• Molecules and Cells
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• v.25 no.1
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• pp.78-85
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• 2008

In a search for new molecular pathways associated with asthma, we performed an mRNA differential display analysis using total RNA extracted from the tracheal tissues of ovalbumin (OVA)-challenged mice and sham controls. cDNAs corresponding to mRNAs for which expression levels were altered by OVA-challenge were isolate and sequenced. Twenty-eight genes differentially expressed in sham and OVA challenged mice were identified. A GenBank BLAST homology search revealed that they were related to cytoskeleton remodeling, transcription, protein synthesis and modification, energy production, and cell growth and differentiation. Two were selected for further characterization. Up-regulation of both the perinatal skeletal myosin heavy chain (skMHC) and fast skeletal muscle myosin light chain (skMLC) genes was confirmed by RT-PCR of trachea tissue from OVA challenged mice. Overexpression of skMLC protein was observed in the smooth muscle layers of OVA-challenged mice by immunohistochemistry, and the surface areas stained with skMLC antibody increased in the OVA-challenged mice. The overexpression of skMLC in murine asthma may be associated with the changes of bronchial smooth muscle.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.4
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• pp.239-245
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• 2013

The data retention characteristics depending on neighbor cell's threshold voltage (Vt) in a multilevel NAND flash memory is studied. It is found that a Vt shift (${\Delta}Vt$) of the noted cell during a thermal retention test is increased as the number of erase-state (lowest Vt state) cells surrounding the noted cell increases. It is because a charge loss from a floating gate is originated from not only intrinsic mechanism but also lateral electric field between the neighboring cells. From the electric field simulation, we can find that the electric field is increased and it results in the increased charge loss as the device is scaled down.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.1
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• pp.36-42
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• 2016

In multi-level-cell based storage devices, TLC NAND has been employed solid state drive due to cost effectiveness. Since TLC has slow performance and low endurance compared with MLC, TLC based storage has adopted SLC buffer scheme to improve performance. To improve SLC buffer scheme, this paper proposes page overwriting method in SLC block. This method provides data updates without erase operation within a limited number. When SLC buffer area is filled up, FTL should execute copying valid pages and erasing it. The proposed method reduces erase counts by 50% or more compared with previous SLC buffer scheme. Simulation results show that the proposed SLC buffer overwrite method achieves 2 times write performance improvement.

• The Journal of Korean Society for Radiation Therapy
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• v.10 no.1
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• pp.88-93
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• 1998

Multileaf collimator is essential equipment in conformal radiation therapy, however the use is limitted by increase of penumbra width and undulating dose distribution at the field edge. The purpose of this study is to improve the penumbra and dose distribution in the multileaf collimator field edge. Measurement were performed with X-omat V film in solid water phantom using 6MV photon beam from Siemens linear accelerator. All the measurement were made along the central axis of $5{\times}5cm,\;10{\times}10cm$ circular field for constant SSD of 100 cm. To improve the penumbra and dose distribution collimator was rotated by 15 degrees from 0 to 90 degrees (collimator rotation method) and center was shifted to the longitudinal direction by fourth of lead width (center shift method). We compare the penumbra and dose distribution at the field edge to alloy block. Dose distribution and penumbra width at the feild edge of MLC showed undulated dose pattern and increased penumbra compared with alloy block. However, in the collimator rotation method and center shift method we abtained simular results with alloy block. Through the study we expected that clinical use of MLC will be increase.