• 한국수산과학회지
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• 제32권4호
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• pp.404-408
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• 1999

본 연구에서는 나일틸라피아의 초기성장에 대한 유전적 개량의 가능성을 알아보기 위해 60일령 나일틸라피아를 대상으로 체고(BH1, BH2)를 비롯한 8 가지의 계측형질에 대해 형매분석 (sib analysis)에 의하여 유전모수를 추정하였다. 각 계측형질에서의 sire 유전율 ($h^2_s$)은 0.08$\~$0.70, dam 유전율 ($h^2_d$)은 0.22$\~$0.41, 전형매 유전율 ($h^2_{s+d}$)은 0.18$\~$0.55의 범위였다. SL의 경우 각각 0.13, 0.22 및 0.18로 추정되었다. 한편, 본 연구에서 계측형질로 채택한 BH2의 "$h^2_s$, $h^2_d$ 및 $h^2_{s+d}$은 각각 0.08, 0.38 및 0.23으로서 새로운 선발 대상 형질로의 활용 가능성을 보였다. 또한 이들 8 개 계측형질간의 표현형상관 및 유전상관을 추정하였는데, 표현형상 관계수는 0.86$\~$0.97의 범위였고, 유전상관계수는 0.90$\~$0.99로 나타났다. 앞으로 더욱 정확한 유전모수의 추정을 위한 지속적인 연구가 필요하나, 본 연구 결과 개체선발에 의해서 나일틸라피아의 초기성장에 대한 유전적 개량의 가능성을 확인할 수 있었다.

• 대한치과교정학회지
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• 제49권1호
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• pp.3-11
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• 2019

Objective: The purpose of this study was to investigate the influence of heritability on the craniofacial soft tissue cephalometric characteristics of monozygotic (MZ) twins, dizygotic (DZ) twins, and their siblings (SIB). Methods: The samples comprised Korean adult twins and their siblings (mean age, 39.8 years; MZ group, n = 36 pairs; DZ group, n = 13 pairs of the same gender; and SIB group, n = 26 pairs of the same gender). Thirty cephalometric variables were measured to characterize facial profile, facial height, soft-tissue thickness, and projection of nose and lip. Falconer's method was used to calculate heritability (low heritability, $h^2$ < 0.2; high heritability, $h^2$ > 0.9). After principal components analysis (PCA) was performed to extract the models, we calculated the intraclass correlation coefficient (ICC) value and heritability of each component. Results: The MZ group exhibited higher ICC values for all cephalometric variables than DZ and SIB groups. Among cephalometric variables, the highest ${h^2}_{(MZ-DZ)}$ and ${h^2}_{(MZ-SIB)}$ values were observed for the nasolabial angle (NLA, 1.544 and 2.036), chin angle (1.342 and 1.112), soft tissue chin thickness (2.872 and 1.226), and upper lip thickness ratio (1.592 and 1.026). PCA derived eight components with 84.5% of a cumulative explanation. The components that exhibited higher values of ${h^2}_{(MZ-DZ)}$ and ${h^2}_{(MZ-SIB)}$ were PCA2, which includes facial convexity, NLA, and nose projection (1.026 and 0.972), and PCA7, which includes chin angle and soft tissue chin thickness (2.107 and 1.169). Conclusions: The nose and soft tissue chin were more influenced by genetic factors than other soft tissues.

• 구강회복응용과학지
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• 제28권4호
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• pp.349-357
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• 2012

이번 연구의 목적은 콘빔형 전산화단층촬영술(cone-beam computed tomography)을 이용하여 상악동 측벽의 두께를 측정하고, 이를 바탕으로 상악동 거상술을 위한 측벽창(lateral wall window)형성 시 가장 적절한 수직적 위치를 평가하는 것이다. 2010년 7월부터 2012년 6월까지 경북대학교 치과병원에 내원한 53명(남 : 36명, 여 : 17명, 평균나이 : 51.5세)의 상악동거상술 예정 환자의 콘빔형 전산화단층영상을 대상으로 하였다. 상악동 측벽의 두께는 상악 제2소구치, 제1대구치, 제2대구치 부위에서 상악동 하연을 포함하여 상악동 하연을 기준으로 수직적으로 1 mm 간격으로 6 mm 까지 측정하였고, 2회 반복 측정하여 평균을 구하였다. 상악동 측벽의 두께는 상악동 하연(Sinus Inferior Border, SIB)을 기준으로 상방 2 mm (SIB+2)까지는 2 mm 이상으로 관찰되었고, 상악동의 하연을 기준으로 3 mm 상방 (SIB+3)에서는 2 mm 미만으로 나타났으며, 상악동 하연을 기준으로 4 mm 상방에서는 두께가 거의 일정한 것으로 나타났다. 이번 연구 결과를 바탕으로 측방 접근법을 이용한 상악동 거상술에서 측벽창의 하방 위치는 상악동 측벽의 두께를 고려할 때 상악동의 하연을 기준으로 약 3 mm 상방에서 형성하는 것이 적절할 것으로 생각된다.

• 대한한의학원전학회지
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• 제20권1호
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• pp.39-48
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• 2007

The first chapter of the Oh Sib Young(五十營) explains that the length of the measurement of channels(脈度) is sixteen zahngs two cheocks(16丈2尺). The second chapter says that nourishing gi(營氣) circles around(周行) the whole body 50 times during 13,500 times of breathing in twenty-four hours. The third chapter explains that the total length reaches 810 zhangs(810丈) if it circles around 50 times. Through construction of word, comparison of annotation, investigation, literal translation, free translation, conclusion analysis of these ancient writings, the following results were obtained. In the second chapter, "twenty five bun(二十五分)" should be modified into "twenty bun one Ii six ho(二十分一釐六毫) " or "twenty bun and the rest(二十分有奇)", "forty bun(四十分)" should be changed into "forty bun sam Ii two ho(四十分三釐二毫)" or "forty bun and the rest", and "five su twenty bun(五宿二十分)" should be modified into "five su twenty one bun six li(五宿二十分六釐)" or "two hundred ten bun and the rest(二百十分有奇)" in order to clarify their meanings.

• Communications for Statistical Applications and Methods
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• 제17권5호
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• pp.733-743
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• 2010

가족기반 유전연구에서 단일염기다형성(SNP) 및 일배체형(haplotype)을 이용한 질병-유전자간 연관성 분석은 주요 관심부분 중 하나이다. 이진형질인 경우 사용되는 고전적인 TDT(transmission/disequilibrium test)는 부/모/자의 유전정보를 모두 알 수 있을 때에 쓸 수 있다. 그러나 경우에 따라서는 부모의 유전자형에 대한 정보를 사용할 수 없을 수가 있는데, 치매등과 같이 늦게 발병하는 질환에서 이런 경우가 자주 발생한다. 부모의 유전자형을 모를 때 이를 대체할 수 있는 방법으로 형매(sib)의 유전정보를 이용하는 방법이 있다. 본고에서는 가족기반연구에서 형매의 유전정보를 이용하는 분석방법에 대해 고찰하고 모의실험을 통해 이들의 검정력을 비교하였다.

• 한국한의학연구원논문집
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• 제18권2호
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• pp.25-38
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• 2012

Objective : This study was conducted to underpin the theory of Taegeuk Acupuncture systematically and increase the utility of clinical trial and a range of application. Method : This study analysed ByungHaeng Lee's theory, who is the originator of Taegeuk Acupuncture, by focusing on "Young Chu GuChimSibYiWon" Result & Conclusion : 1. ByungHaeng Lee's thought about Viscera and Bowels is following medicine of Internal Classic. Even though JeMa Lee's thought about Viscera and Bowels has same name with ByungHaeng Lee's, but the functional meaning and related part is totally different. So, four constitution types in Taegeuk Acupuncture are different from four constitution types in Four-Constitution Medicine. Therefore, Taegeuk Acupuncture isn't related with Four-Constitution Medicine 2. On the authority of "Young Chu GuChimSibYiWon", we can extend 4 therapeutic acupuncture point combinations of Taegeuk Acupuncture to ten therapeutic acupuncture point combinations which tentatively named 'Five Viscera Source Point Acupuncture'. 3. To consider an example of eight constitutional acupuncture, Taegeuk Acupuncture thoroughly says constitutional acupuncture. Especially, JaeGyuKim's Taegeuk Acupuncture has specific diagnosis standard that after treating a patient with acupuncture, he checks an oppressive pain at the precordial region and a voiced sound at liver and then he makes sure constitution of patient. So we can consider JaeGyuKim's Taegeuk Acupuncture as constitutional acupuncture. However, it has to change the name of four constitution types to taegeuk greater yang person, taegeuk lesser yang person, taegeuk greater yin person, taegeuk lesser yin person so as to avoid confusion. 4. Taegeuk Acupuncture is markedly simple in comparison with other acupuncture, so it needs to extend the utility of clinics by enlarging treatment acupuncture points.

• Communications for Statistical Applications and Methods
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• 제16권2호
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• pp.373-381
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• 2009

Evidence of linkage is expressed as a decreasing trend of the squared trait difference of two siblings with increasing identical by descent scores. In contrast to successes in the application of a parametric approach of Haseman-Elston regression, notably low powers are demonstrated in the nonparametric linkage analysis methods for complex traits and diseases with sib-pairs data. We report that the Genehunter nonparametric linkage statistic is biased and furthermore the variance formula that they used is an inflated one, and this is one reason for a low performance. Thus, we propose bias-corrected nonparametric linkage statistics. Simulation studies comparing our proposed nonparametric test statistics versus the existing test statistics suggest that the bias-corrected new nonparametric test statistics are more powerful and attains efficiencies close to that of Haseman-Elston regression.

• 대한치매학회지
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• 제22권3호
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• pp.100-108
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• 2023

Background and Purpose: The efficacy and safety of GV1001 have been demonstrated in patients with moderate-to-severe Alzheimer's disease (AD). In this study, we aimed to further demonstrate the effectiveness of GV1001 using subscales of the Severe Impairment Battery (SIB), which is a validated measure to assess cognitive function in patients with moderate-to-severe AD. Methods: We performed a post hoc analysis of data from a 6 month, multicenter, phase 2, randomized, double-blind, placebo-controlled trial with GV1001 (ClinicalTrials.gov, NCT03184467). Patients were randomized to receive either GV1001 or a placebo for 24 weeks. In the current study, nine subscales of SIB-social interaction, memory, orientation, language, attention, praxis, visuospatial ability, construction, and orientation to name-were compared between the treatment (GV1001 1.12 mg) and placebo groups at weeks 12 and 24. The safety endpoints for these patients were also determined based on adverse events. Results: In addition to the considerable beneficial effect of GV1001 on the SIB total score, GV1001 1.12 mg showed the most significant effect on language function at 24 weeks compared to placebo in both the full analysis set (FAS) and per-protocol set (PPS) (p=0.017 and p=0.011, respectively). The rate of adverse events did not differ significantly between the 2 groups. Conclusions: Patients with moderate-to-severe AD receiving GV1001 had greater language benefits than those receiving placebo, as measured using the SIB language subscale.

• The Plant Pathology Journal
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• 제38권5호
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• pp.541-549
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• 2022

Potato late blight caused by Phytophthora infestans is a destructive disease in Korea. To elucidate the genomic variation of the mitochondrial (mt) genome, we assembled its complete mt genome and compared its sequence among different haplotypes. The mt genome sequences of four Korean P. infestans isolates were revealed by Illumina HiSeq. The size of the circular mt genome of the four major genotypes, KR_1_A1, KR_2_A2, SIB-1, and US-11, was 39,872, 39,836, 39,872, and 39,840 bp, respectively. All genotypes contained the same 61 genes in the same order, comprising two RNA-encoding genes, 16 ribosomal genes, 25 transfer RNA, 17 genes encoding electron transport and ATP synthesis, 11 open reading frames of unknown function, and one protein import-related gene, tatC. The coding region comprised 91% of the genome, and GC content was 22.3%. The haplotypes were further analyzed based on sequence polymorphism at two hypervariable regions (HVRi), carrying a 2 kb insertion/deletion sequence, and HVRii, carrying 36 bp variable number tandem repeats (VNTRs). All four genotypes carried the 2 kb insertion/deletion sequence in HVRi, whereas HVRii had two VNTRs in KR_1_A1 and SIB-1 but three VNTRs in US-11 and KR_2_A2. Minimal spanning network and phylogenetic analysis based on 5,814 bp of mtDNA sequences from five loci, KR_1_A1 and SIB-1 were classified as IIa-6 haplotype, and isolates KR_1_A2 and US-11 as haplotypes IIa-5 and IIb-2, respectively. mtDNA sequences of KR_1_A1 and SIB-1 shared 100% sequence identity, and both were 99.9% similar to those of KR_2_A2 and US-11.

• Radiation Oncology Journal
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• 제37권2호
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• pp.82-90
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• 2019

Purpose: To evaluate the results of hypofractionated radiotherapy (HFX) for early glottic cancer. Materials and Methods: Eighty-five patients with cT1-2N0M0 squamous cell carcinoma of the glottis who had undergone HFX, performed using intensity-modulated radiotherapy (IMRT, n = 66) and three-dimensional conformal radiotherapy (3D CRT, n = 19) were analyzed. For all patients, radiotherapy was administered at 60.75 Gy in 27 fractions. Forty-three patients received a simultaneous integrated boost (SIB) of 2.3-2.5 Gy per tumor fraction. Results: The median follow-up duration was 29.9 months (range, 5.5 to 76.5 months). All patients achieved complete remission at a median of 50 days after the end of radiotherapy (range, 14 to 206 days). The 5-year rates for locoregional recurrence-free survival was 88.1%, and the 5-year overall survival rate was 86.2%. T2 stage was a prognostic factor for locoregional recurrence-free survival after radiotherapy (p = 0.002). SIB for the tumor did not affect disease control and survival (p = 0.191 and p = 0.387, respectively). No patients experienced acute or chronic toxicities of ≥grade 3. IMRT significantly decreased the dose administered to the carotid artery as opposed to 3D CRT (V₃₅, p < 0.001; V₅₀, p < 0.001). Conclusions: Patients treated with HFX achieved acceptable locoregional disease control rates and overall survival rates compared with previous HFX studies. A fraction size of 2.25 Gy provided good disease control regardless of SIB administration.