• Proceedings of the Korean Society of Medical Physics Conference
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• 2002.09a
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• pp.341-344
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• 2002

Neurodegenerative disorders, like Alzheimer's disease, are often accompanied by reduced brain perfusion (cerebral blood flow). Using the intrinsic magnetic properties of water, arterial spin labeling magnetic resonance imaging (ASLMRI) can map brain perfusion without injection of radioactive tracers or contrast agents. However, accuracy in measuring perfusion with ASL-MRI can be limited because of contributions to the signal from stationary spins and because of signal modulations due to transient magnetic field effects. The goal was to optimize ASL-MRI for perfusion measurements in the aging human brain, including brains with Alzheimer's disease. A new ASL-MRI sequence was designed and evaluated on phantom and humans. Image texture analysis was performed to test quantitatively improvements. Compared to other ASL-MRI methods, the newly designed sequence provided improved signal to noise ratio improved signal uniformity across slices, and thus, increased measurement reliability. This new ASL-MRI sequence should therefore provide improved measurements of regional changes of brain perfusion in normal aging and neurodegenerative disorders.

• Journal of the Korean Magnetic Resonance Society
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• v.26 no.4
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• pp.51-58
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• 2022

The baseline flattened NMR spectrum has been achieved by several methodologies including pulse manipulation with a series of phase cycling. The background signal inherent in the probe is also main source of baseline distortion both in solution and solid NMR. The simple direct polarization with 90° pulse flipping the magnetization from the z-axis onto the receiver coil requires the strong rf pulse enough to encompass the wide frequency range to excite the resonance of interest nuclei. Albeit the perfect polarization 90° pulse, the signal from the unwanted magnetic fields such as background signal can not be completely suppressed by suitable phase cycling. Moreover, slowly baseline wiggling signal from the low 𝛾 nuclei is not easy to eliminate with multiple pulse manipulation. So there is still need to contrive the new scheme for that purpose in an adroit manner. In this article new triple pulse excitation schemes for TIP and modified DEPTH pulse sequence are analytically examined in terms of arbitrary phase and flip angle of pulse. The suitable phase cycling for these pulse trains is necessary for the good sensitivity and resolution of the spectrum. It is observed that the ¹³C sensitivity TIP experiment is almost equal to the CP/MAS with modified DEPTH sequence, both of which are applicable to both solid and solution state NMR.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.20 no.2
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• pp.187-198
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• 1990

Examinations of the temporomandibular joints were performed on a 1.5 Tesla magnetic resonance (MR) system. An MR surface receiver coil 3 inch in diameter was placed on plastic frame, the patient's head being placed in the frame so that the coil was pressed against the temporal region. In taking advantage of the magnetic resonance imaging that has been studied briskly till now, author obtained the images of parasagittal and paracoronal planes about the temporomandibular joint by using MPGR (Multi-Planar Gradient Recalled), GRASS (Gradient Recalled Acquisition in the Steady State), and CSMEMP (Contiguous Slice Multiple Echo, Multi-Planar), that differ from the Spin Echo pulse sequence which the previous authors used. Five subjects with no symptoms of temporomandibular joint pain and dysfunction were studied. The plane images obtained by these methods were compared with those by Spin Echo pulse sequence. The results were as follows: 1. The optimal repetition times (TR) and echo times (TE) for T.M.J. image were; a. 400 msec and 18 msec in PMGR pulse sequence. b. 40 msec and 12 msec in GRASS pulse sequence. c. 700 msec and 30 msec in CSMEMP pulse sequence. d. 500 msec and 20 msec in Spin Echo pulse sequence. 2. When the MPGR pulse sequence was using, T2-weighted image was obtained in very short time. On the image of the paracoronal plane by GRASS pulse sequence, meniscus showed the moderate signal intensity, and the meniscus and its anteromedial, posterolateral attachments were observed definitely with gray color. 4. The signal intensity of Spin Echo pulse sequence was equal to that of CSMEMP pulse sequence, but the image by CSMEMP pulse sequence showed relatively lower level in its resolution.

• The Journal of the Korea institute of electronic communication sciences
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• v.7 no.2
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• pp.263-269
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• 2012

Code-Division Multiple-Access(CDMA) allows several users simultaneous access to a common channel by assigning a distinct pseudonoise sequence called spectrum code to each user. Each user in a CDMA system uses a assigned spectrum code to modulate their signal. Choosing the codes used to modulate the signal is very important in the performance of CDMA systems. The best performance will occur when there is good separation between the signal of a desired user and the signals of other users. The receiver synchronizes the code to recover the data. The use of an independent code allows multiple users to access the same frequency band at the same time. In this paper we propose a generalized model of non-linear binary sequence using trace function and analyze cross-correlation of these sequences. These sequences with low correlation, large linear span and large family size, in a direct-sequence spread spectrum communication system, help to minimize multiple access interference, increase security degree of system and enlarge user number.

• Microbiology and Biotechnology Letters
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• v.31 no.1
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• pp.36-41
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• 2003

In order to increase the production and secretion rate of mouse salivary $\alpha$-amylase from Saccharomyces cerevisiae, various experiments were attempted. A plasmid pCNNinv (AMY) was constructed by the substitution of ADCl promoter and native signal sequence of mouse salivary $\alpha$-amylase cDNA gene with PRBI promoter and yeast invertase leader sequence, which resulted in 25% increase in the production of $\alpha$-amylase in the culture medium. The respiratory deficient transformant carrying pCNNinv (AMY) were obtained by treating yeast cells with ethidium bromide, and the $\alpha$-amylase activities in the culture brothes of the respiratory-deficient transformants were 5-8 times higher than that of parental wild type strain. $\alpha$-Amylase activity was also increased 3 times when the 0.015% (w/v) of 2-mercaptoethanol was added to the culture medium.

• BMB Reports
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• v.37 no.4
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• pp.429-438
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• 2004

Complementary DNAs encoding $\alpha$-amylases (Amyl I, Amyl III) and glucoamylase (GA I) were cloned from Aspergillus awamori KT-11 and their nucleotide sequences were determined. The sequence of Amyl III that was a raw starch digesting $\alpha$-amylase was found to consist of a 1,902 bp open reading frame encoding 634 amino acids. The signal peptide of the enzyme was composed of 21 amino acids. On the other hand, the sequence of Amyl I, which cannot act on raw starch, consisted of a 1,500 bp ORF encoding 499 amino acids. The signal peptide of the enzyme was composed of 21 amino acids. The sequence of GA I consisted of a 1,920 bp ORF that encoded 639 amino acids. The signal peptide was composed of 24 amino acids. The amino acid sequence of Amyl III from the N-terminus to the amino acid number 499 showed 63.3% homology with Amyl I. However, the amino acid sequence from the amino acid number 501 to C-terminus, including the raw-starch-affinity site and the TS region rich in threonine and serine, showed 66.9% homology with GA I.

• ETRI Journal
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• v.28 no.2
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• pp.250-252
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• 2006

In this letter, a discrete state, discrete time chaotic pseudo random number generator (CPRNG) is presented for stream ciphering of text, audio, or image data. The CPRNG is treated as a finite state machine, and its state is modulated according to the input bit sequence of the signal to be encrypted. The modulated state sequence obtained can be transmitted as a spread spectrum or encrypted data.

• Journal of Positioning, Navigation, and Timing
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• v.2 no.1
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• pp.1-8
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• 2013

A signal system for improving the code acquisition complexity of Global Navigation Satellite System (GNSS) receiver is proposed and the receiving correlator scheme is presented accordingly. The proposed signal system is a hierarchical code type with a duplexing configuration which consists of the Zadoff-Chu (ZC) code having a good auto-correlation characteristic and the Pseudo Random Noise (PRN) code for distinguishing satellites. The receiving correlator has the scheme that consists of the primary correlator for the ZC code and the secondary correlator which uses the PRN code for the primary correlation results. The simulation results of code acquisition using the receiving correlator of the proposed signal system show that the proposed signal scheme improves the complexity of GNSS receiver and has the code acquisition performance comparable to the existing GNSS signal system using Coarse/Acquisition (C/A) code.

• Journal of the Korea Institute of Military Science and Technology
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• v.19 no.6
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• pp.762-768
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• 2016

In this paper, a method for generating ranging signal to reduce the effects of interference and overcome intentional jamming is proposed in slow frequency hopping(SFH) communication system. A terminal uses ranging signal for initial Up-link synchronization in the frequency hopping communication systems using multi-terminal. However, ranging signal generated by unsynchronized terminal acts as an interference signal to another terminal. Therefore, we propose the design of the ranging signal with PN sequence in order to minimize the affection to the other terminal and simulated its performance. From the simulated result, we confirm synchronization performance.

• Journal of Biomedical Engineering Research
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• v.28 no.1
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• pp.24-28
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• 2007

Presuming that firing neurons have motions inside the MRI magnet due to the interaction between the neuronal magnetic field and the main magnetic field, we applied motion encoding gradients to dissected snail ganglia to observe faster responding MRI signal than the BOLD signal. To activate the snail ganglia in synchronization with the MRI pulse sequence, we used electrical stimulation with the frequency of 30 Hz and the pulse width of 2s. To observe the fast responding signal, we used the volume selected MRI sequence. The magnetic resonance signal intensity, measured with 8 ms long motion encoding gradient with a 20mT/m gradient strength, decreased about $3.46{\pm}1.48%$ when the ganglia were activated by the electrical stimulation.