voids, our methods have various advantages: 1) The information of both the high and low dense regions of the LSS are taken into account. 2) The redshift space distortion as the main contamination to the AP effect can be easily removed.

• Geomechanics and Engineering
• /
• 제8권2호
• /
• pp.257-282
• /
• 2015

In this study, the authors present a coupled fluid-structures-seabed interaction analysis of a monopile type of wind turbine foundations in liquefiable soils. A two dimensional analysis is performed with a nonlinear stiffness degradation model incorporated in the finite difference program Fast Lagrangian Analysis of Continua (FLAC), which captured the fundamental mechanisms of the monopiles in saturated granular soil. The effects of inertia and the kinematic flow of soil are investigated separately, to highlight the importance of considering the combined effect of these phenomena on the seismic design of offshore monopiles. Different seismic loads, such as those experienced in the Kobe, Santa Cruz, Loma Prieta, Kocaeli, and Morgan Hill earthquakes, are analyzed. The pore water pressure development, relative displacements, soil skeleton deformation and monopile bending moment are obtained for different predominant frequencies and peak accelerations. The findings are verified with results in the liter.

• 한국가금학회지
• /
• 제21권3호
• /
• pp.157-168
• /
• 1994

This study was carried out to elucidate the time course variation of vitamin $D_{3}$ (V$D_{3}$) and 25-hydroxyvitamin $D_{3}$ [25(OH)$D_{3}$] contents in the liver and skeleton of 3-wk old broiler chicks when treated with different UV irradiation procedure. Day-old Hubbard chicks were fed vitamin D deficient diet for 3 wk and exposed to medium wave ultraviolet(UVB) light with different irradiation procedures. Procedure I was 30 min continuous irradiation(O.204 mJ /$cm^{2}$) and Procedure II was three seperate 10 min irradiation with 12 h intervals, and Procedure III was three seperate 10 min irradiation with 24 h intervals. The liver and skeleton samples were collected at 10 different times between 0000~2400 h after the last irradiation. The V$D_{3}$ and 25(OH)$D_{3}$ fractions wereseparated by Sep-Pak silica cartridge and the concentrations were determined by normal phase HPLC. The mean content of V$D_{3}$ in the liver of the birds treated by Procedure II was 6.68 ng /g, which was higher than 5.60 and 5.30 ng /g from Procedure I and Ill, respectively(P<.O5). With regard to the effect of elapsed time after UVB irradiation on the V$D_{3}$ concentration of the liver, 96 h treatment showed the highest value(13.08 ng/g)(P<.05). There was a significant(P$D_{3}$ were significantly(P$D_{3}$ in the skeleton of tibia and femur, there were no significant differences among Procedure I, II and III, but significant differences were found among those from various elapsed time after irradiation, The highest value was shown at 96 h(O.99 ng /g) treatment, and interaction between irradiation procedure and elapsed time was not significant. With regard to the mean content of 25(OH)$D_{3}$ in bone, the Procedure II(18.79 ng /g) and III(17.73 ng /g) showed higher values than Procedure I did (P<.05), and the 12 h elapsed time showed the highest value(31.17 ng /g) among 10 treatments (P<.05), however, there was no significant interaction between exposing procedure and elapsed time. In conclusion, the Procedure II would he more desirable than Procedure I or III to produce more V$D_{3}$ and 25(OH)$D_{3}$ in the liver and skeleton of birds by exposing to the UVB light. Also, it was verified that 25(OH)$D_{3}$ increases more quickly than V$D_{3}$ in both tissues tested and is utilized more quickly to recover from the rickets of chicks.