• Korean Journal of Biological Psychiatry
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• v.16 no.2
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• pp.121-126
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• 2009

Objectives : The serotonin transporter gene(SLC6A4) is one of the most widely studied candidate genes in autism spectrum disorder(ASD), but there have been conflicting results from studies into the association between SLC6A4 and ASD. The aim of this study was to evaluate the association between single nucleotide polymorphisms(SNPs) in the SLC6A4 gene and ASD in the Korean population. Methods : We selected 12 SNPs in SLC6A4 and observed the genotype of 151 Korean ASD trios. We tested the family-based association for each individual polymorphism and haplotype by using the standard TDT method in Haploview(http://www.broad.mit.edu/mpg/haploview/). Results : Through transmission-disequilibrium testing and haplotype analysis, we could not find any statistically significant transmitted allele or haplotype. In addition, a case-control association test with Korean HapMap data did not reveal any statistical significance. Conclusion : Although serotonin-related genes must be considered candidate genes for ASD, we suggest that common SNPs of SLC6A4 are not important markers for associations with Korean ASD.

• Journal of Korean Academy of Nursing
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• v.48 no.5
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• pp.521-533
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• 2018

Purpose: The aims of this study are to provide a theoretical framework for improving the self-care of adults with severe hypertension and to examine the practical suitability of a middle-range theory of self-care for chronic illness by validating the structural model. Methods: Data were collected at a university hospital in D metropolitan city from July 1 to August 14, 2015. A total of 224 Korean adult patients with severe hypertension were recruited. Data were analyzed using SPSS 22.0 and AMOS 22.0. Results: The results show that the fit index of the hypothetical model meets the recommended level; 7 out of 8 hypothetical model paths were statistically significant. Motivation, self-efficacy, support from others, and accessibility to care showed statistical significance and explained 67.3% of the self-care process. The self-care process explained 45.3%, 63.6%, and 26.5% of quality of life, health, and illness stability, respectively. Conclusion: This model can be used as a theoretical framework for improving self-care among adult Korean patients with severe hypertension. Moreover, the practical suitability and validity of the middle-range theory of self-care for chronic illness is secured.

• The Journal of Asian Finance, Economics and Business
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• v.6 no.1
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• pp.83-89
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• 2019

The purpose of this paper is to examine how the social system of deposit insurance affected the financial market in Korea. Specifically, we want to know how much the risk-seeking behavior of financial institutions has increased or decreased. The most important feature of the deposit insurance system is to prevent the insolvency of financial institutions and to properly protect depositors. In recent studies, it has been argued that characteristics of deposit insurance bring moral hazard of financial institutions and that financial institutions make unreasonably risky investments. Therefore, in this study, we will first examine whether such previous research can be applied to the Korean financial market. Next, we will examine the appropriateness of the differential premium rate that is currently used for each financial institution in the Korean financial market. In order to test the first hypothesis, we used the Capital Asset Pricing Model (CAPM) to calculate the total risk for each financial institution. As a result, significant changes were found in all regions before and after the introduction of the deposit insurance system. As for testing the second hypothesis, we conducted a variance analysis of financial institutions' indexes before and after the introduction of the deposit insurance and we discovered significance of the total risk difference.

• Korean Journal of Childcare and Education
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• v.17 no.5
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• pp.43-61
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• 2021

Objective: This study aimed to examine the sequential mediating effects of children's perceived maternal acceptance and peer acceptance in the relationship between maternal warmth and first grade children's school adjustment. Methods: Participants in this study were 979 seven-year-old children(498 boys, 481 girls) recruited for the Korea Child Panel Study. Data were analyzed by analyzing descriptive statistics, correlations, and significance of serial mediation pathways using SPSS 18.0 and PROCESS Macro 3.4. Results: Maternal warmth at age five effected perception of maternal acceptance at age six. Perceived maternal acceptance at age six effected perceived peer acceptance at age six. Perceived peer acceptance at age six effected school adjustment at age seven. Lastly, perceived maternal acceptance and peer acceptance at age six had a serial mediation effect between maternal warmth at age five and school adjustment at age seven. Conclusion/Implications: Perceived social acceptance during preschool years should be emphasized in order to promote school adjustment for first grade children. Parent education for promoting better parent child relationships should be considered and teachers should encourage peer play interaction to help children perceive acceptance from their peers.

• Computers and Concrete
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• v.24 no.2
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• pp.95-102
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• 2019

Current article proposes a cheap prototype of an embedded wireless sensor to monitor concrete structures. The prototype can measure temperature and relative humidity concurrently at a controlled through smartphone time interval. It implements a maturity method to estimate in-place concrete strength, which is considered as an alternative for traditional shock impulse method and compression tests used in Kazakhstan. The prototype was tested and adequately performed in the laboratory and field conditions. Tests aimed to study the effect of internal and ambient temperature and relative humidity on the concrete strength gain. According to test results revealed that all parameters influence the strength gain to some extent. For a better understanding of how strongly parameters influence the strength as well as each other, proposed a multicolored cross-correlation matrix technique. The technique is based on the determination coefficients. It is able to show the value of significance of correlation, its positivity or negativity, as well as the degree of inter-influence of parameters. The prototype testing also recognized the inconvenience of Bluetooth control due to weakness of signal and inability to access several prototypes simultaneously. Therefore, further improvement of the prototype presume to include the replacement of Bluetooth by Narrow Band IoT standard.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.19 no.1
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• pp.75-85
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• 2021

Evaluating the quantitative damage to rocks through acoustic emission (AE) has become a research focus. Most studies mainly used one or two AE parameters to evaluate the degree of damage, but several AE parameters have been rarely used. In this study, several data-driven models were employed to reflect the combined features of AE parameters. Through uniaxial compression tests, we obtained mechanical and AE-signal data for five granite specimens. The maximum amplitude, hits, counts, rise time, absolute energy, and initiation frequency expressed as the cumulative value were selected as input parameters. The result showed that gradient boosting (GB) was the best model among the support vector regression methods. When GB was applied to the testing data, the root-mean-square error and R between the predicted and actual values were 0.96 and 0.077, respectively. A parameter analysis was performed to capture the parameter significance. The result showed that cumulative absolute energy was the main parameter for damage prediction. Thus, AE has practical applicability in predicting rock damage without conducting mechanical tests. Based on the results, this study will be useful for monitoring the near-field rock mass of nuclear waste repository.

• Journal of Genetic Medicine
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• v.18 no.1
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• pp.31-37
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• 2021

Purpose: To summarize the results of chromosomal microarray analysis (CMA) for copy number variants (CNVs) detection and clinical utility in a single tertiary hospital. Materials and Methods: We performed CMA in 46 patients over the course of two years. Detected CNVs were classified into five categories according to the American College of Medical Genetics and Genomics guidelines and correlated with clinical manifestations. Results: A total of 31 CNVs were detected in 19 patients, with a median CNV number per patient of two CNVs. Among these, 16 CNVs were classified as pathogenic (n=3) or likely pathogenic (LP) (n=11) or variant of uncertain significance (n=4). The 16p11.2 deletion and 16p13.11 deletion classified as LP were most often detected in 6.5% (3/46), retrospectively. CMA diagnostic yield was 24.3% (9/37 patients) for symptomatic patients. The CNVs results of the commercial newborn screening test using next generation sequencing platforms showed high concordance with CMA results. Conclusion: CMA seems useful as a first-tier test for developmental delay with or without congenital anomalies. However, the classification and interpretation of CMA still remained a challenge. Further research is needed for evidence-based interpretation.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.4
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• pp.1067-1078
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• 2021

This research examines the mediation of intrinsic motivation (IP) in the relationship between psychological capital (Psycap) and innovative performance (IP) in the educational environment of the transitioning economy. A test was based on a convenient sample of 440 University lecturers participating in a hardcopy survey was collected from ten universities and colleges in Southern Vietnam, from April 2020 to December 2020, while social isolation is strictly enforced by the government (Covid-19). The hypotheses are then proposed and conducted using confirmatory factor analysis (CFA) and the structural equation modeling technique (SEM). The testing structural model results reveal that all the hypotheses are satisfied at the 5% significance level. Intrinsic motivation is a partial mediator in the linkage between psychological capital and innovative performance. These findings suggest that the importance of Psychological Capital (PsyCap) of workers promotes job performance in general, especially in individuals' creativity in a transitioning market, Vietnam. In addition, Based on the research results, several solutions are also proposed to promote innovative performance in the conditions of education in Vietnam. Besides, the author also gave a few comments on the findings as well as the limitations that this study encountered, especially how the survey samples were collected.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.2
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• pp.123-133
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• 2021

The purpose of this study was to analyze the influence of product quality factors, product risk, company reputation, and service quality on the purchase intention of insurance policies by customers in Indonesia. The variables in this study are product quality, service quality, company reputation, perceived risk, and purchase intention. This study uses a quantitative approach. Primary data were obtained from 154 respondents. Data processing and model testing use the Structural Equation Modeling procedure with Lisrel 8.80. At the significance level of 0.05, the research found that product quality had a positive and significant effect on purchase intention; product quality had a positive and significant effect on company reputation; product quality had a positive and significant effect on perceived risk perception; company reputation had a positive and significant effect on purchase intention; company reputation has a positive and insignificant effect on service quality; product quality has a positive, but non-significant effect on service quality; service quality has a positive and significant effect on purchase intention; perceived risk has a negative and significant effect on purchase intention; perceived risk has a positive and significant impact on service quality; and perceived risk has a positive and significant effect on company reputation.

• Journal of Korea Trade
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• v.26 no.1
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• pp.99-112
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• 2022

Purpose - This paper empirically investigates via a spatial lag model from the perspective of space economy to find the influencing factors of South Korea's OFDI along with 60 countries. Design/methodology - In the study of regional economic phenomena, we must first test the corresponding spatial correlation, and on this basis, complete the construction of the spatial model. For the target research object, after testing the spatial correlation, if there is spatial correlation, a spatial measurement model is needed. This paper uses the global Moran's I index for calculation. Based on the characteristics and research needs of the research object, this paper selects the spatial lag model to verify the existence of the spatial effect and factors affecting OFDI. Findings - Our results show that export scale, infrastructure, technology level, political stability, resource endowment, market size, distance and labor cost have a certain impact on Korea's OFDI, but at present the distance and market size factors are the most important influencing factors for South Korea's OFDI, The technical level and political stability have little effect on South Korea's OFDI, and are not main factors determining South Korea's OFDI. Originality/value - Through spatial measurement verification, it was found that the spatial effect has a significant impact on OFDI, along with more than 60 countries. On this basis, relevant suggestions are put forward, which have strong practical significance for South Korea's OFDI to achieve healthy and sustainable development.