• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2014.06a
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• pp.107-108
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• 2014

As the demand for precise navigation has increased, more focus is put on the precise positioning, RTK(Real Time Kinematics) which has been used in the surveying field. The Position of Single Reference Station RTK or two-way network RTK such as VRS (Virtual Reference Station) is accurate enough to be used as a main technology in land surveying, however its service area and number of users is limited and the users are assumed static. This characteristic is not suitable to the navigation, whose service target is infinite number of users moving over a wide area. One-way network RTK has recently been suggested as a solution for the precise navigation technique for the mobile user. This paper shows the performance prediction of the one-way network RTK such as MAC(Master-Auxiliary Concept), or FKP (Flachenkorrekturparameter). To show the performance variation by the rover position, we constructed a simulation data of users on the grid with 0.1 degree spacing between 36.5 and 37 degree latitude and between 127 and 127.5 degree longitude.

• Korean Journal of Pharmacognosy
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• v.48 no.3
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• pp.179-186
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• 2017

Pyrrosia lingua which belongs to Polypodiaceae has been used as a traditional medicine for the treatment of urinary system inflammation, urination disorder, and bronchitis. However, there are not enough phytochemical and pharmacological studies of P. lingua up to now. Here in this study, the protective effect of MeOH extract of whole plant of Pyrrosia lingua (MPL) against 2% glucose-induced toxicity was investigated using Caenorhabditis elegans (C. elegans) model system. We found that MPL significantly extended the lifespan of wild-type nematode under normal culture condition. MPL also effectively recovered the decreased lifespan caused by 2% glucose-toxicity. In addition, MPL efficiently attenuated the increased glucose concentration inside of nematode. Further studies evaluating diabetes-related factors revealed that MPL reduced both intracellular ROS and lipid accumulation which were up-regulated under 2% glucose supplement condition. Our data also showed that MPL improved the 2% glucose-induced shortened body movement of nematode. Lastly, we carried out genetic studies using several single gene knockout mutants to establish the possible target of MPL. Our results demonstrated that genes such as daf-2 and daf-16 were responsible for the protective activity of MPL against 2% glucose-induced toxicity. These results indicate that MPL exerts protective action against 2% glucose via regulation of insulin/IGF-1 sinaling pathway and FOXO activation.

• Journal of KIISE:Computing Practices and Letters
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• v.14 no.2
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• pp.246-250
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• 2008

This paper presents the design of network vulnerability analysis system which can integrate various vulnerability assessment tools to improve the preciseness of the vulnerability scan result. Manual checking method performed by a security expert is the most precise and safe way. But this is not appropriate for the large-scale network which has a lot of systems and network devices. Therefore automatic scanning tool is recommended for fast and convenient use. The scanning targets may be different according to the kind of vulnerability scanners, or otherwise even for the same scanning target, the scanning items and the scanning results may be different by each vulnerability scanner, Accordingly, there are the cases in which various scanners, instead of a single scanner, are simultaneously utilized with the purpose of complementing each other. However, in the case of simultaneously utilizing various scanners on the large-scale network, the integrative analysis and relevance analysis on vulnerability information by a security manager becomes time-consumable or impossible. The network vulnerability analysis system suggested in this paper provides interface which allows various vulnerability assessment tools to easily be integrated, common policy which can be applied for various tools at the same time, and automated integrative process.

• Herbal Formula Science
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• v.25 no.2
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• pp.135-143
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• 2017

Objectives : This trial aimed to determine if Wasong (Orostachys japonicus) extract can enhance immune system and is safe enough to be approved as a health functional food. Methods : Total 62 people, aged 45 and older, will be recruited to participate in a randomized, double-blind, placebo-controlled clinical trial. This study will compare Wasong extract and placebo. Wasong group will take 1g of Wasong extract, once a day, for 8 weeks. Placebo group will take 1g of crystalline cellulose as placebo, once a day, for 8 weeks. Outcomes will be measured at the baseline, the end of 4th week, and 8th week. Primary outcomes are the ratio of NK cells/total lymphocytes and the ratio of T-helper cells/T-suppressor cells. Secondary outcomes are total white blood cell count, the ratio of neutrophils, lymphocytes, and monocytes in total leukocytes, the ratio of total T cells, T-helper cells, T-suppressor cells, and B cells to lymphocytes, the amount of blood IgM, IgG, IgA, and cytomegalovirus (CMV) IgG, and blood metabolite target &global analysis. Results : This trial was approved by institutional review board of Pusan National University Korean Medicine Hospital (registry number: 2016006), and registered in Clinical Research information Service, one of WHO International Clinical Trials Registry Platform (registry number: PRE20161006-002). Recruitment opened in February 2017 and is supposed to be completed by August 2017. The result is expected to be published by June 2018. Conclusion : This trial will provide clinical information to determine the efficacy and safety of Wasong in enhancing immune system of middle-aged and older people.

• Journal of Microbiology and Biotechnology
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• v.17 no.10
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• pp.1670-1674
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• 2007

Duffy binding protein (DBP) plays a critical role in Plasmodium vivax invasion of human red blood cells. We previously reported a single-chain antibody fragment (scFv) that was specific to P. vivax DBP (PvDBP). However, the stabilization and the half-life of scFvs have not been studied. Here, we investigated the effect of PEGylated scFvs on their biological activity and stability in vitro. SDS-PAGE analysis showed that three clones (SFDBII-12, -58, and -92) were formed as monomers (about 70 kDa) with PEGylation. Clone SFDBII-58 gave the highest yield of PEGylated scFv. Binding analysis using BIAcore between DBP and scFv showed that both SFDBII-12 and -58 were decreased approximately by two folds at the level of binding affinity to DBP after PEGylation. However, the SFDBII-92 clone still showed a relatively high level of binding affinity ($K_D=1.02{\times}10^{-7}\;M$). Binding inhibition assay showed that PEGylated scFv was still able to competitively bind the PvDBP and playa critical role in inhibiting the interactions between PvDBP protein expressed on the surface of Cos-7 cells and Duffy receptor on the surface of erythrocytes. When both scFvs and their PEGylated counterparts were exposed to trypsin, scFv was completely degraded only after 24 h, whereas 35% of PEGylated scFvs remained intact, maintaining their stability against the proteolytic attack of trypsin until 72 h. Taken together, these results suggest that the PEGylated scFvs retain their stability against proteolytic enzymes in vivo, with no significant loss in their binding affinity to target antigen, DBP.

• Journal of Microbiology and Biotechnology
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• v.19 no.3
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• pp.323-330
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• 2009

Nontuberculous mycobacteria (NTM) are a major cause of opportunistic infections in immunocompromised patients, making the reliable and rapid identification of NTM to the species level very important for the treatment of such patients. Therefore, this study evaluated the usefulness of the novel target genes tuf and tmRNA for the identification of NTM to the species level, using a PCRrestriction fragment length polymorphism analysis (PRA). A total of 44 reference strains and 17 clinical isolates of the genus Mycobacterium were used. The 741 bp or 744 bp tuf genes were amplified, restricted with two restriction enzymes (HaeIII/MboI), and sequenced. The tuf gene-PRA patterns were compared with those for the tmRNA (AvaII), hsp65 (HaeIII/HphI), rpoB (MspI/HaeIII), and 16S rRNA (HaeIII) genes. For the reference strains, the tuf gene-PRA yielded 43 HaeIII patterns, of which 35 (81.4%) showed unique patterns on the species level, whereas the tmRNA, hsp65, rpoB, and 16S rRNA-PRAs only showed 10 (23.3%), 32 (74.4%), 19 (44.2%), and 3 (7%) unique patterns after single digestion, respectively. The tuf gene-PRA produced a clear distinction between closely related NTM species, such as M. abscessus (557-84-58) and M. chelonae (477-84-80-58), and M. kansasii (141-136-80-63-58-54-51) and M. gastri (141-136-117-80-58-51). No difference was observed between the tuf-PRA patterns for the reference strains and clinical isolates. Thus, a diagnostic algorithm using a tuf gene-targeting PRA is a promising tool with more advantages than the previously used hsp65, rpoB, and 16S rRNA genes for the identification of NTM to the species level.

• Environmental and Resource Economics Review
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• v.20 no.3
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• pp.595-628
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• 2011

This study investigates the issues and suggests reform measures in applying CV methods to the Korea Development Institute's (KDI's) Preliminary Feasibility Test (PFT) of public projects. Most public projects on culture, science and environment evaluated under the PFT system belong to the category of "nonstandard" projects whose outputs are non-marketed, and CV is currently the main tool used for their benefit estimation. A careful discussion and investigation is recommended for the selection of target population, payment vehicle, and number of payment times. Operating expert reviews, focus group interviews, and pre-tests is highly recommended to reduce the potential bias involved in the CV studies. A single or double bounded dichotomous choice format is the most popular design of questionnaire, but we identify several undissolved issues in designing and implementing the format. Some other forms of inducing WTPs may still deserve our consideration. Various specifications of the WTP function need to be tried and tested based on their stability, in particular. Employing a nonparametric approach is also recommended. Treatments of 0 or negative WTPs and protest bids are shown to be the most serious issues that affect the estimation results significantly. We review diverse measures of handling those issues and summarize their advantages and shortcomings.

• Journal of Broadcast Engineering
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• v.3 no.1
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• pp.69-84
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• 1998

In digital broadcasting, services such as digital satellite TV, cable TV and digital terrestrial TV, several video programs are compressed by MPEG-2, and then simultaneously transmitted over a conventional CBR (Constant Bit Rate) broadcasting channel. In this paper, we propose a joint quality control scheme to be able to accurately control the relative picture quality among the video programs, which is achieved by simdt;,nL'Ously controlling the video encoders to generate the VBR (Variable Bit Rate) compressed video streams. Our quality control scheme can prevent the video buffer overflow and underflow by total target bit allocation process, and also exactly control the relative picture quality in terms of PSNR (Peak Signal to Noise Ratio) between some programs requiring higher picture quality and others by rate-distortion modification. Furthermore we present a rate-distortion estimation method for MPEG-2 video, which is base of our joint quality control, and verify its performance by experiments. The most attractive features of this estimation method are as follows: 1) computational complexity is low because main operation for the estimation is to calculate the histogram of OCT coefficients into quantizer; 2) estimation results are very accurate enough to be applied to the practical MPEG-2 video coding applications. Simulation results show that the proposed joint quality control scheme accurately controls the relative picture quality among the video progran1s transmitted over a single channel as well as provides more consistent and higher picture quality than independent coding scheme that encodes each program independently.

• The Journal of the Korea Contents Association
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• v.7 no.4
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• pp.241-249
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• 2007

This article addresses considerations, processes of drawing concepts and design approaches in compiling a corporate brochure set in the practice of editorial design. A well-made brochure does not simply refer to listings of the current state of a company and a fantastic visualization of their visions. It necessarily involves the utilization of strategic core keywords appropriate to the industry, proper and classy metaphors that fit the target, a certain harmony between direct and indirect narratives, and bringing all of these aspects under the hat of creative and purposeful design in a single brochure. Thus, it also calls for variety and changes to captivate the eye when leafing through brochures. 1. Does the brochure reflect accurate diagnoses on the position of the market environment, the industry and their needs? 2. Does it offer solutions to given tasks, does it claim to be able to solve problems a company may have, does it satisfy their expectations, and does it cover the topics in an in-depth manner? 3. Referring to questions 1 & 2, does it address existing cases of competitors, leading players and global trends? 4. Does it have an appropriate design language that can communicate intrinsic issues and global trends as well as appropriate rhetorical visual aids that stand out?

• The Journal of the Korea Contents Association
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• v.15 no.8
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• pp.579-587
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• 2015

The purpose of this study is to investigate how Korean learners perceive English vowels and further to test SLM which claims that new L2 vowel categories are more easily acquired than similar L2 vowel categories. Twenty Korean learners participated in English-to-Korean mapping test and English vowel identification test with target vowels /i, ɪ, u, ʊ, ɛ, æ/. The result revealed that Korean participants mapped the English pairs /i/-/ɪ/ and /u/-/ʊ/ onto single Korean vowel /i/ and /u/, respectively. in addition, both of English /ɛ/ and /æ/ were simultaneously mapped onto Korean /e/ and /ɛ/. This indicated that the Korean participants seemed to have perceptual difficulty for the pairs /i-ɪ/, /u-ʊ/, and /ɛ-æ/. The result of the forced-choice identification test showed that the accuracy of /ɪ, ʊ, æ/(ɪ: 81.3%, ʊ: 62.5%, æ: 60.0%) was significantly higher than that of /i, u, ɛ/(i: 28,8%, u: 28.8%, ɛ: 32.4%). Thus, the claim of SLM is confirmed given that /ɪ, ʊ, æ/ are new vowel categories whereas /i, u, ɛ/ are similar vowel categories. Further, the conspicuously low accuracy of the similar L2 vowel categories /i, u, ɛ/ was accounted for by over-generalization whereby the Korean participants excessively replaced L2 similar /i, u, ɛ/ with L2 new /ɪ, ʊ, æ/ as the participants were learning the L2 new vowel categories in the process of acquisition. Based on the findings this study, pedagogical suggestions are provided.