• 제목/요약/키워드: simultaneous administration

검색결과 272건 처리시간 0.036초

Direct Observation of Radiative Flux in the Southern Yellow Sea

  • Lu, Lian-Gang;Yu, Fei;Diao, Xinyuan;Guo, Jingsong;Wang, Huiwu;Wei, Chuanjie
    • Ocean Science Journal
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    • 제43권2호
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    • pp.115-126
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    • 2008
  • Direct measurements of four radiative components at air-sea boundary layer were conducted in the southern Yellow Sea during three cruises (seasons) in 2007. Simultaneous observations of meteorological (cloud cover, air temperature and humidity) and oceanographic (sea surface temperature) parameters were carried out. Observational results of radiative fluxes and meteorological and oceanographic parameters are presented. Mean diurnal cycles of four radiative components, net radiation, and sea surface albedo are calculated to achieve averages in different seasons. Net radiative fluxes in three seasons (winter, spring, autumn) are 8, 146, $60\;W/m^2$, respectively. Comparisons between the observed radiative fluxes and those estimated with formulas are taken.

Simultaneous Determination of Baicalin and Glycyrrhizin in Eul-Ja-Tang by HPLC/DAD

  • Lee, Mi-Kyeong;Lee, Ki-Yong;Kim, Seung-Hyun;Park, Jung-Hyun;Cho, Jung-Hee;Oh, Mi-Hyun;Baek, Ju-Hyun;Kim, Hyo-JIn;Kim, Young-Choong;Sung, Sang-Hyun
    • Natural Product Sciences
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    • 제14권3호
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    • pp.147-151
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    • 2008
  • A high performance liquid chromatographic (HPLC) method for the simultaneous determination of marker constituents, baicalin and glycyrrhizin was established for the quality control of traditional herbal medicinal preparation, Eul-Ja-Tang (EJT). Separation and quantification were successfully achieved with a Waters XTerra RP18 column ($5{\mu}m$, 4.6 mm I.D. ${\times}$ 150 mm) by gradient elution of a mixture of acetonitrile and water containing 0.03% phosphoric acid (pH 2.03) at a flow rate of 1.0 mL/min. The diode-array UV/VIS detector (DAD) was used for the detection and the wavelength for quantification was set at 250 nm. The presence of baicalin and glycyrrhizin in this decoction was ascertained by retention time, spiking with each authentic standard and UV spectrum. Both baicalin and glycyrrhizin showed good linearity ($r^2$ > 0.999) in a relatively wide concentration ranges. The R.S.D. for intra-day and inter-day precision was less than 5% and the limits of detection (LOD) were about 30 ng. The mean recovery of each compound was 99.5 - 101.2% with R.S.D. values less than 4.0%. This method was successfully applied to the determination of contents of baicalin and glycyrrhizin in three commercial products of EJT, which resulted in the difference in the contents of these compounds. These results suggest that the developed HPLC method is simple, effective and could be readily utilized as a quality control method for commercial EJT products.

Simultaneous Determination of Paeoniflorin and Glycyrrhizin in Sayuk-san by HPLC/DAD

  • Lee, Mi-Kyeong;Lee, Ki-Yong;Kim, Seung-Hyun;Jeon, Min-Ji;Cho, Jung-Hee;Oh, Mi-Hyun;Baek, Ju-Hyun;Kim, Hyo-Jin;Sung, Sang-Hyun
    • Journal of Pharmaceutical Investigation
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    • 제39권1호
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    • pp.23-27
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    • 2009
  • A high performance liquid chromatographic (HPLC) method for the simultaneous determination of marker constituents, paeoniflorin and glycyrrhizin was established for the quality control of traditional herbal medicinal preparation, Sayuk-san (SYS). Separation and quantification were successfully achieved with a Waters XTerra RP18 column ($5{\mu}m$, $4.6mm\;I.D.{\times}150mm$) by gradient elution of a mixture of acetonitrile and water containing 0.03% phosphoric acid (pH 2.03) at a flow rate of 1.0 mL/min. The diode-array UV/vis detector (DAD) was used for the detection and the wavelength for quantification was set at 230 nm. The presence of paeoniflorin and glycyrrhizin in this decoction was ascertained by retention time, spiking with each authentic standard and UV spectrum. All two compounds showed good linearity ($r^2$>0.996) in a relatively wide concentration ranges. The R.S.D. for intra-day and inter-day precision was less than 7.3% and the limits of detection (LOD) were less than 55.7 ng. The mean recovery of each compound was $102.3{\sim}111.1%$ with R.S.D. values less than 4.6%. This method was successfully applied to the determination of contents of paeoniflorin and glycyrrhizin in three commercial products of SYS. These results suggest that the developed HPLC method is simple, effective and could be readily utilized as a quality control method for commercial SYS products.

글로벌 기업에 대한 환경보조금과 환경투자지출이 중국 기업의 수익성에 미치는 영향 (The Effects of Government Environmental Subsidies and Corporate Environmental Expenditure for Globalization on the Profitability of Chinese Firms)

  • 리원시;황이;김성환
    • 아태비즈니스연구
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    • 제12권3호
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    • pp.175-192
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    • 2021
  • Purpose - In this study, we investigate the effects of government environmental subsidies and the globalization Chinese firms on their profitability using return on assets (ROA). Design/methodology/approach - In this study, a merged data including accounting, financial market, subsidization of the Chinese governments, local and the central, and export activities of 19,563 year-firms, for those listed on Shanghai Stock and Shenzhen Stock Exchange for 11 years from 2008 to 2018 is used. We collect subsidy data from RESSET database and financial data from CSMAR database. Then, we empirically test the test hypotheses using fixed effects models (FEM) separately and in a simultaneous equation model (SEM). Findings - Firstly, the globalization of Chinese firms has a negative impact on their profitability for some years after the year. Secondly, environmental subsidies just like other subsidies have ameliorating effects on financial performance for global firms. Such effects have lasted some years. Thirdly, environmental investments have a mostly negative impact on short- and long-term profitability for global firms. Lastly, the government's environmental subsidies in China have a positive effect on their profitability for both global and domestic firms. Research implications or Originality - We can infer that environmental investments with the help of the governmental subsidies can help Chinese firms deploy global strategies to expand markets to surpass competitors in the long run despite worsening profitability in global markets in the short run.

시판 유산균및 낙산균제제의 항결핵제및 항생물질에 대한 감수성과 내성 (Susceptibility and Resistance of Lactobacilli and Clostridia in the Commercially Available Preparations to Antituberculosis Agents and Antibiotics)

  • 김정우;김형수;이승희;최응칠;김병각
    • 약학회지
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    • 제29권3호
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    • pp.159-164
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    • 1985
  • To investigate the susceptibility and resistance in case of simultaneous administrations of Lactobacilli and Clostridia prekparations with antituberculosis agents and antibiotics, five strains of Lactobacilli, i.e., Lactobacillus bulgaricus, L. casei, L. helveticus, L. acidophilus, L. sporogenes, and Clostridium butyricum were isolated from commercially available preparation. Minimal inhibitory concentrations (MIC) of nine antituberculosis agents and 21 antibiotics against these strains were determined. The results shwoed that these strains were very sensitive only to rifampicin among antituberculosis agents, and sensitive to other antibiotics. Since the simultaneous oral administration of rifampicin and other antibkiotics with these sensitive strains is ineffective, development of new resistant mutants is desirable.

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A simultaneous occurrence of feline mammary carcinoma and uterine cystic endometrial hyperplasia in a cat

  • Yoo, Ji-Hyun;Kim, Okjin
    • 대한수의학회지
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    • 제57권4호
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    • pp.245-248
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    • 2017
  • At the time of visiting, the cat was 6-year-old female Siamese cat. The mammary mass was solid and firm and measured $2{\times}5cm^2$ in greatest diameter. The uterus revealed thick uterine horn and cross sectioned wall. Histopathologically, the mammary mass revealed feline mammary carcinoma. In the uterus, cystic endometrial hyperplasia was observed. Feline leukemia virus positive reaction was detected by polymerase chain reaction. As far as we know, this is the first report of the simultaneous feline mammary carcinoma and uterine endometrial cystic hyperplasia with Feline leukemia virus infection in a cat.

녹두(綠豆) 전탕액(煎湯液)의 Rat의 장기(臟器) 조직내(組織內) 카드뮴 독성(毒性) 해독(解毒)에 관한 연구(硏究) (Antitoxic Effects of Semen Mungo Water Extracts against Cadmium Toxicity in Organs of Rats)

  • 지정옥;김정필;이기남;이종섭
    • 대한예방한의학회지
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    • 제2권1호
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    • pp.175-192
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    • 1998
  • A study on the antitoxic effects of Semen Mungo extracts against Cadmium Chloride Toxicity in Rats This study was performed to find out the effect of Semen mungo against Cadmium toxicity. The experimental rats were divided into 5 groups such as control group, Cadmium alone treatment group, three simultaneous treatment groups of semen mungo and cadmium. Rats were given pellets administration with three dosage of semen mungo glabrae such as 4mg/kg body weight for four weeks. The results were summarized as follows on: ' 1. The simultaneously administration of semen mungo and cadmium significantly more decreased cadmium concentration in liver and kidney tissues compared to the administration of cadmium alone.(p<0.05) 2. The simultaneously administration of semen mungo and cadmium significantly more decreased metallothionein concentration in liver and kidney tissues compared to administration of cadmium alone(p<0.05) 3. When liver and kidney tissues were observed with optical microscope obvious changes were visible in those tissues.1

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UPLC를 이용한 프로폴리스 중 p-Coumaric Acid와 Trans-cinnamic Acid 분석법 (A New Analysis of p-Coumaric Acid and Trans-cinnamic Acid in Propolis By UPLC)

  • 김세건;홍인표;우순옥;장혜리;한상미
    • 생약학회지
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    • 제47권2호
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    • pp.186-191
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    • 2016
  • A new UPLC-DAD method for simultaneous determination of p-coumaric acid and trans-cinnamic acid in propolis was developed using Halo-C18 column and step gradient elution of MeCN and $0.1%H_3PO_4$ in 8 min. The method was validated by specificity, linearity, limit of detection, limit of quantification, precision(intra- and inter-day variability) and recovery tests. The validated method was sufficiently applicable for quantitative analysis of propolis products as well as propolis collected from different regions in Korea. The established method is simple, appropriate and efficient, and can be used for quality assessment of Korean propolis.

포공영(蒲公英) 전탕액(煎湯液)을 이용한 카드뮴 독성 해독(解毒) 효과연구 (Antitoxic Effects of Herba Taraxaci Water Extracts Against Cadmium Toxicity in Rats)

  • 박재수;이종섭;이기남
    • 대한예방한의학회지
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    • 제1권1호
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    • pp.76-84
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    • 1997
  • A study on the antitoxic effects of Herba Taraxaci extracts against Cadmium Chloride Toxicity in Rats. This study was performed to find out the effect of taraxacum platy carpum against Cadmium toxicity. The experimental rats were divided into 5 groups such as control group, Cadmium alone treatment group, three simultaneous treatment groups of taraxacum platy carpum and cadmium. Rat were given pellets administration with three dosage of taraxacum platy carpum such as 4 mg/kg body weight for four weeks. The results were summarized as follows on: 1. The simultaneously administration of taraxacum platy carpum and cadmium significantly more decreased cadmium concentration in liver and kidney tissues compared to the administration of cadmium alone. (p<0.05) 2. The simultaneously administration of taraxacum platy carpum and cadmium significantly more increased metallothionein concentration in liver and kidney tissues compared to administration alone. (p<0.05) 3. When liver and kidney tissues were observed with optical microscope obvious changes were visible in those tissue.

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HPLC를 사용한 쌀 중 잔류농약 동시분석법 (Multiresidue analytical method of pesticides in rice by HPLC)

  • 최재천;이영자;김소희;최수영;최희주;정성욱;박흥재;김우성
    • 한국환경과학회지
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    • 제14권4호
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    • pp.445-449
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    • 2005
  • A simple and sensitive analytical method based on RP-HPLC with UV detector$(225{\cal}nm)$ and mobile phases using $0.1{\%}$ phosphoric acid and acetonitrile was developed for simultaneous determination of quinclorac, bentazone, 2,4-D, bensulfuron-methyl, dymuron, capropamide, pencycuron, ethofenprox. This method was resulted in recovery of $78{\~}96{\%}$ with RSD $3.3{\~}7.5{\%}$, LODs $0.12{\~}0.84$ and LOQs $0.34{\~}1.20{\cal}mg/L$. Calibration curves were linear with r of $0.9995{\~}0.9999$.