• Journal of the Korean Society of Radiology
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• v.16 no.2
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• pp.103-113
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• 2022

In this paper, a combined ¹⁸F-FDG(fluorodeoxyglucose) and MNP(magnetic nanoparticles) contrast agent was synthesized using N-(p-maleimidophenyl) isocyanate as the crosslinker for use in simultaneous PET-MRI scans. PET-MRI images were acquired and evaluated before and after injection of the combined contrast imaging agent (¹⁸F-FDG labeled MNP) from a glioma stem cell mouse model. After setting the region of interest (ROI) on each acquired image, the area of the lesion was calculated by segmentation. As a result, the PET image was larger than the MRI. In particular, the simultaneous PET-MRI images showed accurate lesions along with the surrounding soft tissue. The mean and standard deviation values were higher in the MRI images alone than in the PET images or the simultaneous PET-MRI images, regardless of whether the contrast agent was injected. In addition, the simultaneous PET-MRI image values were higher than for the PET images. For PSNR experiments, the original image was PET Image using 18F-FDG, MRI using MNPs, and MRI without contrast medium, and the target image was simultaneous PET-MRI image using 18F-FDG labeled MNPs contrast medium. As a result, all of them appeared significantly, suggesting that the 18F-FDG labeled MNPs contrast medium is useful. Future research is needed to develop an agent that can simultaneously diagnose and treat through SPECT-MRI imaging research that can use various nuclides.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.02a
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• pp.1-1
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• 2011

We developed a new generalized synthetic procedure, called as "heat-up process," to produce uniform-sized nanocrystals of many transition metals and oxides without a size selection process. We were able to synthesize uniform magnetite nanocrystals as much as 1 kilogram-scale from the thermolysis of Fe-oleate complex. Clever combination of different nanoscale materials will lead to the development of multifunctional nano-biomedical platforms for simultaneous targeted delivery, fast diagnosis, and efficient therapy. In this presentation, I would like to present some of our group's recent results on the designed fabrication of multifunctional nanostructured materials based on uniform-sized magnetite nanoparticles and their medical applications. Uniform ultrasmall iron oxide nanoparticles of <3 nm were synthesized by thermal decomposition of iron-oleate complex in the presence of oleyl alcohol. These ultrasmall iron oxide nanoparticles exhibited good T1 contrast effect. In in vivo T1 weighted blood pool magnetic resonance imaging (MRI), iron oxide nanoparticles showed longer circulation time than commercial gadolinium complex, enabling high resolution imaging. We used 80 nm-sized ferrimagnetic iron oxide nanocrystals for T2 MRI contrast agent for tracking transplanted pancreatic islet cells and single-cell MR imaging. We reported on the fabrication of monodisperse magnetite nanoparticles immobilized with uniform pore-sized mesoporous silica spheres for simultaneous MRI, fluorescence imaging, and drug delivery. We synthesized hollow magnetite nanocapsules and used them for both the MRI contrast agent and magnetic guided drug delivery vehicle.

• Proceedings of the Safety Management and Science Conference
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• 2008.04a
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• pp.295-299
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• 2008

This paper discusses tests of factor effect or contrast by the use of saturated design $k^n$ factorial design. The nine nonparametric rank measures in normality test using normal probability pot are proposed. Length's PSE(Pseduo Standard Error) test [4] which relies on the concept of effect sparsity is also introduced and extended to the margin of error(ME) and Simultaneous margin of error(SME).

• Proceedings of the IEEK Conference
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• 2002.06d
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• pp.251-254
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• 2002

Currently many devices reproduce electronic images in a variety of ways. However, the colors that are reproduced are different from the original color due to the differences in the gamut between devices. In this paper, a gamut mapping method utilizing a simultaneous mapping function and a lightness rescaling is proposed. This method enhance the local-color characteristics and lightness contrast. The experimental result shows that the overall contrast and the colorfulness were increased.

• Journal of applied mathematics & informatics
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• v.3 no.2
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• pp.129-148
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• 1996

This paper propose the inference mechanism for handling linear polynomial constraints called consistency checking algorithm based on the feasibility checking algorithm borrowed from linear pro-gramming. in contrast with other approaches proposed algorithm can efficiently and coherented by linear polynomial forms. The developed algorithm is successfully applied to the symbolic simulation that offers a convenient means to conduct multiple simultaneous exploration of model behaviors.

• Journal of the Korean Society of Visualization
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• v.4 no.2
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• pp.69-75
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• 2006

The microbubbles were used in various fields, such as turbulent control, drag reduction, material science and life science. The X-ray PTV using X-ray micro-imaging technique was employed to mea-sure the size and velocity of micro-bubbles moving in an opaque tube simultaneously. Micro-bubbles of $10{\sim}60{\mu}m$ diameter moving upward in an opaque tube (${\phi}$=2.7mm) were tested. Due to the different refractive indices of water and air, phase contrast X-ray images clearly show the exact size and shape of over-lapped microbubbles. In all of the working fluids tested (deionized water, tap water, 0.01 and 0.10M NaCl solutions), the measured terminal velocity of the microbubbles rising through the solution was proportional to the square of the bubble diameter. The rising velocity was increased with increasing mole concentration. The microbubble can be useful as contrast agent or tracer in life science and biology. The X-ray PTV technique should be able to extract useful information on the behavior of various bio/microscale fluid flows that are not amenable to analysis using conventional methods.

• Journal of the Korea Fashion and Costume Design Association
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• v.5 no.2
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• pp.103-113
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• 2003

This paper analyses the geometric aspect of Sonia Delaunay′s works on the basis of design elements and principles. Geometric pattern is one of the distinct features of early 20th century avant-garde works. The significance of its pattern and colour comes from the fact that it has not only influenced the contemporary fine art but also offered the basic principle of modern costume design. In 1925 she was designing clothes which could be worn today without appearing old-fashioned. She foresaw the future trends in fashion and interior decoration. One might claim she belongs to the avant-garde even today and no less astonishing a phenomenon than she was in 1925. Sonia Delaunay′s art was one of the first expressions of abstract painting and her "simultaneous contrasts" are among the earliest example of the aesthetic. In Delaunay′s geometric abstraction it is found that the technique of "simultaneous contrasts" is exploited almost without exception. Colour as well as Collage was the favourite technique Delnaunay used in creating a distinct simultaneity. Many "inobjective" paintings as she herself called unite the rigour of simple geometric forms with an inner life and poetry which emanate from the richness of the colour, the musicality of the rhythm, the vibrant breadth of the execution.

• Journal of the Korean Society of Costume
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• v.50 no.6
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• pp.47-58
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• 2000

This paper analyses the geometric aspect of Soma Delaunay's works on the basis of design elements and principles. Geometric pattern is one of the distinct features of early 20th century avant-garde works. The significance of its pattern and colour comes from the fact that it has not only influenced the contemporary fine art but also offered the basic principle of modern costume design. In 1925 she was designing clothes which could be worn today without appearing old-fashioned. She foresaw the future trends in fashion and interior decoration, One might claim she belongs to the avant-garde even today and no less astonishing a phenomenon than she was in 1925. Soma Delaunay's art was one of the first expressions of abstract painting and her "simultaneous contrasts"are among the earliest example of the aesthete. In Delaunay's geometric abstraction it is found that the technique of"simultaneous contrasts" is exploited almost without exception. colour as well as collage was the favourite technique Delnaunay used in creating a distinct simultaneity, Many "inobjective" paintings as she herself called unite the rigour of simple geometric forms with an inner life and poetry which emanate from the richness of the colour, the musicality of the rhythm, the vibrant breadth of the execution.rant breadth of the execution.

• Journal of Pharmaceutical Investigation
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• v.36 no.5
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• pp.309-314
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• 2006

The multicellular layers(MCL) of human cancer cells is a three dimensional(3D) in vitro model for human solid tumors which has been used primarily for the assessment of avascular penetration of anti-cancer drugs. For anti-cancer drugs with penetration problem, MCL represents a good experimental model that can provide clinically relevant data. Calcein-AM is a fluorescent dye that demonstrates the cellular vitality in a graded manner in cancer cell culture system. In the present study, we evaluated the use of calcein-AM for determination of anti-proliferative activity of anti-cancer agents in MCL model of DLD-1 human colorectal cancer cells. Optical sectioning of confocal imaging was compromised with photonic attenuation and penetration barrier in the deep layers of MCL. By contrast, fluorescent measurement on the cryo-sections provided a feasible alternative. Cold pre-incubation did not enhance the calcein-AM distribution to a significant degree in MCL of DLD-1 cells. However, the simultaneous determination of drug penetration and cellular vitality appeared to be possible in drug treated MCL. In conclusion, these data suggest that calcein-AM can be used for the simultaneous determination of drug-induced anti-proliferative effect and drug penetration in MCL model.

• Journal of Institute of Control, Robotics and Systems
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• v.10 no.7
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• pp.590-596
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• 2004

A passivity-based dynamic output feedback controller design is considered for a finite collection of non-square linear systems. Design of a single controller for a set of plants i.e. simultaneous stabilization is an important issue in the area of robust control design. We first determine a squaring gain matrix and an additional dynamics that is connected to the systems in a feedforward way, then a static passivating control law is designed. Consequently, the actual feedback controller will be the static control law combined with the feedforward dynamics. A necessary and sufficient condition for the existence of the parallel feedforward compensator is given by the static output feedback formulation. In contrast to the previous result [1], a technical condition for constructing the parallel feedforward compensator is removed by proposing a new type of the parallel compensator.