• KSCE Journal of Civil and Environmental Engineering Research
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• v.35 no.3
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• pp.725-735
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• 2015

The aim of this study is to specifically understand the officetel market by empirical analysis for the determining factors that affect determining the price of the officetel in Busan. In my opinion, it can help officetel providers to select the appropriate size and location that analysis for the factors determining officetel price with market price, and also it can help customers officetel to choice depending on the purpose. So I was conducting this study. In this study, I analyzes the factors determining the price of Officetel using a OLS linear regression, semi-log model, and a robust regression-Busan area Officetel Real Transaction Price as the dependent variable and factors representing the physical characteristics, locational characteristics and regional characteristics as independent variables.

• Korean Journal of Veterinary Research
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• v.45 no.2
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• pp.223-231
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• 2005

A quantitative risk assessment tool was used to provide estimates of the probability that foot-and-mouth (FMD) virus-contaminated, smuggled animal products are fed to susceptible swine in Korea. Sensitivity analyses were conducted to attempt to distinguish between parameter uncertainty and variability, using different assumptions on the effect of cooking at home, the effect of the fresh meat, and the effect of heat treatment at garbage processing facility. The median risk estimate was about 20.1% with a mean value of 27.4%. In a scenario regarding all beef and pork were considered as fresh meat the estimated median risk was 3.4%. The risk was greatly dependent on the survival parameters of the FMD virus during the cooking or heat treatment at garbage processing facility. Uncertainty about the proportion of garbage that is likely contaminated with FMD had a major positive influence on the risk, whereas conversion rate representing the size of a load had a major negative effect. This model was very useful in assessing the risk explored. However, the model also requires enhancements, such as the availability of more accurate data to verify the various assumptions considered such as FMD prevalence in a specific country, proportion of garbage which is recycled as feed, proportion of food discarded as garbage. Other factors including the effect of selection of animals for slaughter, ante- and post-mortem inspection, the domestic distribution of the smuggled products, and susceptible animals other than pigs, are need to be taken into account in the future model development.

• Smart Structures and Systems
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• v.13 no.2
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• pp.177-201
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• 2014

With the increased size and flexibility of the tower and blades, structural vibrations are becoming a limiting factor towards the design of even larger and more powerful wind turbines. Research into the use of vibration mitigation devices in the turbine tower has been carried out but the use of dampers in the blades has yet to be investigated in detail. Mitigating vibrations will increase the design life and hence economic viability of the turbine blades and allow for continual operation with decreased downtime. The aim of this paper is to investigate the effectiveness of Semi-Active Tuned Mass Dampers (STMDs) in reducing the edgewise vibrations in the turbine blades. A frequency tracking algorithm based on the Short Time Fourier Transform (STFT) technique is used to tune the damper. A theoretical model has been developed to capture the dynamic behaviour of the blades including the coupling with the tower to accurately model the dynamics of the entire turbine structure. The resulting model consists of time dependent equations of motion and negative damping terms due to the coupling present in the system. The performances of the STMDs based vibration controller have been tested under different loading and operating conditions. Numerical analysis has shown that variation in certain parameters of the system, along with the time varying nature of the system matrices has led to the need for STMDs to allow for real-time tuning to the resonant frequencies of the system.

• Health Policy and Management
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• v.29 no.2
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• pp.160-171
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• 2019

Background: This study purposed to compare the difference on medical utilization and health expenditure of baby boomer generation by depression between gender. Methods: Korea Welfare Panel Survey 2016, provided by the Korea Institute for Health and Social Affairs, was used for the analysis. For the research, we used the two-part model, yes or no of use (part 1), and frequency of use (part 2) for medical utilization. The dependent variables are the whether or not to use of hospitalization services, outpatient services, length of stay, outpatient service visits, and health expenditure. And the independent variables are used as the predisposing (education, spouse presence), enabling (insurance type, private insurance, economic activity, income), and need (chronic disease, self-rated health, disability) factors in the Andersen behavior model. Depression was used as intervening variables. Structural equation model and multiple group analysis by gender were used. Results: There were differences in the medical care usage and cost between men and women in baby boomer. For men, mediating effects of depression were present at the hospitalization (yes/no), length of stay, and health expenditure. On the other hand, for women, the mediating effect of depression was found only at the outpatient visits. Specially, depression was working at the medical services by the different way between gender. The size of effect (multiple group analysis) was affected by significant differences between men and women. Conclusion: This study found that the mediating effect of depression is increased medical usage and health expenditure and the effect factors are different by gender. Therefore, it is necessary to establish a medical care policy considering the socio-economic characteristics of baby boomers.

• Nutrition Research and Practice
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• v.13 no.3
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• pp.205-213
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• 2019

BACKGROUND/OBJECTIVES: Myocardial infarction (MI) is caused by extensive myocardial damage attributed to the occlusion of coronary arteries. Our previous study in a rat model of ischemia/reperfusion (I/R) demonstrated that administration of arabinoxylan (AX), comprising arabinose and xylose, protects against myocardial injury. In this study, we undertook to investigate whether psyllium seed husk (PSH), a safe dietary fiber containing a high level of AX (> 50%), also imparts protection against myocardial injury in the same rat model. MATERIALS/METHODS: Rats were fed diets supplemented with PSH (1, 10, or 100 mg/kg/d) for 3 d. The rats were then subjected to 30 min ischemia through ligation of the left anterior descending coronary artery, followed by 3 h reperfusion through release of the ligation. The hearts were harvested and cut into four slices. To assess infarct size (IS), an index representing heart damage, the slices were stained with 2,3,5-triphenyltetrazolium chloride (TTC). To elucidate underlying mechanisms, Western blotting was performed for the slices. RESULTS: Supplementation with 10 or 100 mg/kg/d of PSH significantly reduces the IS. PSH supplementation (100 mg/kg/d) tends to reduce caspase-3 generation and increase BCL-2/BAX ratio. PSH supplementation also upregulates the expression of nuclear factor erythroid 2-related factor 2 (NRF2), and its target genes including antioxidant enzymes such as glutathione S-transferase mu 2 (GSTM2) and superoxide dismutase 2 (SOD2). PSH supplementation upregulates some sirtuins ($NAD^+$-dependent deacetylases) including SIRT5 (a mitochondrial sirtuin) and SIRT6 and SIRT7 (nuclear sirtuins). Finally, PSH supplementation upregulates the expression of protein kinase A (PKA), and increases phosphorylated cAMP response element-binding protein (CREB) (pCREB), a target protein of PKA. CONCLUSIONS: The results from this study indicate that PSH consumption reduces myocardial I/R injury in rats by inhibiting the apoptotic cascades through modulation of gene expression of several genes located upstream of apoptosis. Therefore, we believe that PSH can be developed as a functional food that would be beneficial in the prevention of MI.

• Biomolecules & Therapeutics
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• v.30 no.2
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• pp.151-161
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• 2022

This study elucidates the anti-cancer potential of gallic acid (GA) as a promising therapeutic agent that exerts its effect by regulating the PI3K/Akt pathway. To prove our research rationale, we used diverse experimental methods such as cell viability assay, colony formation assay, tumor spheroid formation assay, cell cycle analysis, TUNEL assay, Western blot analysis, xenograft mouse model and histological analysis. Treatment with GA inhibited cell proliferation in dose-dependent manner as measured by cell viability assay at 48 h. GA and cisplatin (CDDP) also inhibited colony formation and tumor spheroid formation. In addition, GA and CDDP induced apoptosis, as determined by the distribution of early and late apoptotic cells and DNA fragmentation. Western blot analysis revealed that inhibition of the PI3K/Akt pathway induced upregulation of p53 (tumor suppressor protein), which in turn regulated cell cycle related proteins such as p21, p27, Cyclin D1 and E1, and intrinsic apoptotic proteins such as Bax, Bcl-2 and cleaved caspase-3. The anti-cancer effect of GA was further confirmed in an in vivo mouse model. Intraperitoneal injection with GA for 4 weeks in an A549-derived tumor xenograft model reduced the size of tumor mass. Injection of them downregulated the expression of proliferating cell nuclear antigen and p-Akt, but upregulated the expression of cleaved caspase-3 in tumor tissues. Taken together, these results indicated that GA hindered lung cancer progression by inducing cell cycle arrest and apoptosis, suggesting that GA would be a potential therapeutic agent against non-small cell lung cancer.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.5
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• pp.1159-1165
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• 2006

This study was done to investigate the effects of Gamisojaganggi-tang(GSGT) on immunopathologic changes in OVA-induced asthma model of mice. Pathologic indicators associated with this immune disease, which include cytokines, the number of immune-cells, immunoglobin E (IgE), were examined, and histological changes of bronchial tissues were also examined. The administration of GSGT significantly reduced the lung weight compared with control mice of OVA-induced asthma model. The administration of GSGT significantly reduced the number of total cells in BALF compared with control mice of OVA-induced asthma model. The administration of GSGT significantly reduced the number of eosinophil in BALF compared with control mice of OVA-induced asthma model. The administration of GSGT insignificantly increased the number of monocyte in BALF compared with control mice of OVA-induced asthma model. The administration of GSGT significantly reduced the number of lymphocyte in BAL compared with control mice of OVA-induced asthma model. The administration of GSGT significantly reduced the gene expression of eotaxin in lung tissue compared with control mice of OVA-induced asthma model. The administration of GSGT insignificantly reduced the IL-4 and IL-5 production in BALF compared with control mice of OVA-induced asthma model. The administration of GSGT insignificantly reduced the levels of total IgE and ovalbumin-specific IgE in BALF. The administration of GSGT significantly reduced the levels of ovalbumin-specific IgE whereas the serum levels of total IgE were insignificantly reduced compared with control mice of OVA-induced asthma model. The administration of GSGT moderately reduced bronchial alveolar narrowing, bronchiovascular edema and increase in the size of alveolar space, which shown in control mice of OVA-induced asthma model, in a dose dependent manner. Furthermore, GSGT reduced invasion of inflammatory cells, and proliferation of smooth muscle cells in bronchial tissue. These results suggested that GSGT has suppressive effects on pathologic changes associated with disease progression in asthma through the modulation of immune system. GSGT has potential to use as an anti-asthmatic agents.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.8B
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• pp.667-680
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• 2008

In this work, we present the results of our empirical study on 802.11 wireless LAN network traffic. We collect the packet trace from existing campus wireless LAN infra-structure. We analyzed four different data sets: aggregate traffic, upstream traffic, downstream traffic, tcp only packet trace from aggregate traffic. We analyze the time series aspect of underlying traffic (byte count process and packet count process), marginal distribution of time series, and packet size distribution. We found that in all four data sets there exist long-range dependent property in byte count and packet count process. Inter-arrival distribution is well fitted with Pareto distribution. Upstream traffic, i.e. from the user to Internet, exhibits significant difference in its packet size distribution from the rests. Average packet size of upstream traffic is 151.7 byte while average packet size of the rest of the data sets are all greater than 260 bytes. Packets with full data payloads constitutes 3% and 10% in upstream traffic and the downstream traffic, respectively. Despite the significant difference in packet size distribution, all four data sets have similar Hurst values. The Hurst alone does not properly explain the stochastic characteristics of the underlying traffic. We model the underlying traffic using fractional-ARIMA (FARIMA) and fractional Gaussian Noise (FGN). While the fractional Gaussian Noise based method is computationally more efficient, FARIMA exhibits superior performance in accurately modeling the underlying traffic.

• 한국신재생에너지학회:학술대회논문집
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• 2010.11a
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• pp.122.2-122.2
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• 2010

Knowledge of ground thermal properties is most important for the proper design of BHE(borehole heat exchanger) systems. The configure type, pipe size and thermal performance of the BHE is highly dependent on the ground source heatpump system-efficiency and instruction cost. Thermal response tests with mobile measurement devices were developed primarily for in-situ determination of design data for Standing Column Well apply. The main purpose has been to determine in-situ values of effective ground thermal conductivity and thermal resistance, including the effect of ground-water flow and natural convection in the boreholes. The test rig is set up on a some trailer, and contains a sub-circulation pump, a boiler, temperature sensors, flow meter and a data logger for recording the temperature and circulation fluid flow data. A constant heating power is injected into the SCW through the test rig and the resulting temperature change in the SCW is recorded. The recorded temperature data are analysed with a line-source model, which gives the effective in-situ values of rock thermal conductivity and thermal resistance of SCW.

• Advances in nano research
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• v.9 no.3
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• pp.157-172
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• 2020

The aim of this present research is the effect of the higher-order terms of the governing equation on the forced longitudinal vibration of a nanorod model and making comparisons of the results with classical nonlocal elasticity theory. For this purpose, the free axial vibration along with forced one under the two various linear and harmonic axial concentrated forces in zigzag Single-Walled Carbon Nanotube (SWCNT) are analyzed dynamically. Three various theories containing the classical theory, which is called Eringen's nonlocal elasticity, along with Rayleigh and Bishop theories (higher-order theories) are established to justify the nonlocal behavior of constitutive relations. The governing equation and the related boundary conditions are derived from Hamilton's principle. The assumed modes method is adopted to solve the equation of motion. For the free axial vibration, the natural frequencies are calculated for the various values of the nonlocal parameter only based on Eringen's theory. The effects of the nonlocal parameter, thickness, length, and ratio of the excitation frequency to the natural frequency over time in dimensional and non-dimensional axial displacements are investigated for the first time.