• Title/Summary/Keyword: silla

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Deodorization of Purified Fish Oil from Squids by Organic Acids (유기산물 이용한 오징어 어유의 어취 개선)

  • Jang, Min-Kyung;Lee, Ok-Hee;Kim, Nam-Young;Yu, Ki-Hwan;Jang, Hye-Ji;Lee, Seung-Woo;Park, Mi-Ra;Park, Joung--Hyun;Kim, Mi-Hyang;Ha, Jong-Myung;Bae, Song-Ja;Lee, Sang-Hyeon
    • Journal of Life Science
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    • v.19 no.9
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    • pp.1284-1288
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    • 2009
  • To produce high quality fish oil products, additional deodorization experiments on purified fish oil from squid using columns filled with citric acid or gluconic acid were performed. A deodorization effect on the fish oil was observed on both the citric acid and gluconic acid columns. These effects were more efficient on the columns packed with 3 g of organic acid than those with 1 g or 2 g of organic acid. In addition, a better effect was observed in the column packed with gluconic acid than that with citric acid. Peroxide value (POV) and acid value (AV) of the sample treated with citric acid was the as same as the non-treated sample. However, POV and AV of the sample treated with gluconic acid were about 10% higher than the non-treated sample. Contents of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) of the samples treated with citric acid or gluconic acid columns were about 0.5% higher than the non-treated sample. In conclusion, deodorization of squid fish oil by organic acid could be an efficient method to produce high quality fish oil products.

The Effect of Inhibition of Uncaria rhynchophylla as an Inhibitor of Melanogenesis and an Antioxidant in B16F10 Melanoma Cells (B16F10세포에서 멜라닌 생성 억제제 및 항산화제로서 조구등의 억제 효과)

  • Dong, Yuanyuan;Woo, Young Min;Cha, Ji Hyun;Cha, Jae Young;Lee, Nai Wei;Back, Min Woo;Park, Joon-sung;Lee, Sang-Hyeon;Ha, Jong-Myung;Kim, Andre
    • Journal of Life Science
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    • v.30 no.12
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    • pp.1033-1041
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    • 2020
  • Many people of all ages wish to have lighter skin for cosmetic reasons, and natural products attract more attention than chemically synthesized compounds. Uncaria rhynchophylla is widely used in Asia as a traditional herbal medicine. In order to find novel skin whitening agents, the present study evaluated the antioxidant activity and potential tyrosinase-inhibiting properties of U. rhynchophylla. Specifically, this study analyzed the antioxidant capacity of a 70% ethanolic extract of U. rhynchophylla as well as its effects on tyrosinase activity and melanin synthesis. Total mRNA levels were examined using reverse transcription polymerase chain reaction. The results revealed that U. rhynchophylla extracts exhibit great antioxidant capacity and significant levels of polyphenol and flavonoid compounds. U. rhynchophylla extracts can also powerfully inhibit tyrosinase activity. This same capacity was observed in melanoma B16F10 cells; that is, U. rhynchophylla extracts suppressed intracellular tyrosinase activity and reduced the amount of melanin in treated cells. In addition, a 1 mg/ml concentration of U. rhynchophylla extract significantly reduced the mRNA expression levels of tyrosinase. U. rhynchophylla extracts decrease tyrosinase and inhibit melanogenesis in B16F10 cells. This finding suggests that U. rhynchophylla has great potential as a natural whitening agent in skincare products.

The Ruling System of Silla to Gangneung Area Judged from Archaeological Resources in 5th to 6th Century (고고자료로 본 5~6세기 신라의 강릉지역 지배방식)

  • Shim, Hyun Yong
    • Korean Journal of Heritage: History & Science
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    • v.42 no.3
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    • pp.4-24
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    • 2009
  • This paper examined archaeological resources that discuss how Silla entered the Gangneung area, the coastal region along the East Sea that has been excavated most actively. Silla expanded its territories while organizing the its system as an ancient state and acquired several independent townships in various regions, stretching its forces to the East Sea area faster than any other ancient states of the time. In particular, many early relics and heritages of Silla have been found in Gangneung, the center of the East Sea area. Many archaeological resources prove these circumstances of that time and provide brief texts that are valuable for our interpretation of historical facts. In this respect, it was possible for me to examine these resources to answer my question as to why early relics and heritages of Silla are found in the Gangneung area. Based on my research on Silla's advancement into the Gangneung area, I have acquired the following results: How did Silla rule this area after conquering Yeguk in the Gangneung area? After conquering the Gangneung area, Silla attempted an indirect ruling at first. Later, Silla adopted a direct ruling system. I divided the indirect ruling period into two phases: introduction and settlement. In detail, Silla's earthenware and stone chamber tombs first appeared in Hasi-dong in the fourth quarter of the 4th Century and the tombs spread to Chodang-dong in the second quarter of the 5th Century. A belt with dragon pattern openwork, which seems to be from the second quarter of the 5th Century, was found to tell us that the Gangneung region began receiving rewards from Silla during this time. Thus, the period from the fourth quarter of the 4th Century to the second quarter of the 5th Century is designated as the 1st Phase (Introduction) of indirect ruling in terms of aechaeological findings. This is when Silla was first advanced to the Gangneung area and tolerated independent administration of the conquered. In the third and fourth quarters of the 5th Century, old mound tombs appeared and burials of relics that symbolized power emerged. In the third quarter of the 5th Century, stone chamber tombs were prevalent, but wooden chamber tombs, stone mounded wooden chamber tombs, and lateral entrance stone chamber tombs began to emerge. Also, tombs that were clustered in Hasi-dong and Chodang-dong began to scatter to Byeongsan-dong, Yeongjin-ri, and Bangnae-ri nearby. Steel pots were the symbol of power that emerged at this time. In the fourth quarter of the 5th Century, stone chamber tombs were still dominating, but wooden chamber tombs, stone mounded wooden chamber tombs, and lateral entrance stone chamber tombs became more popular. More crowns, crown ornaments, big daggers, and belts were bestowed by Silla, mostly in Chodang-dong and Byeongsan-dong. The period from the third quarter to the fourth quarter of the 5th Century was designated as the 2nd Phase (Settlement) of indirect ruling in terms of aechaeological findings. At this time, Silla bestowed items of power to the ruling class of the Gangneung area and gave equal power to the rulers of Chodang-dong and Byeongsan-dong to keep them restrained by each other. However, Silla converted the ruling system to direct ruling once it recognized the Gangneung area as the base of its expedition of conquest to the north. In the first quarter of the 6th Century, old mound tombs disappeared and small/medium-sized mounds appeared in the western inlands and the northern areas. In this period, the tunnel entrance stone chamber tombs were large enough for people to enter with doors. A cluster of several tunnel entrance stone chamber tombs was formed in Yeongjin-ri and Bangnae-ri at this time, probably with the influence of Silla's direct ruling. In the first quarter of the 6th Century, Silla dispatched officers from the central government to complete the local administration system and replaced the ruling class of Chodang-dong and Byeongsan-dong with that of Silla-friendly Yeonjin-ri and Bangnae-ri to reorganize the local administration system and gain full control of the Gangneung area.

Comparison of methods for proanthocyanidin extraction from pine (Pinus densiflora) needles and biological activities of the extracts

  • Kim, Nam-Young;Jang, Min-Kyung;Lee, Dong-Geun;Yu, Ki-Hwan;Jang, Hye-Ji;Kim, Mi-Hyang;Kim, Sung-Gu;Yoo, Byung-Hong;Lee, Sang-Hyeon
    • Nutrition Research and Practice
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    • v.4 no.1
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    • pp.16-22
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    • 2010
  • Flavonoids are known to be effective scavengers of free radicals. In particular, proanthocyanidins are flavonoids that possess cardiovascular protection, antioxidative activities, and immunomodulatory activities. Here, we evaluated proanthocyanidin contents in the total polyphenolic compounds of pine needle extracts prepared by hot water, ethanol, hexane, hot water-hexane (HWH), and hot water-ethanol (HWE). Analysis of each extract indicated that the ethanol extract contained the highest proanthocyanidin concentration. The HWH and hexane extracts also contained relatively high concentrations of proanthocyanidin. On the other hand, proanthocyanidin content analyses out of the total polyphenolic compounds indicated that the HWH extract contained the highest content. These results suggest that HWH extraction is a suitable method to obtain an extract with a high level of pure proanthocyanidins and a relatively high yield. The HWH extract possessed superior activity in diverse antioxidative analyses such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferrous ion chelating (FIC), and ferric-ion reducing power (FRAP) assays. In addition, upon assessing the effects of the pine needle extracts on macrophages (Raw 264.7 cell), the HWH extract exhibited the highest activity. In this study, we discerned an efficient extraction method to achieve relatively pure proanthocyanidins from pine needles and evaluated the biological functions of the resulting extract, which could potentially be used for its efficacious components in functional food products.

Characteristics and in vitro Anti-diabetic Properties of the Korean Rice Wine, Makgeolli Fermented with Laminaria japonica

  • Choi, Jae-Suk;Seo, Hyo Ju;Lee, Yu-Ri;Kwon, Su-Jung;Moon, Sun Hwa;Park, Sun-Mee;Sohn, Jae Hak
    • Preventive Nutrition and Food Science
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    • v.19 no.2
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    • pp.98-107
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    • 2014
  • New in vitro anti-diabetes makgeolli was produced from rice by adding various quantities of Laminaria japonica, and the fermentation characteristics of the L. japonica makgeolli during the fermentation process were investigated. The contents of alcohol and reducing sugar, and viable count of yeast, of L. japonica makgeolli were not significantly changed when the proportion of L. japonica was increased. The total acid content decreased with an increase in L. japonica concentration; the pH and total bacterial cell count increased in proportion with the increase in L. japonica concentration. The L. japonica makgeolli contents of free sugars, such as fructose, glucose, and sucrose, and of organic acids, such as acetic acid, citric acid, succinic acid, and lactic acid, were altered during fermentation and showed various patterns. The effects of the quantity of L. japonica added on the acceptability and anti-diabetes activities of L. japonica makgeolli were also investigated. In a sensory evaluation, L. japonica makgeolli brewed by adding 2.5 or 5% L. japonica to the mash showed the best overall acceptability; the 12.5% L. japonica sample was least favored due to its seaweed flavor. L. japonica addition did not increase the peroxynitrite-scavenging activity of makgeolli. L. japonica makgeolli showed potent anti-diabetes activity, particularly that containing >7.5% L. japonica. Therefore, L. japonica makgeolli may represent a new functional makgeolli with anti-diabetes properties.

Anti-Oxidative Effects of Ulva lactuca Extract Fractions Against CCl4 Toxification (갈파래 추출 분획물의 CCl4 독성에 대한 항산화 효과)

  • Nam, Chun-Suk;Kang, Kum-Suk;Ha, Jong-Myung;Lee, Sang-Hyeon;Lee, Jae-Hwa;Lee, Dong-Geun;Jang, Jeong-Su;Kang, Hwan-Yul;Ha, Bae-Jin
    • Toxicological Research
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    • v.22 no.4
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    • pp.333-338
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    • 2006
  • This study was to investigate the preventive effects in anti-oxidation of Ulva lactuca extract fractions (ULEF) against $CCl_4$ toxification in liver total homogenate and mitochondrial fraction of ULEF-pretreated and carbon tetrachloride $(CCl_4)-posttreated$ rats. ULEF was intraperitoneally administered into rats at dose of 1 ml/kg for14 days. On the day 15, 3.3 ml/kg of $CCl_4$ dissolved in olive oil (1:1) was injected 12 hr before anesthetization. Activities of superoxide dismutase(SOD) in mitochondrial fraction were measured and catalase (CAT), glutathione peroxidase (GPx), malondialdehyde (MDA) in liver total homogenate. SOD, CAI and GPx were higher in the ULEF-pretreated and $CCl_4-posttreated$ group than those in the $CCl_4-posttreated$ group, and the pretreatment of ULEF decreased MDA. These results showed that the pretreatment of ULEF had the preventive role in the activities of anti-oxidative enzymes, SOD, CAT and GPx

Influences of changes in natural environments by natural hazards and human activities in ancient times in Korea on collapse of the Unified Silla Dynasty (자연재해와 인위적 환경변화가 통일신라 붕괴에 미친 영향)

  • Hwang, Sangill;Yoon, Soon-Ock
    • Journal of the Korean association of regional geographers
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    • v.19 no.4
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    • pp.580-599
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    • 2013
  • After the unification of Three Kingdoms, Silla Dynasty had been on the prosperity with continuous population growth during approximately 120 years. However, Unified Silla Dynasty experienced 11 times of famine and bad year by frequent droughts during 50 years since the late 8th century, and these caused to political, economic and social changes. It is evident that Silla Dynasty slowly declined by the droughts and famines, although ancient records described as still on glory days. Since then, national power of Unified Silla Dynasty was abruptly weakened by migration of residents, and 9 times of rebellion or revolt occurred during 50 years in the late 9th century. As a result, political and social agitations reached the maximum. These led to the collapse of the Unified Silla Dynasty, and King Gyeongsoon handed over the dynasty to King Wanggeon, a founder of Goryeo Dynasty. These resulted from the 500-year-cycle droughts and human activities that seriously devastated the vegetations by using trees as an energy source for hundreds of thousands people during several centuries. The devastation of vegetation destroyed farm lands and led to large changes in river and groundwater systems, and eventually, increased damages by droughts.

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Inhibitory Effects of Seaweed Extracts on Growth of Malassezia furfur and Malassezia restricta

  • Choi, Jae-Suk;Lee, Bo-Bae;Joo, Chi-Un;Shin, Su-Hwa;Ha, Yu-Mi;Bae, Hee-Jung;Choi, In-Soon
    • Fisheries and Aquatic Sciences
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    • v.12 no.1
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    • pp.29-34
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    • 2009
  • Fifty seven species of common seaweed from the coast of Korea were screened for antifungal activity against Malassezia species. Seaweeds as a source of bioactive compounds are able to produce a great variety of secondary metabolites with different activities. There are numerous reports on the biological activities of seaweeds against human pathogens, fungi, and yeasts, but only few contain data regarding inhibitory effects against Malassezia sp., a major cause of dandruff and seborrheic dermatitis. To help address this paucity of information, this work was carried out to examine the antifungal effects of seaweed extracts against M. furfur and M. restricta. Of the fifty seven species of marine algae screened for their potential antifungal activity, only 17 species (29.8%) exhibited inhibitory activity. In agar disc diffusion method, the ether extracts of Corallina pilulifera, Enteromorpha linza, Laminaria japonica, Symphyocladia latiuscula and Ulva sp. showed strong antifungal activity. To identify major constituents in seaweed extracts, four selected extracts were analyzed on' a GC-MS equipped with a flame ionization detector, and compared to spectral data from databases WILEY229.LIB and NIST107.LIB. Most constituents in seaweed extracts are fatty acid-related compounds. When we evaluated any acute toxicity, the ether extracts of the selected four species were not toxic in mice. According to these results, it can be suggested that these seaweed extracts are valuable for the development of therapeutic agents in treating dandruff and seborrheic dermatitis. Further investigations to determine its bioactive compound(s) are currently in progress.

Effects of Cancer Prevention and Immune Stimulation of Fractions from Capsosiphon fulvescens (매생이 추출분획의 암 예방 및 면역증진 효과)

  • Kim, Nam-Young;Jang, Min-Kyung;Lee, Dong-Geun;Lee, Jae-Hwa;Ha, Jong-Myung;Ha, Bae-Jin;Jang, Jeong-Su;Lee, Sang-Hyeon
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.20 no.5
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    • pp.1249-1253
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    • 2006
  • The fractions of Capsosiphon fulvescens were studied to verify the anticancer and immunostimulating activity. The fractions from the ethanol extract of C. fulvescens were prepared by the systematic extraction procedure with the solvents such as hexane, ethyl ether, methanol, butanol and H$_2$O. The cytotoxic effects of C. fulvescens fractions against human leukemia cell line U937, mouse neuroblastoma cell line (NB41A3), human hepatoma cell line (HepG2)and rat glioma cell line (C6) were investigated. Ethyl ether fraction of C. fulvescens showed the highest cytotoxicity against all four cell lines tested. In addition, H$_2$O fraction also showed relatively high cytotoxicity. Dose dependent patterns were observed on all four cell lines. The immune-stimulating effects of C. fulvescens fractions on rat macrophage cell line (RAW 264.7) were also investigated. All five fractions of C. fulvescens extract stimulated NO production with concentration dependant manner. These results suggest that C. fulvescens may be a useful candidate for a natural antitumor and immune-stimulating agent.

Principles of Stone Elevation Formation for Walls and Wells in the Silla Dynasty from 5th to 7th Centuries (5~7세기 신라시대 성곽과 우물에 대한 석축입면조형원리)

  • Kang, Seong-Bin;Seo, Seong-Hyeok;Jung, Tae-Yeol
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.41 no.1
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    • pp.47-55
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    • 2023
  • In this study, the following conclusions were drawn by analyzing the size, proportion, shape, angle, distribution, etc. of stones in order to identify the principles of facade molding of stonework of the 5th to 7th centuries of the Silla Dynasty. First, the uniformity of the size of the stones of the stone foundations of the Silla Dynasty was low at -0.8 to 4.1. This means that stones of various sizes were used, from small stones to large stones. In addition, the distribution of large stones in stonework of the Silla Dynasty appeared evenly regardless of height. This was common in the stonework of the Silla Dynasty, regardless of structural classification such as wells and mountain fortresses. It is thought that the Silla people did not only pursue practicality and efficiency in stone construction, but also considered design elements. Second, the proportional deviation of the stones of the stone walls of the Silla Dynasty was high, ranging from 0.861 to 1.515. This means that the stonework of the Silla Dynasty did not use only long flagstone-shaped stones, but used a mixture of long and short stones. Third, the shape average of the stones of the stonework of the Silla Dynasty was low at 0.45, and the shape deviation was high at the maximum of 0.15. This means that the stones as a whole have irregular shapes, and each stone has a high difference in shape. Fourth, the angle deviation of the stones of the Silla Dynasty was 4.3 to 16.2, and the average angle was 2. This means that the angle of each stone on the stone axis of the Silla Dynasty is tilted to the left and right. Fifth, there was no correlation between stone size, slenderness ratio, shape, and angle in the stone axes of the Silla Dynasty. In the case of stone axes in the Joseon Dynasty, there was a positive correlation between stone size and slenderness, and a negative correlation between stone size and shape. It can be said that the stones of the Joseon Dynasty were relatively standardized, but the Silla Dynasty showed the beauty of moderation by keeping the nature of the material and becoming one with the material.