• Title/Summary/Keyword: simulation model

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Development of $^{166}Ho$-Stent for the Treatment of Esophageal Cancer (식도암 치료용 $^{166}Ho$-Stent 개발)

  • Park, Kyung-Bae;Kim, Young-Mi;Kim, Kyung-Hwa;Shin, Byung-Chul;Park, Woong-Woo;Han, Kwang-Hee;Chung, Young-Ju;Choi, Sang-Mu;Lee, Jong-Doo
    • The Korean Journal of Nuclear Medicine
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    • v.34 no.1
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    • pp.62-73
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    • 2000
  • Purpose: Esophageal cancer patients have a difficulty in the intake of meals through the blocked esophageal lumen, which is caused by an ingrowth of cancer cells and largely influences on the prognosis. It is reported that esophageal cancer has a very low survival rate due to the lack of nourishment and immunity as the result of this. In this study a new radioactive stent, which prevents tumor ingrowth and restenosis by additional radiation treatment, has been developed. Materials and Methods: Using ${\ulcorner}HANARO{\lrcorner}$ research reactor, the radioactive stent assembly ($^{166}Ho$-SA) was prepared by covering the metallic stent with a radioactive sleeve by means of a post-irradiation and pre-irradiation methods. Results: Scanning electron microscopy and autoradiography exhibited that the distribution of $^{165/166}Ho\;(NO_3)$ compounds in polyurethane matrix was homogeneous. A geometrical model of the esophagus considering its structural properties, was developed for the computer simulation of energy deposition to the esophageal wall. The dose distributions of $^{166}Ho$-stent were calculated by means of the EGS4 code system. The sources are considered to be distributed uniformly on the surface in the form of a cylinder with a diameter of 20 mm and length of 40 mm. As an animal experiment, when radioactive stent developed in this study was inserted into the esophagus of a Mongrel dog, tissue destruction and widening of the esophageal lumen were observed. Conclusion: We have developed a new radioactive stent comprising of a radioactive tubular sleeve covering the metallic stent, which emits homogeneous radiation. If it is inserted into the blocked or narrowed lumen, it can lead to local destruction of the tumor due to irradiation effect with dilatation resulting from self-expansion of the metallic property. Accordingly, it is expected that restenosis esophageal lumen by the continuous ingrowth and infiltration of cancer after insertion of our radioactive stent will be decreased remarkably.

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The Effects of amino acid balance on heat production and nitrogen utilization in broiler chickens : measurement and modeling

  • Kim, Jj-Hyuk;MacLeod, Murdo G.
    • Proceedings of the Korea Society of Poultry Science Conference
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    • 2004.11a
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    • pp.80-90
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    • 2004
  • Three experiments were performed to test the assumption that imbalanced dietary amino acid mixtures must lead to increased heat production (HP). The first experiment was based on diets formulated to have a wide range of crude protein (CP) concentrations but a fixed concentration of lysine, formulated to be the first-limiting amino acid. In the second (converse) experiment, lysine concentration was varied over a wide range while CP content was kept constant. To prevent the masking of dietary effects by thermoregulatory demands, the third experiment was performed at 30 $^{\circ}C$ with the diets similar to the diets used in the second experiment. The detailed relationships among amino acid balance, nitrogen (N) metabolism and energy (E) metabolism were investigated in a computer-controlled chamber calorimetry system. The results of experiments were compared with the predictions of a computerised simulation model of E metabolism. In experiment 1. with constant lysine and varying CP, there was a 75 % increase in N intake as CP concentration increased. This led to a 150 % increase in N excretion. with no significant change in HP. Simulated HP agreed with the empirically determined results in not showing a trend with dietary CP. In experiment 2, with varying lysine but constant CP, there was a 3-fold difference in daily weight gain between the lowest and highest lysine diets. HP per bird increased significantly with dietary lysine concentration. There was still an effect when HP was adjusted for body weight differences, but it failed to maintain statistical significance. Simulated HP results agreed in showing little effect of varying lysine concentration and growth rate on HP. Based on the results of these two experiments, the third experiment was designed to test the response of birds to dietary lysine in high ambient temperature. In experiment 3 which performed at high ambient temperature (30 $^{\circ}C$), HP per bird increased significantly with dietary lysine content, whether or not adjusted for body-weight. The trend was greater than in the previous experiment (20 $^{\circ}C$).

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Simulation of Soil Moisture in Gyeongan-cheon Watershed Using WEP Model (WEP 모형을 이용한 경안천 토양수분 모의)

  • Noh, Seong-Jin;Kim, Hyeon-Jun;Kim, Cheol-Gyeom;Jang, Cheol-Hee
    • Proceedings of the Korea Water Resources Association Conference
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    • 2006.05a
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    • pp.720-725
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    • 2006
  • 토양수분은 식물의 생장 및 가용수자원 산정 등에 있어서 중요한 요소로서 토양층 상부의 수 m내에 존재하는 수분의 양을 일컫는다. 토양수분과 토양수분의 공간적 시간적 특징들은 증발, 침투, 지하수 재충전, 토양침식, 식생 분포 등을 지배하는 중요한 요소이다. 강우 등으로 인한 지면과 지표하에서의 순간적인 포화공간의 형성 및 유출의 생성 등을 포함하는 과정과 증발산 등은 모두 비포화대(vadose zone) 혹은 토양층에서의 토양수분의 함량에 크게 의존하게 된다(이가영 등(2005)). 분포형 수문모형은 유역을 격자단위로 세분화하여 매개변수를 부여하고, 증발산, 침투, 지표면유출, 중간유출, 지하수유출, 하도 흐름 등 여러 가지 수문요소를 해석하는 종합적인 수문모형이다. 지표면에 내린 강우가 증발, 침투, 유출될 지는 토양수분의 함량에 크게 의존하게 되며, 따라서 토양수분에 대한 적절한 모의가 분포형 수문모형의 정확도를 좌우하는 핵심이라 할 수 있다. 본 연구에서는 분포형 수문모형인 WEP 모형을 경안천 유역(유역면적: $575km^2$, 유로연장: 49.3㎞)에 적용하여 토양수분의 시공간분포를 모의하였다. 지점별 토양수분 모의결과, 토양 매개변수의 최대, 최소값 내에서 적절히 모의됨을 확인하였으나, 관측값이 없어 실질적으로 타당한지 여부는 검증하지 못하였다. 토양수분비율, 연간 증발산량, 지표면 유출량 공간분포를 비교한 결과, 토양수분비율이 연간 증발산량 모의에 직접적인 영향을 주는 것을 확인할 수 있었다. 일부격자에서는 토양수분이 지나치게 높게 모의되었는데, 지하수위와 관련있는 것으로 보이며, 구축된 자료가 부족한 지하대수층에 대한 정보부족이 토양수분 계산에도 영향을 준 것으로 보인다. 본 연구는 WEP 모형의 토양수분 해석능력에 대한 시험적용에 그 의의가 있으며, 향후 토양 및 지표하 매개변수 정보가 충분히 갖추어지고, 토양수분 관측결과 있는 대상유역에 대한 적용이 요구된다.-Moment 방법에 의해 추정된 매개변수를 사용한 Power 분포를 적용하였으며 이들 분포의 적합도를 PPCC Test를 사용하여 평가해봄으로써 낙동강 유역에서의 저수시의 유출량 추정에 대한 Power 분포의 적용성을 판단해 보았다. 뿐만 아니라 이와 관련된 수문요소기술을 확보할 수 있을 것이다.역의 물순환 과정을 보다 명확히 규명하고자 노력하였다.으로 추정되었다.면으로의 월류량을 산정하고 유입된 지표유량에 대해서 배수시스템에서의 흐름해석을 수행하였다. 그리고, 침수해석을 위해서는 2차원 침수해석을 위한 DEM기반 침수해석모형을 개발하였고, 건물의 영향을 고려할 수 있도록 구성하였다. 본 연구결과 지표류 유출 해석의 물리적 특성을 잘 반영하며, 도시지역의 복잡한 배수시스템 해석모형과 지표범람 모형을 통합한 모형 개발로 인해 더욱 정교한 도시지역에서의 홍수 범람 해석을 실시할 수 있을 것으로 판단된다. 본 모형의 개발로 침수상황의 시간별 진행과정을 분석함으로써 도시홍수에 대한 침수위험 지점 파악 및 주민대피지도 구축 등에 활용될 수 있을 것으로 판단된다. 있을 것으로 판단되었다.4일간의 기상변화가 자발성 기흉 발생에 영향을 미친다고 추론할 수 있었다. 향후 본 연구에서 추론된 기상변화와 기흉 발생과의 인과관계를 확인하고 좀 더 구체화하기 위한 연구가 필요할 것이다.게 이루어질 수 있을 것으로 기대된다.는 초과수익률이 상승하지만, 이후로는 감소하므로, 반전거래전략을 활용하는 경우 주식투자기간은 24개월이하의 중단기가 적합함을 발견하였다. 이상의 행태적 측면과 투자성과측면의 실증결과를 통하여 한국주식시장에 있어서 시장수익률을 평균적으로 초과할 수 있는 거래전략은 존재하므로 이러한 전략을 개발 및 활용할 수 있으며, 특히, 한국주식시장에 적합한 거래전략은 반전거래전략이고, 이 전략의 유용성은 투자자가 설정한 투자기간보다 더욱 긴 분석기간의 주식가격정보에 의하여 최대한 발휘될 수 있음을 확인하였다.(M1), 무역적자의

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Emission Rate of Greenhouse Gases from Bedding Materials of Cowshed Floor: Lab-scale simulation study (우사깔짚에서 발생되는 온실가스 배출량 산정: 모의 실험결과)

  • Cho, Won Sil;Lee, Jin Eui;Park, Kyu Hyun;Kim, Jeong Dae;Ra, Chang Six
    • Journal of Animal Science and Technology
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    • v.55 no.1
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    • pp.67-74
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    • 2013
  • To know the emission amount of greenhouse gases from bedding materials of cowshed floor, the emission rates of methane ($CH_4$) and nitrous oxide ($N_2O$) gases from a simulated cowshed floor (SCF) with sawdust that manure loading rate into the bedding material could be accurately controlled were assessed in this study. The manure loading rates of Korean beef and Holstein dairy cattle into the SCF of $0.258m^2$ surface area with 10 to 15 cm height sawdust were $1.586kg/m^2/d$ and $3.588kg/m^2/d$, respectively, and those were calculated on the basis of "Standard model for sustainable livestock" and "Data for excretion amount of manure from livestock". All experiments were done in triplicates in three different seasons (May to July, Sep. to Nov., and Feb. to Apr.) using 12 SCFs. The effects of bedding material thickness on $CH_4$ and $N_2O$ emission from SCFs for both Korean beef cattle and Holstein dairy cattle were not statistically significant (p<0.05). Emission amount of $CH_4$ and $N_2O$ per square meter of SCF for Holstein dairy cattle was 7.5 and 1.2 times higher than that of Korean beef cattle, respectively. The yearly $CH_4$ amount per head was 17.7 times higher in Holstein dairy cattle, obtaining 130.4 g/head/year from SCF for Holstein dairy cattle and 7.4 g/head/year from SCF for Korean beef cattle, and $N_2O$ was also 3.8 times higher in Holstein dairy cattle (3,267 g/head/year in Korean beef cattle and 14,719 g/head/year in Holstein dairy cattle). However, the $N_2O$-N per loaded nitrogen into SCF was higher in Korean beef cattle, having 0.2148 and 0.1632 kg $N_2O$-N/kg N in Korean beef cattle and Holstein dairy cattle, respectively, and those values were 3.07 and 2.33 times higher than that of Intergovernmental Panel on Climate Change (IPCC) 2006 guideline (GL) (0.07 kg $N_2O$-N/kg N).

Building an Efficient Supply Chain by reduction of lead time with a Focus on Korea Server Manufacturer (리드타임 감소에 의한 효율적 공급체인 구축 - 국내 서버 공급체인을 대상으로 -)

  • 신용석;김태현;문성암
    • Journal of Distribution Research
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    • v.6 no.2
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    • pp.1-17
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    • 2002
  • The recent dot-com craze has been one of the main causes that accelerated the growth of internet-related companies in diversity as well as in size. Meanwhile, the domestic market of supplies and equipment for internet businesses has been dominated by major foreign companies. To regain their market positions, the domestic manufacturers had to find the way to build up their competitive advantages, such as meeting their customers needs and reducing overall costs. In this study, one domestic PC server manufacturer, which competes fiercely with foreign manufacturers for the top place, has been chosen as a model to evaluate its current supply chain and to find an area that can be improved for a better performance. System Dynamics is used throughout the study. The central concept to system dynamics is understanding how all the objects in a system interact with one another. It focuses on feedback and secondary effects to think through how a strategy might or might not work, depending on how organizational changes are received, and what kinds of consequences emerge. Then, computerized models were built for simulations, each with different conditions, and, finally, the results were evaluated based on some criteria which are considered to be important and meaningful. The inefficiency that exists in the supply chain was proved to be a thirty-day long purchasing order leadtime, and it was expected that more effective supply chain could be formed if the leadtme were reduced to 14 days or 7 days. The results of simulations showed that the overall expected costs in supply chain was the least with the purchasing leadtime being 7 days. The lower average number of parts held as inventory, along with the reduced lost sales, acted as the factor reducing the expected overall costs. Although there was a slight increase in the average number of final products held as inventory and the total ordering cost, the benefits from lower parts inventory and reduced lost sales were large enough to justify the overall cost reduction.

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A Study on Construction and Application of Nuclear Grade ESF ACS Simulator (원자력등급 ESF 공기정화계통 시뮬레이터 제작 및 활용에 관한 연구)

  • Lee, Sook-Kyung;Kim, Kwang-Sin;Sohn, Soon-Hwan;Song, Kyu-Min;Lee, Kei-Woo;Park, Jeong-Seo;Hong, Soon-Joon;Kang, Sun-Haeng
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.8 no.4
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    • pp.319-327
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    • 2010
  • A nuclear plant ESF ACS simulator was designed, built, and verified to perform experiment related to ESF ACS of nuclear power plants. The dimension of 3D CAD model was based on drawings of the main control room(MCR) of Yonggwang units 5 and 6. The CFD analysis was performed based on the measurement of the actual flow rate of ESF ACS. The air flowing in ACS was assumed to have $30^{\circ}C$ and uniform flow. The flow rate across the HEPA filter was estimated to be 1.83 m/s based on the MCR ACS flow rate of 12,986 CFM and HEPA filter area of 9 filters having effective area of $610{\times}610mm^2$ each. When MCR ACS was modeled, air flow blocking filter frames were considered for better simulation of the real ACS. In CFD analysis, the air flow rate in the lower part of the active carbon adsorber was simulated separately at higher than 7 m/s to reflect the measured value of 8 m/s. Through the CFD analyses of the ACSes of fuel building emergency ventilation system, emergency core cooling system equipment room ventilation cleanup system, it was confirmed that all three EFS ACSes can be simulated by controlling the flow rate of the simulator. After the CFD analysis, the simulator was built in nuclear grade and its reliability was verified through air flow distribution tests before it was used in main tests. The verification result showed that distribution of the internal flow was uniform except near the filter frames when medium filter was installed. The simulator was used in the tests to confirm the revised contents in Reg. Guide 1.52 (Rev. 3).

Performance Evaluation of Hydrocyclone Filter for Treatment of Micro Particles in Storm Runoff (Hydrocyclone Filter 장치를 이용한 강우유출수내 미세입자 제거특성 분석)

  • Lee, Jun-Ho;Bang, Ki-Woong;Hong, Sung-Chul
    • Journal of Korean Society of Environmental Engineers
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    • v.31 no.11
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    • pp.1007-1018
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    • 2009
  • Hydrocyclone is widely used in industry, because of its simplicity in design, high capacity, low maintenance and operational cost. The separation action of a hydrocyclone treating particulate slurry is a consequence of the swirling flow that produces a centrifugal force on the fluid and suspended particles. In spite of hydrocyclone have many advantage, the application for treatment of urban stormwater case study were rare. We conducted a laboratory scale study on treatable potential of micro particles using hydrocyclone filter (HCF) that was a combined modified hydrocyclone with perlite filter cartridge. Since it was not easy to use actual storm water in the scaled-down hydraulic model investigations, it was necessary to reproduce ranges of particles sizes with synthetic materials. The synthesized storm runoff was made with water and addition of particles; ion exchange resin, road sediment, commercial area manhole sediment, and silica gel particles. Experimental studies have been carried out about the particle separation performance of HCF-open system and HCF-closed system. The principal structural differences of these HCFs are underflow zone structure and vortex finder. HCF was made of acryl resin with 120 mm of diameter hydrocyclone and 250 mm of diameter filter chamber and overall height of 800 mm. To determine the removal efficiency for various influent concentrations of suspended solids (SS) and chemical oxygen demand (COD), tests were performed with different operational conditions. The operated maximum of surface loading rate was about 700 $m^3/m^2$/day for HCF-open system, and 1,200 $m^3/m^2$/day for HCF-closed system. It was found that particle removal efficiency for the HCF-closed system is better than the HCF-open system under same surface loading rate. Results showed that SS removal efficiency with the HCF-closed system improved by about 8~20% compared with HCF-open system. The average removal efficiency difference for HCF-closed system between measurement and CFD particle tracking simulation was about 4%.

Numerical Simulation of the Formation of Oxygen Deficient Water-masses in Jinhae Bay (진해만의 빈산소 수괴 형성에 관한 수치실험)

  • CHOI Woo-Jeung;PARK Chung-Kill;LEE Suk-Mo
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.27 no.4
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    • pp.413-433
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    • 1994
  • Jinhae Bay once was a productive area of fisheries. It is, however, now notorious for its red tides; and oxygen deficient water-masses extensively develop at present in summer. Therefore the shellfish production of the bay has been decreasing and mass mortality often occurs. Under these circumstances, the three-dimensional numerical hydrodynamic and the material cycle models, which were developed by the Institute for Resources and Environment of Japan, were applied to analyze the processes affecting the oxygen depletion and also to evaluate the environment capacity for the reception of pollutant loads without dissolved oxygen depletion. In field surveys, oxygen deficient water-masses were formed with concentrations of below 2.0mg/l at the bottom layer in Masan Bay and the western part of Jinhae Bay during the summer. Current directions, computed by the $M_2$ constituent, were mainly toward the western part of Jinhae Bay during flood flows and in opposite directions during ebb flows. Tidal currents velocities during the ebb tide were stronger than that of the flood tide. The comparision between the simulated and observed tidal ellipses showed fairly good agreement. The residual currents, which were obtained by averaging the simulated tidal currents over 1 tidal cycle, showed the presence of counterclockwise eddies in the central part of Jinhae Bay. Density driven currents were generated southward at surface and northward at the bottom in Masan Bay and Jindong Bay, where the fresh water of rivers entered. The material cycle model was calibrated with the data surveyed in the field of the study area from June to July, 1992. The calibrated results are in fairly good agreement with measured values within relative error of $28\%$. The simulated dissolved oxygen distributions of bottom layer were relatively high with the concentration of $6.0{\sim}8.0mg/l$ at the boundaries, but an oxygen deficient water-masses were formed within the concentration of 2.0mg/l at the inner part of Masan Bay and the western part of Jinhae Bay. The results of sensitivity analyses showed that sediment oxygen demand(SOD) was one of the most important influence on the formation of oxygen depletion. Therefore, to control the oxygen deficient water-masses and to conserve the coastal environment, it is an effective method to reduce the SOD by improving the polluted sediment. As the results of simulations, in Masan Bay, oxygen deficient water-masses recovered to 5.0mg/l when the $50\%$ reduction in input COD loads from Masan basin and $70\%$ reduction in SOD was conducted. In the western part of Jinhae Bay, oxygen deficient water-masses recovered to 5.0mg/l when the $95\%$ reduction in SOD and $90\%$ reduction in culturing ground fecal loads was conducted.

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Effects and Improvement of Carbon Reduction by Greenspace Establishment in Riparian Zones (수변구역 조성녹지의 탄소저감 효과 및 증진방안)

  • Jo, Hyun-Kil;Park, Hye-Mi
    • Journal of the Korean Institute of Landscape Architecture
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    • v.43 no.6
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    • pp.16-24
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    • 2015
  • This study quantified storage and annual uptake of carbon for riparian greenspaces established in watersheds of four major rivers in South Korea and explored desirable strategies to improve carbon reduction effects of riparian greenspaces. Greenspace structure and planting technique in the 40 study sites sampled were represented by single-layered planting of small trees in low density, with stem diameter at breast height of $6.9{\pm}0.2cm$ and planting density of $10.4{\pm}0.8trees/100m^2$ on average. Storage and annual uptake of carbon per unit area by planted trees averaged $8.2{\pm}0.5t/ha$ and $1.7{\pm}0.1t/ha/yr$, respectively, increasing as planting density got higher. Mean organic matter and carbon storage in soils were $1.4{\pm}0.1%$ and $26.4{\pm}1.5t/ha$, respectively. Planted trees and soils per ha stored the amount of carbon emitted from gasoline consumption of about 61 kL, and the trees per ha annually offset carbon emissions from gasoline use of about 3 kL. These carbon reduction effects are associated with tree growth over five years to fewer than 10 years after planting, and predicted to become much greater as the planted trees grow. This study simulated changes in annual carbon uptake by tree growth over future 30 years for typical planting models selected as different from the planting technique in the study sites. The simulation revealed that cumulative annual carbon uptake for a multilayered and grouped ecological planting model with both larger tree size and higher planting density was approximately 1.9 times greater 10 years after planting and 1.5 times greater 30 years after than that in the study sites. Strategies to improve carbon reduction effects of riparian greenspaces suggest multilayered and grouped planting mixed with relatively large trees, middle/high density planting of native species mixed with fast-growing trees, and securing the soil environment favorable for normal growth of planting tree species. The research findings are expected to be useful as practical guidelines to improve the role of a carbon uptake source, in addition to water quality conservation and wildlife inhabitation, in implementing riparian greenspace projects under the beginning stage.

Analysis of Suspended Solids Reduction by Vegetative Filter Strip for Cultivated Area Using Web GIS-Based VFSMOD (VFSMOD를 이용한 경작지의 고형물질 유출 저감효과)

  • Ahn, Jae Hwan;Yun, Sang Leen;Kim, Seog Ku;Park, Youn Shik;Lim, Kyoung Jae
    • Journal of Korean Society of Environmental Engineers
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    • v.34 no.12
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    • pp.792-800
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    • 2012
  • The study was performed to simulate the reduction efficiency of suspended solids (SS) for cultivated land located at riverine area at the Namhan River and the Bukhan River watershed sites (site A, B, C) under the rainfall conditions using HUFF & SCS UH-based VFS Design module of Web GIS-based VFSMOD System. The study indicates that the field 5% sloped, located at Bukhan River watershed (site A), requires at least 0.5 m width of Vegetative Filter Strip (VFS) to reduce 70% of SS while the field 10% sloped requires the at least 1.0~1.5 m width of VFS to reduce 70% SS, under the condition 106.2 mm of rainfall event and bell pepper or corn of crops. Against the conditions 95.1 mm of rainfall event and sweet potato or soy bean of crops, the field 5% sloped, located at Namhan River watershed (site B) requires at least 0.5 m width of VFS to reduce 70% of SS while the field 10% sloped requires at least 1.0 m width of VFS to reduce 50% SS. The crops sweet potato and soy bean are cultivated in the site C, located at Namhan River watershed, 1 m of VFS is capable of 64.0% and 62.0% of SS reduction against 102.6 mm and 151.2 mm rainfall conditions respectively, for the 5% sloped field. The result supports that VFS is one of most potential methods to reduce SS from cultivated area, which is environment-friendly hydrologic structure. The VFS design, however, needs to be simulated before its installation in the field, the simulation needs to consider not only various characteristics of the field but also different conditions affecting the VFS, using a model capable to consider a lot of factors.