• Proceedings of the KSR Conference
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• 2011.05a
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• pp.125-131
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• 2011

TSI(Technical Specification for Interoperability) is the highest technical specification in the Europe Railway and is composed by assessment items and essential requirements included by safety, reliability, availability, health, environment protection and technical compatibility. It is used on the research and development in the next generation railway technical. Currently, TSI procedures have been asked to bid for high speed rail business in Europe and Brazil. Also, all the railway systems such as infrastructure, signaling, electric and rolling stock system corresponding with standard of TSI procedures are exported and imported. Recently, Safety Critical System which has been studied on future railway R&D business in Korea is the state of the art train control system. And it is needed for system assessment of TSI procedures before system test and operation. In this paper, basic research is performed for analyzing TSI procedures suitable for the state of the art train control system in Korean railway.

• Korean Management Science Review
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• v.33 no.4
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• pp.65-75
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• 2016

We study limit pricing in a price-based duopoly market under asymmetric information on the demand state. An incumbent, who is a monopolist in the initial period, has complete information on the size of a market, while a potential entrant only knows it partially. After observing the sales price of the incumbent in the first period, the entrant decides whether to enter a duopoly market and the sales price if she chooses to. We present a separating perfect Bayesian equilibrium, which indicates that limit pricing can deter the entry of a potential entrant under price competition when there is information asymmetry about the demand state.

• ETRI Journal
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• v.31 no.1
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• pp.31-41
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• 2009

Optical burst switching is a promising switching paradigm for the next IP-over-optical network backbones. However, its burst loss performance is greatly affected by burst contention. Several methods have been proposed to address this problem, some of them requiring the network to be flooded by frequent state dissemination signaling messages. In this work, we present a traffic engineering approach for path selection with the objective of minimizing contention using only topological information. The main idea is to balance the traffic across the network to reduce congestion without incurring link state dissemination protocol penalties. We propose and evaluate two path selection strategies that clearly outperform shortest path routing. The proposed path selection strategies can be used in combination with other contention resolution methods to achieve higher levels of performance and support the network reaching stability when it is pushed under stringent working conditions. Results show that the network connectivity is an important parameter to consider.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.41 no.7
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• pp.723-731
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• 2016

A core technological base to provide enhanced data rates required by 5G mobile wireless communications is the improved bandwidth efficiency using massive multiple-input multiple-output (MIMO) transmission. MIMO transmission requires the channel estimation using the channel state information reference signaling (CSI-RS) and appropriate beamforming, thus the design of the codebook defining proper beamforming vectors is an important issue. In this paper, we propose a multi-rank codebook based on the discrete Fourier transform (DFT) matrix, by utilizing statistical properties of the channel generated by the spatial channel model (SCM). The proposed method includes a structural change of the precoding matrix indicator (PMI) by considering the phase difference distributions between adjacent antenna elements, as well as the selected codevector characteristics of each transmission layer. Performance gain of the proposed method is evaluated and verified by making the performance comparison to the 3GPP standard codebooks adopted by Long-Term Evolution (LTE) systems.

• Ocean and Polar Research
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• v.39 no.2
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• pp.149-158
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• 2017

The opsin family of light sensitive proteins family makes up are the universal photoreceptor molecules of all visual systems in the vertebrates including teleosts. They can change their conformation from a resting state to a signaling state upon light absorption, which activates the G-protein coupled receptor, thereby resulting in a signaling cascade that produces physiological responses. However, this species is poorly characterized at molecular level due to little sequence information available in public databases. We have investigated the opsin family of nocturnal cutlass fish using the whole transcriptome sequencing method. The opsin genes were cloned and its expression in the tissues and organs were examined by qPCR. We cloned 6 opsin genes (RRH, Opn4, Rh1, Rh2, VA-opsin, and Opn3) in retina and brain tissue. It contained the seven presumed transmembrane domains that are characteristic of the G-protein-coupled receptor family. However, short wavelength sensitive pigment (SWS) and long wavelength sensitive pigment (LWS) were not detected in this study. The mRNA expression of the 6 photoreceptor genes were detected in retina and peripheral tissue. Our studies will lead to further investigation of the photic entrainment mechanism at molecular and cellular levels in cutlass fish and can be used in comparative studies of other fishes.

• Proceedings of the KSR Conference
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• 2003.10c
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• pp.236-246
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• 2003

This paper is implemented a control algorithm in order to be stable and minimized to entire train traffic system at delayed case. Signal ing system is described wi th algebraic equations given for train headway, Discrete-event simulation principles are reviewed and a demonstration block signaling model using the technique is implemented. Train congestion at station entrance for short headway operation is demonstrated and the propagation of delays along a platform of trains from any imposed delay to the leading train is also shown. A rail way signaling system is by nature a distributed operation with event triggered at discrete intervals. Although the train kinematic variables of position, velocity, and acceleration are continually changing, the changes are triggered when the trains pass over section boundaries and arrive at signals and route switches. This paper deals with linear-mode1ing, stability and optimal control for the traffic on such metro line of the model is reconstructed in order to adapt the circuits. This paper propose optimal control laws wi th state feedback ensuring the stability of the modeled system for circuits. Simulation results show the benefit to be expected from an efficient traffic control. The main results are summarized as follows: 1. In this paper we develop a linear model describing the traffic for both loop lines, two state space equations have been analyzed. The first one is adapted to the situation where a complete nominal time schedule is available while second one is adapted when only the nominal time interval between trains is known, in both cases we show the unstability of the traffic when the proceeding train is delayed following properties, - They are easily implemented at law cost on existing lines. - They ensure the exponetial stability of loop system. 2. These control laws have been tested on a traffic simulation software taking into the non-linearites and the physical constraints on a metro line. By means of simulation, the efficiency of the proposed optimal control laws are shown.

• Journal of Life Science
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• v.18 no.9
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• pp.1219-1224
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• 2008

The embryonic zebrafish (Danio rerio) is rapidly becoming an important model organism for studies of early events in vertebrate development. Neural crest-derived pigment cell precursors of the embryonic zebrafish give rise to melanophores, xanthophores, and/or iridophores. Cell-signaling mechanisms related to the development of pigmentation and pigment pattern formation remain obscure. In this study, zebrafish embryos were treated with various signaling-related molecules - LiCl (an inositol-phosphatase inhibitor), forskolin (a protein kinase-A activator), a combination of LiCl/forskolin, and LiCl/heparin (an IP3 inhibitor) in order to identify the mechanisms involved in pigmentation. LiCl treatment resulted in ultrastructural and morphological alterations of melanophores. To identify the possible proteins responsible for this ultrastructural and morphological change, phosphorylation patterns in vitro and in vivo were analyzed. LiCl and LiCl/forskolin treatment elicited dramatic increases in the phosphorylation of a 55-kDa protein which was inhibited by heparin treatment. LiCl treatment also induced phosphorylation of a 55-kDa protein in melanophores purified from adult zebrafish. Collectively these results suggest that a LiCl-induced 55-kDa phosphoprotein plays a role in melanophore morphology and ultrastructure and ultimately effects gross pigmentation.

• Journal of Photoscience
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• v.9 no.2
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• pp.534-536
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• 2002

A halophilic archaeon, Halobacterium salinarum, exhibits phototactic behaviors, by which the organism is guided to red-orange light and evades shorter wavelengths of light. The phototaxis is mediated by two retinal proteins, sensory rhodopsin I and II (SRI and SRII), whose structures are analogous to the cognate protein bacteriorhodopsin, a light-driven proton pump. SRI mediates both attractant and repellent swimming behaviors to orange light and near- UV light, respectively. The two different signaling through the single photoreceptor have been ascribed to the presence of two active structures of SRI (S$\_$373/ and P$\_$520), which are produced upon orange light illumination of SRI and upon subsequent near-UV illumination of S$\_$373/, respectively. In the present study, we have measured the difference FTIR spectra of S$\_$373/ and P$\_$520/ states. In P$\_$520/, the isomeric structure of the chromophore is assignable to all-trans, and the Schiff base of the chromophore is protonated with concomitant deprotonation of Asp76, a combination which allows for the formation of a salt bridge between them. It was suggested that the way of interaction between the Schiff base and the counterion, which is different among SRI$\_$587/, S$\_$373/ and P$\_$520/ and which has been shown to drive the conformational changes in the cognate protein, bacteriorhodopsin, is the key to controlling conformational changes for the attractant and the repellent signaling by SRI.

• International Journal of Vascular Biomedical Engineering
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• v.2 no.2
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• pp.1-9
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• 2004

The history of studies in biology regarding reactive oxygen species (ROS) is approximately 40 years. During the initial 30 years, it appeared that these studies were mainly focused on the toxicity of ROS. However, recent studies have identified another action regarding oxidative signaling, other than toxicity of ROS. Basically, it is suggested that ROS are reactive, and degenerate to biomolecules such as DNA and proteins, leading to deterioration of cellular functions as an oxidative stress. On the other hand, recent studies have shown that ROS act as oxidative signaling in cells, resulting in various gene expressions. Recently ROS emerged as critical signaling molecules in cardiovascular research. Several studies over the past decade have shown that physiological effects of vasoactive factors are mediated by these reactive species and, conversely, that altered redox mechanisms are implicated in the occurrence of metabolic and cardiovascular diseases ROS is a collective term often used by scientist to include not only the oxygen radicals($O2^{-{\cdot}},\;{^{\cdot}}OH$), but also some non-radical derivatives of oxygen. These include hydrogen peroxide, hypochlorous acid (HOCl) and ozone (O3). The superoxide anion ($O2^{-{\cdot}}$) is formed by the univalent reduction of triplet-state molecular oxygen ($^3O_2$). Superoxide dismutase (SOD)s convert superoxide enzymically into hydrogen peroxide. In biological tissues superoxide can also be converted nonenzymically into the nonradical species hydrogen peroxide and singlet oxygen ($^1O_2$). In the presence of reduced transition metals (e.g., ferrous or cuprous ions), hydrogen peroxide can be converted into the highly reactive hydroxyl radical (${^{\cdot}}OH$). Alternatively, hydrogen peroxide may be converted into water by the enzymes catalase or glutathione peroxidase. In the glutathione peroxidase reaction glutathione is oxidized to glutathione disulfide, which can be converted back to glutathione by glutathione reductase in an NADPH-consuming process.

• Journal of Microbiology
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• v.45 no.3
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• pp.187-192
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• 2007

REOviruses (Respiratory Enteric Orphan viruses) are ubiquitous, non-enveloped viruses containing 10 segments of double-stranded RNA (dsRNA) as their genome. They are common isolates of the respiratory and gastrointestinal tract of humans but are not associated with severe disease and are therefore considered relatively benign. An intriguing characteristic of reovirus is its innate oncolytic potential, which is linked to the transformed state of the cell. When immortalized cells are transfected in vitro with activated oncogenes such as Ras, Sos, v-erbB, or c-myc, they became susceptible to reovirus infection and subsequent cellular lysis, indicating that oncogene signaling pathways are exploited by reovirus. This observation has led to the use of the virus in clinical trials as an anti-cancer agent against oncogenic tumors. In addition to the exploitation of oncogene signaling, reovirus may further utilize host immune responses to enhance its antitumor activity in vivo due to its innate interferon induction ability. Reovirus is, however, not entirely benign to immunocompromised animal models. Reovirus causes so-called "black feet syndrome" in immunodeficient mice and can also harm neonatal animals. Because cancer patients often undergo immunosuppression due to heavy chemo/radiation-treatments or advanced tumor progression, this pathogenic response may be a hurdle in virus-based anticancer therapies. However, a genetically attenuated reovirus variant derived from persistent reovirus infection of cells in vitro is able to exert potent anti-tumor activity with significantly reduced viral pathogenesis in immunocompromised animals. Importantly, in this instance the attenuated, reovirus maintains its oncolytic potential while significantly reducing viral pathogenesis in vivo.