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http://dx.doi.org/10.5351/CKSS.2010.17.5.733

Comparison of Genetic Association Analyses Using Sib Information in Family-Based Study  

Jung, Ji-Won (Department of Statistics, Chungnam National University)
Lee, Suk-Hoon (Department of Statistics, Chungnam National University)
Kim, Soon-Ae (Department of Pharmacology Medicine, Eulji University)
Park, Mi-Ra (Department of Preventive Medicine, Eulji University)
Publication Information
Communications for Statistical Applications and Methods / v.17, no.5, 2010 , pp. 733-743 More about this Journal
Abstract
Recently, disease-genetic association analyses using single nucleotide polymorphisms(SNPs) and haplotypes in family-based genetic study have come into the spotlight. In binary trait, the classic transmission disequilibrium test(TDT) can only be applied if genetic information of parents and their offspring is available. However, in case of diseases having a late age of onset such as dementia, the TDT cannot be applied due to the fact that parental genotype data are unavailable. For this reason, alternate methods using genetic sib information instead of parental genotype data are proposed. In this study, methods using genetic sib information are reviewed and power of analysis tests is also compared throughout simulation experiment.
Keywords
Genetic association; TDT; SNP; simulation;
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Times Cited By KSCI : 2  (Citation Analysis)
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